NIC Workshop 2006, From Computational Biophysics to Systems Biology, (2009)
Faruck Morcos, Mike Boxem, Niels Klitgord, Marc Vidal, Jesús A. Izaguirre, Jan Meinke, ...
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An empirical framework for binary interactome mapping (2009)
Venkatesan, Kavitha, Rual, Jean-Francois, Vazquez, Alexei, Stelzl, Ulrich, Lemmens, Irma, Hirozane-Kishikawa, Tomoko, ...
Several attempts have been made to systematically map protein-protein interaction, or 'interactome', networks. However, it remains difficult to assess the quality and coverage of existing data sets....
Simonis, Nicolas, Rual, Jean-Francois, Carvunis, Anne-Ruxandra, Tasan, Murat, Lemmens, Irma, Hirozane-Kishikawa, Tomoko, ...
Abstract: To provide accurate biological hypotheses and elucidate global properties of cellular networks, systematic identification of protein-protein interactions must meet high quality standards....
Prediction of domain interactions in C. elegans (2008)
Faruck Morcos, Mike Boxem, Niels Klitgord, Marc Vidal, Jesús A. Izaguirre
High throughput experiments and computational methods allow the elucidation of networks of protein-protein interactions (PPI) in several organisms. Since about 80 % of all proteins consist of...
A protein domain-based interactome network for C. elegans early embryogenesis (2008)
Boxem, Mike, Maliga, Zoltan, Klitgord, Niels, Li, Na, Lemmens, Irma, Mana, Miyeko, ...
Many protein-protein interactions are mediated through independently folding modular domains. Proteome-wide efforts to model protein-protein interaction or "interactome" networks have largely ignored...
Novel insights into RNAi off-target effects using C. elegansparalogs (2007)
Rual, Jean-François, Klitgord, Niels, Achaz, Guillaume
Abstract Background In the few years since its discovery, RNAi has turned into a very powerful tool for the study of gene function by allowing post-transcriptional gene silencing. The RNAi mechanism,...
Intrinsic Disorder Is a Common Feature of Hub Proteins from Four Eukaryotic Interactomes (2006)
Chad Haynes, Christopher J. Oldfield, Fei Ji, Niels Klitgord, Michael E. Cusick, Predrag Radivojac, ...
Recent proteome-wide screening approaches have provided a wealth of information about interacting proteins in various organisms. To test for a potential association between protein connectivity and...
Intrinsic Disorder is a Common Feature of Hub Proteins from Four Eukaryotic Interactomes (2006)
Chad Haynes, Christopher J Oldfield, Fei Ji, Niels Klitgord, Michael E Cusick, Predrag Radivojac, ...
Recent proteome-wide screening approaches have provided a wealth of information about interacting proteins in various organisms. To test for a potential association between protein connectivity and...
Interactome: Gateway into systems biology (2005)
Cusick, Michael, Klitgord, Niels, Vidal, Marc, Hill, David E.
Protein-protein interactions are fundamental to all biological processes, and a comprehensive determination of all protein-protein interactions that can take place in an organism provides a framework...
Adult Myogenesis in Drosophila melanogaster Can Proceed Independently of Myocyte Enhancer Factor-2
Baker, Phillip W., Tanaka, Kathleen K. Kelly, Klitgord, Niels, Cripps, Richard M.
Myocyte enhancer factor-2 (MEF2) is a transcription factor that is necessary for embryonic muscle development in Drosophila and vertebrates; however, whether this factor is required during later...
Intrinsic Disorder Is a Common Feature of Hub Proteins from Four Eukaryotic Interactomes
Haynes, Chad, Oldfield, Christopher J, Ji, Fei, Klitgord, Niels, Cusick, Michael E, Radivojac, Predrag, ...
Recent proteome-wide screening approaches have provided a wealth of information about interacting proteins in various organisms. To test for a potential association between protein connectivity and...
Adult Myogenesis in Drosophila melanogaster Can Proceed Independently of Myocyte Enhancer Factor-2
Baker, Phillip W., Tanaka, Kathleen K. Kelly, Klitgord, Niels, Cripps, Richard M.
Myocyte enhancer factor-2 (MEF2) is a transcription factor that is necessary for embryonic muscle development in Drosophila and vertebrates; however, whether this factor is required during later...
Intrinsic Disorder Is a Common Feature of Hub Proteins from Four Eukaryotic Interactomes
Haynes, Chad, Oldfield, Christopher J, Ji, Fei, Klitgord, Niels, Cusick, Michael E, Radivojac, Predrag, ...
Recent proteome-wide screening approaches have provided a wealth of information about interacting proteins in various organisms. To test for a potential association between protein connectivity and...