Nigel P. Groome

Human fetal testis Leydig cell disruption by exposure to the pesticide dieldrin at low concentrations (2007)

Fowler, Paul A., Abramovich, David R., Haites, Neva E., Cash, Phillip, Groome, Nigel P., Al-Qahtani, Ahmed, ...

BACKGROUND Declining human reproductive health over the last 60 years has been proposed to be due to effects of environmental chemicals, especially endocrine disrupting compounds, on fetal...

Cell-specific expression of βC-activin in the rat reproductive tract, adrenal and liver (2004)

Gold, Elspeth J., O'Bryan, Moira K., Mellor, Sally L., Cranfield, Mark, Risbridger, Gail P., Groome, Nigel P., ...

BetaC-activin expression was assessed in rat tissues, using reverse transcription and real-time polymerase chain reaction, Western blotting and immunohistochemistry with a specific monoclonal...

Cell-specific expression of βC-activin in the rat reproductive tract, adrenal and liver (2004)

Gold, Elspeth J., O'Bryan, Moira K., Mellor, Sally L., Cranfield, Mark, Risbridger, Gail P., Groome, Nigel P., ...

BetaC-activin expression was assessed in rat tissues, using reverse transcription and real-time polymerase chain reaction, Western blotting and immunohistochemistry with a specific monoclonal...

Cell-specific expression of βC-activin in the rat reproductive tract, adrenal and liver (2004)

Gold, Elspeth J., O'Bryan, Moira K., Mellor, Sally L., Cranfield, Mark, Risbridger, Gail P., Groome, Nigel P., ...

BetaC-activin expression was assessed in rat tissues, using reverse transcription and real-time polymerase chain reaction, Western blotting and immunohistochemistry with a specific monoclonal...

Anti-Mullerian hormone expression pattern in the human ovary: potential implications for initial and cyclic follicle recruitment (2004)

Weenen, Christien, Laven, Joop S.E., Cranfield, Mark, Groome, Nigel P., Visser, Jenny A., ...

Anti‐Müllerian hormone (AMH) is a member of the transforming growth factor‐β superfamily, which plays an important role in both ovarian primordial follicle recruitment and dominant...

Ovarian Dynamics and Their Associations with Peripheral Concentrations of Gonadotropins, Ovarian Steroids, and Inhibin During the Estrous Cycle in Goats1 (2003)

Mohamed S. Medan, Gen Watanabe, Kazuaki Sasaki, Sayed Sharawy, Nigel P. Groome, Kazuyoshi Taya

Ovarian changes determined by daily transrectal ultrasound and its relationship with FSH, LH, estradiol-17β, progesterone, and inhibin were investigated in six goats for three consecutive...

Oocyte-Mediated Suppression of Follicle-Stimulating Hormone- and Insulin-Like Growth Factor-Induced Secretion of Steroids and Inhibin-Related Proteins by Bovine Granulosa Cells In Vitro: Possible Role of Transforming Growth Factor α1 (2003)

Claire Glister, Nigel P. Groome, Philip G. Knight

The objective was to investigate the potential role of the oocyte in modulating proliferation and basal, FSH-induced and insulin-like growth factor (IGF)-induced secretion of inhibin A (inh A),...

Localization and Secretion of Inhibins in the Equine Fetal Ovaries1 (2003)

Yumiko Tanaka, Hiroyuki Taniyama, Nobuo Tsunoda, Chandana B. Herath, Rie Nakai, Hiromi Shinbo, ...

To clarify the source of inhibins in equine female fetuses, concentrations of immunoreactive (ir-) inhibin, inhibin pro-αC, and inhibin A in both fetal and maternal circulation and in fetal ovaries...

Changes in activin and activin receptor subunit expression in rat liver during the development of CCl4-induced cirrhosis (2003)

Gold, Elspeth J., Francis, Richard J.B., Zimmermann, Arthur, Mellor, Sally L., Cranfield, Mark, Risbridger, Gail P., ...

Amounts of betaA-activin, betaC-activin, activin receptor subunits ActRIIA and ActRIIB mRNA, and betaA- and betaC-activin subunit protein immunoreactivity were investigated in male Lewis rats, either...

Changes in activin and activin receptor subunit expression in rat liver during the development of CCl4-induced cirrhosis (2003)

Gold, Elspeth J., Francis, Richard J.B., Zimmermann, Arthur, Mellor, Sally L., Cranfield, Mark, Risbridger, Gail P., ...

Amounts of betaA-activin, betaC-activin, activin receptor subunits ActRIIA and ActRIIB mRNA, and betaA- and betaC-activin subunit protein immunoreactivity were investigated in male Lewis rats, either...

Changes in activin and activin receptor subunit expression in rat liver during the development of CCl4-induced cirrhosis (2003)

Gold, Elspeth J., Francis, Richard J.B., Zimmermann, Arthur, Mellor, Sally L., Cranfield, Mark, Risbridger, Gail P., ...

Amounts of betaA-activin, betaC-activin, activin receptor subunits ActRIIA and ActRIIB mRNA, and betaA- and betaC-activin subunit protein immunoreactivity were investigated in male Lewis rats, either...

Growth Differentiation Factor 9 and Bone Morphogenetic Protein 15 Are Essential for Ovarian Follicular Development in Sheep1 (2002)

Jennifer L. Juengel, Norma L. Hudson, Derek A. Heath, Peter Smith, Karen L. Reader, Steve B. Lawrence, ...

The aim of this study was to test the hypothesis that both growth differential factor 9 (GDF9) and bone morphogenetic protein (BMP15; also known as GDF9B) are essential for normal ovarian follicular...

Women with poor response to IVF have lowered circulating gonadotrophin surge-attenuating factor (GnSAF) bioactivity during spontaneous and stimulated cycles (2002)

Martinez, Francisca, Barri, P.N., Coroleu, B., Tur, R., Sorsa-Leslie, Tarja, Harris, William J., ...

BACKGROUND: Up to 13% of IVF cancellations are due to poor responses during down-regulated cycles. Because premature luteinization occurs more frequently in older or `poor responder' patients,...

Circulating follistatin concentrations are higher and activin concentrations are lower in polycystic ovarian syndrome (2001)

Norman, Robert J., Milner, Clyde R., Groome, Nigel P., Robertson, David M.

Familial polycystic ovarian syndrome (PCOS) has been proposed to be linked to a site near the follistatin gene. We studied the concentrations of circulating follistatin, activin A and inhibin B in...

Maternal serum inhibin A concentrations in early pregnancy after IVF and embryo transfer reflect the corpus luteum contribution and pregnancy outcome (2000)

Treetampinich, Chatchai, O'Connor, Anne E., MacLachlan, Vivien, Groome, Nigel P., De Kretser, David M.

To compare maternal serum inhibin A concentrations in early pregnancy with pregnancy outcomes and treatment protocols, serum samples were collected from 237 women undergoing in-vitro fertilization...

Dose-finding study of oral desogestrel with testosterone pellets for suppression of the pituitary-testicular axis in normal men (2000)

Martin, Cameron W., Riley, Simon C., Everington, Dawn, Groome, Nigel P., Riemersma, Rudolph A., Baird, David T., ...

Prototype hormonal male contraceptive regimens generally achieve only incomplete suppression to azoospermia with potentially adverse metabolic effects. We have carried out a short-term dose-finding...

Changes in serum inhibin, activin and follistatin concentrations during puberty in girls (2000)

Foster, Carol M., Phillips, David J., Wyman, Tammy, Evans, Lee W., Groome, Nigel P., Padmanabhan, Vasantha

Serum concentrations of inhibin A, inhibin B, activin A and follistatin were determined using two-site enzyme-linked immunosorbent assays (ELISA) during pubertal ovarian development in 28 girls and...

Production of inhibin forms by the fetal membranes, decidua, placenta and fetus at parturition (2000)

Riley, Simon C., Leask, Rosemary, Balfour, Claire, Brennand, Janet E., Groome, Nigel P.

Inhibins are regulators of paracrine and endocrine function during pregnancy, but their intrauterine sites of secretion are not well established. In amniotic fluid, inhibin A-, inhibin B- and inhibin...

Inhibin in extra-embryonic coelomic and amniotic fluids and maternal serum in early pregnancy (1996)

Riley, Simon C., Wathen, Neville C., Chard, Tim, Groome, Nigel P., Wallace, Euan M.

Inhibins are present in maternal serum during pregnancy. However, the presence of inhibins in the compartments surrounding the fetus in early pregnancy is not well defined. Using novel specific...