Domain-Oriented Reduction of Rule-Based Network Models (2008)
Borisov, Nikolay M., Chistopolsky, Alexander S., Faeder, James R., Kholodenko, Boris N.
The coupling of membrane-bound receptors to transcriptional regulators and other effector functions is mediated by multi-domain proteins that form complex assemblies. The modularity of protein...
Borisov, Nikolay M., Markevitch, Nick I., Hoek, Jan B., Kholodenko, Boris N.
Membrane receptors and proteins involved in signal transduction display numerous binding domains and operate as molecular scaffolds generating a variety of parallel reactions and protein complexes....
Signaling through Receptors and Scaffolds: Independent Interactions Reduce Combinatorial Complexity
Borisov, Nikolay M., Markevich, Nick I., Hoek, Jan B., Kholodenko, Boris N.
After activation, many receptors and their adaptor proteins act as scaffolds displaying numerous docking sites and engaging multiple targets. The consequent assemblage of a variety of protein...
Signaling through Receptors and Scaffolds: Independent Interactions Reduce Combinatorial Complexity
Borisov, Nikolay M., Markevich, Nick I., Hoek, Jan B., Kholodenko, Boris N.
After activation, many receptors and their adaptor proteins act as scaffolds displaying numerous docking sites and engaging multiple targets. The consequent assemblage of a variety of protein...