Curating Genetic Association Literature for Common Diseases (2009)
Elana Silver, Eran Halperin, Kord M. Kober, Badri Padhukasahasram, Nila Patil, Michelle Sommargren, ...
Papers describing genetic associations with common diseases are currently being published at a rapid rate. These new papers add to an already large body of literature which includes candidate gene...
Fine-scale recombination patterns differ between chimpanzees and humans (2005)
Ptak, Susan E., Hinds, David A., Koehler, Kathrin, Nickel, Birgit, Patil, Nila, Ballinger, Dennis G., ...
Frazer, Kelly A., Wade, Claire M., Hinds, David A., Patil, Nila, Cox, David R., Daly, Mark J.
High-density SNP screening of panels of inbred mouse strains has been proposed as a method to accelerate the identification of genes associated with complex biomedical phenotypes. To evaluate the...
Genomic DNA Insertions and Deletions Occur Frequently Between Humans and Nonhuman Primates (2003)
Frazer, Kelly A., Chen, Xiyin, Hinds, David A., Pant, P.V. Krishna, Patil, Nila, Cox, David R.
Genomic DNA Insertions and Deletions Occur Frequently Between Humans and Nonhuman Primates (2003)
Frazer, Kelly A., Chen, Xiyin, Hinds, David A., Pant, P.V. Krishna, Patil, Nila, Cox, David R.
Comparative DNA sequence studies between humans and nonhuman primates will be important for understanding the genetic basis of the phenotypic differences between these species. Here we compare ∼27...
Naef, Felix, Hacker, Coleen R, Patil, Nila, Magnasco, Marcelo
Abstract Background High-density oligonucleotide arrays (HDONAs) are a powerful tool for assessing differential mRNA expression levels. To establish the statistical significance of an observed change...
Naef, Felix, Hacker, Coleen R, Patil, Nila, Magnasco, Marcelo
Abstract Background High-density oligonucleotide microarrays provide a powerful tool for assessing differential mRNA expression levels. Characterizing the noise resulting from the enzymatic and...
DNA hybridization to mismatched templates: a chip study (2001)
Naef, Felix, Lim, Daniel A., Patil, Nila, Magnasco, Marcelo
High-density oligonucleotide arrays are among the most rapidly expanding technologies in biology today. In the {\sl GeneChip} system, the reconstruction of the target concentration depends upon the...
From features to expression: High-density oligonucleotide array analysis revisited (2001)
Naef, Felix, Lim, Daniel A., Patil, Nila, Magnasco, Marcelo O.
One of the most popular tools for large scale gene expression studies are high-density oligonucleotide (GeneChip(R)) arrays. These currently have 16-20 small probe cells (``features'') for evaluating...
Sequence Diversity in Genes of Lipid Metabolism (2001)
Garcia, Christine Kim, Mues, Gabriele, Liao, Yuanlan, Hyatt, Tommy, Patil, Nila, Cohen, Jonathan C., ...
Evolutionarily Conserved Sequences on Human Chromosome 21 (2001)
Frazer, Kelly A., Sheehan, John B., Stokowski, Renee P., Chen, Xiyin, Hosseini, Roya, Cheng, Jan-Fang, ...
Genome-wide Detection of Allelic Imbalance Using Human SNPs and High-density DNA Arrays (2000)
Mei, Rui, Galipeau, Patricia C., Prass, Cynthia, Berno, Anthony, Ghandour, Ghassan, Patil, Nila, ...
A transcript map of the Down syndrome critical region on chromosome 21 (1994)
Peterson, Andrew, Patil, Nila, Robbins, Carolyn, Wang, Lisa, Cox, David R., Myers, Richard M.
A catalogue of the genes encoded by chromosome 21 would provide a framework for assigning roles in the etiology of Down syndrome (DS) to individual genes. We have begun generating such a catalogue,...
A high resolution physical map of 2.5 Mbp of the Down syndrome region on chromosome 21 (1994)
Patil, Nila, Peterson, Andrew, Rothman, Alana, Jong, Pieter J.de, Myers, Richard M., Cox, David R.
The region surrounding D21S55 in band 21q22 of human chromosome 21 has been implicated in the etiology of Down syndrome (DS). In this paper, we report the construction of a high resolution map of a...
Sequence Diversity in Genes of Lipid Metabolism
Garcia, Christine Kim, Mues, Gabriele, Liao, Yuanlan, Hyatt, Tommy, Patil, Nila, Cohen, Jonathan C., ...
Elevated plasma lipoprotein levels play a crucial role in the development of coronary artery disease. Genetic factors strongly influence the levels of plasma lipoproteins, but the genes and sequence...
Evolutionarily Conserved Sequences on Human Chromosome 21
Frazer, Kelly A., Sheehan, John B., Stokowski, Renee P., Chen, Xiyin, Hosseini, Roya, Cheng, Jan-Fang, ...
Comparison of human sequences with the DNA of other mammals is an excellent means of identifying functional elements in the human genome. Here we describe the utility of high-density oligonucleotide...
Genomic DNA Insertions and Deletions Occur Frequently Between Humans and Nonhuman Primates
Frazer, Kelly A., Chen, Xiyin, Hinds, David A., Pant, P.V. Krishna, Patil, Nila, Cox, David R.
Comparative DNA sequence studies between humans and nonhuman primates will be important for understanding the genetic basis of the phenotypic differences between these species. Here we compare ∼27...
Frazer, Kelly A., Wade, Claire M., Hinds, David A., Patil, Nila, Cox, David R., Daly, Mark J.
High-density SNP screening of panels of inbred mouse strains has been proposed as a method to accelerate the identification of genes associated with complex biomedical phenotypes. To evaluate the...
Sequence Diversity in Genes of Lipid Metabolism
Garcia, Christine Kim, Mues, Gabriele, Liao, Yuanlan, Hyatt, Tommy, Patil, Nila, Cohen, Jonathan C., ...
Elevated plasma lipoprotein levels play a crucial role in the development of coronary artery disease. Genetic factors strongly influence the levels of plasma lipoproteins, but the genes and sequence...
Evolutionarily Conserved Sequences on Human Chromosome 21
Frazer, Kelly A., Sheehan, John B., Stokowski, Renee P., Chen, Xiyin, Hosseini, Roya, Cheng, Jan-Fang, ...
Comparison of human sequences with the DNA of other mammals is an excellent means of identifying functional elements in the human genome. Here we describe the utility of high-density oligonucleotide...
Genomic DNA Insertions and Deletions Occur Frequently Between Humans and Nonhuman Primates
Frazer, Kelly A., Chen, Xiyin, Hinds, David A., Pant, P.V. Krishna, Patil, Nila, Cox, David R.
Comparative DNA sequence studies between humans and nonhuman primates will be important for understanding the genetic basis of the phenotypic differences between these species. Here we compare ∼27...
Frazer, Kelly A., Wade, Claire M., Hinds, David A., Patil, Nila, Cox, David R., Daly, Mark J.
High-density SNP screening of panels of inbred mouse strains has been proposed as a method to accelerate the identification of genes associated with complex biomedical phenotypes. To evaluate the...
Matching Strategies for Genetic Association Studies in Structured Populations
Hinds, David A., Stokowski, Renee P., Patil, Nila, Konvicka, Karel, Kershenobich, David, Cox, David R., ...
Association studies in populations that are genetically heterogeneous can yield large numbers of spurious associations if population subgroups are unequally represented among cases and controls. This...