Bartuma, Hammurabi, Panagopoulos, Ioannis, Collin, Anna, Trombetta, Domenico, Domanski, Henryk A, Mandahl, Nils, ...
Abstract Background The HMGA2 gene encodes a protein that alters chromatin structure. Deregulation, typically through chromosomal rearrangements, of HMGA2 has an important role in the development of...
Tiling resolution array comparative genomic hybridization analysis of a fibrosarcoma of bone. (2007)
Hallor, Karolin H, Heidenblad, Markus, Brosjo, Otte, Mandahl, Nils, Mertens, Fredrik
Abstract is not available
Bartuma, Hammurabi, Hallor, Karolin H, Panagopoulos, Ioannis, Collin, Anna, Rydholm, Anders, Gustafson, Pelle, ...
Abstract is not available
Persson, Oscar, Krogh, Morten, Saal, Lao, Englund, Elisabet, Liu, Jian, Parsons, Ramon, ...
Abstract is not available
Unstable translocation (8;22) in a case of giant cell reparative granuloma. (2007)
Johnsson, Anna, Collin, Anna, Rydholm, Anders, Domanski, Henryk A, Mertens, Fredrik, Mandahl, Nils
Abstract is not available
Comparison of the proximal promoter regions of the PAX3 and PAX7 genes. (2007)
Moller, Emely, Isaksson, Margareth, Mandahl, Nils, Mertens, Fredrik, Panagopoulos, Ioannis
Abstract is not available
Molecular identification of COL6A3-CSF1 fusion transcripts in tenosynovial giant cell tumors. (2007)
Moller, Emely, Mandahl, Nils, Mertens, Fredrik, Panagopoulos, Ioannis
Abstract is not available
Panagopoulos, Ioannis, Mandahl, Nils, Mertens, Fredrik, ...
Subungual exostosis is a benign bone- and cartilage-producing tumor occurring in the hands and feet of children and young adults. The recent identification of a recurrent chromosomal translocation...
Successful treatment of a child with t(15;19)-positive tumor. (2006)
Mertens, Fredrik, Wiebe, Thomas, Adlercreutz, Catharina, Mandahl, Nils, French, Christopher A
Abstract is not available
Characterization of the native CREB3L2 transcription factor and the FUS/CREB3L2 chimera. (2006)
Panagopoulos, Ioannis, Moller, Emely, Dahlén, Anna, Isaksson, Margareth, Mandahl, Nils, Vlamis-Gardikas, Alexios, ...
Abstract is not available
Fusion genes in angiomatoid fibrous histiocytoma. (2006)
Hallor, Karolin H, Micci, Francesca, Meis-Kindblom, Jeanne M, Kindblom, Lars-Gunnar, Bacchini, Patrizia, Mandahl, Nils, ...
Abstract is not available
Fletcher, Christopher D M, Antonescu, Cristina R, Coindre, Jean-Michel, Colecchia, Maurizio, Domanski, Henryk A, ...
Low-grade fibromyxoid sarcoma (LGFMS) is an indolent, late-metastasizing malignant soft-tissue tumor that is often mistaken for either more benign or more malignant tumor types. Cytogenetic analyses...
Panagopoulos, Ioannis, Mertens, Fredrik, Isaksson, Margareth, Mandahl, Nils
Abstract is not available
Mertens, Fredrik, Fletcher, Christopher D M, Antonescu, Cristina R, Coindre, Jean-Michel, Colecchia, Maurizio, Domanski, Henryk A, ...
Abstract is not available
Atypical lipomatous tumor with rare structural rearrangements involving chromosomes 8 and 12. (2005)
Nilsson, Malin, Domanski, Henryk, Mertens, Fredrik, Mandahl, Nils
Abstract is not available
Stewénius, Ylva, Gorunova, Ludmila, Jonson, Tord, Larsson, Nina, Höglund, Mattias, Mandahl, Nils, ...
Abstract is not available
Höglund, Mattias, Gisselsson, David, Mandahl, Nils, Mitelman, Felix
Abstract is not available
Hallor, Karolin Hansén, Mertens, Fredrik, Jin, Yuesheng, Meis-Kindblom, Jeanne M, Kindblom, Lars-Gunnar, Behrendtz, Mikael, ...
Abstract is not available
Fusion of the SEC31L1 and ALK genes in an inflammatory myofibroblastic tumor. (2005)
Panagopoulos, Ioannis, Nilsson, Therese, Domanski, Henryk A, Isaksson, Margareth, Lindblom, Pia, Mertens, Fredrik, ...
Abstract is not available
Gene expression profiles relate to SS18/SSX fusion type in synovial sarcoma. (2005)
Fernebro, Josefin, Francis, Princy, Edén, Patrik, Borg, Ake, Panagopoulos, Ioannis, Mertens, Fredrik, ...
Abstract is not available
Surace, Cecilia, Storlazzi, Clelia, Engellau, Jacob, Domanski, Henryk, Gustafson, Pelle, Panagopoulos, Ioannis, ...
Abstract is not available
Prognostic Significance of Chromosome Aberrations in High-Grade Soft Tissue Sarcomas. (2005)
Mertens, Fredrik, Stromberg, Ulf, Rydholm, Anders, Gustafson, Pelle, Bauer, Henrik C F, Brosjo, Otte, ...
Abstract is not available
Fletcher, Christopher D M, Mertens, Fredrik, Fletcher, Jonathan A, Perez-Atayde, Antonio R, Hicks, M John, ...
Activation of the GLI oncogene is an important step in the sonic hedgehog signaling pathway, and leads to, eg, tissue-specific cell proliferation during embryogenesis. GLI activity in adult tissues...
Amplification of chromosome 1 sequences in lipomatous tumors and other sarcomas. (2004)
Nilsson, Malin, Meza-Zepeda, Leonardo A, Mertens, Fredrik, Forus, Anne, Myklebost, Ola, Mandahl, Nils
Abstract is not available
Mitotic instability associated with late genomic changes in bone and soft tissue tumours. (2004)
Gisselsson, David, Pålsson, Eva, Yu, Christina, Mertens, Fredrik, Mandahl, Nils
Abstract is not available
Dahlén, Anna, Fletcher, Christopher D M, Mertens, Fredrik, Fletcher, Jonathan A, Perez-Atayde, Antonio R, Hicks, M John, ...
Abstract is not available
The chimeric FUS/CREB3l2 gene is specific for low-grade fibromyxoid sarcoma. (2004)
Panagopoulos, Ioannis, Tiziana Storlazzi, Clelia, Fletcher, Christopher D M, Fletcher, Jonathan A, Nascimento, Antonio, Domanski, Henryk A, ...
Abstract is not available
A novel FISH assay for SS18-SSX fusion type in synovial sarcoma. (2004)
Surace, Cecilia, Panagopoulos, Ioannis, Pålsson, Eva, Rocchi, Mariano, Mandahl, Nils, Mertens, Fredrik
Abstract is not available
Panagopoulos, Ioannis, Mertens, Fredrik, Isaksson, Margareth, Mandahl, Nils
Abstract is not available
Combined binary ratio labeling fluorescence in situ hybridization analysis of chordoma. (2004)
Kuźniacka, Alina, Mertens, Fredrik, Strömbeck, Bodil, Wiegant, Joop, Mandahl, Nils
Abstract is not available
Nilsson, Malin, Domanski, Henryk A, Mertens, Fredrik, Mandahl, Nils
Abstract is not available
Molecular genetic characterization of the genomic ACTB-GLI fusion in pericytoma with t(7;12). (2004)
Dahlén, Anna, Mertens, Fredrik, Mandahl, Nils, Panagopoulos, Ioannis
Abstract is not available
Clustering of deletions on chromosome 13 in benign and low-malignant lipomatous tumors (2003)
Pedeutour, Florence, Domanski, Henryk A, Höglund, Mattias, Bauer, Henrik C F, ...
Deletions and structural rearrangements of the long arm of chromosome 13 are frequently observed in benign and low-malignant lipomatous tumors, but nothing is known about their molecular genetic...
Clustering of deletions on chromosome 13 in benign and low-malignant lipomatous tumors. (2003)
Dahlén, Anna, Debiec-Rychter, Maria, Pedeutour, Florence, Domanski, Henryk A, Höglund, Mattias, Bauer, Henrik C F, ...
Abstract is not available
A novel fusion gene, SS18L1/SSX1, in synovial sarcoma. (2003)
Storlazzi, Clelia Tiziana, Mertens, Fredrik, Mandahl, Nils, Gisselsson, David, Isaksson, Margareth, Gustafson, Pelle, ...
Abstract is not available
Fusion of the FUS and BBF2H7 genes in low grade fibromyxoid sarcoma. (2003)
Storlazzi, Clelia Tiziana, Mertens, Fredrik, Nascimento, Antonio, Isaksson, Margareth, Wejde, Johan, Brosjo, Otte, ...
Abstract is not available
Fusion, disruption, and expression of HMGA2 in bone and soft tissue chondromas. (2003)
Dahlén, Anna, Mertens, Fredrik, Rydholm, Anders, Brosjö, Otte, Wejde, Johan, Mandahl, Nils, ...
Abstract is not available
Fusion of the FUS and BBF2H7 genes in low grade fibromyxoid sarcoma (2003)
Storlazzi, Clelia Tiziana, Mertens, Fredrik, Nascimento, Antonio, Isaksson, Margareth, Wejde, Johan, Brosjö, Otte, ...
The FUSgene at 16p11 fuses with DDIT3and ATF1 as the result of translocations with chromosome band 12q13 in myxoid liposarcoma and angiomatoid fibrous histiocytoma, respectively, and with ERG as the...
Fusion of the FUS and BBF2H7 genes in low grade fibromyxoid sarcoma (2003)
Storlazzi, Clelia Tiziana, Mertens, Fredrik, Nascimento, Antonio, Isaksson, Margareth, Wejde, Johan, Brosjö, Otte, ...
The FUS gene at 16p11 fuses with DDIT3 and ATF1 as the result of translocations with chromosome band 12q13 in myxoid liposarcoma and angiomatoid fibrous histiocytoma, respectively, and with ERG as...
Fusion of the FUS and BBF2H7 genes in low grade fibromyxoid sarcoma (2003)
Storlazzi, Clelia Tiziana, Mertens, Fredrik, Nascimento, Antonio, Isaksson, Margareth, Wejde, Johan, Brosjö, Otte, ...
The FUSgene at 16p11 fuses with DDIT3and ATF1 as the result of translocations with chromosome band 12q13 in myxoid liposarcoma and angiomatoid fibrous histiocytoma, respectively, and with ERG as the...
Mertens, Fredrik, Isaksson, Margareth, Domanski, Henryk A, Brosjö, Otte, Heim, Sverre, ...
Extraskeletal myxoid chondrosarcoma (EMC) is a soft-tissue neoplasm cytogenetically characterized by the translocations t(9;22)(q22;q11-12) or t(9;17)(q22;q11), generating EWS/CHN or RBP56/CHN fusion...
Strömberg, Ulf, Mandahl, Nils, Fletcher, Christopher D M, ...
Cytogenetic analysis has not only provided important information on the pathogenesis of soft tissue tumors but, by disclosing distinct chromosomal rearrangements in different histopathological...
Mertens, Fredrik, Isaksson, Margareth, Limon, Janusz, Kardas, Iwona, ...
Clear cell sarcoma (CCS) is a rare malignant soft tissue tumor particularly associated with tendons and aponeuroses. The cytogenetic hallmark is the translocation t(12;22)(q13;q12) resulting in a...
Fadl-Elmula, Imad, Kytola, Soili, Leithy, Mona EL, Abdel-Hameed, Mohamed, Mandahl, Nils, Elagib, Atif, ...
Abstract Background Bilharzia-associated bladder cancer (BAC) is a major health problem in countries where urinary schistosomiasis is endemic. Characterization of the genetic alterations in this...
Differentially amplified chromosome 12 sequences in low- and high-grade osteosarcoma (2002)
Pålsson, Eva, Höglund, Mattias, Domanski, Henryk, Mertens, Fredrik, Pandis, Nikos, ...
Most osteosarcomas are highly aggressive malignancies characterized by a complex pattern of chromosome abnormalities. However, a subgroup of low-grade, parosteal tumors exhibits a relatively simple...
Dorfman, Howard, Brys, Peter, Fletcher, Christopher D M, ...
The evaluation of chondroid lesions requires full integration of clinical, radiographic, and pathological data; tumour typing is often a challenge for the diagnostic pathologist. Although a variety...
Cytogenetic aberrations and their prognostic impact in chondrosarcoma. (2002)
Mandahl, Nils, Gustafson, Pelle, Mertens, Fredrik, Akerman, Måns, Baldetorp, Bo, Gisselsson, David, ...
Chondrosarcoma is the second most common primary malignancy of bone. Cytogenetic data are available from close to 100 cases, including all subtypes of chondrosarcoma. Specific chromosomal...
Differentially amplified chromosome 12 sequences in low- and high-grade osteosarcoma. (2002)
Gisselsson, David, Pålsson, Eva, Höglund, Mattias, Domanski, Henryk, Mertens, Fredrik, Pandis, Nikos, ...
Most osteosarcomas are highly aggressive malignancies characterized by a complex pattern of chromosome abnormalities. However, a subgroup of low-grade, parosteal tumors exhibits a relatively simple...
Fadl-Elmula, Imad, Kytola, Soili, Leithy, Mona, Abdel-Hameed, Mohamed, Mandahl, Nils, Elagib, Atif, ...
BACKGROUND: Bilharzia-associated bladder cancer (BAC) is a major health problem in countries where urinary schistosomiasis is endemic. Characterization of the genetic alterations in this cancer might...
Panagopoulos, Ioannis, Mertens, Fredrik, Dêbiec-Rychter, Maria, Isaksson, Margareth, Limon, Janusz, Kardas, Iwona, ...
Clear cell sarcoma (CCS) is a rare malignant soft tissue tumor particularly associated with tendons and aponeuroses. The cytogenetic hallmark is the translocation t(12;22)(q13;q12) resulting in a...
Broberg, Karin, Zhang, Miao, Strombeck, Bodil, Isaksson, Margareth, Nilsson, Malin, Mertens, Fredrik, ...
Rearrangements of chromosome bands 12q13-15 are frequent in various benign mesenchymal and epithelial tumors, and the gene HMGA2 seems to be the most common target within this chromosome region. In...
Mertens, Fredrik, Strömberg, Ulf, Mandahl, Nils, Cin, Paola Dal, De Wever, Ivo, Fletcher, Christopher D M, ...
Cytogenetic analysis has not only provided important information on the pathogenesis of soft tissue tumors but, by disclosing distinct chromosomal rearrangements in different histopathological...
Panagopoulos, Ioannis, Mertens, Fredrik, Isaksson, Margareth, Domanski, Henryk A, Brosjö, Otte, Heim, Sverre, ...
Extraskeletal myxoid chondrosarcoma (EMC) is a soft-tissue neoplasm cytogenetically characterized by the translocations t(9;22)(q22;q11-12) or t(9;17)(q22;q11), generating EWS/CHN or RBP56/CHN fusion...
Buckley, Patrick G., Mantripragada, Kiran K., Benetkiewicz, Magdalena, Tapia-Páez, Isabel, Diaz De Ståhl, Teresita, Rosenquist, Magnus, ...
Abstract is not available
Buckley, Patrick G., Mantripragada, Kiran K., Benetkiewicz, Magdalena, Tapia-Páez, Isabel, Diaz De Ståhl, Teresita, Rosenquist, Magnus, ...
We have constructed the first comprehensive microarray representing a human chromosome for analysis of DNA copy number variation. This chromosome 22 array covers 34.7 Mb, representing...
Fletcher, Christopher D. M, Mandahl, Nils, Mertens, Fredrik, Mitelman, Felix, ...
Afdeling Oncologische heelkunde. Departement Menselijke erfelijkheid.
Oncogenic conversion of a novel orphan nuclear receptor by chromosome translocation (1995)
Labelle, Yves, Zucman, Jessica, Stenman, Göran, Kindblom, Lars-Gunnar, Knight, Jennifer, Turc-Carel, Claude, ...
A recurrent t(9;22) (q22;q12) chromosome translocation has been described in extraskeletal myxoid chondrosarcoma (EMC). Fluorescent in situ hybridization experiments performed on one EMC tumour...
Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity
Gisselsson, David, Pettersson, Louise, Höglund, Mattias, Heidenblad, Markus, Gorunova, Ludmila, Wiegant, Joop, ...
It has long been known that rearrangements of chromosomes through breakage-fusion-bridge (BFB) cycles may cause variability of phenotypic and genetic traits within a cell population. Because...
Gisselsson, David, Jonson, Tord, Petersén, Åsa, Strömbeck, Bodil, Dal Cin, Paola, Höglund, Mattias, ...
Although mechanisms for chromosomal instability in tumors have been described in animal and in vitro models, little is known about these processes in man. To explore cytogenetic evolution in human...
Fadl-Elmula, Imad, Kytola, Soili, Leithy, Mona EL, Abdel-Hameed, Mohamed, Mandahl, Nils, Elagib, Atif, ...
Stewénius, Ylva, Gorunova, Ludmila, Jonson, Tord, Larsson, Nina, Höglund, Mattias, Mandahl, Nils, ...
Telomere dysfunction has been associated with chromosomal instability in colorectal carcinoma, but the consequences of telomere-dependent instability for chromosome integrity and clonal evolution...
Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity
Gisselsson, David, Pettersson, Louise, Höglund, Mattias, Heidenblad, Markus, Gorunova, Ludmila, Wiegant, Joop, ...
It has long been known that rearrangements of chromosomes through breakage-fusion-bridge (BFB) cycles may cause variability of phenotypic and genetic traits within a cell population. Because...
Gisselsson, David, Jonson, Tord, Petersén, Åsa, Strömbeck, Bodil, Dal Cin, Paola, Höglund, Mattias, ...
Although mechanisms for chromosomal instability in tumors have been described in animal and in vitro models, little is known about these processes in man. To explore cytogenetic evolution in human...
Fadl-Elmula, Imad, Kytola, Soili, Leithy, Mona EL, Abdel-Hameed, Mohamed, Mandahl, Nils, Elagib, Atif, ...
Stewénius, Ylva, Gorunova, Ludmila, Jonson, Tord, Larsson, Nina, Höglund, Mattias, Mandahl, Nils, ...
Telomere dysfunction has been associated with chromosomal instability in colorectal carcinoma, but the consequences of telomere-dependent instability for chromosome integrity and clonal evolution...
Dahlén, Anna, Fletcher, Christopher D. M., Mertens, Fredrik, Fletcher, Jonathan A., Perez-Atayde, Antonio R., Hicks, M. John, ...
Activation of the GLI oncogene is an important step in the sonic hedgehog signaling pathway, and leads to, eg, tissue-specific cell proliferation during embryogenesis. GLI activity in adult tissues...
Wallenius, Ville, Hisaoka, Masanori, Helou, Khalil, Levan, Göran, Mandahl, Nils, Meis-Kindblom, Jeanne M., ...
Enhanced hepatocyte growth factor (HGF) receptor (Met) signaling has been suggested to play an important role in the development and progression of various epithelial and nonepithelial tumors....
Fletcher, Christopher D. M., Dal Cin, Paola, De Wever, Ivo, Mandahl, Nils, Mertens, Fredrik, Mitelman, Felix, ...
Soft-tissue tumors have proved to be a fruitful area for the identification of reproducible cytogenetic aberrations, especially among pediatric round-cell sarcomas and lipomatous tumors. Thus far,...
Gisselsson, David, Höglund, Mattias, Mertens, Fredrik, Dal Cin, Paola, Mandahl, Nils
Hibernomas are benign tumors of brown fat, frequently characterized by aberrations of chromosome band 11q13. In this study, the chromosome 11 changes in five hibernomas were analyzed in detail by...
Abnormal Nuclear Shape in Solid Tumors Reflects Mitotic Instability
Gisselsson, David, Björk, Jonas, Höglund, Mattias, Mertens, Fredrik, Dal Cin, Paola, Åkerman, Måns, ...
Abnormalities in nuclear morphology are frequently observed in malignant tissues but the mechanisms behind these phenomena are still poorly understood. In this study, the relation between abnormal...