Nils Wierup

Characterisation of CART-containing neurons and cells in the porcine pancreas, gastro-intestinal tract, adrenal and thyroid glands (2007)

Wierup, Nils, Gunnarsdóttir, Anna, Ekblad, Eva, Sundler, Frank

Abstract Background The peptide CART is widely expressed in central and peripheral neurons, as well as in endocrine cells. Known peripheral sites of expression include the gastrointestinal (GI)...

beta-cell PDE3B regulates Ca(2+)-stimulated exocytosis of insulin. (2007)

Walz, Helena A, Wierup, Nils, Vikman, Jenny, Manganiello, Vincent C, Degerman, Eva, Eliasson, Lena, ...

Abstract is not available

DPP-4 inhibition improves glucose tolerance and increases insulin and GLP-1 responses to gastric glucose in association with normalized islet topography in mice with beta-cell-specific overexpression of human islet amyloid polypeptide. (2007)

Ahrén, Bo, Winzell, Maria Sorhede, Wierup, Nils, Sundler, Frank, Burkey, Bryan, Hughes, Thomas E

Abstract is not available

Ghrelin and motilin are co-secreted from a prominent endocrine cell population in the small intestine. (2007)

Wierup, Nils, Bjorkqvist, Maria, Westrom, Bjorn, Pierzynowski, Stefan, Sundler, Frank, Sjolund, Kristina

Abstract is not available

Characterisation of CART-containing neurons and cells in the porcine pancreas, gastro-intestinal tract, adrenal and thyroid glands. (2007)

Wierup, Nils, Gunnarsdóttir, Anna, Ekblad, Eva, Sundler, Frank

Abstract is not available

Rat insulin promoter 2-Cre recombinase mice bred onto a pure C57BL/6J background exhibit unaltered glucose tolerance. (2007)

Fex, Malin, Wierup, Nils, Nitert, Marloes Dekker, Ristow, Michael, Mulder, Hindrik

Abstract is not available

Increased metabolism in the R6/2 mouse model of Huntington's disease. (2007)

Bacos, Karl, Wood, Nigel I, Lindqvist, Andreas, Wierup, Nils, Woodman, Ben, ...

Abstract is not available

A Paleolithic diet confers higher insulin sensitivity, lower C-reactive protein and lower blood pressure than a cereal-based diet in domestic pigs (2006)

Jönsson, Tommy, Ahrén, Bo, Pacini, Giovanni, Sundler, Frank, Wierup, Nils, Steen, Stig, ...

Abstract Background A Paleolithic diet has been suggested to be more in concordance with human evolutionary legacy than a cereal based diet. This might explain the lower incidence among...

CART Regulates Islet Hormone Secretion and Is Expressed in the {beta}-Cells of Type 2 Diabetic Rats. (2006)

Wierup, Nils, Bjorkqvist, Maria, Kuhar, Michael J, Mulder, Hindrik, Sundler, Frank

Abstract is not available

Early and rapid development of insulin resistance, islet dysfunction and glucose intolerance after high-fat feeding in mice overexpressing phosphodiesterase 3B. (2006)

Walz, Helena A, Harndahl, Linda, Wierup, Nils, Zmuda-Trzebiatowska, Emilia, Svennelid, Fredrik, Manganiello, Vincent C, ...

Abstract is not available

CART is a novel islet regulatory peptide. (2006)

Wierup, Nils, Sundler, Frank

Abstract is not available

Inflammatory response in white adipose tissue in the non-obese hormone-sensitive lipase null mouse model. (2006)

Hansson, Ola, Strom, Kristoffer, Güner, Nuray, Wierup, Nils, Sundler, Frank, Hoglund, Peter, ...

Abstract is not available

A Paleolithic diet confers higher insulin sensitivity, lower C-reactive protein and lower blood pressure than a cereal-based diet in domestic pigs. (2006)

Jonsson, Tommy, Ahrén, Bo, Pacini, Giovanni, Sundler, Frank, Wierup, Nils, Steen, Stig, ...

Abstract is not available

Neuropeptides and the regulation of islet function. (2006)

Ahrén, Bo, Wierup, Nils, Sundler, Frank

Abstract is not available

Ghrelin and CART. Two new islet peptides. Expression, regulation and function. (2005)

Wierup, Nils

Until recently, the islets of Langerhans were thought to harbour four main cell types characterised with respect to principal hormone product. Here we show that the novel hormone ghrelin is expressed...

Ultrastructure of islet ghrelin cells in the human fetus. (2005)

Wierup, Nils, Sundler, Frank

Abstract is not available

The R6/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient {beta}-cell mass and exocytosis. (2005)

Björkqvist, Maria, Fex, Malin, Renström, Erik, Wierup, Nils, Petersén, Asa, Gil, Joana, ...

Abstract is not available

Reduced ghrelin, IAPP and PYY expression in the stomach of gastrin-cholecystokinin knockout mice. (2005)

Friis-Hansen, Lennart, Wierup, Nils, Rehfeld, Jens F, Sundler, Frank

Abstract is not available

The R6/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient {beta}-cell mass and exocytosis (2005)

Björkqvist, Maria, Fex, Malin, Renström, Erik, Wierup, Nils, Petersén, Åsa, Gil, Joana, ...

Diabetes frequently develops in Huntington's disease (HD) patients and in transgenic mouse models of HD such as the R6/2 mouse. The underlying mechanisms have not been clarified. Elucidating the...

Orexin loss in Huntington's disease (2005)

Petersén, Åsa, Gil, Joana, Björkqvist, Maria, Tanila, Heikki, Araújo, Inês M., ...

Huntington's disease (HD) is a devastating neurodegenerative disorder caused by an expanded CAG repeat in the gene encoding huntingtin, a protein of unknown function. Mutant huntingtin forms...

Beta-cell-targeted overexpression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance and deranged glucose morphology. (2004)

Härndahl, Linda, Wierup, Nils, Enerbäck, Sven, Mulder, Hindrik, Manganiello, Vincent C, Sundler, Frank, ...

Abstract is not available

Loss-of-Function Mutation of the Galanin Gene is Associated with Perturbed Islet Function in Mice. (2004)

Ahren, BO, Pacini, GIOVANNI, Wynick, DAVID, Wierup, NILS, Sundler, FRANK

Abstract is not available

Orexin loss in Huntington's disease. (2004)

Petersén, Asa, Gil, Joana, Maat-Schieman, Marion Lc, Björkqvist, Maria, Tanila, Heikki, Araújo, Ines M, ...

Abstract is not available

Orexin loss in Huntington's disease (2004)

Petersén, Åsa, Gil, Joana, Maat-Schieman, Marion LC, Björkqvist, Maria, Tanila, Heikki, Araújo, Ines M, ...

Huntington's disease is a devastating neurodegenerative disorder caused by an expanded CAG repeat in the gene encoding huntingtin, a protein of unknown function. Mutant huntingtin forms intracellular...

Orexin loss in Huntington's disease (2004)

Petersén, Åsa, Gil, Joana, Maat-Schieman, Marion LC, Björkqvist, Maria, Tanila, Heikki, Araújo, Ines M, ...

Huntington's disease is a devastating neurodegenerative disorder caused by an expanded CAG repeat in the gene encoding huntingtin, a protein of unknown function. Mutant huntingtin forms intracellular...

A Paleolithic diet confers higher insulin sensitivity, lower C-reactive protein and lower blood pressure than a cereal-based diet in domestic pigs

Jönsson, Tommy, Ahrén, Bo, Pacini, Giovanni, Sundler, Frank, Wierup, Nils, Steen, Stig, ...

A Paleolithic diet confers higher insulin sensitivity, lower C-reactive protein and lower blood pressure than a cereal-based diet in domestic pigs

Jönsson, Tommy, Ahrén, Bo, Pacini, Giovanni, Sundler, Frank, Wierup, Nils, Steen, Stig, ...

Characterisation of CART-containing neurons and cells in the porcine pancreas, gastro-intestinal tract, adrenal and thyroid glands

Wierup, Nils, Gunnarsdóttir, Anna, Ekblad, Eva, Sundler, Frank

Phosphodiesterase 3B Is Localized in Caveolae and Smooth ER in Mouse Hepatocytes and Is Important in the Regulation of Glucose and Lipid Metabolism

Berger, Karin, Lindh, Rebecka, Wierup, Nils, Zmuda-Trzebiatowska, Emilia, Lindqvist, Andreas, Manganiello, Vincent C., ...

Cyclic nucleotide phosphodiesterases (PDEs) are important regulators of signal transduction processes mediated by cAMP and cGMP. One PDE family member, PDE3B, plays an important role in the...