Nir Hacohen

Minimizing the risk of reporting false positives in large-scale RNAi screens (2006)

Echeverri, Christophe J, Beachy, Philip A, Baum, Buzz, Boutros, Michael, Buchholz, Frank, Chanda, Sumit K, ...

Large-scale RNA interference (RNAi)-based analyses, very much as other 'omic' approaches, have inherent rates of false positives and negatives. The variability in the standards of care applied to...

Requirement for the NF-kappa B family member Re1A in the development of secondary lymphoid organs (2002)

Alcamo, Elizabeth, Hacohen, Nir, Schulte, Leah C., Rennert, Paul D., Hynes, Richard O., Baltimore, David

The transcription factor nuclear factor (NF)-kappaB has been suggested to be a key mediator of the development of lymph nodes and Peyer's patches. However, targeted deletion of NF-kappaB/ Rel family...

Adaptation and Regulation of the Transduction Mechanism in Vestibular Hair Cells. (1998)

Corey, David P., Assad, John A., Hacohen, Nir, Smith, Wendy J.

The research objectives are to characterize the time and displacement dependence of adaptation in hair cells; to localize the site of action of calcium and determine its calcium specificity; to...

RNA Interference Knockdown of hU2AF35 Impairs Cell Cycle Progression and Modulates Alternative Splicing of Cdc25 Transcripts

Pacheco, Teresa Raquel, Moita, Luís Ferreira, Gomes, Anita Quintal, Hacohen, Nir, Carmo-Fonseca, Maria

U2AF is a heterodimeric splicing factor composed of a large (U2AF65) and a small (U2AF35) subunit. In humans, alternative splicing generates two U2AF35 variants, U2AF35a and U2AF35b. Here, we used...

RNA Interference Knockdown of hU2AF35 Impairs Cell Cycle Progression and Modulates Alternative Splicing of Cdc25 Transcripts

Pacheco, Teresa Raquel, Moita, Luís Ferreira, Gomes, Anita Quintal, Hacohen, Nir, Carmo-Fonseca, Maria

U2AF is a heterodimeric splicing factor composed of a large (U2AF65) and a small (U2AF35) subunit. In humans, alternative splicing generates two U2AF35 variants, U2AF35a and U2AF35b. Here, we used...

Branching morphogenesis in the Drosophila tracheal system /

Hacohen, Nir.

Submitted to the Department of Biochemistry and the Committee on Graduate Studies of Stanford University.

Requirement for the NF-κB Family Member RelA in the Development of Secondary Lymphoid Organs

Alcamo, Elizabeth, Hacohen, Nir, Schulte, Leah C., Rennert, Paul D., Hynes, Richard O., Baltimore, David

The transcription factor nuclear factor (NF)-κB has been suggested to be a key mediator of the development of lymph nodes and Peyer's patches. However, targeted deletion of NF-κB/ Rel family...

Highly parallel identification of essential genes in cancer cells

Luo, Biao, Cheung, Hiu Wing, Subramanian, Aravind, Sharifnia, Tanaz, Okamoto, Michael, Yang, Xiaoping, ...

More complete knowledge of the molecular mechanisms underlying cancer will improve prevention, diagnosis and treatment. Efforts such as The Cancer Genome Atlas are systematically characterizing the...

Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36

Means, Terry K., Mylonakis, Eleftherios, Tampakakis, Emmanouil, Colvin, Richard A., Seung, Edward, Puckett, Lindsay, ...

Receptors involved in innate immunity to fungal pathogens have not been fully elucidated. We show that the Caenorhabditis elegans receptors CED-1 and C03F11.3, and their mammalian orthologues, the...