Atsushi Ohori, Nobuaki Yoshida
This paper denes an extended polymorphic type system for an ML-style programming language, and develops a sound and complete type inference algorithm. Dierent from the conventional ML type...
Morphological Change Caused by Loss of the Taxon-Specific Polyalanine Tract in Hoxd-13 (2007)
Anan, Keiiti, Yoshida, Nobuaki, Kataoka, Yuki, Sato, Mitsuharu, Ichise, Hirotake, Nasu, Makoto, ...
Sequence comparison of Hoxd-13 among vertebrates revealed the presence of taxon-specific polyalanine tracts in amniotes. To investigate their function at the organismal level, we replaced the...
Morphological Change Caused by Loss of the Taxon-Specific Polyalanine Tract in Hoxd-13 (2006)
Anan, Keiiti, Yoshida, Nobuaki, Kataoka, Yuki, Sato, Mitsuharu, Ichise, Hirotake, Nasu, Makoto, ...
Sequence comparison of Hoxd-13 among vertebrates revealed the presence of taxon-specific polyalanine tracts in amniotes. To investigate their function at the organismal level, we replaced the...
Phospholipase C-�1 and-�3 Are Essential in the Trophoblast for Placental Development (2005)
Yoshikazu Nakamura, Yoshio Hamada, Takashi Fujiwara, Hiroko Enomoto, Takeshi Hiroe, Satoshi Tanaka, ...
Phosphoinositide-specific phospholipase C (PLC) is a key enzyme in phosphoinositide turnover and is involved in a variety of physiological functions. We analyzed PLC�1 knockout mice and found that...
Nuclear Mass Dependence of Chaotic Dynamics in Ginocchio Model (1995)
Yoshinaga, Naotaka, Yoshida, Nobuaki, Shigehara, Takaomi, Cheon, Taksu
The chaotic dynamics in nuclear collective motion is studied in the framework of a schematic shell model which has only monopole and quadrupole degrees of freedom. The model is shown to reproduce the...
Lack of tactile pain (allodynia) in lipocalin-type prostaglandin D synthase-deficient mice
Eguchi, Naomi, Minami, Toshiaki, Shirafuji, Naoki, Kanaoka, Yoshihide, Tanaka, Takashi, Nagata, Akihisa, ...
Prostaglandin (PG) D2 is the most abundant prostanoid produced in the central nervous system of mammals and has been implicated in the modulation of neural functions such as sleep induction,...
Hizaki, Hiroko, Segi, Eri, Sugimoto, Yukihiko, Hirose, Masaya, Saji, Tomomi, Ushikubi, Fumitaka, ...
Female mice lacking the gene encoding the prostaglandin (PG) E2 receptor subtype EP2 (EP2−/−) become pregnant and deliver their pups at term, but with a much reduced litter size. A decrease in...
Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality
Takeda, Kiyoshi, Noguchi, Koichi, Shi, Wei, Tanaka, Takashi, Matsumoto, Makoto, Yoshida, Nobuaki, ...
Signal transducer and activator of transcription (STAT) proteins have been shown to mediate biological actions in response to cytokines. Stat3, a member of the STAT family, is activated by a variety...
Nagasawa, Takashi, Nakajima, Toshihiro, Tachibana, Kazunobu, Iizasa, Hisashi, Bleul, Conrad C., Yoshie, Osamu, ...
Pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 (PBSF/SDF-1) is a member of the CXC group of chemokines that is initially identified as a bone marrow stromal cell-derived factor...
Paranodal junction formation and spermatogenesis require sulfoglycolipids
Honke, Koichi, Hirahara, Yukie, Dupree, Jeffrey, Suzuki, Kinuko, Popko, Brian, Fukushima, Kikuro, ...
Mammalian sulfoglycolipids comprise two major members, sulfatide (HSO3-3-galactosylceramide) and seminolipid (HSO3-3-monogalactosylalkylacylglycerol). Sulfatide is a major lipid component of the...
SH2-B Is Required for Both Male and Female Reproduction
Ohtsuka, Satoshi, Takaki, Satoshi, Iseki, Masanori, Miyoshi, Kanta, Nakagata, Naomi, Kataoka, Yuki, ...
Many growth factors and hormones modulate the reproductive status in mammals. Among these, insulin and insulin-like growth factor I (IGF-I) regulate the development of gonadal tissues. SH2-B has been...
Zinc Finger Protein Sall2 Is Not Essential for Embryonic and Kidney Development
Sato, Akira, Matsumoto, Yuko, Koide, Urara, Kataoka, Yuki, Yoshida, Nobuaki, Yokota, Takashi, ...
SALL/Sall is a mammalian homolog of the Drosophila region-specific homeotic gene spalt (sal), and heterozygous mutations in SALL1 in humans lead to Townes-Brocks syndrome. We earlier reported that...
Mammalian Twisted Gastrulation Is Essential for Skeleto-Lymphogenesis
Nosaka, Tetsuya, Morita, Sumiyo, Kitamura, Hidetomo, Nakajima, Hideaki, Shibata, Fumi, Morikawa, Yoshihiro, ...
Dorsoventral patterning depends on the local concentrations of the morphogens. Twisted gastrulation (TSG) regulates the extracellular availability of a mesoderm inducer, bone morphogenetic protein 4...
Phospholipase Cδ1 is required for skin stem cell lineage commitment
Nakamura, Yoshikazu, Fukami, Kiyoko, Yu, Haiyan, Takenaka, Kei, Kataoka, Yuki, Shirakata, Yuji, ...
Phosphoinositide-specific phospholipase C (PLC) is a key enzyme in phosphoinositide turnover and is involved in a variety of physiological functions. Here we report that PLCδ1-deficient mice...
Takenaka, Kei, Fukami, Kiyoko, Otsuki, Makiko, Nakamura, Yoshikazu, Kataoka, Yuki, Wada, Mika, ...
Phospholipase C (PLC) plays important roles in phosphoinositide turnover by regulating the calcium-protein kinase C signaling pathway. PLC-L2 is a novel PLC-like protein which lacks PLC activity,...
Iseki, Masanori, Kubo, Chiyomi, Kwon, Sang-Mo, Yamaguchi, Akiko, Kataoka, Yuki, Yoshida, Nobuaki, ...
APS (adaptor molecule containing PH and SH2 domains) is an intracellular adaptor protein that forms an adaptor family along with Lnk and SH2-B. While experiments using cultured cell lines have...
Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice
Sakurai, Yoshiko, Ohgimoto, Kaori, Kataoka, Yuki, Yoshida, Nobuaki, Shibuya, Masabumi
Flk-1 (human counterpart, KDR) tyrosine kinase, which is one of the two VEGF receptors, is crucial for vascular development. Recently, we showed that, among tyrosine residues of KDR, tyrosine...
Urano, Atsushi, Endoh, Masaki, Wada, Tadashi, Morikawa, Yoshihiro, Itoh, Miyuki, Kataoka, Yuki, ...
AF5q31 (also called MCEF) was identified by its involvement in chromosomal translocation with the gene MLL (mixed lineage leukemia), which is associated with infant acute lymphoblastic leukemia....
Ono, Ryoichi, Ihara, Masafumi, Nakajima, Hideaki, Ozaki, Katsutoshi, Kataoka-Fujiwara, Yuki, Taki, Tomohiko, ...
Septins are evolutionarily conserved GTP-binding proteins that can heteropolymerize into filaments. Recent studies have revealed that septins are involved in not only diverse normal cellular...
Phospholipase C-δ1 and -δ3 Are Essential in the Trophoblast for Placental Development
Nakamura, Yoshikazu, Hamada, Yoshio, Fujiwara, Takashi, Enomoto, Hiroko, Hiroe, Takeshi, Tanaka, Satoshi, ...
Phosphoinositide-specific phospholipase C (PLC) is a key enzyme in phosphoinositide turnover and is involved in a variety of physiological functions. We analyzed PLCδ1 knockout mice and found that...
Lack of tactile pain (allodynia) in lipocalin-type prostaglandin D synthase-deficient mice
Eguchi, Naomi, Minami, Toshiaki, Shirafuji, Naoki, Kanaoka, Yoshihide, Tanaka, Takashi, Nagata, Akihisa, ...
Prostaglandin (PG) D2 is the most abundant prostanoid produced in the central nervous system of mammals and has been implicated in the modulation of neural functions such as sleep induction,...
Hizaki, Hiroko, Segi, Eri, Sugimoto, Yukihiko, Hirose, Masaya, Saji, Tomomi, Ushikubi, Fumitaka, ...
Female mice lacking the gene encoding the prostaglandin (PG) E2 receptor subtype EP2 (EP2−/−) become pregnant and deliver their pups at term, but with a much reduced litter size. A decrease in...
Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality
Takeda, Kiyoshi, Noguchi, Koichi, Shi, Wei, Tanaka, Takashi, Matsumoto, Makoto, Yoshida, Nobuaki, ...
Signal transducer and activator of transcription (STAT) proteins have been shown to mediate biological actions in response to cytokines. Stat3, a member of the STAT family, is activated by a variety...
Nagasawa, Takashi, Nakajima, Toshihiro, Tachibana, Kazunobu, Iizasa, Hisashi, Bleul, Conrad C., Yoshie, Osamu, ...
Pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 (PBSF/SDF-1) is a member of the CXC group of chemokines that is initially identified as a bone marrow stromal cell-derived factor...
Paranodal junction formation and spermatogenesis require sulfoglycolipids
Honke, Koichi, Hirahara, Yukie, Dupree, Jeffrey, Suzuki, Kinuko, Popko, Brian, Fukushima, Kikuro, ...
Mammalian sulfoglycolipids comprise two major members, sulfatide (HSO3-3-galactosylceramide) and seminolipid (HSO3-3-monogalactosylalkylacylglycerol). Sulfatide is a major lipid component of the...
SH2-B Is Required for Both Male and Female Reproduction
Ohtsuka, Satoshi, Takaki, Satoshi, Iseki, Masanori, Miyoshi, Kanta, Nakagata, Naomi, Kataoka, Yuki, ...
Many growth factors and hormones modulate the reproductive status in mammals. Among these, insulin and insulin-like growth factor I (IGF-I) regulate the development of gonadal tissues. SH2-B has been...
Zinc Finger Protein Sall2 Is Not Essential for Embryonic and Kidney Development
Sato, Akira, Matsumoto, Yuko, Koide, Urara, Kataoka, Yuki, Yoshida, Nobuaki, Yokota, Takashi, ...
SALL/Sall is a mammalian homolog of the Drosophila region-specific homeotic gene spalt (sal), and heterozygous mutations in SALL1 in humans lead to Townes-Brocks syndrome. We earlier reported that...
Mammalian Twisted Gastrulation Is Essential for Skeleto-Lymphogenesis
Nosaka, Tetsuya, Morita, Sumiyo, Kitamura, Hidetomo, Nakajima, Hideaki, Shibata, Fumi, Morikawa, Yoshihiro, ...
Dorsoventral patterning depends on the local concentrations of the morphogens. Twisted gastrulation (TSG) regulates the extracellular availability of a mesoderm inducer, bone morphogenetic protein 4...
Phospholipase Cδ1 is required for skin stem cell lineage commitment
Nakamura, Yoshikazu, Fukami, Kiyoko, Yu, Haiyan, Takenaka, Kei, Kataoka, Yuki, Shirakata, Yuji, ...
Phosphoinositide-specific phospholipase C (PLC) is a key enzyme in phosphoinositide turnover and is involved in a variety of physiological functions. Here we report that PLCδ1-deficient mice...
Takenaka, Kei, Fukami, Kiyoko, Otsuki, Makiko, Nakamura, Yoshikazu, Kataoka, Yuki, Wada, Mika, ...
Phospholipase C (PLC) plays important roles in phosphoinositide turnover by regulating the calcium-protein kinase C signaling pathway. PLC-L2 is a novel PLC-like protein which lacks PLC activity,...
Iseki, Masanori, Kubo, Chiyomi, Kwon, Sang-Mo, Yamaguchi, Akiko, Kataoka, Yuki, Yoshida, Nobuaki, ...
APS (adaptor molecule containing PH and SH2 domains) is an intracellular adaptor protein that forms an adaptor family along with Lnk and SH2-B. While experiments using cultured cell lines have...
Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice
Sakurai, Yoshiko, Ohgimoto, Kaori, Kataoka, Yuki, Yoshida, Nobuaki, Shibuya, Masabumi
Flk-1 (human counterpart, KDR) tyrosine kinase, which is one of the two VEGF receptors, is crucial for vascular development. Recently, we showed that, among tyrosine residues of KDR, tyrosine...
Urano, Atsushi, Endoh, Masaki, Wada, Tadashi, Morikawa, Yoshihiro, Itoh, Miyuki, Kataoka, Yuki, ...
AF5q31 (also called MCEF) was identified by its involvement in chromosomal translocation with the gene MLL (mixed lineage leukemia), which is associated with infant acute lymphoblastic leukemia....
Ono, Ryoichi, Ihara, Masafumi, Nakajima, Hideaki, Ozaki, Katsutoshi, Kataoka-Fujiwara, Yuki, Taki, Tomohiko, ...
Septins are evolutionarily conserved GTP-binding proteins that can heteropolymerize into filaments. Recent studies have revealed that septins are involved in not only diverse normal cellular...
Phospholipase C-δ1 and -δ3 Are Essential in the Trophoblast for Placental Development
Nakamura, Yoshikazu, Hamada, Yoshio, Fujiwara, Takashi, Enomoto, Hiroko, Hiroe, Takeshi, Tanaka, Satoshi, ...
Phosphoinositide-specific phospholipase C (PLC) is a key enzyme in phosphoinositide turnover and is involved in a variety of physiological functions. We analyzed PLCδ1 knockout mice and found that...
Kawa, Seiji, Ito, Chizuru, Toyama, Yoshiro, Maekawa, Mamiko, Tezuka, Tohru, Nakamura, Takahisa, ...
Brek/Lmtk2 (brain-enriched kinase/lemur tyrosine kinase 2) is a member of the Aatyk family of kinases that comprises Aatyk1, Brek/Lmtk2/Aatyk2, and Aatyk3. Although several potential roles have been...
Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo
Oyama, Toshinao, Harigaya, Kenichi, Muradil, Ablimit, Hozumi, Katsuto, Habu, Sonoko, Oguro, Hideyuki, ...
Mastermind (Mam) is one of the elements of Notch signaling, an ancient system that plays a pivotal role in metazoan development. Genetic analyses in Drosophila and Caenorhabditis elegans have shown...
Kaisho, Tsuneyasu, Tsutsui, Hiroko, Tanaka, Takashi, Tsujimura, Tohru, Takeda, Kiyoshi, Kawai, Taro, ...
We have investigated in vivo roles of CCAAT/enhancer binding protein γ (C/EBPγ) by gene targeting. C/EBPγ-deficient (C/EBPγ2/−) mice showed a high mortality rate within 48 h after birth. To...
CXCR4/fusin Is Not a Species-specific Barrier in Murine Cells for HIV-1 Entry
Tachibana, Kazunobu, Nakajima, Toshihiro, Sato, Akihiko, Igarashi, Kenji, Shida, Hisatoshi, Iizasa, Hisashi, ...
Since some murine cells expressing human CD4 fail to internalize HIV-1, another block was thought to be located at the level of viral entry in addition to CD4. Recently, CXCR4 was shown to function...
A Small Molecule CXCR4 Inhibitor that Blocks T Cell Line–tropic HIV-1 Infection
Murakami, Tsutomu, Nakajima, Toshihiro, Koyanagi, Yoshio, Tachibana, Kazunobu, Fujii, Nobutaka, Tamamura, Hirokazu, ...
Several members of the chemokine receptor family have been shown to function in association with CD4 to permit human immunodeficiency virus type 1 (HIV-1) entry and infection. The CXC chemokine...
Phospholipase Cδ4 is required for Ca2+ mobilization essential for acrosome reaction in sperm
Fukami, Kiyoko, Yoshida, Manabu, Inoue, Takafumi, Kurokawa, Manabu, Fissore, Rafael A., Yoshida, Nobuaki, ...
Zona pellucida (ZP)–induced acrosome reaction in sperm is a required step for mammalian fertilization. However, the precise mechanism of the acrosome reaction remains unclear. We previously...