Analysis of the mouse transcriptome for genes involved in the function of the nervous system (2003)
Gustincich, Stefano, Batalov, Serge, Beisel, Kirk W., Bona, Hidemasa, Carninci, Piero, Fletcher, Colin F., ...
We analyzed the mouse Representative Transcript and Protein Set for molecules involved in brain function. We found full-length cDNAs of many known brain genes and discovered new members of known...
Analysis of the Mouse Transcriptome for Genes Involved in the Function of the Nervous System (2003)
Gustincich, Stefano, Batalov, Serge, Beisel, Kirk W., Bono, Hidemasa, Carninci, Piero, Fletcher, Colin F., ...
We analyzed the mouse Representative Transcript and Protein Set for molecules involved in brain function.We found full-length cDNAs of many known brain genes and discovered new members of known brain...
Kinesin Superfamily Proteins (KIFs) in the Mouse Transcriptome (2003)
Miki, Harukata, Setou, Mitsutoshi, GSL Members,, Hirokawa, Nobutaka
In the post genomic era where virtually all the genes and the proteins are known, an important task is to provide a comprehensive analysis of the expression of important classes of genes, such as...
Okada, Yasushi, Hirokawa, Nobutaka
A motor-domain construct of KIF1A, a single-headed kinesin superfamily protein, was demonstrated to take more than 600 steps before detaching from a microtubule. However, its molecular mechanism...
Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome
Nakagawa, Terunaga, Tanaka, Yosuke, Matsuoka, Eiji, Kondo, Satoru, Okada, Yasushi, Noda, Yasuko, ...
KIF (kinesin superfamily) proteins are microtubule-dependent molecular motors that play important roles in intracellular transport and cell division. The extent to which KIFs are involved in various...
All kinesin superfamily protein, KIF, genes in mouse and human
Miki, Harukata, Setou, Mitsutoshi, Kaneshiro, Kiyofumi, Hirokawa, Nobutaka
Intracellular transport is essential for morphogenesis and functioning of the cell. The kinesin superfamily proteins (KIFs) have been shown to transport membranous organelles and protein complexes in...
Binding of Murine Leukemia Virus Gag Polyproteins to KIF4, a Microtubule-Based Motor Protein
Kim, Wankee, Tang, Yao, Okada, Yasushi, Torrey, Ted A., Chattopadhyay, Sisir K., Pfleiderer, Michael, ...
A cDNA clone encoding a cellular protein that interacts with murine leukemia virus (MuLV) Gag proteins was isolated from a T-cell lymphoma library. The sequence of the clone is identical to the C...
Nakajima, Kazuo, Takei, Yosuke, Tanaka, Yosuke, Nakagawa, Terunaga, Nakata, Takao, Noda, Yasuko, ...
KIF1C is a new member of the kinesin superfamily of proteins (KIFs), which act as microtubule-based molecular motors involved in intracellular transport. We cloned full-length mouse kif1C cDNA, which...
Overexpression of motor protein KIF17 enhances spatial and working memory in transgenic mice
Wong, Richard Wing-Chuen, Setou, Mitsutoshi, Teng, Junlin, Takei, Yosuke, Hirokawa, Nobutaka
The kinesin superfamily proteins (KIFs) play essential roles in receptor transportation along the microtubules. KIF17 transports the N-methyl-d-aspartate receptor NR2B subunit in vitro, but its role...
Analysis of the Mouse Transcriptome for Genes Involved in the Function of the Nervous System
Gustincich, Stefano, Batalov, Serge, Beisel, Kirk W., Bono, Hidemasa, Carninci, Piero, Fletcher, Colin F., ...
We analyzed the mouse Representative Transcript and Protein Set for molecules involved in brain function.We found full-length cDNAs of many known brain genes and discovered new members of known brain...
Kinesin Superfamily Proteins (KIFs) in the Mouse Transcriptome
Miki, Harukata, Setou, Mitsutoshi, Hirokawa, Nobutaka
In the post genomic era where virtually all the genes and the proteins are known, an important task is to provide a comprehensive analysis of the expression of important classes of genes, such as...
Dynein and kinesin share an overlapping microtubule-binding site
Mizuno, Naoko, Toba, Shiori, Edamatsu, Masaki, Watai-Nishii, Junko, Hirokawa, Nobutaka, Toyoshima, Yoko Y, ...
Dyneins and kinesins move in opposite directions on microtubules. The question of how the same-track microtubules are able to support movement in two directions remains unanswered due to the absence...
Buceta, Javier, Ibañes, Marta, Rasskin-Gutman, Diego, Okada, Yasushi, Hirokawa, Nobutaka, Izpisúa-Belmonte, Juan Carlos
Nodal cilia dynamics is a key factor for left/right axis determination in mouse embryos through the induction of a leftward fluid flow. So far it has not been clearly established how such dynamics is...
Okada, Yasushi, Hirokawa, Nobutaka
A motor-domain construct of KIF1A, a single-headed kinesin superfamily protein, was demonstrated to take more than 600 steps before detaching from a microtubule. However, its molecular mechanism...
Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome
Nakagawa, Terunaga, Tanaka, Yosuke, Matsuoka, Eiji, Kondo, Satoru, Okada, Yasushi, Noda, Yasuko, ...
KIF (kinesin superfamily) proteins are microtubule-dependent molecular motors that play important roles in intracellular transport and cell division. The extent to which KIFs are involved in various...
All kinesin superfamily protein, KIF, genes in mouse and human
Miki, Harukata, Setou, Mitsutoshi, Kaneshiro, Kiyofumi, Hirokawa, Nobutaka
Intracellular transport is essential for morphogenesis and functioning of the cell. The kinesin superfamily proteins (KIFs) have been shown to transport membranous organelles and protein complexes in...
Binding of Murine Leukemia Virus Gag Polyproteins to KIF4, a Microtubule-Based Motor Protein
Kim, Wankee, Tang, Yao, Okada, Yasushi, Torrey, Ted A., Chattopadhyay, Sisir K., Pfleiderer, Michael, ...
A cDNA clone encoding a cellular protein that interacts with murine leukemia virus (MuLV) Gag proteins was isolated from a T-cell lymphoma library. The sequence of the clone is identical to the C...
Nakajima, Kazuo, Takei, Yosuke, Tanaka, Yosuke, Nakagawa, Terunaga, Nakata, Takao, Noda, Yasuko, ...
KIF1C is a new member of the kinesin superfamily of proteins (KIFs), which act as microtubule-based molecular motors involved in intracellular transport. We cloned full-length mouse kif1C cDNA, which...
Overexpression of motor protein KIF17 enhances spatial and working memory in transgenic mice
Wong, Richard Wing-Chuen, Setou, Mitsutoshi, Teng, Junlin, Takei, Yosuke, Hirokawa, Nobutaka
The kinesin superfamily proteins (KIFs) play essential roles in receptor transportation along the microtubules. KIF17 transports the N-methyl-d-aspartate receptor NR2B subunit in vitro, but its role...
Analysis of the Mouse Transcriptome for Genes Involved in the Function of the Nervous System
Gustincich, Stefano, Batalov, Serge, Beisel, Kirk W., Bono, Hidemasa, Carninci, Piero, Fletcher, Colin F., ...
We analyzed the mouse Representative Transcript and Protein Set for molecules involved in brain function.We found full-length cDNAs of many known brain genes and discovered new members of known brain...
Kinesin Superfamily Proteins (KIFs) in the Mouse Transcriptome
Miki, Harukata, Setou, Mitsutoshi, Hirokawa, Nobutaka
In the post genomic era where virtually all the genes and the proteins are known, an important task is to provide a comprehensive analysis of the expression of important classes of genes, such as...
Dynein and kinesin share an overlapping microtubule-binding site
Mizuno, Naoko, Toba, Shiori, Edamatsu, Masaki, Watai-Nishii, Junko, Hirokawa, Nobutaka, Toyoshima, Yoko Y, ...
Dyneins and kinesins move in opposite directions on microtubules. The question of how the same-track microtubules are able to support movement in two directions remains unanswered due to the absence...
Buceta, Javier, Ibañes, Marta, Rasskin-Gutman, Diego, Okada, Yasushi, Hirokawa, Nobutaka, Izpisúa-Belmonte, Juan Carlos
Nodal cilia dynamics is a key factor for left/right axis determination in mouse embryos through the induction of a leftward fluid flow. So far it has not been clearly established how such dynamics is...
Kikkawa, Masahide, Hirokawa, Nobutaka
Kinesin is an ATP-driven microtubule (MT)-based motor fundamental to organelle transport. Although a number of kinesin crystal structures have been solved, the structural evidence for coupling...
Three-dimensional structures of the flagellar dynein–microtubule complex by cryoelectron microscopy
Oda, Toshiyuki, Hirokawa, Nobutaka, Kikkawa, Masahide
The outer dynein arms (ODAs) of the flagellar axoneme generate forces needed for flagellar beating. Elucidation of the mechanisms underlying the chemomechanical energy conversion by the dynein arms...
A standardized kinesin nomenclature
Lawrence, Carolyn J., Dawe, R. Kelly, Christie, Karen R., Cleveland, Don W., Dawson, Scott C., Endow, Sharyn A., ...
In recent years the kinesin superfamily has become so large that several different naming schemes have emerged, leading to confusion and miscommunication. Here, we set forth a standardized kinesin...
Impairment of Inhibitory Synaptic Transmission in Mice Lacking Synapsin I
Terada, Sumio, Tsujimoto, Tetsuhiro, Takei, Yosuke, Takahashi, Tomoyuki, Hirokawa, Nobutaka
Deletion of the synapsin I genes, encoding one of the major groups of proteins on synaptic vesicles, in mice causes late onset epileptic seizures and enhanced experimental temporal lobe epilepsy....
Takeda, Sen, Yonekawa, Yoshiaki, Tanaka, Yosuke, Okada, Yasushi, Nonaka, Shigenori, Hirokawa, Nobutaka
KIF3A is a classical member of the kinesin superfamily proteins (KIFs), ubiquitously expressed although predominantly in neural tissues, and which forms a heterotrimeric KIF3 complex with KIF3B or...
Takei, Yosuke, Kondo, Satoru, Harada, Akihiro, Inomata, Satomi, Noda, Tetsuo, Hirokawa, Nobutaka
Microtubule-associated protein 1B (MAP1B), one of the microtubule-associated proteins (MAPs), is a major component of the neuronal cytoskeleton. It is expressed at high levels in immature neurons...
Visualization of the Dynamics of Synaptic Vesicle and Plasma Membrane Proteins in Living Axons
Nakata, Takao, Terada, Sumio, Hirokawa, Nobutaka
Newly synthesized membrane proteins are transported by fast axonal flow to their targets such as the plasma membrane and synaptic vesicles. However, their transporting vesicles have not yet been...
Yonekawa, Yoshiaki, Harada, Akihiro, Okada, Yasushi, Funakoshi, Takeshi, Kanai, Yoshimitsu, Takei, Yosuke, ...
The nerve axon is a good model system for studying the molecular mechanism of organelle transport in cells. Recently, the new kinesin superfamily proteins (KIFs) have been identified as candidate...
Teng, Junlin, Takei, Yosuke, Harada, Akihiro, Nakata, Takao, Chen, Jianguo, Hirokawa, Nobutaka
MAP1B and MAP2 are major members of neuronal microtubule-associated proteins (MAPs). To gain insights into the function of MAP2 in vivo, we generated MAP2-deficient (map2−/−) mice. They developed...
Noda, Yasuko, Okada, Yasushi, Saito, Nobuhito, Setou, Mitsutoshi, Xu, Ying, Zhang, Zheizeng, ...
We have identified and characterized a COOH-terminal motor domain–type kinesin superfamily protein (KIFC), KIFC3, in the kidney. KIFC3 is a minus end–directed microtubule motor protein, therefore...
Nakata, Takao, Hirokawa, Nobutaka
Post-Golgi carriers of various newly synthesized axonal membrane proteins, which possess kinesin (KIF5)-driven highly processive motility, were transported from the TGN directly to axons. We found...
Role of KIFC3 motor protein in Golgi positioning and integration
Xu, Ying, Takeda, Sen, Nakata, Takao, Noda, Yasuko, Tanaka, Yosuke, Hirokawa, Nobutaka
KIFC3, a microtubule (MT) minus end–directed kinesin superfamily protein, is expressed abundantly and is associated with the Golgi apparatus in adrenocortical cells. We report here that disruption...
Harada, Akihiro, Teng, Junlin, Takei, Yosuke, Oguchi, Keiko, Hirokawa, Nobutaka
Microtubule-associated protein 2 (MAP2) is a major component of cross-bridges between microtubules in dendrites, and is known to stabilize microtubules. MAP2 also has a binding domain for the...
Takeda, Sen, Yamazaki, Hiroto, Seog, Dae-Hyun, Kanai, Yoshimitsu, Terada, Sumio, Hirokawa, Nobutaka
Kinesin superfamily proteins (KIFs) comprise several dozen molecular motor proteins. The KIF3 heterotrimer complex is one of the most abundantly and ubiquitously expressed KIFs in mammalian cells. To...
Defects in Axonal Elongation and Neuronal Migration in Mice with Disrupted tau and map1b Genes
Takei, Yosuke, Teng, Junlin, Harada, Akihiro, Hirokawa, Nobutaka
Tau and MAP1B are the main members of neuronal microtubule-associated proteins (MAPs), the functions of which have remained obscure because of a putative functional redundancy (Harada, A., K. Oguchi,...
Left–Right Determination: Involvement of Molecular Motor KIF3, Cilia, and Nodal Flow
Hirokawa, Nobutaka, Tanaka, Yosuke, Okada, Yasushi
Mammalian left–right determination is a good example for how multiple cell biological processes coordinate in the formation of a basic body plan. The leftward movement of fluid at the ventral node,...