Hishida, Asahi, Koyama, Atsushi, Tomota, Akiko, Katase, Shirou, Asai, Yatami, Hamajima, Nobuyuki
Abstract Background Metabolic syndrome (MetS) is potentially effective measures to identify individuals at risk of coronary heart disease (CHD) and type 2 diabetes. To verify the hypothesis that...
Hishida, Asahi, Matsuo, Keitaro, Goto, Yasuyuki, Naito, Mariko, Wakai, Kenji, Tajima, Kazuo, ...
Abstract Background Previous studies have revealed the significance of Helicobacter pylori ( H. pylori ) infection as a risk factor of gastric cancer. Cytotoxin-associated gene A ( cagA ) positivity...
NAITO, MARIKO, EGUCHI, HIDETAKA, OKADA, RIEKO, ISHIDA, YOSHIKO, NISHIO, KAZUKO, HISHIDA, ASAHI, ...
Cohort studies commonly store blood samples to measure the associations of biomarkers with disease risks for a long time after the study subjects are enrolled. To obtain valid measurements of the...
Yasui, Yutaka, Hamajima, Nobuyuki, Nakamura, Tsuneya, El-Din, Noha, Tajima, Kazuo, Potter, John D
Abstract Background Multiple sclerosis (MS) risk, over 10-fold higher in Western than in Asian countries, is associated with elevated IgG antibody titers against Epstein-Barr viral capcid antigen...
Taki, Kentaro, Nishio, Kazuko, Hamajima, Nobuyuki, Niwa, Toshimitsu
Metabolic syndrome (MetS) is characterized by the presence of atherogenic risk factors, and is associated with a marked increase in the risk of cardiovascular disease. Recently, the criteria of MetS...
Keitaro Matsuo, Ritsuro Suzuki, Nobuyuki Hamajima, Michinori Ogura, Yoshitoyo Kagami, Hirofumi Taji, ...
doi:10.1182/blood.V97.10.3205 Association between polymorphisms of folate- and methionine-metabolizing enzymes and susceptibility to malignant lymphoma
Kano, Mayuko, Goto, Yasuyuki, Atsuta, Yoshiko, Naito, Mariko, Hamajima, Nobuyuki
In order to examine whether a notification of genotypes related to a susceptibility to smoking has any influence on an intention to quit, a pilot study was conducted for 61 smokers out of 66...
Enkhbold, Sereenen, Tugsdelger, Sovd, Morita, Satoshi, Sakamoto, Junichi, Hamajima, Nobuyuki
The prevalence of HIV/AIDS in Mongolia is still low. Only 29 HIV/AIDS cases have been registered in Mongolia with a population of 2.6 millions, as of April, 2007. In all of the cases the infection...
Goto, Yasuyuki, Nishio, Kazuko, Ishida, Yoshiko, Kawai, Sayo, Osafune, Tomo, Naito, Mariko, ...
Our previous epidemiologic study reported that NAD(P)H:quinone oxidoreductase 1 (NQO1) 609C/C with full enzyme activity was a high risk genotype for Helicobacter pylori (H. pylori) seropositivity....
Shimarova, Memerian, Nishimura, Akio, Ito, Katsuki, Hamajima, Nobuyuki
The introduction of a clinical protocol for the treatment of gastric and duodenal ulcer (GDU) may be one of the solutions for the high morbidity and complications of these diseases. This descriptive...
Tran, Thu Minh T, Nguyen, Hien T, Yatsuya, Hiroshi, Hamajima, Nobuyuki, Nishimura, Akio, Ito, Katsuki
Abstract Background Sufficient targeted HIV prevention activities aiming at reducing HIV transmission within and from an extremely marginalized population of injection drug users (IDUs) must urgently...
Ito, Yoshiyuki, Fuwa, Nobukazu, Kikuchi, Yuzo, Yokoi, Norio, Hamajima, Nobuyuki, Morita, Kozo, ...
A prospective study was performed to assess the effi cacy of elective neck irradiation (ENI) on the ipsilateral side in patients with early tongue cancer among a high-risk group with late cervical...
Tanaka, Daisuke, Hishida, Asahi, Matsuo, Keitaro, Iwata, Hiroji, Shinoda, Masayuki, Yamamura, Yoshitaka, ...
Dihydropyrimidine dehydrogenase (DPD) is the enzyme catalyzing the first step of pyrimidine metabolism. To date, genetic polymorphisms of pyrimidine-synthesizing enzymes have been reported to be...
Nishio, Kazuko, Tanaka, Daisuke, Atsuta, Yoshiko, Yamamoto, Kazuhito, Tamakoshi, Akiko, Nakamura, Sakurako, ...
On June 9, 2003, we started free genetic tests of eight polymorphisms for health checkup examinees who attended a basic course at Nagoya University Hospital. They were informed of their genotypes...
Nishio, Kazuko, Nakamura, Sakurako, Sekido, Yoshitaka, Niwa, Toshimitsu, Hamajima, Nobuyuki
Genetic polymorphisms have the potential to predict disease susceptibility. This may be especially useful among individuals with a high-risk lifestyle, so that the genotyping could be adopted for...
Ito, Hidemi, Matsuo, Keitaro, Hamajima, Nobuyuki, Mitsudomi, Tetsuya, Sugiura, Takahiko, Saito, Toshiko, ...
APE1 (apurinic/apyrimidinic endonuclease 1) and XRCC1 (X-ray cross-complementing group1) are DNA repair proteins that play important roles in the base excision repair (BER) pathway. Polymorphisms in...
Ito, Hidemi, Matsuo, Keitaro, Hamajima, Nobuyuki, Mitsudomi, Tetsuya, Sugiura, Takahiko, Saito, Toshiko, ...
APE1 (apurinic/apyrimidinic endonuclease 1) and XRCC1 (X-ray cross-complementing group 1) are DNA repair proteins that play important roles in the base excision repair (BER) pathway....
Persistent helicobactor pylori infection and genetic polymorphisms of the host (2003)
Helicobacter pylori (HP) infection elevates the risk of gastric diseases including peptic ulcer and gastric cancer. The infection induces inflammatory cytokines, which could work both for and against...
Inoue, Manami, Tajima, Kazuo, Takezaki, Toshiro, Hamajima, Nobuyuki, Hirose, Kaoru, Ito, Hidemi, ...
Background To clarify lifestyle factors that affect the risk of pancreatic cancer among the Japanese population, a nested case-control study was conducted using data from the Hospital-based...
Tamakoshi, Akiko, Hamajima, Nobuyuki, Kawase, Haruya, Wakai, Kenji, Katsuda, Nobuyuki, Saito, Toshiko, ...
Aims: Alcohol dehydrogenase β subunit (ADH2) Arg47His and aldehyde dehydrogenase 2 (ALDH2) Glu487Lys were genotyped by a duplex polymerase chain reaction (PCR) with confronting two-pair primers...
Yang, Chunxia, Hamajima, Nobuyuki, Iwata, Hiroji, Saito, Toshiko, Matsuo, Keitaro, Hirose, Kaoru, ...
Abstract Background Breast cancer is hormone related, as are cancers of the endometrium, ovary, and prostate. Several studies have suggested that higher extracellular levels of androgens are...
Ito, Lucy Sayuri, Iwata, Hiroji, Hamajima, Nobuyuki, Saito, Toshiko, Matsuo, Keitaro, Mizutani, Mitsuhiro, ...
Objective: The present case-control study aimed to examine the associations between breast cancer risk and three functional polymorphisms (Interleukin (IL) –1A C-889T, IL-1B C-31T and IL-1RN 86-bp...
Re: Population-Based, CaseControl Study of HER2 Genetic Polymorphism and Breast Cancer Risk (2002)
Hishida, Asahi, Hamajima, Nobuyuki, Iwata, Hiroji, Matsuo, Keitaro, Hirose, Kaoru, Emi, Nobuhiko, ...
Huang, Xin-En, Hamajima, Nobuyuki, Saito, Toshiko, Matsuo, Keitaro, Mizutani, Mitsuhiro, Iwata, Hiroji, ...
Abstract Background The involvement of β 2 -adrenergic receptor (ADRB2) and β 3 -adrenergic receptor (ADRB3) in both adipocyte lipolysis and thermogenic activity suggests that polymorphisms in the...
Matsuo, Keitaro, Hamajima, Nobuyuki, Shinoda, Masayuki, Hatooka, Shunzo, Inoue, Manami, Takezaki, Toshiro, ...
Aldehyde dehydrogenase-2 (ALDH2) degrades acetaldehyde metabolized from ethanol. Its encoding gene ALDH2 has a functional polymorphism: ALDH2 Glu487Lys. An association between this polymorphism and...
Shibata, Atsuko, Hamajima, Nobuyuki, Tamakoshi, Akiko, Suzuki, Sadao, Sasaki, Ryuichiro, Aoki, Kunio
In order to examine the proportional hazards assumption implicit in the proportional hazards model, three types of simulations were carried out on two groups of hypothetical survival data. Simulation...
Analysis and simulation on vital statistical data focussed on birth cohort effect / (1986)
Thesis (M. Pub. Health)--University of Washington, 1986.
Huang, Xin-En, Hamajima, Nobuyuki, Saito, Toshiko, Matsuo, Keitaro, Mizutani, Mitsuhiro, Iwata, Hiroji, ...
Yang, Chunxia, Hamajima, Nobuyuki, Iwata, Hiroji, Saito, Toshiko, Matsuo, Keitaro, Hirose, Kaoru, ...
Eradication rate of Helicobacter pylori according to genotypes of CYP2C19, IL-1B, and TNF-A
Ishida, Yoshiko, Goto, Yasuyuki, Kondo, Takaaki, Kurata, Mio, Nishio, Kazuko, Kawai, Sayo, ...
Background: Lansoprazole, amoxicillin, and clarithromycin are commonly used drugs for eradication of Helicobacter pylori (H. pylori). A few studies reported that the eradication rate was influenced...
Tran, Thu Minh T, Nguyen, Hien T, Yatsuya, Hiroshi, Hamajima, Nobuyuki, Nishimura, Akio, Ito, Katsuki
Huang, Xin-En, Hamajima, Nobuyuki, Saito, Toshiko, Matsuo, Keitaro, Mizutani, Mitsuhiro, Iwata, Hiroji, ...
Yang, Chunxia, Hamajima, Nobuyuki, Iwata, Hiroji, Saito, Toshiko, Matsuo, Keitaro, Hirose, Kaoru, ...
Eradication rate of Helicobacter pylori according to genotypes of CYP2C19, IL-1B, and TNF-A
Ishida, Yoshiko, Goto, Yasuyuki, Kondo, Takaaki, Kurata, Mio, Nishio, Kazuko, Kawai, Sayo, ...
Background: Lansoprazole, amoxicillin, and clarithromycin are commonly used drugs for eradication of Helicobacter pylori (H. pylori). A few studies reported that the eradication rate was influenced...
Tran, Thu Minh T, Nguyen, Hien T, Yatsuya, Hiroshi, Hamajima, Nobuyuki, Nishimura, Akio, Ito, Katsuki
Goto, Yasuyuki, Ando, Takafumi, Nishio, Kazuko, Kawai, Sayo, Ishida, Yoshiko, Naito, Mariko, ...
Background: Various single nucleotide polymorphisms (SNPs) have explained the association between Helicobacter pylori (H. pylori) and gastric atrophy and cancer. This study investigated the...
Itou, Simon, Goto, Yasuyuki, Kondo, Takaaki, Nishio, Kazuko, Kawai, Sayo, Ishida, Yoshiko, ...
Recent studies have suggested that Helicobacter pylori (H. pylori) infection might be a risk factor for atherosclerosis. Since the bacterium has not been isolated from atherosclerotic lesions, a...
Suzuki, Ritsuro, Takemura, Kazuo, Tsutsumi, Masayoshi, Nakamura, Shigeo, Hamajima, Nobuyuki, Seto, Masao
The diagnosis of mantle cell lymphoma (MCL) is particularly important for clinical management because of a remarkable prognostic difference between MCL and other types of B-cell lymphoma. In addition...
Hamajima, Nobuyuki, Saito, Toshiko, Matsuo, Keitaro, Tajima, Kazuo
Polymerase chain reaction with confronting two-pair primers (PCR-CTPP) is an inexpensive, time-saving genotyping method that is applicable for most single nucleotide polymorphisms. To date, we have...
Association between vitamin D receptor gene haplotypes and chronic periodontitis among Japanese men
Naito, Mariko, Miyaki, Koichi, Naito, Toru, Zhang, Ling, Hoshi, Keika, Hara, Asako, ...
Background: The vitamin D receptor (VDR) is involved in a variety of biological processes, such as bone metabolism and modulation of the immune response. Recent findings suggest that the pathway...
Yasui, Yutaka, Hamajima, Nobuyuki, Nakamura, Tsuneya, El-Din, Noha Sharaf, Tajima, Kazuo, Potter, John D
Significant association between Helicobacter pylori infection and serum C-reactive protein
Ishida, Yoshiko, Suzuki, Koji, Taki, Kentaro, Niwa, Toshimitsu, Kurotsuchi, Shozo, Ando, Hisao, ...
Background: Helicobacter pylori (H. pylori) infection in gastric mucosa may cause systemic inflammatory reaction. This study aimed to examine the association between the infection and serum high...
Gao, Chang-Ming, Takezaki, Toshiro, Wu, Jian-Zhong, Zhang, Xiao-Mei, Cao, Hai-Xia, Ding, Jian-Hua, ...
AIM: To evaluate the relationship between drinking and polymorphisms of alcohol dehydrogenase 2 (ADH2) and/or aldehyde dehydrogenase 2 (ALDH2) for risk of colorectal cancer (CRC) in Chinese males.