A Dynamic Analysis of the Green Electricity Fund: Threshold Models Revisited (2009)
Ito, Nobuyuki, Takeuchi, Kenji, Tsuge, Takahiro, Kishimoto, Atsuo
ロス・ナランホスからみた先スペイン期都市の政治史に関する一考察 (2008)
Se analiza el sistema político a través de las investigaciones arqueológicas de Los Naranjos y de la historia arquitectónica de Costa Sur de Mesoamérica. En la Costa Sur de Mesoamérica se...
チャルチュアパ遺跡タスマル地区B1-1建造物南側より出土した供物に関する一考察 (2007)
伊藤, 伸幸, ITO, Nobuyuki, 柴田, 潮音, SHIBATA, Shione
El objetivo del proyecto de la Universidad de Nagoya era comprobar una hipótesis sobre el desarrollo arquitectónico del sitio. Se cree que en los lados este y sur de la Estructura B1-1 existían...
Hasta la fecha se han realizado varias investigaciones arquelógicas enfocadas en el período Preclásico. Estas se concentran, principalmente, en las estructuras importantes y hay muy pocas que se...
メソアメリカ先古典期における植物遺存体に関する一考察 (2005)
En Mesoamérica había una gran diversidad de plantas utilizadas por el ser humano. Las más importantes son maiz, frijol y calabaza. Estas plantas fueron domesticadas durante el período Arcaico....
マヤ南部地域に於ける石彫の一生に関する一考察 : グァテマラ高地からグァテマラ太平洋岸まで (1996)
名古屋大学文学部研究論集. 史学. 42, 1996, p. 101-123
Ogawa, Kumiko, Imaida, Katsumi, Masui, Tsuneo, Kawabe, Mayumi, Hasegawa, Ryohei, Kato, Koji, ...
Susceptibility to lung carcinogens and genetic changes in neoplastic lesions were investigated in transgenic mice carrying a human hybrid c-Ha-ras gene, encoding a prototype p21 gene product....
Hirose, Masao, Hasegawa, Ryohei, Kimura, Juki, Akagi, Keisuke, Yoshida, Yasunori, Tanaka, Hikaru, ...
The effects of 1-0-hexyl-2,3,5-trimethylhydroquinone (HTHQ), green tea catechins (GTC), α-tocopherol, β-carotene, chlorophyllin, phenylethylisothiocyanate (PEITC), 3-0-ethylascorbic acid (EAsA),...
Hirose, Masao, Akagi, Keisuke, Hasegawa, Ryohei, Yaono, Makoto, Satoh, Toshio, Hara, Yukihiko, ...
Chemopreventive effects of the antioxidants 1-O-hexyl-2, 3, 5-trimethylhydroquinone (HTHQ), 3-0-ethylascorbic acid (EAsA), 3-O-dodecylcarbomethylascorbic acid (DAsA), green tea catechins (GTC) and...
Hirose, Masao, Iwata, Shinjiro, Ito, Eiji, Nihro, Yasunori, Takahashi, Satoru, Mizoguchi, Yasumoto, ...
Antimutagenic effects of a novel lipophilic antioxidant, 1-O-hexyl-2,3,5-trimethylhydroquinone (HTHQ), and other known antioxidants against heterocyclic amine- or other mutagen-induced mutagenesis...
Inhibitory effect of chlorophyllin on PhIP-induced mammary carcinogenesis in female F344 rats (1995)
Hasegawa, Ryohei, Hirose, Masao, Kato, Toshio, Hagiwara, Akihiro, Boonyaphiphat, Plemjit, Nagao, Minako, ...
Chlorophyll and chlorophyllin, a water-soluble salt of chlorophyll, have been reported to inhibit carcinogen—DNA binding and exert antimutagenic activity for some carcinogenic heterocyclic amines...
Tamano, Seiko, Hasegawa, Ryohei, Hagiwara, Akihiro, Nagao, Minako, Sugimura, Takashi, Ito, Nobuyuki
Carcinogenicity of 2-amino-3-methyl-9H-pyrido[2,3-b]-indole (MeAαC) was investigated at dietary levels of 0 (control), 0.01, 0.02, 0.04 and 0.08% using male F344/DuCrj rats. The administration of...
Hasegawa, Ryohei, Tanaka, Hikaru, Tamano, Seiko, Shirai, Tomoyuki, Nagao, Minako, Sugimura, Takashi, ...
The carcinogenic potential of five heterocyclic amines In combination was analyzed using a medium-term multiorgan bioassay. Male F344 rats were Initially treated with five known carcinogens...
Hasegawa, Ryohei, Miyata, Emiko, Futakuchi, Mitsuru, Hagiwara, Akihiro, Nagao, Minako, Sugimura, Takashi, ...
Potential synergism between 10 carcinogenic heterocyclic amines [3-amino-l,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1), 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2), 2-amino-6...
Shibata, Masa-Aki, Hirose, Masao, Kagawa, Masataka, Boonyaphiphat, Pleumjit, Ito, Nobuyuki
The effects of the synthetic antioxidant butylated hydroxyanisole (BHA) and naturally occurring antioxidants such as L-ascorbic acid (AsA; vitamin C), citric acid, benzoic acid or gallic acid in...
Effects of green tea catechins in a rat multi-organ carcinogenesis model (1993)
Hirose, Masao, Hoshiya, Toru, Akagi, Keisuke, Takahashi, Satoru, Hara, Yukihiko, Ito, Nobuyuki
The effects of dietary administration of green tea catechins (GTC) were examined using a multi-organ carcinogenesis model. Groups of 15 F344 male rats were initially treated with a single i.p....
Hirose, Masao, Yada, Hideaki, Hakoi, Kazuo, Takahashi, Satoru, Ito, Nobuyuki
Effects of the dietary antioxidants α-tocopherol (α-Toc), t-butylhydroquinone (TBHQ), propyl gallate (PG) and butylated hydroxytoluene (BHT) were examined using a multi-organ carcinogenesis model....
Thamavit, Witaya, Pairojkul, Chawalit, Tiwawech, Danai, Itoh, Makoto, Shirai, Tomoyuki, Ito, Nobuyuki
Administration of hepatocardnogenic nitrosamines before or after infection with the liver fluke, Opisthorchis viverrini (OV), results in marked development of cholangiocellular and hepatocellular...
Carcinogenicity of catechol in F344 rats and B6C3F1 mice (1993)
Hirose, Masao, Fukushima, Shoji, Tanaka, Hikaru, Asakawa, Emiko, Takahashi, Satoru, Ito, Nobuyuki
Carcinogenicity of catechol, a naturally occurring and industrial chemical which has been shown to have strong cell proliferating potential on rat glandular stomach epithelium, was investigated in...
Hasegawa, Ryobei, Sano, Masashi, Tamano, Seiko, Imaida, Katsumi, Shirai, Tomoyuki, Nagao, Minako, ...
The dose-dependence of 2-amino-1-methyl-6-phenylimidazo-[4, 5-b]pyridine (PhIP) carcinogenicity was investigated in F344 rats of both sexes administered the heterocyclic amine in the diet at...
Thamavit, Witaya, Moore, Malcolm A., Ruchirawat, Somsak, Ito, Nobuyuki
The effects of repeated Praziquantel administration, subsequent to infection and reinfection w Opisthorchis viverrini (OV), on lesion development in the Syrian hamster liver were investigated. Five...
Takahashi, Satoru, Hakoi, Kazuo, Yada, Hideaki, Hirose, Masao, Ito, Nobuyuki, Fukushima, Shoji
It has been reported that diallyl sulfide (DS) and diallyl disulfide (DDS), major volatile compounds in garlic (Alliunt sativum), exert anticarcinogenic activity in several organs in rodents. The...
Effect of dietary fiber on cytochrome P450IA1 induction in rat colonic mucosa (1992)
Kawata, Sumio, Tamura, Shinji, Matsuda, Yukihiko, Ito, Nobuyuki, Matsuzawa, Yuji
The effect of dietary fiber on the induction of cytochrome P450IA1 in rat colonic mucosa after a single intragastric injection of 3-methylcholanthrene (3MC, 20 mg/kg) was investigated by...
Ueno, Yoshio, Yabe, Takeshi, Hashimoto, Hideaki, Sekijima, Masaru, Masuda, Tatsuki, Kim, Dae Joong, ...
In order to elucidate whether T-2 toxin (T-2) and nivalenol (NIV), the naturally occurring trichothecene mycotoxins in food and feed, are carcinogenic or possess an ability to modulate aflatoxin B1...
Hirose, Masao, Kawabe, Mayumi, Shibata, M., Takahashi, Satoru, Okazaki, Shuzo, Ito, Nobuyuki
Promotion effects of the o-dihydroxybenzene derivatives, protocatechuic acid (PCA), dopamine hydrochloride (DAH), dl-dopa and caffeic acid on forestomach and glandular stomach carcinogenesis were...
Hasegawa, Ryohei, Takahashi, Satoru, Shirai, Tomoyuki, Iwasaki, Shogo, Kim, Dae Joong, Ochiai, Masako, ...
Dose responses to two heterocyclic amines, 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeAαC) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), in induction of glutathione Stransferase...
Ito, Nobuyuki, Hasegawa, Ryohei, Shirai, Tomoyuki, Fukushima, Shoji, Hakoi, Kazuo, Takaba, Katsumi, ...
Potential synergism between five heterocyclic amines at low doses was evaluated in a medium-term liver bioassay system for carcinogens. F3-44 male rats were given a single i.p. injection of...
Hirose, Masao, Uwagawa, Satoshi, Ozaki, Keisuke, Takaba, Katsumi, Ito, Nobuyuki
The effects of butylated hydroxyanisole (BHA) pretreatment on subsequent low dose N-methyl-N' -nitro-N-nitrosoguanidine (MINNG) or N,N-dibutylnitrosamine (DBN) treatment on forestomach or esophageal...
Shirai, Tomoyuki, Fukushima, Shoji, Kawabe, Mayumi, Shibata, Masa-Aki, Iwasaki, Shogo, Tada, Mariko, ...
Modification of 3,2'-dimethyl-4-aminobiphenyl (DMAB) multi-organ carcinogenesis by simultaneous treatment with butylated hydroxyanisole (BHA) or butylated hydroxytoluene (BHT) was studied using young...
Tiwawech, Danai, Hasegawa, Ryohei, Kurata, Yasushi, Tatematsu, Masae, Shibata, Masa-Aki, Thamavit, Witaya, ...
Dose-dependent development of pre-neoplastk liver cell foci induced by 2-acetylaminofluorene (2-AAF) was investigated in relation to cell-proliferative activity. Male F344 rats were initially given a...
13-Week Oral Toxicity Study of Captafol in F344/DuCrj Rats (1991)
TAMANO, SEIKO, KURATA, YASUSHI, SHIBATA, MASA-AKI, TANAKA, HIKARU, OGISO, TADASHI, ITO, NOBUYUKI
13-Week Oral Toxicity Study of Captafol in F344/DuCrj Rats TAMANO, S., KURATA, Y., SHIBATA, M.-A., TANAKA, H., OGISO, T., AND ITO, N. (1991). Fundarm Appl Toxicol. 17,390–398. Captafol fed at...
Kobayasi, Shoiti, Tatematsu, Masae, Ogawa, Kumiko, Rodrigues, Maria Aparecida Marchesan, Ito, Nobuyuki
Morphological and phenotypical patterns of proliferative epithelial lesions induced in the gastric stump mucosa by duodenal content reflux after Billroth II partial gastrectomy (BII) were evaluated...
Ito, Nobuyuki, Hasegawa, Ryohei, Sano, Masashi, Tamano, Seiko, Esumi, Hiroyasu, Takayama, Shozo, ...
2-Amlno-1-methyl-6-phenylimidazo[4,5-b]pyrldine (PhIP), which is produced during cooking and is mutagenic to bacteria and cultured mammalian cells, was found to induce high incidences of colon and...
Hirose, Masao, Masuda, Atsuko, Hasegawa, Ryohei, Wada, Shigetsugu, Ito, Nobuyuki
The reversibility of butylated hydroxyanisole (BHA)-induced hamster forestomach hyperplasia was examined histopathologically. Groups of 10–15 male Syrian golden hamsters were treated with 2%...
Shirai, Tomoyuki, Nakamura, Atsushi, Fukushima, Shoji, Yamamoto, Atsushi, Tada, Mariko, Ito, Nobuyuki
Tumorigemc response in the prostate of F344, ACI, Lewis, CD and Wistar rat strains to 3,2′-dimethyl-4-amtnobiphenyl (DMAB) was examined in relation to development of other types of tumors. Rats of...
Wada, Shigetsugu, Hirose, Masao, Takahashi, Satoru, Okazaki, Shuzo, Ito, Nobuyuki
The modifying effects of para-methoxyphenol (PMP) second stage treatment on N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-initiated rat forestomach carcinogenesis were investigated. Groups of 15 6 week...
Shibata, Masa-Aki, Fukushima, Shoji, Takahashi, Satoru, Hasegawa, Ryohei, Ito, Nobuyuki
A wide-spectrum organ carcinogenesis model for detection of cancer modifiers in various organs was assessed in F344 male rats. After sequential treatment with diethylnitrosamine, N-methytaitrosourea,...
Shibata, Masa-Aki, Hirose, Masao, Yamada, Mayumi, Tatematsu, Masae, Uwagawa, Satoshi, Ito, Nobuyuki
An investigation of antioxidant-induced lesions in stomach epithelia was performed using F344 rats of both sexes. Histopathological changes, levels of DNA synthesis and pepsinogen isozyme 1 altered...
Shibata, Masa-Aki, Yamada, Mayumi, Hirose, Masao, Asakawa, Emiko, Tatematsu, Masae, Ito, Nobuyuki
The effects of 8 weeks of oral administration of five different phenolic antioxidants, e.g. catechol (CC), resorcinol, hydroquinone (HQ), 2-tert-butyl-4-methylphenol (TBMP) and propylparabene (PP),...
Tatematsu, Masae, Ozaki, Keisuke, Mutai, Mamoru, Shichino, Yutaka, Furihata, Chie, Ito, Nobuyuki
To assess the possibility of establishing an in vivo, medium-term bioassay system for gastric carcinogens and promoters, a total of 220 male WKY rats were divided into two groups. Group 1 animals...
Thornton, Mary, Moore, Malcolm Anthony, Ito, Nobuyuki
Dietary administration of dehydroepiandrosterone (DHEA) (0.6%) or butylated hydroxytoluene (BHT) (1%) during or subsequent to two i.p. injections of azaserine (30 mg/kg body wt)...
Transient induction of single GST-P positive hepatocytes by DEN (1989)
Satoh, Kimihiko, Hatayama, Ichiro, Tateoka, Noboru, Tamai, Katsuto, Shimizu, Toshio, Tatematsu, Masae, ...
The single cells positive for placental glutathione S-transferase (GST-P), detectable in livers of rats soon after treatment with hepatocarcinogens, are possible ‘initiated cells’, the hypothesis...
Tada, Mariko, Aoki, Hiromoto, Kojima, Misaki, Morita, Toshiteru, Shirai, Tomoyuki, Yamada, Hideyuki, ...
Polyclonal antibodies for 3,2'-dimethyl-4-aminobiphenyl (DMAB)–DNA adducts were obtained from the sera of rabbits immunized with N-OH-DMAB-modified DNA. Using the enzyme linked immunosorbent assay...
Co-carcinogenic effects of NaHCO3 on o-phenylphenol-induced rat bladder carcinogenesis (1989)
Fukushima, Sboji, Inoue, Tadashi, Uwagawa, Satoshi, Shibata, Masa-Aki, Ito, Nobuyuki
The role of urinary pH and Na+ concentration on the bladder carcinogenesis of o-phenylphenol (OPP) was examined in male F344 rats. The rats were given powdered diet containing 2% sodium...
WARD, JERROLD M., TSUDA, HIROYUKI, TATEMATSU, MASAE, HAGIWARA, AKIHIRO, ITO, NOBUYUKI
Hepatotoxicity of Agents That Enhance Formation of Focal Hepatocellular Proliferative Lesions (Putative Preneoplastic Foci) in a Rapid Rat Liver Bioassay. WARD, J. M., TSUDA, H., TATEMATSU, M.,...
Hirose, Masao, Kagawa, Masataka, Ogawa, Kumiko, Yamamoto, Atsushi, Ito, Nobuyuki
The effects of diethyhaleate (DEM), previously demonstrated to inhibit butylated hydroxyanisole (BHA)-induced forestomach hyperplasia, on BHA promotion of forestomach carcinogenesis in rats...
Hosokawa, Satoru, Tatematsu, Masae, Aoki, Toyohiko, Nakanowatari, Junichi, Igarashi, Toshiji, Ito, Nobuyuki
The effect of clofibrate (CF) on proliferation of diethylnitrosamine (DEN)-initiated glutathione S-transferase placental form (GST-P)-positive preneoplastic and neoplastic lesions was studied in male...
Ito, Nobuyuki, Hirose, Masao, Shibata, Masa-Aki, Tanaka, Hikaru, Shirai, Tomoyuki
The modifying effects of concurrent treatment with high or low doses of butylated hydroxyanisole (BHA) on widespectrum carcinogen-induced carcinogenesis were studied in male F344 rats. Groups of 20...
Tsuda, Hiroyuki, Tatematsu, Masae, Rodrigues, Maria Aparecida M., Yamada, Massao, Tzuji, Kozo, ...
Expression of the human placental form of glutathione Stransferase (GST-π), an enzyme proposed as a marker for human and experimental neoplasia, was immunohistochemically evaluated in 51 samples of...
Tatematsu, Masae, Katsuyama, Tsutomu, Mutai, Mamoru, Asakawa, Emiko, Ito, Nobuyuki
Mucin histochemistry of experimental gastric caresearch-articlencers induced in rats by N-methyl-N‘-nitro-N-nitrosoguanidine or 4-nitro-quinoline 1-oxide was analysed by labelled lectin staining...
Pancreatic acinar cell tumors in rats induced by 3, 2'-dimethyl-4-aminobiphenyl (1989)
Shirai, Tomoyuki, Nakamura, Atsushi, Wada, Shigetsugu, Ito, Nobuyuki
Pancreatic acinar cell lesions, including foci, nodules, adenomas and in situ carcinomas, were found in male F344 rats given s.c. injections of 3, 2'-dimethyl-4-aminobiphenyl (DMAB) at doses ranging...
Thamavit, Witaya, Moore, Malcolm A., Hiasa, Yoshio, Ito, Nobuyuki
Infection with 100 Opirthorchis viverrini (OP) metacercariae prior to two injections of dihydroxy-di-n-propyl nitrosamine (DHPN) (1000 mg/kg body weight) brought about significant enhancement of...
Tsuda, Hiroyuki, Asamoto, Makoto, Kagawa, Masataka, Uwagawa, Satoshi, Kazuhiko, Inoue, Inui, Masahiko, ...
The effect of deoxycholic acid (DCA) treatment subsequent to initiation of F344 male rats with N-methyl-N-nitrosourea (MNU), a wide spectrum carcinogen inducing tumors in many organs, was...
Ito, Nobuyuki, Tsuda, Hiroyuki, Tatematsu, Masae, Inoue, Tadashi, Tagawa, Yoshiaki, Aoki, Toyohiko, ...
A large series of assays of the hepatocarcinogenic potential of 112 different compounds werecarried out using a rapid bioassay system developed in this laboratory based on the two-step concept of...
Tatematsu, Masae, Aoki, Toyohiko, Inoue, Tadashi, Mutai, Mamoru, Furihata, Chie, Ito, Nobuyuki
Sequential changes of numbers of pepsinogen 1 (Pg 1)-decreased pyloric glands (PDPG) detected by immunohistochemistry and of the incidence of gastric carcinomas were examined in five different...
Tsuda, Hiroyuki, Moore, Malcolm A., Asamoto, Makoto, Inoue, Tadashi, Ito, Nobuyuki, Satoh, Kimihiko, ...
The expression of A and P forms of glutathione S-transferase (GST-A and P), two cytochrome P-450 isoenzymes (P-450 PB3a and P-450 MC2), microsomal epoxide hydrolase (mEHb), glucose-6-phosphate...
Hirose, Masao, Masuda, Atsuko, Fukushima, Shoji, Ito, Nobuyuki
The effects of the antioxidants tetramethyl-p-phenylenediamine (TMPD), propyl gallate (PG), quercetin (QC), 2-tert-butyl-4-methylphenol (TBMP), tert-butylhydroquinone (TBHQ), 3,3′-thiodipropionic...
Fujita, Jun, Ohuchi, Noriaki, Ito, Nobuyuki, Reynolds, Steven H., Yoshida, Osamu, Nakayama, Hiroki, ...
Ras-oncogene activation was investigated in the bladder tumors of F344 male rats given N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in drinking water. DNA from one of the nine transitional cell...
Masui, Tsuneo, Fukushima, Shoji, Katoh, Fumitaka, Yamasaki, Hiroshi, Ito, Nobuyuki
To study the mechanism of tumor promotion by different classes of urinary bladder promoters, the effect of sodium L-ascorbate, uracil and butylated hydroxyanisole (BHA) on junctional intercellular...
Moore, Malcolm A., Thamavit, Witaya, Hiasa, Yoshio, Ito, Nobuyuki
The effects of concomitant Opisthorchis infestation and dehydroepiandrosterone (DHEA) or butylated hydroxyanisole (BHA) administration on dihydroxy-di-n-propylnitrosamine (DHPN) induction of...
Fukushima, Shoji, Tamano, Seiko, Shibata, Masa-Aki, Kurata, Yasushi, Hirose, Masao, Ito, Nobuyuki
The promoting activities of NaHCO3 and NaCl in two-stage urinary bladder carcinogenesis in rats initiated with N-butylN-(4-hydroxybutyl)nitrosamine (BBN) were investigated. Male F344 rats were given...
Tatematsu, Masae, Mera, Yukinori, Inoue, Tadashi, Satoh, Kimihiko, Sato, Kiyomi, Ito, Nobuyuki
Using immunohistochemical demonstration of glutathione S-transferase placental type (GST-P) and histochemical demonstration of γ-glutamyltransferase (γ-GT), the long-term development of...
Tatematsu, Masae, Aoki, Toyohiko, Kagawa, Masataka, Mera, Yukinori, Ito, Nobuyuki
The effects of 2-acetylaminofluorene (2-AAF), pbenobarbital (PB) and butylated hydroxyanisole (BHA) on the competitive proliferation of glutathione S-transferase (GST-P) positive liver cell foci...
Tsuda, Hiroyuki, Moore, Malcolm A., Asamoto, Makoto, Inoue, Tadashi, Fukushima, Shoji, Ito, Nobuyuki, ...
A comparison of N-ethyl-N-hydroxyethylnistrosamine (EHEN)-induced preneoplastic and neoplastic lesions in the rat liver and kidney was made with respect to the expression of different drug...
Tsuda, Hiroyuki, Ogiso, Tadashi, Hasegawa, Ryohei, Imaida, Katsumi, Masui, Tsuneo, Ito, Nobuyuki
The modifying effects of 4,4'-diaminodiphenylmethane (DDPM) (0.1% in diet) administration on liver carcinogenesis induced by 2-acetylaminofluorene (2-AAF) (0.02% in diet),...
Shirai, Tomoyuki, Tsuda, Hiroyuki, Ogiso, Tadashi, Hirose, Masao, Ito, Nobuyuki
Estrogen has been shown to exert a modifying potential on carcinogenesis in various organs, and in particular the hormone-dependent tissues. The present experiments were carried out to detennine the...
Kurata, Yasushi, Tsuda, Hiroyuki, Sakata, Takao, Yamashita, Takao, Ito, Nobuyuki
The effects of four isomeric forms of aminophenols, ortho-, meta-, para-aminophenol and acetaminophen (o-, m-, p-AP and AAP, respectively) on liver and kidney carcinogenesis initiated by...
Hirose, Masao, Inoue, Tadashi, Masuda, Atsuko, Tsuda, Hiroyuki, Ito, Nobuyuki
Male F344 rats were administered phenobarbital, polychiorinated biphenyl (PCB), retinol acetate, indomethacin, 6-aminocaproic acid, dexamethazone (DEX) or diethylinaleate (DEM) for one week and then...
Hirose, Masao, Masuda, Atsuko, Tsuda, Hiroyuki, Uwagawa, Satoshi, Ito, Nobuyuki
Synergistic effects of butylated hydroxyanisole (BHA) and other antioxidants on induction of rat forestomach lesions were investigated. Groups of F344 male rats were treated with 1% BHA phis...
Moore, Malcolm A., Nakamura, Toshikazu, Ito, Nobuyuki
Comparison of binding of specific antibodies to glu-cose-6-phosphate dehydrogenase (G6PD), γ-glutamyl trans-peptidase (GT), ornithine decarboxylase (ODQ and the glutathione S-transferase B and P...
Hirose, Masao, Inoue, Tadashi, Asamoto, Makoto, Tagawa, Yoshiaki, Ito, Nobuyuki
Groups of 6-week-old male Syrian golden hamsters were given 13 different phenolic compounds for 20 weeks. Of these compounds, 2(3)-te/f-butyl-4-methoxyphenol (BHA), 2-tert-butyl-4-methylphenol (TBMP)...
Moore, Malcolm A., Thamavit, Witaya, Tsuda, Hiroyuki, Sato, Kiyomi, Ichihara, Akira, Ito, Nobuyuki
Following initial treatment of F344 rats with dihydroxy-di-n-propyinitrosamine, exposure to dehydroepiandrosterone (DHEA) administered in the diet at a concentration of 0.6% brought about...
Moore, Malcolm A., Tsuda, Hiroyuki, Ito, Nobuyuki
Histochemical investigation of altered dehydrogenase enzyme activity in putative pre-neoplastic lesions induced by N-ethyl-N-hydroxyethylnitrosamine in the rat liver revealed a clear increase in...
Moore, Malcolm A., Thamavit, Witaya, Ichihara, Akira, Sato, Kiyomi, Ito, Nobuyuki
The effects of concomitant treatment with dehydroepiandro-sterone, an inhibitor of glucose-6-phosphate dehydrogenase (G6PD), diaminopropane (DAP), an inhibitor of onuithine decarboxylase or the...
Hirose, Masao, Masuda, Atsuko, Inoue, Tadashi, Fukushima, Shoji, Ito, Nobuyuki
The effects of antioxidants on mammary gland carcinogenesis pretreated with 7, 12-dimethylbenz[a]anthracene (DMBA) in female Sprague-Dawley rats were examined. The antioxidants used were butylated...
Shirai, Tomoyuki, Ikawa, Etsuo, Hirose, Masao, Thamavit, Witaya, Ito, Nobuyuki
The effects of antioxidants given in the post initiation phase of colon tumor development were investigated in male F344 rats treated with 1 ,2-dimethylhydrazine (DMH). Animals (20/group) were...
Tatematsu, Masae, Mera, Yukinori, Ito, Nobuyuki, Satoh, Kimihiko, Sato, Kiyomi
The values of the immunohistochemical demonstrations of glutathione S-transferases (GSTs) A, B, C and P and histo-chemical demonstrations of γ-glutamyl transpeptidase (γ-GT) for detection of enzyme...
Sato, Kiyomi, Kitahara, Akio, Yin, Zongzhu, Waragai, Fusako, Nishimura, Koya, Hatayama, Ichiro, ...
Effects of an antioxidant, butylated (3-tert-butyl-4-) hydroxyanisole (BHA) on the induction of specific molecular forms of glutathione S-transferase (GST), UDP-glucuronyltransferase (UDP-GT) and...
Tsuda, Hiroyuki, Sakata, Takao, Masui, Tsuneo, Imaida, Katsumi, Ito, Nobuyuki
Studies were made on the effects of butylated hydroxyanisole (BHA), ethoxyquin (EQ) and acetaminophen (AAP) on the induction of neoplastic lesions in the liver and kidney of rats initiated by...
Ito, Nobuyuki, Moore, Malcolm A., Bannasch, Peter
The effects of 2-acetylaminofluorene (2-AAF), sodium phenobarbital (PB) and 4,4′ -diaminodiphenylmethane (DDPM) on the developmental sequence of N-nitrosomorpholine (NNM) induced changes in the rat...
Tsuda, Hiroyuki, Sakata, Takao, Tamano, Seiko, Okumara, Masanao, Ito, Nobuyuki
Sequential observations were carried out on the induction of preneoplastic lesions in the liver and the kidney. Rats were initially given N-ethyl-N-hydroxyethylnitrosamine (EHEN) in their drinking...
Imaida, Katsumi, Oshima, Masato, Fukushima, Shoji, Ito, Nobuyuki, Hotta, Ken
Membrane potentials of the urinary bladder epithelium in F344 male rats treated with N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) or sodium saccharin were measured. In experiment 1, membrane...
Imaida, Katsumi, Fukushima, Shoji, Shirai, Tomoyuki, Ohtani, Mikinobu, Nakanishi, Keisuke, Ito, Nobuyuki
Butylated hydroxyanisole (BHA) and butylated hydroxy-toluene (BHT) were evaluated for possible promoting activity for urinary bladder carcinogenesis in male F344 rats initiated by...
Tatematsu, Masae, Hasegawa, Ryohei, Imaida, Katsumi, Tsuda, Hiroyuki, Ito, Nobuyuki
The effects of pre- (initiation stage) and post- (promotion stage) administration of 17 chemical carcinogens (including both hepatic and non-hepatic carcinogens), 3 promoters and 2 non-carcinogenic...
Moore, Malcom A., Takahashi, Michihito, Ito, Nobuyuki, Bannasch, Peter
The early lesions which arise in the Syrian hamster pancreas prior to the appearance of carcinomas induced by treatment with the related carcinogens di-hydroxy-di-n-propyl nitrosamine or...
Moore, Malcom A., Takahashi, Michihito, Ito, Nobuyuki, Bannasch, Peter
The ultrastructure of multi-locular cystic lesions and atypical epithelial proliferations arising in the Syrian hamster pancreas prior to the appearance of carcinomas during treatment with the...
Shirai, Tomoyuki, Imaida, Katsumi, Fukushima, Shoji, Hasegawa, Ryohei, Tatematsu, Masae, Ito, Nobuyuki
Effects of NaCI, Tween 60 and N-ethyl-N' -nitro-N-nitrosoguanidine (ENNG) on gastric carcinogenesis were investigated in male Wistar rats. Animals received a single dose of N-methyl-N'...
Hirose, Masao, Imaida, Katsumi, Ito, Hiroshi, Hayashi, Masatoshi, Ishihara, Yuichi, Ito, Nobuyuki
Factors enhancing renal carcinogenesis induced by formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl]hydrazide (FNT) were studied. Five groups of rats were used. Groups 1 and 2 were subjected to right...
Hirose, Masao, Shirai, Tomoyuki, Tsuda, Hiroyuki, Fukushima, Shoji, Ogiso, Tadashi, Ito, Nobuyuki
The effects of phenobarbital (PB), polychlorinated biphenyl (PCB) and sodium saccharin (SS) on hepatic and renal carcinogenesis induced by N-ethyl-N-hydroxyethylnitrosamine (EHEN) were examined in...
Fukushima, Shoji, Hirose, Masao, Hagiwara, Akihiro, Hasegawa, Ryohei, Ito, Nobuyuki
The effects of 4,4′-diaminodiphenylmethane (DDPM) administration in the ‘post-initiation’ stage of liver, kidney and bladder carcinogenesis were examined in male F344 rats. In experiment I,...
Polynucleotide Ligase from Kidney Tumors in Rats Induced by N-Nitrosodimethylamine (1972)
Polynucleotide ligase, which catalyzes the covalent joining of two segments of an interrupted strand in a DNA duplex, was studied in normal rat kidney and kidney tumors induced by...
Claesson-Welsh, Lena, Welsh, Michael, Ito, Nobuyuki, Anand-Apte, Bela, Soker, Shay, Zetter, Bruce, ...
Angiostatin, a fragment of plasminogen, has been identified and characterized as an endogenous inhibitor of neovascularization. We show that angiostatin treatment of endothelial cells in the absence...
Kamada, Yoshihiro, Nagaretani, Hiroyuki, Tamura, Shinji, Ohama, Tohru, Maruyama, Takao, Hiraoka, Hisatoyo, ...
Although L-arginine is the only substrate for nitric oxide (NO) production, no studies have yet been reported on the effect of an L-arginine deficiency on vascular function in humans. Lysinuric...
Modifying factors in urinary bladder carcinogenesis
Ito, Nobuyuki, Fukushima, Shoji, Shirai, Tomoyuki, Nakanishi, Keisuke, Hasegawa, Ryohei, Imaida, Katsumi
N-Butyl-N-(4-hydroxybutyl)nitrosamine (BBN) is a potent carcinogen in the urinary bladder of animals. The BBN model of bladder cancer is an excellent model of human urinary bladder cancer and has...
Claesson-Welsh, Lena, Welsh, Michael, Ito, Nobuyuki, Anand-Apte, Bela, Soker, Shay, Zetter, Bruce, ...
Angiostatin, a fragment of plasminogen, has been identified and characterized as an endogenous inhibitor of neovascularization. We show that angiostatin treatment of endothelial cells in the absence...
Kamada, Yoshihiro, Nagaretani, Hiroyuki, Tamura, Shinji, Ohama, Tohru, Maruyama, Takao, Hiraoka, Hisatoyo, ...
Although L-arginine is the only substrate for nitric oxide (NO) production, no studies have yet been reported on the effect of an L-arginine deficiency on vascular function in humans. Lysinuric...
Modifying factors in urinary bladder carcinogenesis
Ito, Nobuyuki, Fukushima, Shoji, Shirai, Tomoyuki, Nakanishi, Keisuke, Hasegawa, Ryohei, Imaida, Katsumi
N-Butyl-N-(4-hydroxybutyl)nitrosamine (BBN) is a potent carcinogen in the urinary bladder of animals. The BBN model of bladder cancer is an excellent model of human urinary bladder cancer and has...
Nobuyuki Ito, Kenji Takeuchi, Koichi Kuriyama, Yasushi Shoji, Takahiro Tsuge, Yohei Mitani
We conduct an experimental survey to analyze how rules for collective decision-making influence individual preferences concerning nature restoration projects. Our study compares two decision-making...
A Dynamic Analysis of the Green Electricity Fund:Threshold Models Revisited
Nobuyuki Ito, Kenji Takeuchi, Takahiro Tsuge, Atsuo Kishimoto
This study applies a threshold model proposed by Granovetter (1978) to analyze the dynamic diffusion process of donating behavior for renewable energy. Using data on people's willingness to donate...
Ito, Nobuyuki, Takeuchi, Kenji, Kuriyama, Koichi, Shoji, Yasushi, Tsuge, Takahiro, Mitani, Yohei
We conduct an experimental survey to analyze how rules for collective decision-making influence individual preferences regarding nature restoration plans. Our study compares two decision-making...