Norbert Brieske

Detection of novel skeletogenesis target genes by comprehensive analysis of a Runx2−/− mouse model (2007)

Hecht, Jochen, Seitz, Volkhard, Urban, Maren, Wagner, F., Robinson, P. N., Stiege, A., ...

Runx2 is an essential factor for skeletogenesis and heterozygous loss causes cleidocranial dysplasia in humans and a corresponding phenotype in the mouse. Homozygous Runx2-deficient mice lack...

Comparative expression pattern of Odd-skipped related genes Osr1 and Osr2 in chick embryonic development (2006)

Stricker, Sigmar, Brieske, Norbert, Haupt, Julia, Mundlos, Stefan

Odd-skipped genes encode zinc-finger transcription factors with widespread roles in embryonic development. In Drosophila, odd-skipped acts as a pair-rule gene, while its orthologous gene in...

Cloning and expression pattern of chicken Ror2 and functional characterization of truncating mutations in Brachydactyly type B and Robinow syndrome (2006)

Stricker, Sigmar, Van Wijk, Nicole Verhey, Witte, Florian, Brieske, Norbert, Seidel, Kathrin, Mundlos, Stefan

Ror2 is a receptor tyrosine kinase mutated in the human syndromes Brachydactyly type B (BDB) and recessive Robinow syndrome (RS). In this study, we used the chick as a model to investigate the role...

Ror2 knockout mouse as a model for the developmental pathology of autosomal recessive Robinow syndrome (2004)

Schwabe,Georg C., Trepczik,Britta, Süring,Kathrin, Brieske,Norbert, Tucker,Abigail S., Sharpe,Paul T., ...

Robinow syndrome (RS) is a human dwarfism syndrome characterized by mesomelic limb shortening, vertebral and craniofacial malformations and small external genitals. We have analyzed Ror2-/- mice as a...

Ror2 knockout mouse as a model for the developmental pathology of autosomal recessive Robinow syndrome (2004)

Schwabe, Georg C., Trepczik, Britta, Süring, Kathrin, Brieske, Norbert, Tucker, Abigail S., Sharpe, Paul T., ...

Robinow syndrome (RS) is a human dwarfism syndrome characterized by mesomelic limb shortening, vertebral and craniofacial malformations and small external genitals. We have analyzed Ror2-/- mice as a...

Fit genotypes and escape variants of subgroup III Neisseria meningitidis during three pandemics of epidemic meningitis

Zhu, Peixuan, Van Der Ende, Arie, Falush, Daniel, Brieske, Norbert, Morelli, Giovanna, Linz, Bodo, ...

The genetic variability at six polymorphic loci was examined within a global collection of 502 isolates of subgroup III, serogroup A Neisseria meningitidis. Nine “genoclouds” were identified,...

An inversion involving the mouse Shh locus results in brachydactyly through dysregulation of Shh expression

Niedermaier, Michael, Schwabe, Georg C., Fees, Stephan, Helmrich, Anne, Brieske, Norbert, Seemann, Petra, ...

Short digits (Dsh) is a radiation-induced mouse mutant. Homozygous mice are characterized by multiple defects strongly resembling those resulting from Sonic hedgehog (Shh) inactivation. Heterozygous...

Fit genotypes and escape variants of subgroup III Neisseria meningitidis during three pandemics of epidemic meningitis

Zhu, Peixuan, Van Der Ende, Arie, Falush, Daniel, Brieske, Norbert, Morelli, Giovanna, Linz, Bodo, ...

The genetic variability at six polymorphic loci was examined within a global collection of 502 isolates of subgroup III, serogroup A Neisseria meningitidis. Nine “genoclouds” were identified,...

An inversion involving the mouse Shh locus results in brachydactyly through dysregulation of Shh expression

Niedermaier, Michael, Schwabe, Georg C., Fees, Stephan, Helmrich, Anne, Brieske, Norbert, Seemann, Petra, ...

Short digits (Dsh) is a radiation-induced mouse mutant. Homozygous mice are characterized by multiple defects strongly resembling those resulting from Sonic hedgehog (Shh) inactivation. Heterozygous...