Norbert Lameire

Dose of dialysis in the intensive care unit: is the venom in the dose or in the clinical experience? (2009)

Lameire, Norbert, Van Biesen, Wim, Vanholder, Raymond

Abstract Many studies on the most 'adequate' dose of renal replacement therapy (RRT) in critically ill patients with acute kidney injury have obtained contradictory results. The previous issue of...

distinction between glomerular and tubular renal disease (2009)

Wim Van Biesen, Guido Sieben, Norbert Lameire, Raymond Vanholder

Abstract Conclusion. We conclude that a Kohonen map is cap-Background. A Kohonen topological map is an artifiable of classifying the patients as having glomerular cial intelligence system of the...

A novel bio-assay increases the detection yield of microbiological impurity of dialysis fluid, in comparison to the LAL-test (2009)

GLORIEUX, GRIET, Schepers, Eva, Schindler, Ralf, Lemke, Horst-Dieter, VERBEKE, FRANCIS, Dhondt, Annemieke, ...

Background. Biological purity of dialysis water is considered as one of the primary conditions to deliver optimal haemodialysis. Methods. The present study explores the added value of a novel...

The prevention of acute kidney injury an in-depth narrative review (2009)

Lameire, Norbert, Van Biesen, Wim, Hoste, Eric, Vanholder, Raymond

The second part of this in-depth clinical review focuses on drugs used in the prevention of AKI in the patient at risk and/or in the management of the patient with incipient AKI. Among the drugs used...

The prevention of acute kidney injury an in-depth narrative review: Part 2: Drugs in the prevention of acute kidney injury (2009)

Lameire, Norbert, Van Biesen, Wim, Hoste, Eric, Vanholder, Raymond

The second part of this in-depth clinical review focuses on drugs used in the prevention of AKI in the patient at risk and/or in the management of the patient with incipient AKI. Among the drugs used...

A novel bio-assay increases the detection yield of microbiological impurity of dialysis fluid, in comparison to the LAL-test (2009)

Glorieux, Griet, Schepers, Eva, Schindler, Ralf, Lemke, Horst-Dieter, Verbeke, Francis, Dhondt, Annemieke, ...

Background. Biological purity of dialysis water is considered as one of the primary conditions to deliver optimal haemodialysis. Methods. The present study explores the added value of a novel...

Residual renal function and volume status in peritoneal dialysis patients: a conflict of interest? (2008)

Van Biesen, Wim, Lameire, Norbert, VERBEKE, FRANCIS, Vanholder, Raymond

Fluid status and volume homeostasis are extremely important in patients with CKD stage 5, as cardiovascular disease, including congestive heart failure and hypertension, is one of the leading causes...

Acute renal problems in the critically ill cancer patient (2008)

Lameire, Norbert, Van Biesen, Wim, Vanholder, Raymond

This review addresses three major topics relevant for the management of renal problems in the critically ill cancer patient; the assessment of kidney function in patients with cancer, serious water...

Two-tier approach for the detection of alpha-galactosidase A deficiency in kidney transplant recipients (2008)

De Schoenmakere, Gert, Poppe, Bruce, Wuyts, Birgitte, Claes, Kathleen, Cassiman, David, Maes, Bart, ...

Background. Anderson-Fabry disease (AFD) is an X-linked condition originating from a deficiency in alpha-galactosidase, a lysosomal enzyme. Multi-organ involvement ensues in early adulthood and vital...

The prevention of acute kidney injury: an in-depth narrative review Part 1: volume resuscitation and avoidance of drug- and nephrotoxin-induced AKI (2008)

Lameire, Norbert, Van Biesen, Wim, Hoste, Eric, Vanholder, Raymond

This narrative clinical review in two parts discusses the prevention of clinical acute kidney injury (AKI). The first part focuses on general prevention measures, including identification of...

A practice-related risk score (PRS): a DOPPS-derived aggregate quality index for haemodialysis facilities (2008)

Mendelssohn, David C., Pisoni, Ronald L., Arrington, Charlotte J., Yeates, Karen E., Leblanc, Martine, Deziel, Clement, ...

Background. The Dialysis Outcomes and Practice Patterns Study (DOPPS) database was used to develop and validate a practice-related risk score (PRS) based on modifiable practices to help facilities...

Two-tier approach for the detection of alpha-galactosidase A deficiency in a predominantly female haemodialysis population (2008)

Terryn, Wim, Poppe, Bruce, Wuyts, Birgitte, Claes, Kathleen, Maes, Bart, Verbeelen, Dierik, ...

Introduction. Fabry's disease (AFD) is an X-linked lysosomal storage disease, resulting from a deficiency in alpha-galactosidase A (AGALA). Untreated, this leads to precocious failure of vital organ...

The prevention of acute kidney injury: an in-depth narrative review Part 1: volume resuscitation and avoidance of drug- and nephrotoxin-induced AKI (2008)

Lameire, Norbert, Van Biesen, Wim, Hoste, Eric, Vanholder, Raymond

This narrative clinical review in two parts discusses the prevention of clinical acute kidney injury (AKI). The first part focuses on general prevention measures, including identification of...

Two-tier approach for the detection of alpha-galactosidase A deficiency in kidney transplant recipients (2008)

Schoenmakere, Gert De, Poppe, Bruce, Wuyts, Birgitte, Claes, Kathleen, Cassiman, David, Maes, Bart, ...

Background. Anderson–Fabry disease (AFD) is an X-linked condition originating from a deficiency in alpha-galactosidase, a lysosomal enzyme. Multi-organ involvement ensues in early adulthood and...

The glomerular filtration rate in an apparently healthy population and its relation with cardiovascular mortality during 10 years (2007)

Van Biesen, Wim, De Bacquer, Dirk, Verbeke, Francis, Delanghe, Joris, Lameire, Norbert, Vanholder, Raymond

Aims Moderate-to-severe chronic renal failure is an established risk factor for cardiovascular disease and mortality. However, most studies have been performed in selected populations and the impact...

Belgium's mixed private/public health care system and its impact on the cost of end-stage renal disease (2007)

Van Biesen, Wim, Lameire, Norbert, Peeters, Patrick, Vanholder, Raymond

Belgium has a mixed, public-private health care system, with state-organized reimbursements but private providers. The system is fee for service. For end-stage renal disease (ESRD), the...

Clamping of the dialysate outlet line in the Genius(R) dialysis system does not alter dialysate flow or clearances (2006)

Biesen, Wim Van, Eloot, Sunny, Verleysen, Annick, Glorieux, Griet, Veys, Nic, Vanholder, Raymond, ...

Background. The Genius® dialysis system is advocated as a tool to perform slow extended daily dialysis (SLEDD) in patients with acute renal failure at the intensive care unit. At low blood flows...

Clamping of the dialysate outlet line in the Genius(R) dialysis system does not alter dialysate flow or clearances (2006)

Van Biesen, Wim, Eloot, Sunny, Verleysen, Annick, Glorieux, Griet, Veys, Nic, Vanholder, Raymond, ...

Background. The Genius® dialysis system is advocated as a tool to perform slow extended daily dialysis (SLEDD) in patients with acute renal failure at the intensive care unit. At low blood flows...

The importance of standardization of creatinine in the implementation of guidelines and recommendations for CKD: implications for CKD management programmes (2006)

Van Biesen, Wim, Vanholder, Raymond, Veys, Nic, Verbeke, Francis, Delanghe, Joris, De Bacquer, Dirk, ...

Background. In an attempt to reduce late referral and to improve the care of patients with chronic kidney disease (CKD), different organizations have issued guidelines on when to refer patients to...

Clamping of the dialysate outlet line in the Genius(R) dialysis system does not alter dialysate flow or clearances (2006)

Biesen, Wim Van, Eloot, Sunny, Verleysen, Annick, Glorieux, Griet, Veys, Nic, Vanholder, Raymond, ...

Background. The Genius® dialysis system is advocated as a tool to perform slow extended daily dialysis (SLEDD) in patients with acute renal failure at the intensive care unit. At low blood flows...

Immunopathological changes in a uraemic rat model for peritoneal dialysis (2005)

Zareie, Mohammad, De Vriese, An S., Hekking, Liesbeth H. P., Ter Wee, Piet M., Schalkwijk, Casper G., Driesprong, Bas A. J., ...

Background. Peritoneal dialysis (PD) is a treatment modality for patients with renal failure. Both the uraemic state of these patients and chronic exposure to PD fluid are associated with the...

The importance of standardization of creatinine in the implementation of guidelines and recommendations for CKD: implications for CKD management programmes (2005)

Van Biesen, Wim, Vanholder, Raymond, Veys, Nic, Verbeke, Francis, Delanghe, Joris, De Bacquer, Dirk, ...

Background. In an attempt to reduce late referral and to improve the care of patients with chronic kidney disease (CKD), different organizations have issued guidelines on when to refer patients to...

Immunopathological changes in a uraemic rat model for peritoneal dialysis (2005)

Zareie, Mohammad, De Vriese, An S., Hekking, Liesbeth H. P., Ter Wee, Piet M., Schalkwijk, Casper G., Driesprong, Bas A. J., ...

Background. Peritoneal dialysis (PD) is a treatment modality for patients with renal failure. Both the uraemic state of these patients and chronic exposure to PD fluid are associated with the...

Immunopathological changes in a uraemic rat model for peritoneal dialysis (2005)

Zareie, Mohammad, De Vriese, An S., Hekking, Liesbeth H. P., Ter Wee, Piet M., Schalkwijk, Casper G., Driesprong, Bas A. J., ...

Background. Peritoneal dialysis (PD) is a treatment modality for patients with renal failure. Both the uraemic state of these patients and chronic exposure to PD fluid are associated with the...

The importance of standardization of creatinine in the implementation of guidelines and recommendations for CKD: implications for CKD management programmes (2005)

Van Biesen, Wim, Vanholder, Raymond, Veys, Nic, Verbeke, Francis, Delanghe, Joris, De Bacquer, Dirk, ...

Background. In an attempt to reduce late referral and to improve the care of patients with chronic kidney disease (CKD), different organizations have issued guidelines on when to refer patients to...

Hantavirus infections in Europe (2003)

Lameire, Norbert

Laboratory of Clinical and Epidemiological Virology, Department of Microbiology and Virology, Rega Institute and University Hospitals Leuven, Leuven, Belgium. jan.clement@uz.kuleuven.ac.be

Specific characteristics of peritoneal leucocyte populations during sterile peritonitis associated with icodextrin CAPD fluids (2003)

Glorieux, Griet, Lameire, Norbert, Van Biesen, Wim, Dequidt, Clement, Vanholder, Raymond

Background. Icodextrin dialysate used for peritoneal dialysis contains an iso-molar glucose polymer solution, which provides sustained ultrafiltration over long dwell times and is considered a...

Specific characteristics of peritoneal leucocyte populations during sterile peritonitis associated with icodextrin CAPD fluids (2003)

Glorieux, Griet, Lameire, Norbert, Van Biesen, Wim, Dequidt, Clement, Vanholder, Raymond

Background. Icodextrin dialysate used for peritoneal dialysis contains an iso-molar glucose polymer solution, which provides sustained ultrafiltration over long dwell times and is considered a...

Outcome in a post-cardiac surgery population with acute renal failure requiring dialysis: does age make a difference? (2003)

Van Den Noortgate, Nele, Mouton, Veerle, Lamot, Caroline, Van Nooten, Guido, Dhondt, Annemieke, Vanholder, Raymond, ...

Background. Acute renal failure (ARF), requiring dialysis (ARF‐d), develops in 1–5% of patients undergoing cardiac surgery and is associated with higher...

The role of trace elements in uraemic toxicity (2002)

Vanholder, Raymond, Cornelis, Rita, Dhondt, Annemieke, Lameire, Norbert

Although most research on uraemic toxicity has focused on the retention or removal of organic solutes, subtle changes in the concentration of inorganic compounds are also of importance because these...

The Marmara earthquake: admission laboratory features of patients with nephrological problems (2002)

Sever, Mehmet Sükrü, Erek, Ekrem, Vanholder, Raymond, Özener, Çetin, Yavuz, Mahmut, Ergin, Hülya, ...

Background. Earthquakes are major causes of morbidity and mortality. North‐western Turkey was struck by a devastating earthquake in August 1999, which caused several thousand deaths. Among...

Clinical findings in the renal victims of a catastrophic disaster: the Marmara earthquake (2002)

Sever, Mehmet Sukru, Erek, Ekrem, Vanholder, Raymond, Akoglu, Emel, Yavuz, Mahmut, Ergin, Hulya, ...

Background. The clinical course of acute renal failure (ARF) related to crush syndrome is very complex, because of co‐existing surgical and/or medical complications. After the...

Relationship between gastric emptying and clinical and biochemical factors in chronic haemodialysis patients (2001)

De Schoenmakere, Gert, Vanholder, Raymond, Rottey, Sylvie, Duym, Philippe, Lameire, Norbert

Background. Gastroparesis is an important side‐effect of end‐stage renal disease because of its influence on nutritional status. Methods. In this study, 56 equilibrated...

The anti-proliferative effect of calcitriol on HL-60 cells is neutralized by uraemic biological fluids (2001)

Glorieux, Griet, Hsu, Chen, De Smet, Rita, Dhondt, Annemieke, Van Emmelo, John, Waterloos, Marie-Anne, ...

Background. It has been demonstrated that uraemic serum/ultrafiltrate inhibits cell‐mediated immune response in vitro, and that it suppresses calcitriol synthesis and its biological...

Intradialytic removal of protein-bound uraemic toxins: role of solute characteristics and of dialyser membrane (2000)

Lesaffer, Gerrit, De Smet, Rita, Lameire, Norbert, Dhondt, Annemieke, Duym, Philippe, Vanholder, Raymond

Background. The efficiency of dialysis membranes is generally evaluated by assessing their capacity to remove small, water-soluble and non-protein-bound reference markers such as urea or creatinine....

Functional analysis of vascular dysfunction in cyclosporin treated rats (1994)

Verbeke, Marleen, Voorde, Johan Van De, Ridder, Leo De, Lameire, Norbert

Objective: The aim was to analyse vascular damage after chronic cyclosporin treatment (20 mg·kg–1 during 10 d) in rats. Methods: The reactivity to different vasoactive agents was studied on...

Belgium’s mixed private/public health care system and its impact on the cost of end-stage renal disease

Wim Biesen, Norbert Lameire, Patrick Peeters, Raymond Vanholder

End-stage renal disease, Dialysis, Health care financing, Medical Costs, Reimbursement, Belgium, I10, I11, I12, I18,

Dose of dialysis in the intensive care unit: is the venom in the dose or in the clinical experience?

Lameire, Norbert, Van Biesen, Wim, Vanholder, Raymond

Many studies on the most 'adequate' dose of renal replacement therapy (RRT) in critically ill patients with acute kidney injury have obtained contradictory results. The previous issue of Critical...