Nishibori, Masahiro, Takahashi, Hide K., Katayama, Hiroshi, Mori, Shuji, Saito, Shinya, Iwagaki, Hiromi, ...
Lipopolysaccharide (LPS) is one of the major causes of septic shock. The polymyxin B-immobilized filter column (PMX) was developed for the adsorption of endotoxin by direct hemoperfusion and has been...
Analysis of Fecal DNA Methylation to Detect Gastrointestinal Neoplasia (2009)
Nagasaka, Takeshi, Tanaka, Noriaki, Cullings, Harry M., Sun, Dong-Sheng, Sasamoto, Hiromi, Uchida, Takuyuki, ...
BackgroundThe development of noninvasive screening tests is important to reduce mortality from gastrointestinal neoplasia. We sought to develop such a test by analysis of DNA methylation from...
Otani, Satoru, Kuinose, Masahiko, Murakami, Takashi, Saito, Shinya, Iwagaki, Hiromi, Tanaka, Noriaki, ...
Activation of inflammatory response during cardiopulmonary bypass (CPB) may lead to considerable post-operative mortality. Recently, pentoxifylline (PTX), a methylxanthine derivative, has been...
Endoderm Induction for Hepatic and Pancreatic Diff erentiation of ES Cells (2008)
Soto-Gutierrez, Alejandro, Navarro-Alvarez, Nalu, Caballero-Corbalan, Jose, Tanaka, Noriaki, Kobayashi, Naoya
Hepatic and pancreatic differentiation from ES cells is of great interest for the impact that this knowledge could have on the treatment of hepatic and diabetic patients. The liver and pancreas...
Ono, Minoru, Tanaka, Noriaki, Orita, Kunzo
Antibody-dependent cellular cytotoxicity (ADCC) increased with the development of tumors in C3H/He mice bearing spontaneous breast cancer or the syngeneic hepatoma MH-134 and in C57BL/6 mice bearing...
Surgical treatment for Crohn's disease. (2007)
Perdomo, Jose Antonio, Iwagaki, Hiromi, Hizuta, Akio, Mizuno, Motowo, Nakagawa, Hitoshi, Tanaka, Noriaki, ...
The medical records of 16 consecutive patients with Crohn's disease surgically treated in our department from 1978 to 1993 were retrospectively reviewed. The indication for surgery was obstructive...
Suo, Jian, Tanaka, Noriaki, Hizuta, Akio, Yunoki, Shigeru, Orita, Kunzo
PSK (Krestin) is a protein-bound polysaccharide with antitumor and immunomodulatory activity. In this study, the effects of the oral administration of PSK were investigated on the natural killer (NK)...
The importance of family study in the patients with familial adenomatous polyposis. (2007)
Perdomo, Jose Antonio, Iwagaki, Hiromi, Hizuta, Akio, Tanaka, Noriaki, Orita, Kunzo
Familial adenomatous polyposis (FAP) is a well-known autosomal dominant disorder characterized by the formation of multiple adenomatous polyps of the colon. Gardner's syndrome is a variant of...
Clinical value of soluble interleukin-2 receptor in infectious complications. (2007)
Iwagaki, Hiromi, Hizuta, Akio, Iwadou, Hironori, Perdomo, Jose Antonio, Tanaka, Noriaki, Orita, Kunzo
In this study, we investigated serum-soluble interleukin-2 receptor (sIL-2r) and neopterin (NPT) levels in five patients with severe postoperative infections. A total of 25 synchronous determinations...
Ariki, Norifumi, Iwagaki, Hiromi, Yoshino, Tadashi, Nonaka, Yasuyuki, Fujiki, Shigeatsu, Perdomo, Jose Antonio, ...
Endoscopical segmental piecemeal tumorectomy (ESPT) for nodular elevation of colorectal tumor is advantageous in terms of minimizing both surgical invasion and postoperative burden to the patients....
Zhang, Wei, Naomoto, Yoshio, Tanaka, Noriaki, Hizuta, Akio, Orita, Kunzo
The effects of the combination of natural human tumor necrosis factor-alpha (nHuTNF-alpha) and natural human interferon-alpha (nHuIFN-alpha) on the induction of apoptosis were investigated by...
Okamoto, Yasuhisa, Tanaka, Noriaki, Orita, Kunzo
We investigated the effects of lymphokine-activated killer (LAK) cells on epidermal hyperplasia induced by cholera toxin (CT). LAK cells showed cytotoxic activity against both tumor cell lines and...
Ovarian Metastasis in Patients with Colorectal Carcinoma (2007)
Perdomo, Jose A, Hizuta, Akio, Iwagaki, Hiromi, Takasu, Shinji, Nonaka, Yasuyuki, Kimura, Toshikazu, ...
The records of 159 patients who underwent surgical resection of colorectal cancer were reviewed to assess the incidence of ovarian metastasis and to define the role of oophorectomy. Four of these...
Multivisceral transplantation in pigs: a clinicopathological analysis of tissue rejection. (2007)
Mitsuoka, Shintaro, Tanaka, Noriaki, Orita, Kunzo
In this study, we established the surgical procedure and postoperative care of multivisceral transplantation (MVTX) in pigs, and examined the functional changes and rejection pattern of transplanted...
Combined therapy with interleukin 2 and indomethacin in mice inoculated with MH134 hepatoma. (2007)
Tanaka, Noriaki, Okamoto, Yasuhisa, Gotoh, Kiyotoshi, Hizuta, Akio, Yunoki, Shigeru, Orita, Kunzo
The antitumor effects of indomethacin and interleukin 2 (IL-2) were studied in C3H/HeJ mice inoculated with MH134 hepatoma cells. Combined treatment with indomethacin and IL-2 augmented natural...
Induction of apoptosis during the early phase of reperfusion after rat liver ischemia (2007)
Sasaki, Hiroshi, Matsuno, Tsuyoshi, Nakagawa, Kazuhiko, Tanaka, Noriaki
This study was designed to investigate the induction of apoptosis during the reperfusion phase following warm liver ischemia in vivo. We evaluated apoptotic bodies (ABs) in sections stained with...
Cancer cachexia and depressive states: a neuro-endocrine-immunological disease? (2007)
Iwagaki, Hiromi, Hizuta, Akio, Uomoto, Masashi, Takeuchi, Yoshiaki, Saito, Shinya, Tanaka, Noriaki
Plasma 5-hydroxytryptamine (serotonin), tryptophan, neopterin and cortisol levels were measured in patients with depressive cancer cachexia and in healthy controls during the same time period....
Matsuoka, Junji, Kojima, Kazushi, Kurose, Masao, Takai, Kenichi, Gochi, Akira, Kamikawa, Yasuaki, ...
We report a method of endoscopic retrograde sphincterotomy in patients in whom the optimal viewing of the papilla of Vater is hardly obtained. Percutaneous transhepatic cholangiodrainage (PTCD)-tube...
Matsuoka, Junji, Tanaka, Noriaki, Kojima, Kazushi, Takai, Kenichi, Hamaya, Kazuo, Gochi, Akira, ...
We experienced a patient with traumatic neuroma of the gallbladder with no history of gallbladder surgery or cholelithiasis. A 74-year-old man was referred to our department after a gallbladder tumor...
Iwagaki, Hiromi, Hizuta, Akio, Fujiwara, Toshiyushi, Perdomo, Jose Antonio, Tanaka, Noriaki, Orita, Kunzo
Patients with far advanced colorectal cancers received chemotherapy consisting of low-dose cyclophosphamide (LDCY) 333 mg/m2 every four weeks intravenously and by oral administration of 5'-DFUR (a...
Iwagaki, Hiromi, Marutaka, Masahito, Mizukawa, Kiminao, Kooka, Hideo, Tanaka, Noriaki, Orita, Kunzo
We report here the time-course of electron microscopic changes induced by gamma-interferon (IFN-gamma) in the human erythromyeloid leukemia cell line K562. In K562 cells treated with IFN-gamma for...
Ishizuka, Shinji, Kamikawa, Yasuaki, Naomoto, Yoshio, Tanaka, Noriaki, Orita, Kunzo
This study was undertaken to assess postoperative gastric motility and gastric acid secretion, and pre- and postoperative carbohydrate metabolism in patients with esophageal cancer. The gastric...
Enhancement of experimental metastasis by gamma-interferon in a murine adenocarcinoma. (2007)
Hirano, Tetsuo, Hizuta, Akio, Tanaka, Noriaki, Orita, Kunzo
This study was conducted to examine the effect of gamma-interferon (IFN-gamma) on experimental metastasis formation by murine colon 26 adenocarcinoma in BALB/c mice. We found that the number of...
Therapeutic effect of neuraminidase-treated LAK cells on liver metastasis of Colon 26. (2007)
Kamitani, Shingo, Tanaka, Noriaki, Yunoki, Shigeru, Hizuta, Akio, Orita, Kunzo
To improve the lymphokine-activated killer (LAK) cell therapy for liver metastasis, two methods which enhance accumulation of LAK cells in the liver were examined for their effects on the liver...
Occlusion of a postoperative rectoabdominocutaneous fistula with fibrin clot: a case report. (2007)
Iwagaki, Hiromi, Hizuta, Akio, Nezu, Masashi, Nonaka, Yasuyuki, Kimura, Toshikazu, Marutaka, Masahito, ...
A 56 year-old rectal cancer patient who developed a chronic rectoabdominocutaneous fistula postoperatively was treated with fibrin clot, and the fistula healed completely. Occlusion of chronic...
Tanaka, Noriaki, Tatemoto, Akihiko, Urabe, Takamitsu, Ono, Minoru, Hizuta, Akio, Naomoto, Yoshio, ...
Lymphokine activated killer (LAK) cells can destroy not only tumor cells but also syngeneic liver cells. In this study, the effects of passive transfer of LAK cells on liver regeneration were...
Acute superior mesenteric artery syndrome following left hemicolectomy: a case report. (2007)
Yerdel, Mehmet Ali, Moreira, Luis Fernando, Iwagaki, Hiromi, Kamikawa, Yasuaki, Tanaka, Noriaki, Orita, Kunzo
Acute superior mesenteric artery syndrome (SMAS) following a major surgical procedure is extremely rare, and represents an iatrogenic cause of postoperative upper gastrointestinal obstruction. In...
Naomoto, Yoshio, Tanaka, Noriaki, Orita, Kunzo
We studied the in vivo antitumor effects of natural human tumor necrosis factor-alpha (nHuTNF-alpha) and natural human interferon-alpha (nHuIFN-alpha), both of which were produced by HVJ...
Kondo, Hidenori, Tanaka, Noriaki, Naomoto, Yoshio, Orita, Kunzo
The development of useful therapy for intraabdominal carcinomatosis originating from gastrointestinal cancer is an important theme in cancer therapy. We developed recently an experimental model of...
Yoshihara, Hisashi, Tanaka, Noriaki, Orita, Kunzo
The influence of surgical stress on the natural killer (NK) activity of peripheral blood lymphocytes in patients with carcinoma of the lung or gastrointestinal system was studied. The peripheral...
Spleen cells from tumor-bearing mice showed decreased natural killer (NK) activity and decreased binding to target cells with progression of the tumor. Treatment of spleen cells from tumor-bearing...
Yada, Yoshihiko, Tanaka, Noriaki, Orita, Kunzo
The anti-tumor effect of immunization with heat-killed Mycobacterium tuberculosis (Tbc) and Tuberculin (PPD)-coupled syngeneic tumor cells was examined in vivo. Three tumor cell lines were employed....
Suppressive influence of surgical stress on the graft-versus-host reaction in mice. (2007)
Fujiwara, Ryoichi, Tanaka, Noriaki, Orita, Kunzo
The influence of surgical stress on the local graft-versus-host reaction (GVHR) in F1 mice was studied. Skin incision 1 day prior to injection of parental spleen cells produced impairment of...
Activation of NK activity and auto-reactive cytotoxicity after hepatectomy. (2007)
Ono, Minoru, Tanaka, Noriaki, Orita, Kunzo
Spleen cells serially sampled from normal mice following partial hepatectomy were tested for antibody-dependent cellular cytotoxicity (ADCC) and natural killer (NK) activity. There was a marked...
Gotohda, Naoto, Iwagaki, Hiromi, Itano, Satoshi, Horiki, Sadayuki, Fujiwara, Toshiya, Saito, Shinya, ...
POSSUM, a Physiological and Operative Severity Score for the enUmeration of Mortality and morbidity, is a scoring system which assesses perioperative surgical risks (Copeland GP et al.: Br J Surg,...
Rivas-Carrillo, Jorge D., Soto-Gutierrez, Alejandro, Navarro-Alvarez, Nalu, Noguchi, Hirofumi, Okitsu, Teru, Chen, Yong, ...
Nagasaka, Takeshi, Goel, Ajay, Matsubara, Nagahide, Tanaka, Noriaki
Aberrant promoter methylation, an 'epigenetic' form of genomic instability that leads to transcriptional silencing of tumor suppressor genes, is increasingly being recognized as a crucial component...
Liu, Jie, Yagi, Takahito, Sadamori, Hiroshi, Matsukawa, Hiroyoshi, Sun, Dong-Sheng, Mitsuoka, Naoshi, ...
Controversy exists over whether the predominant cell death of hepatocytes is due to apoptosis or necrosis after ischemia/reperfusion injury. In this study we investigated the predominant cell death...
Hepatic infarction following abdominal interventional procedures. (2006)
Fujiwara, Hiroyasu, Kanazawa, Susumu, Hiraki, Takao, Mimura, Hidefumi, Yasui, Kotaro, Akaki, Shiro, ...
To clarify the incidence, background, and progress of hepatic infarction following interventional procedures, cases of hepatic infarction following interventional procedures at our department during...
Nakao, Atsunori, Tahara, Kazunori, Inoue, Seichiro, Tanaka, Noriaki, Kobayashi, Eiji
Two kinds of surgical models of small intestinal transplantation (SITx) in rats, namely heterotopic (HIT) and orthotopic transplantion (OIT), have been reviewed. In OIT, the small intestine of the...
Nakao, Atsunori, Sakagami, Kenichi, Mitsuoka, Shintaro, Uda, Masashi, Tanaka, Noriaki
We report a case of retroperitoneal hematoma presenting as femoral nerve pulsy on antiplatelet therapy. The patient, a 78-year-old man who had undergone antiplatelet treatment using ticlopidine, was...
A case of rectal Dieulafoy's ulcer and successful endoscopic sclerotherapy. (2006)
Matsuoka, Junji, Taniai, Kazushi, Kojima, Kazushi, Kenmotsu, Masakazu, Takai, Kenichi, Okabe, Tohru, ...
A 54-year-old woman presented a massive hematochezia 7 days after sigmoidectomy. Repeated colonoscopy and angiography failed to locate the site of bleeding and Hartman's operation was performed....
Nakao, Atsunori, Iwagaki, Hiromi, Notohara, Kenji, Morimoto, Yushinori, Ariki, Norifumi, Kanagawa, Taiichiro, ...
A 69-year-old woman was admitted to our hospital because of anal bleeding and fatigue. The patient was previously diagnosed as having Evans' syndrome on the basis of hematological examination and had...
Rat small intestinal transplantation: a comparison of the cuff and hand-suture methods. (2006)
Nakao, Atsunori, Mitsuoka, Naoshi, Shen, Sun Don, Tanaka, Noriaki, Kobayashi, Eiji
The rat model is ideal for investigating various reactions to small intestinal transplantation (SIT). The conventional surgical model (hand-suture method), however, requires microsurgical techniques...
Endoscopic submucosal tumor biopsy using Stiegmann-Goff endoscopic ligator. (2006)
Matsuoka, Junji, Takai, Kenichi, Kojima, Kazushi, Kenmotsu, Masakazu, Oka, Itsuho, Tanaka, Noriaki
Endoscopic biopsy is an important tool for histological diagnosis of lesions residing in gastrointestinal tracts. However, it is less useful in submucosal lesions due to the existence of normal...
Funaki, Masato, Gouchi, Akira, Iwagaki, Hiromi, Morimoto, Yoshinori, Shimamura, Hiroshi, Ariki, Norifumi, ...
Conventional therapy for colorectal carcinoma using 5-fluorouracil (5-FU) has shown limited antitumor action. The purpose of our study was to investigate synergistic antitumor effects of the...
Kuinose, Masahiko, Iwagaki, Hiromi, Morimoto, Yoshinori, Kohka, Hideo, Kobashi, Kenta, Sadamori, Hiroshi, ...
Tacrolimus (FK-506) and cyclosporin A (CsA) are calcineurin antagonists used widely as T-cell immunosuppressants; however, their relative efficacy on the production of interleukin-18 (IL-18) remains...
Retroperitoneal liposarcoma presenting a indirect inguinal hernia (2006)
Noguchi, Hirofumi, Naomoto, Yoshio, Haisa, Minoru, Yamatsuji, Tomoki, Shigemitsu, Kaori, Uetsuka, Hirokazu, ...
A 60-year-old man was admitted to our hospital with a right inguinal swelling that had been growing in size without any pain for 7 months. We diagnosed the growth as a right inguinal hernia and...
Nakagawa, Kazuhiko, Matsuno, Tsuyoshi, Iwagaki, Hiromi, Fujiwara, Takuzo, Tanaka, Noriaki
The immune status of thirteen living and related kidney transplant recipients with stable allografts were examined. The immunological assays consisted of a mixed lymphocyte reaction (MLR),...
Nakao, Atsunori, Miyazaki, Masashi, Oka, Yoshinari, Matsuda, Hiroaki, Oishi, Masahiro, Kokumai, Yoshiaki, ...
The Thoratec (Vectra) polyurethane vascular access graft (TPVA) is among the most recent additions to the list of materials used to construct prosthetic grafts for vascular access during...
Immunosuppression for islet transplantation. (2006)
Noguchi, Hirofumi, Matsumoto, Shinichi, Matsushita, Masayuki, Kobayashi, Naoya, Tanaka, Koichi, Matsui, Hideki, ...
The development by the Edmonton group of a sirolimus-based, steroid-free, low-tacrolimus regimen is a significant breakthrough that allows the rate of insulin independence after islet transplantation...
Iwagaki, Hiromi, Yagi, Takahito, Urushihara, Naoto, Kobashi, Kenta, Morimoto, Yoshinori, Isozaki, Hiroshi, ...
The relationship between endogenous cytokine antagonists and surgical stress is poorly understood. Surgical stress induces immunosuppression, and the reversed therapy of postoperative...
Kohka, Hideo, Iwagaki, Hiromi, Yoshino, Tadashi, Kobashi, Kenta, Saito, Shinnya, Isozaki, Hiroshi, ...
Corticoids are well known for their immunosuppressive properties. Interleukin-10 (IL-10) is an intrinsic antiinflammatory peptide in immune diseases, originally identified as cytokine synthesis...
Stem cells a Hope for cell therapy and Regenerative Medicine (2006)
Alejandro Soto Gutierrez, Apostolos Koutsaftis, Noriaki Tanaka, Nalu Navarro Alvarez, Naoya Kobayashi
Miki, Atsushi, Rivas-Carrillo, Jorge D., Navarro-Alvarez, Nalu, Soto-Gutierrez, Alejandro, Chen, Yong, Tanaka, Kirniaki, ...
Rivas-Carrillo, Jorge David, Navarro-Alvarez, Nalu, Soto-Gutierrez, Alejandro, Okitsu, Teru, Chen, Yong, Tabata, Yasuhiko, ...
Maki, Yu, Murakami, Jun, Asaumi, Jun-ichi, Tsujigiwa, Hidetsugu, Nagatsuka, Hitoshi, Kokeguchi, Susumu, ...
The DNA repair enzyme, O-6-methylguanine-DNA methyltransferase (MGMT) modulates the effectiveness of alkylating agents. However, the relationship between MGMT and the sensitivities to other agents...
Teraishi, Fuminori, Kagawa, Shunsuke, Watanabe, Takanori, Tango, Yasuhisa, Kawashima, Takeshi, Umeoka, Tatsuo, ...
The EGF (epidermal growth factor) receptor-tyrosine kinase inhibitor ZD1839 (Gefitinib, 'Iressa') blocks the cell signaling pathways involved in cell proliferation, survival, and angiogenesis in...
Kimura, Naoki, Nagasaka, Takeshi, Murakami, Jun, Sasamoto, Hiromi, Murakami, Masahiro, Tanaka, Noriaki, ...
Aberrant methylation of DNA has been shown to play an important role in a variety of human cancers, developmental disorders and aging. Hence, aberrant methylation patterns in genes can be a molecular...
Murakami, Jun, Asaumi, Jun-ichi, Kawai, Noriko, Tsujigiwa, Hidetsugu, Yanagi, Yoshinobu, Nagatsuka, Hitoshi, ...
We speculated whether or not the expression level of telomerase reverse transcriptase (hTERT) would be modulated by agents targeting epigenetics in oral cancer cell lines. Although hTERT is known to...
Umeoka, Tatsuo, Kawashima, Takeshi, Kagawa, Shunsuke, Teraishi, Fuminori, Taki, Masaki, Nishizaki, Masahiko, ...
Currently available methods for detection of tumors in vivo such as X-ray, computed tomography, and ultrasonography are noninvasive and have been well studied; the images, however, are not specific...
Tatsuo Umeoka, Takeshi Kawashima, Shunsuke Kagawa, Fuminori Teraishi, Masaki Taki, Masahiko Nishizaki, ...
Currently available methods for detection of tumors in vivo such as X-ray, computed tomography, and ultrasonography are noninvasive and have been well studied; the images, however, are not specific...
Murakami, Jun, Asaumi, Jun-ichi, Maki, Yuu, Tsujigiwa, Hidetsugu, Kuroda, Masahiro, Nagai, Noriyuki, ...
Maspin, which belongs to the serine protease inhibitor (serpin) superfamily, has been proposed as a potent tumor suppressor that inhibits cell motility, invasion, angiogenesis, and metastasis. In the...
Shigemitsu, Kaori, Naomoto, Yoshio, Shirakawa, Yasuhiro, Haisa, Minou, Gunduz, Mehmet, Tanaka, Noriaki
Advanced esophageal cancer patients with extensive lymph node metastases show extremely poor prognosis and the long-term outcome is poorer with the involvement of more lymph nodes. We report here a...
Shigemitsu, Kaori, Naomoto, Yoshio, Shirakawa, Yasuhiro, Haisa, Minoru, Gunduz, Mehmet, Tanaka, Noriaki
We report seven early gastric cancers in five patients, which arose in the reconstructed gastric tube after radical resection for esophageal cancer. Four of them occurred in the middle gastric tube...
Leiomyosarcoma Arising in a Remnant Esophagus After Esophagectomy: a Case Report (2001)
Nakao, Atsunori, Naomoto, Yoshio, Shigemitsu, Kaori, Shirakawa, Yasuhiro, Yamatsuji, Tomoki, Kataoka, Masafumi, ...
We report an extremely rare case of leiomyosarcoma arising from a remnant esophagus. A 52-year-old Japanese man was referred to our hospital for treatment of a tumor arising from the remnant...
Nakao, Atsunori, Naomoto, Yoshio, Kataoka, Masafumi, Haisa, Minoru, Kataoka, Kazuhiko, Saitoh, Shinya, ...
Multiple endocrine neoplasia type 2 (MEN-2) is a hereditary syndrome characterized by medullary thyroid carcinoma (MTC), pheochromocytoma and hyperplasia or adenoma of the parathyroid gland with...
Shigemitsu, Kaori, Naomoto, Yoshio, Haisa, Minoru, Yamatsuji, Tomoki, Noguchi, Hirofumi, Kataoka, Masafumi, ...
A 65 year-old man had undergone left thyroidectomy for thyroid cancer. The cancer had directly invaded the cervical esophagus and trachea and the patient was referred to our hospital for radical...
Kanazawa, Takashi, Watanabe, Masahiko, Matsushima-Hibiya, Yuko, Kono, Takuo, Tanaka, Noriaki, Koyama, Kotaro, ...
Pierisin-1 is an 850-aa cytotoxic protein found in the cabbage butterfly, Pieris rapae, and has been suggested to consist of an N-terminal region with ADP-ribosyltransferase domain and of a...
Kimura, Naoki, Nagasaka, Takeshi, Murakami, Jun, Sasamoto, Hiromi, Murakami, Masahiro, Tanaka, Noriaki, ...
Aberrant methylation of DNA has been shown to play an important role in a variety of human cancers, developmental disorders and aging. Hence, aberrant methylation patterns in genes can be a molecular...
Effect of Ciprofloxacin-Induced Prostaglandin E2 on Interleukin-18-Treated Monocytes
Takahashi, Hideo Kohka, Iwagaki, Hiromi, Xue, Dong, Katsuno, Goutarou, Sugita, Sachi, Mizuno, Kenji, ...
Ciprofloxacin, a fluorinated 4-quinolone, is useful for the clinical treatment of infections due to its antibacterial properties and also modulates the immune response of monocytes isolated from...
Kanazawa, Takashi, Watanabe, Masahiko, Matsushima-Hibiya, Yuko, Kono, Takuo, Tanaka, Noriaki, Koyama, Kotaro, ...
Pierisin-1 is an 850-aa cytotoxic protein found in the cabbage butterfly, Pieris rapae, and has been suggested to consist of an N-terminal region with ADP-ribosyltransferase domain and of a...
Kimura, Naoki, Nagasaka, Takeshi, Murakami, Jun, Sasamoto, Hiromi, Murakami, Masahiro, Tanaka, Noriaki, ...
Aberrant methylation of DNA has been shown to play an important role in a variety of human cancers, developmental disorders and aging. Hence, aberrant methylation patterns in genes can be a molecular...
Effect of Ciprofloxacin-Induced Prostaglandin E2 on Interleukin-18-Treated Monocytes
Takahashi, Hideo Kohka, Iwagaki, Hiromi, Xue, Dong, Katsuno, Goutarou, Sugita, Sachi, Mizuno, Kenji, ...
Ciprofloxacin, a fluorinated 4-quinolone, is useful for the clinical treatment of infections due to its antibacterial properties and also modulates the immune response of monocytes isolated from...
Yamano, Taketoshi, Murata, Shigeo, Shimbara, Naoki, Tanaka, Noriaki, Chiba, Tomoki, Tanaka, Keiji, ...
Major histocompatibility complex (MHC) class I ligands are mainly produced by the proteasome. Herein, we show that the processing of antigens is regulated by two distinct pathways, one requiring PA28...
A simple biological imaging system for detecting viable human circulating tumor cells
Kojima, Toru, Hashimoto, Yuuri, Watanabe, Yuichi, Kagawa, Shunsuke, Uno, Futoshi, Kuroda, Shinji, ...
The presence of circulating tumor cells (CTCs) in the peripheral blood is associated with short survival, making the detection of CTCs clinically useful as a prognostic factor of disease outcome...