Scientific Commons: Noriyuki Kasahara

Effective in vivoand ex vivogene transfer to intestinal mucosa by VSV-G-pseudotyped lentiviral vectors (2010)

Matsumoto, Hiroshi, Kimura, Takahiro, Haga, Kazunori, Kasahara, Noriyuki, Anton, Peter, McGowan, Ian

Abstract Background Gene transfer to the gastrointestinal (GI) mucosa is a therapeutic strategy which could prove particularly advantageous for treatment of various hereditary and acquired intestinal...

CREB is a critical regulator of normal hematopoiesis and leukemogenesis (2008)

Cheng, Jerry C., Kinjo, Kentaro, Judelson, Dejah R., Chang, Jenny, Wu, Winston S., Schmid, Ingrid, ...

The cAMP-responsive element binding protein (CREB) is a 43-kDa nuclear transcription factor that regulates cell growth, memory, and glucose homeostasis. We showed previously that CREB is amplified in...

Recent advances and current challenges in tumour immunology and immunotherapy (2007)

Guinn, Barbar-ann, Kasahara, Noriyuki, Farzaneh, Farzin, Habib, Nagy A., Norris, James S., Deisseroth, Albert B.

Despite advances in animal studies, where the cure of the majority of mice with pre-established (albeit early-stage) tumors has become almost standard, human clinical trials have been much less...

Lentiviral Vectors with CMV or MHCII Promoters Administered In Vivo: Immune Reactivity Versus Persistence of Expression (2007)

Takahiro Kimura, Richard C Koya, Laura Anselmi, Catia Sternini, He-Jing Wang, Begonya Comin-Anduix, ...

Lentiviral Vector–mediated Autonomous Differentiation of Mouse Bone Marrow Cells into Immunologically Potent Dendritic Cell Vaccines (2007)

Richard C Koya, Takahiro Kimura, Antoni Ribas, Nora Rozengurt, Gregory W Lawson, Emmanuelle Faure-Kumar, ...

13. In Vivo Stable Transduction of Humanized Liver Tissue in Chimeric Mice Via High-Capacity Adenovirus-Lentivirus Hybrid Vector (2006)

Shuji Kubo, Miho Kataoka, Chise Tateno, Donna J. Palmer, Philip Ng, Katsutoshi Yoshizato, ...

993. Optical Bioluminescence and Immunologic Analyses of Lentiviral Vectors Administered In Vivo: Transcriptional Targeting through an MHCII Promoter Yields Persistent Transgene Expression and Lack of CTL Stimulation in Immunocompetent Mice Indicating Tolerance (2006)

Takahiro Kimura, Wang Hejing, Richard Koya, Emmanuelle Faure-Kumar, Robert Prins, Begonya Comin-Anduix, ...

Single-Shot, Multicycle Suicide Gene Therapy by Replication-Competent Retrovirus Vectors Achieves Long-Term Survival Benefit in Experimental Glioma (2005)

Chien-Kuo Tai, Wei Jun Wang, Thomas C. Chen, Noriyuki Kasahara

1093. An Adenovirus-Retrotransposon Hybrid Vector Achieves Stable Transformation of Quiescent and Primary Human Somatic Cells (2005)

Shuji Kubo, Harris S. Soifer, John V. Moran, Haig H. Kazazian, Noriyuki Kasahara

834. Highly Efficient and Tumor-Selective Gene Delivery in Metastatic Colon Cancer Models Using a Replication-Competent Retrovirus Vector (2005)

Kei Hiraoka, Takahiro Kimura, Christopher Logg, Satoshi Kondo, Noriyuki Kasahara

742. Generation and Evaluation of a New Replication-Competent Retrovirus (RCR) Vector Coding for the SuperCD Suicide Gene (2004)

Kai Hauschulz, Stefan Seefried, Andrea Schenk, Irina Smirnow, Wolfgang Wybranietz, Noriyuki Kasahara, ...

A Novel, Helper-Dependent, Adenovirus–Retrovirus Hybrid Vector: Stable Transduction by a Two-Stage Mechanism (2002)

Harris Soifer, Collin Higo, Christopher R. Logg, Toshiaki Shichinohe, Erik Harboe-Schmidt, ...

Stable Integration of Transgenes Delivered by a Retrotransposon–Adenovirus Hybrid Vector (2001)

Soifer, Harris, Higo, Collin, Kazazian, Haig H., Moran, John V., Mitani, Kohnosuke, Kasahara, Noriyuki

Helper-dependent adenoviruses show great promise as gene delivery vectors. However, because they do not integrate into the host chromosome, transgene expression cannot be maintained indefinitely. To...

Improving Retroviral Vectors for Gene Therapy of Prostate Cancer (1998)

Kasahara, Noriyuki

This project aims to increase the transduction efficiency and target cell-specificity of retroviral vectors, thereby improving gene transfer to prostate cancer cells. We have developed a novel...

Improving Retroviral Vectors for Gene Therapy of Breast Cancer (1998)

Kasahara, Noriyuki

This project aims to increase the transduction efficiency and target cell-specificity of retroviral vectors, thereby improving gene transfer to breast cancer cells. We have developed a novel...

Effects of carcinogenesis on colonic thymidine kinase activity in familial adenomatous polyposis (1992)

Sakamoto, Shinobu, Kasahara, Noriyuki, Kudo, Hideki, Iwama, Takeo

Thymidine kinase (TK) activity of polyp tissue from patients with familial adenomatous polyposis (FAP) was measured and compared with that of non-tumorous colon, sporadic polyp and colorectal...

Thymidine kinase and {alpha}-fetoprotein as biochemical markers of hepatocarcinogenesis induced by 3'-methyl-4-dimethylaminoazobenzene treatment in rats (1990)

Sakamoto, Shinobu, Hirai, Hidematsu, Taga, Hiroko, Uchikoshi, Toshiyuki, Sunaga, Tatsuya, Endo, Yasuo, ...

It is known that a high incidence of hepatocellular carcinoma in rat liver can be induced by such azo dye carcinogens as 3′-methyl-4-dimethylaminoazobenzene (3′-MeDAB). Thymidine kinase (TK)...

Genomic Stability of Murine Leukemia Viruses Containing Insertions at the Env-3′ Untranslated Region Boundary

Logg, Christopher R., Logg, Aki, Tai, Chien-Kuo, Cannon, Paula M., Kasahara, Noriyuki

Retroviruses containing inserts of exogenous sequences frequently eliminate the inserted sequences upon spread in susceptible cells. We have constructed replication-competent murine leukemia virus...

Vesicular Stomatitis Virus G-Pseudotyped Lentivirus Vectors Mediate Efficient Apical Transduction of Polarized Quiescent Primary Alveolar Epithelial Cells

Borok, Zea, Harboe-Schmidt, Jens Erik, Brody, Steven L., You, Yingjian, Zhou, Beiyun, Li, Xian, ...

We investigated the use of lentivirus vectors for gene transfer to quiescent alveolar epithelial cells. Primary rat alveolar epithelial cells (AEC) grown on plastic or as polarized monolayers on...

A Replication-Competent Feline Leukemia Virus, Subgroup A (FeLV-A), Tagged with Green Fluorescent Protein Reporter Exhibits In Vitro Biological Properties Similar to Those of the Parental FeLV-A

Chang, Zongli, Pan, Judong, Logg, Christopher, Kasahara, Noriyuki, Roy-Burman, Pradip

We previously established that lymphoid tumors could be induced in cats by intradermal injection of ecotropic feline leukemia virus (FeLV), subgroup A, plasmid DNA. In preparation for in vivo...

Tissue-Specific Transcriptional Targeting of a Replication-Competent Retroviral Vector

Logg, Christopher R., Logg, Aki, Matusik, Robert J., Bochner, Bernard H., Kasahara, Noriyuki

The inability of replication-defective viral vectors to efficiently transduce tumor cells in vivo has prevented the successful application of such vectors in gene therapy of cancer. To address the...

L1 retrotransposition in nondividing and primary human somatic cells

Kubo, Shuji, Del Carmen Seleme, Maria, Soifer, Harris S., Perez, José Luis Garcia, Moran, John V., Kazazian, Haig H., ...

Whether long interspersed element-1 (L1 or LINE-1) retrotransposition can occur in quiescent, nondividing, and/or terminally differentiated somatic cells has remained an unanswered fundamental...