Genotype-phenotype correlation in Costello syndrome: HRAS mutation analysis in 43 cases (2006)
Kerr, B., Delrue, M.A., Sigaudy, S., Perveen, R., Marche, M., Burgelin, I., ...
Genotype-phenotype correlation in Costello syndrome: HRAS mutation analysis in 43 cases (2006)
Kerr, B., Delrue, M.A., Sigaudy, S., Perveen, R., Marche, M., Burgelin, I., ...
Background: Costello syndrome (CS) is a rare multiple congenital abnormality syndrome, associated with failure to thrive and developmental delay. One of the more distinctive features in childhood is...
Vitamin K and childhood cancer: a report from the United Kingdom Childhood Cancer Study (2003)
Fear, N.T., Roman, E., Ansell, P., Simpson, J., Day, N., Eden, O.B.
The relationship between neonatal vitamin K received by the intramuscular (i.m.) route and the development of leukaemia or other cancers was investigated as part of a national case–control study of...
Clinical heterogeneity in childhood acute lymphoblastic leukemia with 11q23 rearrangements (2003)
Pui, C.H., Chessells, J.M., Camitta, B., Baruchel, A., Biondi, A., Boyett, J.M., ...
To assess the clinical heterogeneity among patients with acute lymphoblastic leukemia (ALL) and various 11q23 abnormalities, we analyzed data on 497 infants, children and young adults treated between...
Harrison, G., Richards, S., Lawson, S., Darbyshire, P., Pinkerton, R., Stevens, R., ...
Background Although reinduction rates are good for children with relapsed acute lymphoblastic leukaemia there is no consensus on whether bone marrow transplantation (BMT) is the most effective...
THE HAEMOPOIETIC SYSTEM IN CHILDHOOD (1986)
The complexity of producing all cellular and platelet components of blood and their susceptibility to subtle genetic change is stressed. This is most crucial for the red cell where inborn errors...
Autoimmune neutropenia of infancy.
Lyall, E G, Lucas, G F, Eden, O B
AIM: Assessment of the clinical and haematological course of autoimmune neutropenia of infancy (ANI) in a defined childhood population in the south east of Scotland. METHODS: From January 1986 to...
Lilleyman, J S, Hann, I M, Stevens, R F, Eden, O B, Richards, S M
As part of the Medical Research Council Leukaemia Trial UKALL VIII, 738 unselected children with acute lymphoblastic leukaemia (ALL) had the morphology of their marrow blast cells reviewed by a panel...
Gray, M M, Hann, I M, Glass, S, Eden, O B, Jones, P M, Stevens, R F
Measles is a major cause of mortality and morbidity in children receiving treatment for leukaemia. A review was made of all the documented cases of measles in children in first remission from acute...
Urquhart, J D, Black, R J, Muirhead, M J, Sharp, L, Maxwell, M, Eden, O B, ...
OBJECTIVE--To examine whether the observed excess of childhood leukaemia and non-Hodgkin's lymphoma in the area around the Dounreay nuclear installation is associated with established risk factors,...
Autoimmune neutropenia of infancy.
Lyall, E. G., Lucas, G. F., Eden, O. B.
AIM: Assessment of the clinical and haematological course of autoimmune neutropenia of infancy (ANI) in a defined childhood population in the south east of Scotland. METHODS: From January 1986 to...
Lilleyman, J S, Hann, I M, Stevens, R F, Eden, O B, Richards, S M
As part of the Medical Research Council Leukaemia Trial UKALL VIII, 738 unselected children with acute lymphoblastic leukaemia (ALL) had the morphology of their marrow blast cells reviewed by a panel...
Gray, M M, Hann, I M, Glass, S, Eden, O B, Jones, P M, Stevens, R F
Measles is a major cause of mortality and morbidity in children receiving treatment for leukaemia. A review was made of all the documented cases of measles in children in first remission from acute...
Urquhart, J D, Black, R J, Muirhead, M J, Sharp, L, Maxwell, M, Eden, O B, ...
OBJECTIVE--To examine whether the observed excess of childhood leukaemia and non-Hodgkin's lymphoma in the area around the Dounreay nuclear installation is associated with established risk factors,...
Kerr, J R, Barah, F, Cunniffe, V S, Smith, J, Vallely, P J, Will, A M, ...
Aims: To investigate the association of acute parvovirus B19 infection with new onset of acute lymphoblastic and myeloblastic leukaemia.
Costello syndrome: two cases with embryonal rhabdomyosarcoma.
Kerr, B, Eden, O B, Dandamudi, R, Shannon, N, Quarrell, O, Emmerson, A, ...
Costello syndrome is a well delineated mental retardation syndrome of unknown aetiology in which the occurrence of benign tumours, especially papillomata, is recognised. We report two children in...
Haemorrhage responsive to vitamin K in a 6-week-old infant.
A 6-week-old breast-fed infant presented with vomiting, jaundice, and irritability. Haemorrhage occurred after lumbar puncture, and a coagulation abnormality which responded to vitamin K was found....
Effective treatment for rhinopulmonary mucormycosis in a boy with leukaemia.
Lymphoblastic leukaemia in a 3-year-old child was complicated by rhinopulmonary mucormycosis. This was successfully treated by surgical resection of the nasal mass, pulmonary lobectomy, combined with...
Eden, O B, Rankin, A, Kay, H E M
The presentation, method of treatment, and follow-up of 29 apparently isolated testicular relapses in 522 boys entering Medical Research Council trials I-III are described. The need for intensive...
Growth and endocrine function after treatment for medulloblastoma.
Brown, I H, Lee, T J, Eden, O B, Bullimore, J A, Savage, D C
Children with medulloblastoma in Bristol are treated surgically and with craniospinal irradiation, and in some cases chemotherapy. Thirteen medium or long term survivors were investigated to...
Bleeding disorders and non-accidental injury.
Fifty children with suspected non-accidental injury, most of whom had bruising, were investigated to exclude a bleeding disorder. The following investigations were undertaken in each child: full...
Serological study of Pneumocystis carinii infection in the absence of immunosuppression.
Gerrard, M P, Eden, O B, Jameson, B, Craft, A W
Serum samples from 145 children with no known immunosuppressive illness were examined by indirect immunofluorescence for antibody to Pneumocystis carinii. Positive antibody titres (greater than or...
Vertical transmission of HIV: a prospective study.
Mok, J Y, Hague, R A, Yap, P L, Hargreaves, F D, Inglis, J M, Whitelaw, J M, ...
Forty nine infants of HIV seropositive women were followed up for a median of 24 months, together with 24 controls. The infection status of 11 index children under 18 months of age was indeterminate;...
Intravenous immunoglobulin in HIV infection: evidence for the efficacy of treatment.
Hague, R A, Yap, P L, Mok, J Y, Eden, O B, Coutts, N A, Watson, J G, ...
Eight children with symptoms of HIV infection were treated for 12-26 months (median 14 months) with infusions of intravenous immunoglobulin (200 mg/kg) every three weeks. Significant improvement was...
Genotype‐phenotype correlation in Costello syndrome: HRAS mutation analysis in 43 cases
Kerr, B, Delrue, M‐A, Sigaudy, S, Perveen, R, Marche, M, Burgelin, I, ...
Testicular function following the treatment of Hodgkin's disease in childhood.
Shafford, E. A., Kingston, J. E., Malpas, J. S., Plowman, P. N., Pritchard, J., Savage, M. O., ...
Testicular function was studied in 40 males treated in childhood for Hodgkin's disease at St Bartholomew's Hospital, and the Hospital for Sick Children, London, between 1971-1985. All patients were...
Mott, M. G., Eden, O. B., Palmer, M. K.
From July 1977 to July 1983, 120 children with non-Hodgkin's Lymphoma entered a randomised trial of combination chemotherapy and radiotherapy. The primary site was abdominal in 42 patients,...
Pinkerton, C. R., Hann, I., Eden, O. B., Gerrard, M., Berry, J., Mott, M. G.
Forty-four children aged 3-13 years with Murphy stage III B cell non-Hodgkin's lymphoma were treated between May 1986 and December 1989. All have been followed up for at least 12 months. The primary...
Nuclear terminal deoxynucleotidyl transferase in leukaemic infiltrates of testicular tissue.
Thomas, J. A., Janossy, G., Eden, O. B., Bollum, F. J.
Early detection of testicular leukaemia and the identification of residual leukaemic cells in treated patients are important aims in the management of males with acute lymphoblastic leukaemia (ALL)....
Seasonal variations in the onset of childhood leukaemia and lymphoma.
Westerbeek, R. M., Blair, V., Eden, O. B., Kelsey, A. M., Stevens, R. F., Will, A. M., ...
Infection has long been suspected as a possible factor in the aetiology of leukaemia and lymphoma. If seasonal variation in the onset of disease could be shown in any of the diagnostic subgroups of...
Taylor, G. M., Dearden, S., Payne, N., Ayres, M., Gokhale, D. A., Birch, J. M., ...
Comparison of DQA1 and DQB1 alleles in 60 children with common acute lymphoblastic leukaemia (c-ALL) and 78 newborn infant control subjects revealed that male but not female patients had a higher...
Brennan, B M D, Rahim, A, Adams, J A, Eden, O B, Shalet, S M
Bone mineral density (BMD), serum osteocalcin and type I collagen C-telopeptide (ICTP) were assessed in a cohort of 31 (16 males) adults who had received cranial irradiation in childhood as part of...
Atra, A, Imeson, J D, Hobson, R, Gerrard, M, Hann, I M, Eden, O B, ...
From July 1990 to March 1996, 112 children with stage III or IV B-cell non-Hodgkin's lymphoma (B-NHL) with up to 70% FAB L3-type blasts (n= 42) in the bone marrow without central nervous system (CNS)...
Space–time clustering patterns in childhood leukaemia support a role for infection
Birch, J M, Alexander, F E, Blair, V, Eden, O B, Taylor, G M, McNally, R J Q
Previous studies of space–time clustering in childhood leukaemia have produced equivocal and inconsistent results. To address this issue we have used Manchester Children's Tumour Registry leukaemia...
McNally, R J Q, Cairns, D P, Eden, O B, Alexander, F E, Taylor, G M, Kelsey, A M, ...
To investigate whether infections or other environmental exposures may be involved in the aetiology of childhood central nervous system tumours, we have analysed for space–time clustering and...
Vitamin K and childhood cancer: a report from the United Kingdom Childhood Cancer Study
Fear, N T, Roman, E, Ansell, P, Simpson, J, Day, N, Eden, O B
Eden, O. B., Shaw, M. P., Lilleyman, J. S., Richards, S.
Ten per cent of children entered into the national leukaemia study UKALL VIII were under 2 years at diagnosis. The 6 year event-free survival of this cohort was 39%. Specific adverse features were...