KRAAN, P. M. VANDER, HUBER-BRUNING, O., BIJLSMA, J. W. J.
Osteoarthritis is a degenerative joint disease, characterized by the destruction of the articular cartilage. One of the first changes in the osteoarthritic articular cartilage is a reduction in...
LAFEBER, F., VELDHUIJZEN, J. P., HUBER-BRUNING, O., BIJLSMA, J. W. J.
In paired observations the in vitro proteoglycan turnover was studied of human normal and osteoarthritic cartilage in the absence and presence of intermittent hydrostatic compressive force. Shortly...
WILBRINK, B., NIETFELD, J. J., DEN OTTER, W., BIJLSMA, J. W. J., HUBER-BRUNING, O.
In both young and old human articular cartilage explants, TNFα induced a concentration-dependent, reversible suppression of the proteoglycan (PG) synthesis. Young cartilage was more sensitive to...
BIJLSMA, J. W. J., DUURSMA, S. A., BOSCH, R., RAYMAKERS, J. A., HUBER-BRUNING, O.
Corticosteroids (CS) decrease bone formation and enhance bone resorption and this can lead to osteopenia. Bone metabolism was studied during the administration of huge amounts of CS (1000 mg...
Oral contraceptives and rheumatoid arthritis : Further evidence for a preventive effect (1982)
Vandenbroucke, J.P., Boersma, J.W., Festen, J.J.M., Valkenburg, H.A., Cats, A., Huber-Bruning, O., ...
To investigate a reported negative association between the use of oral contraceptives (OC) and the development of rheumatoid arthritis, a case-control study was undertaken to compare the histories of...
Bone metabolism during methylprednisolone pulse therapy in rheumatoid arthritis.
Bijlsma, J W, Duursma, S A, Huber-Bruning, O
The deleterious effects of corticosteroids (CS) on bone are well known, but probably differ depending on duration and dosage of CS therapy. Presently huge amounts of CS are given over a short period...
Ramselaar, A C, Dekker, A W, Huber-Bruning, O, Bijlsma, J W
A 68 year old man with rheumatoid arthritis developed marrow aplasia during D-penicillamine treatment. Recovery of granulopoiesis and erythropoiesis was ineffective with features of a secondary...
Effect of oestrogen treatment on clinical and laboratory manifestations of rheumatoid arthritis.
Bijlsma, J W, Huber-Bruning, O, Thijssen, J H
The effect of administration of 12.5 micrograms ethinyloestradiol to 10 female patients with active rheumatoid arthritis was investigated in a prospective double blind crossover study. Some...
Degradation of human cartilage by cytokines in vitro.
Nietfeld, J J, Wilbrink, B, Huber-Bruning, O, Bijlsma, J W, Nietfeld, J J, Den Otter, W
Androgens as adjuvant treatment in postmenopausal female patients with rheumatoid arthritis.
Booji, A, Biewenga-Booji, C M, Huber-Bruning, O, Cornelis, C, Jacobs, J W, Bijlsma, J W
OBJECTIVE: To examine the possible beneficial effect of androgens in postmenopausal women with active rheumatoid arthritis. METHODS: 107 women participated in a double blind placebo controlled trial...
Verhoef, C., Gmelig-Meyling, F., Huber-Bruning, O., Lafeber, F., ...
Objectives—To compare peripheral type 1 (T1) and type 2 (T2) T cell activities in rheumatoid arthritis (RA) patients with that found for osteoarthritic (OA) patients and healthy controls and to...
Lafeber, F. P., Van Der Kraan, P. M., Van Roy, H. L., Vitters, E. L., Huber-Bruning, O., Van Den Berg, W. B., ...
Proteoglycan synthesis of mild-to-moderate osteoarthritic human knee cartilage was compared with that of normal cartilage of the same donor. Immediately after cartilage was obtained, the synthesis...