O. Pierrefiche

Hypoxic response of hypoglossal motoneurones in the in vivo cat.

Pierrefiche, O, Bischoff, A M, Richter, D W, Spyer, K M

1. In current and voltage clamp, the effects of hypoxia were studied on resting and synaptic properties of hypoglossal motoneurones in barbiturate-anaesthetized adult cats. 2. Twenty-nine hypoglossal...

NMDA and non-NMDA receptors may play distinct roles in timing mechanisms and transmission in the feline respiratory network.

Pierrefiche, O, Foutz, A S, Champagnat, J, Denavit-Saubié, M

1. Activation of N-methyl-D-aspartate (NMDA) glutamate receptors in the brainstem network of respiratory neurones is required to terminate inspiration in the absence of lung afferents, but it is not...

Protein kinase C pathways modulate respiratory pattern generation in the cat.

Haji, A, Pierrefiche, O, Lalley, P M, Richter, D W

1. The significance of protein kinase C (PKC) in respiratory pattern generation was investigated in forty-three expiratory neurones of anaesthetized cats. 2. Intracellular injection of...

ATP-sensitive K+ channels are functional in expiratory neurones of normoxic cats.

Pierrefiche, O, Bischoff, A M, Richter, D W

1. We analysed spontaneously active expiratory neurones (n = 48) of anaesthetized cats for the presence of ATP-sensitive K+ (KATP) channels. 2. Intracellular injection of ATP reversibly depolarized...

Membrane potentials of respiratory neurones during dizocilpine-induced apneusis in adult cats.

Haji, A, Pierrefiche, O, Takeda, R, Foutz, A S, Champagnat, J, Denavit-Saubié, M

1. In the vagotomized cat, blockade of NMDA receptors by dizocilpine (MK-801) produces an apneustic pattern of respiration characterized by a large increase in the duration of inspiration. 2. To...

Hypoxic response of hypoglossal motoneurones in the in vivo cat.

Pierrefiche, O, Bischoff, A M, Richter, D W, Spyer, K M

1. In current and voltage clamp, the effects of hypoxia were studied on resting and synaptic properties of hypoglossal motoneurones in barbiturate-anaesthetized adult cats. 2. Twenty-nine hypoglossal...

NMDA and non-NMDA receptors may play distinct roles in timing mechanisms and transmission in the feline respiratory network.

Pierrefiche, O, Foutz, A S, Champagnat, J, Denavit-Saubié, M

1. Activation of N-methyl-D-aspartate (NMDA) glutamate receptors in the brainstem network of respiratory neurones is required to terminate inspiration in the absence of lung afferents, but it is not...

Protein kinase C pathways modulate respiratory pattern generation in the cat.

Haji, A, Pierrefiche, O, Lalley, P M, Richter, D W

1. The significance of protein kinase C (PKC) in respiratory pattern generation was investigated in forty-three expiratory neurones of anaesthetized cats. 2. Intracellular injection of...

ATP-sensitive K+ channels are functional in expiratory neurones of normoxic cats.

Pierrefiche, O, Bischoff, A M, Richter, D W

1. We analysed spontaneously active expiratory neurones (n = 48) of anaesthetized cats for the presence of ATP-sensitive K+ (KATP) channels. 2. Intracellular injection of ATP reversibly depolarized...

Membrane potentials of respiratory neurones during dizocilpine-induced apneusis in adult cats.

Haji, A, Pierrefiche, O, Takeda, R, Foutz, A S, Champagnat, J, Denavit-Saubié, M

1. In the vagotomized cat, blockade of NMDA receptors by dizocilpine (MK-801) produces an apneustic pattern of respiration characterized by a large increase in the duration of inspiration. 2. To...

Early chronic ethanol exposure in rats disturbs respiratory network activity and increases sensitivity to ethanol

Dubois, C, Naassila, M, Daoust, M, Pierrefiche, O

Chronic ethanol exposure during the fetal period alters spontaneous neuronal discharge, excitatory and inhibitory amino acid neurotransmission and neuronal sensitivity to ethanol in the adult brain....

Selective lesioning of the cat pre-Bötzinger complex in vivo eliminates breathing but not gasping

Ramirez, J M, Schwarzacher, S W, Pierrefiche, O, Olivera, B M, Richter, D W

To examine the functional importance of the pre-Bötzinger complex for breathing we micro-injected, under in vivo conditions, the calcium channel blocker ω-conotoxin GVIA and the sodium channel...

Synaptic potentials in respiratory neurones during evoked phase switching after NMDA receptor blockade in the cat

Pierrefiche, O, Haji, A, Foutz, A S, Takeda, R, Champagnat, J, Denavit-Saubié, M

Blockade of NMDA receptors by dizocilpine impairs the inspiratory off-switch (IOS) of central origin but not the IOS evoked by stimulation of sensory afferents. To investigate whether this difference...

Blockade of synaptic inhibition within the pre-Bötzinger complex in the cat suppresses respiratory rhythm generation in vivo

Pierrefiche, O, Schwarzacher, S W, Bischoff, A M, Richter, D W

The role of synaptic inhibition in respiratory rhythm generation was analysed by microinjections of GABAA and glycine receptor antagonists into the bilateral pre-Bötzinger complex (PBC) of...

Neurotransmitters and neuromodulators controlling the hypoxic respiratory response in anaesthetized cats

Richter, D W, Schmidt-Garcon, P, Pierrefiche, O, Bischoff, A M, Lalley, P M

The contributions of neurotransmitters and neuromodulators to the responses of the respiratory network to acute hypoxia were analysed in anaesthetized cats.Samples of extracellular fluid were...

Blunted response to low oxygen of rat respiratory network after perinatal ethanol exposure: involvement of inhibitory control

Dubois, C, Houchi, H, Naassila, M, Daoust, M, Pierrefiche, O

Acute ethanol depresses respiration, but little is known about chronic ethanol exposure during gestation and breathing, while the deleterious effects of ethanol on CNS development have been clearly...