O. Varenne

L-arginine administration reduces neointima formation after stent injury in rats by a nitric oxide-mediated mechanism (2001)

Nong, Z, Stabile, E, Varenne, O, Gillijns, H, ...

The clinical outcome of vascular stenting is limited by in-stent stenosis. Increased nitric oxide (NO)/cGMP signaling by L-arginine (L-Arg) supplementation, the substrate for NO synthase (NOS), or...

Prolonged L-arginine administration but not inducible nitric oxide synthase gene transfer reduces neointima formation after stent injury in rats (2001)

Vermeersch, Pieter; U0035259, Nong, ZX, Gillijns, H, Van Pelt, N, Varenne, O, Stabile, E, ...

Soluble guanylate cyclase alpha(1) and beta(1) gene transfer increases NO responsiveness and reduces neointima formation after balloon injury in rats via antiproliferative and antimigratory effects (2001)

Chiche, J D, Nong, Z, Varenne, O, Van Pelt, N, Gillijns, H, ...

In vascular smooth muscle cells, NO stimulates the synthesis of cGMP by soluble guanylate cyclase (sGC), a heterodimer composed of alpha(1) and beta(1) subunits. NO/cGMP signal transduction affects...

Gene therapy in the cardiovascular system: an update (1999)

Varenne, O, Janssens, S

This update reviews the remarkable progression in several cardiovascular gene transfer domains. The first chemical gene therapy protocols to stimulate angiogenesis in ischemic myocardium are...

Adenovirus-mediated transfer of soluble guanylayte cyclase alpha 1 and beta 1 subunits increases nitric oxide responsiveness and reduces neointima formation in balloon-injured rat carotid arteries (1998)

Sinnaeve, Peter; U0011642, Chiche, JD, Nong, ZX, Varenne, O, Van Pelt, N, Gerard, RD, ...

Reduction of in-stent restenosis by adenoviral-mediated NOS3 gene transfer in porcine coronary arteries (1998)

Varenne, O, Gillijns, H, Gold, HK, Van De Werf, Frans; U0009589, Gerard, RD, Collen, Desire; U0016103, ...

Comparison of local delivery catheters for intracoronary gene transfer in pigs (1998)

Varenne, O, Gerard, RD, Sinnaeve, Peter; U0011642, Gillijns, H, Wauterickx, K, Van Pelt, N, ...

Human endothelial nitric oxide synthase gene transfer inhibits vascular smooth muscle cell proliferation and neointima formation after balloon injury in rats (1998)

Flaherty, D, Nong, Z, Varenne, O, Van Pelt, N, ...

BACKGROUND: Loss of endothelial NO production after arterial injury may contribute to restenosis, characterized by neointima formation and elastic recoil. Adenovirus-mediated transfer of the gene...

Comparison of recombinant adenovirus vectors expressing antimigratory and antiproliferative proteins in a porcine coronary restenosis model (1998)

Varenne, O, Sinnaeve, Peter; U0011642, Gillijns, H, Laurysens, Veerle; U0022303, Bout, A, Meurrens, K, ...

Inhibition of platelet activation by pulmonary nitric oxide reduces vascular response to injury (1997)

Nong, Z, Varenne, O, Gerard, R, Collen, Desire; U0016103, Janssens, S

Surgical treatment of infective endocarditis (1995)

Acar, J., Michel, P. L., Varenne, O., Michaud, P., Rafik, T.

Optimal timing of surgery in infective endocarditis (IE) depends mainly on the haemodynamic tolerance of the patient. Emergency surgery is required in cases of refractory heart failure due to...