Harnessing Soluble NK Cell Killer Receptors for the Generation of Novel Cancer Immune Therapy (2008)
Arnon, Tal I., Markel, Gal, Bar-Ilan, Ahuva, Hanna, Jacob, Fima, Eyal, Benchetrit, Fabrice, ...
The natural cytotoxic receptors (NCRs) are a unique set of activating proteins expressed mainly on the surface of natural killer (NK) cells. The NCRs, which include three members; NKp46, NKp44 and...
Hershkovitz, Oren, Jarahian, Mostafa, Zilka, Alon, Bar-Ilan, Ahuva, Landau, Guy, Jivov, Sergey, ...
NKp30 is a natural cytotoxicity receptor expressed by human NK cells and involved in NK lytic activity. We previously published that membranal heparan sulfate serves as a coligand for human NKp30. In...
The involvement of NK cells in ankylosing spondylitis (2005)
Azuz-Lieberman, Niva, Markel, Gal, Mizrahi, Sa'ar, Gazit, Roi, Hanna, Jacob, Achdout, Hagit, ...
A role for NK cells in the regulation of autoimmunity has been demonstrated. Since there is a strong association between Ankylosing Spondylitis (AS) and HLA-B27, which is specifically recognized by...
The involvement of NK cells in ankylosing spondylitis (2005)
Azuz-Lieberman, Niva, Markel, Gal, Mizrahi, Sa'ar, Gazit, Roi, Hanna, Jacob, Achdout, Hagit, ...
A role for NK cells in the regulation of autoimmunity has been demonstrated. Since there is a strong association between Ankylosing Spondylitis (AS) and HLA-B27, which is specifically recognized by...
Mandelboim, Ofer, Kent, Sally, Davis, Daniel M., Wilson, S. Brian, Okazaki, Taku, Jackson, Richard, ...
Proliferation of human CD4+ αβ T cells expressing a natural killer cell activating receptor (NKAR) has been shown to be enhanced, particularly in response to low doses of antigen, if the target...
Self and viral peptides can initiate lysis by autologous natural killer cells
Mandelboim, Ofer, Wilson, S. Brian, Valés-Gómez, Mar, Reyburn, Hugh T., Strominger, Jack L.
Natural killer (NK) cells are inhibited by specific allotypes of class I major histocompatibility complex ligands recognized by polymorphic inhibitory receptors (e.g., NKIR1 and NKIR2). NK1- and...
Human CD16 as a lysis receptor mediating direct natural killer cell cytotoxicity
Mandelboim, Ofer, Malik, Pratap, Davis, Daniel M., Jo, Chang H., Boyson, Jonathan E., Strominger, Jack L.
In addition to their role in peptide antigen presentation, class I MHC proteins also play a critical role in inhibiting natural killer (NK) cytotoxicity through interaction with NK inhibitory...
Porgador, Angel, Mandelboim, Ofer, Restifo, Nicholas P., Strominger, Jack L.
Cancer vaccines used to generate specific cytotoxic T lymphocytes are not effective against tumor cells that have lost or suppressed expression of their class I major histocompatibility complex...
The human natural killer cell immune synapse
Davis, Daniel M., Chiu, Isaac, Fassett, Marlys, Cohen, George B., Mandelboim, Ofer, Strominger, Jack L.
Inhibitory killer Ig-like receptors (KIR) at the surface of natural killer (NK) cells induced clustering of HLA-C at the contacting surface of target cells. In this manner, inhibitory immune synapses...
Characterization of the expression of MHC proteins in human embryonic stem cells
Drukker, Micha, Katz, Gil, Urbach, Achia, Schuldiner, Maya, Markel, Gal, Itskovitz-Eldor, Joseph, ...
Human embryonic stem (ES) cells are pluripotent cells that may be used in transplantation medicine. These cells can be induced to differentiate into cells from the three embryonic germ layers both in...
Pivotal role of CEACAM1 protein in the inhibition of activated decidual lymphocyte functions
Markel, Gal, Wolf, Dana, Hanna, Jacob, Gazit, Roi, Goldman-Wohl, Debra, Lavy, Yuval, ...
Lymphocytes in direct contact with embryonic extravillous trophoblasts constitute more than 40% of decidual cells and appear to play major roles in implantation and early gestation. A unique subset...
Novel APC-like properties of human NK cells directly regulate T cell activation
Hanna, Jacob, Gonen-Gross, Tsufit, Fitchett, Jonathan, Rowe, Tony, Daniels, Mark, Arnon, Tal I., ...
Initiation of the adaptive immune response is dependent on the priming of naive T cells by APCs. Proteomic analysis of unactivated and activated human NK cell membrane–enriched fractions...
Mandelboim, Ofer, Kent, Sally, Davis, Daniel M., Wilson, S. Brian, Okazaki, Taku, Jackson, Richard, ...
Proliferation of human CD4+ αβ T cells expressing a natural killer cell activating receptor (NKAR) has been shown to be enhanced, particularly in response to low doses of antigen, if the target...
Self and viral peptides can initiate lysis by autologous natural killer cells
Mandelboim, Ofer, Wilson, S. Brian, Valés-Gómez, Mar, Reyburn, Hugh T., Strominger, Jack L.
Natural killer (NK) cells are inhibited by specific allotypes of class I major histocompatibility complex ligands recognized by polymorphic inhibitory receptors (e.g., NKIR1 and NKIR2). NK1- and...
Human CD16 as a lysis receptor mediating direct natural killer cell cytotoxicity
Mandelboim, Ofer, Malik, Pratap, Davis, Daniel M., Jo, Chang H., Boyson, Jonathan E., Strominger, Jack L.
In addition to their role in peptide antigen presentation, class I MHC proteins also play a critical role in inhibiting natural killer (NK) cytotoxicity through interaction with NK inhibitory...
Porgador, Angel, Mandelboim, Ofer, Restifo, Nicholas P., Strominger, Jack L.
Cancer vaccines used to generate specific cytotoxic T lymphocytes are not effective against tumor cells that have lost or suppressed expression of their class I major histocompatibility complex...
The human natural killer cell immune synapse
Davis, Daniel M., Chiu, Isaac, Fassett, Marlys, Cohen, George B., Mandelboim, Ofer, Strominger, Jack L.
Inhibitory killer Ig-like receptors (KIR) at the surface of natural killer (NK) cells induced clustering of HLA-C at the contacting surface of target cells. In this manner, inhibitory immune synapses...
Characterization of the expression of MHC proteins in human embryonic stem cells
Drukker, Micha, Katz, Gil, Urbach, Achia, Schuldiner, Maya, Markel, Gal, Itskovitz-Eldor, Joseph, ...
Human embryonic stem (ES) cells are pluripotent cells that may be used in transplantation medicine. These cells can be induced to differentiate into cells from the three embryonic germ layers both in...
Pivotal role of CEACAM1 protein in the inhibition of activated decidual lymphocyte functions
Markel, Gal, Wolf, Dana, Hanna, Jacob, Gazit, Roi, Goldman-Wohl, Debra, Lavy, Yuval, ...
Lymphocytes in direct contact with embryonic extravillous trophoblasts constitute more than 40% of decidual cells and appear to play major roles in implantation and early gestation. A unique subset...
Novel APC-like properties of human NK cells directly regulate T cell activation
Hanna, Jacob, Gonen-Gross, Tsufit, Fitchett, Jonathan, Rowe, Tony, Daniels, Mark, Arnon, Tal I., ...
Initiation of the adaptive immune response is dependent on the priming of naive T cells by APCs. Proteomic analysis of unactivated and activated human NK cell membrane–enriched fractions...
CD100 on NK Cells Enhance IFNγ Secretion and Killing of Target Cells Expressing CD72
Mizrahi, Sa'ar, Markel, Gal, Porgador, Angel, Bushkin, Yuri, Mandelboim, Ofer
Lee, Hannah S. W., Boulton, Ian C., Reddin, Karen, Wong, Henry, Halliwell, Denise, Mandelboim, Ofer, ...
Pathogenic Neisseria bacteria naturally liberate outer membrane “blebs,” which are presumed to contribute to pathology, and the detergent-extracted outer membrane vesicles (OMVs) from Neisseria...
Davis, Daniel M., Mandelboim, Ofer, Luque, Isabel, Baba, Eishi, Boyson, Jonathan, Strominger, Jack L.
Molecular interactions with the extracellular domains of class I major histocompatibility complex proteins are major determinants of immune recognition that have been extensively studied both...
CD11cloB220+ interferon-producing killer dendritic cells are activated natural killer cells
Vosshenrich, Christian A.J., Lesjean-Pottier, Sarah, Hasan, Milena, Corcuff, Erwan, Mandelboim, Ofer, ...
Interferon-producing killer dendritic cells (IKDCs) are a recently described subset of CD11cloB220+ cells that share phenotypic and functional properties of DCs and natural killer (NK) cells (Chan,...
Harnessing Soluble NK Cell Killer Receptors for the Generation of Novel Cancer Immune Therapy
Arnon, Tal I., Markel, Gal, Bar-Ilan, Ahuva, Hanna, Jacob, Fima, Eyal, Benchetrit, Fabrice, ...
The natural cytotoxic receptors (NCRs) are a unique set of activating proteins expressed mainly on the surface of natural killer (NK) cells. The NCRs, which include three members; NKp46, NKp44 and...
Ho, Joanna W., Hershkovitz, Oren, Peiris, Malik, Zilka, Alon, Bar-Ilan, Ahuva, Nal, Beatrice, ...
Antiviral immune defenses involve natural killer (NK) cells. We previously showed that the NK-activating receptor NKp44 is involved in the functional recognition of H1-type influenza virus strains by...
Achdout, Hagit, Manaster, Irit, Mandelboim, Ofer
The killing by natural killer (NK) cells is regulated by inhibitory, costimulatory, and activating receptors. The inhibitory receptors recognize mainly major histocompatibility complex (MHC) class I...