Transduction of rat pancreatic islets with pseudotyped adeno-associated virus vectors (2009)
Craig, Anthony T, Gavrilova, Oksana, Dwyer, Nancy K, Jou, William, Pack, Stephanie, Liu, Eric, ...
Abstract Background Pancreatic islet transplantation is a promising treatment for type I diabetes mellitus, but current immunosuppressive strategies do not consistently provide long-term survival of...
Life without white fat: a transgenic mouse (1998)
Moitra, Jaideep, Mason, Mark M., Olive, Michelle, Krylov, Dmitry, Gavrilova, Oksana, Marcus-Samuels, Bernice, ...
Torpor in mice is induced by both leptin-dependent and -independent mechanisms
Gavrilova, Oksana, Leon, Lisa R., Marcus-Samuels, Bernice, Mason, Mark M., Castle, Arthur L., Refetoff, Samuel, ...
We tested the effect of chronic leptin treatment on fasting-induced torpor in leptin-deficient A-ZIP/F-1 and ob/ob mice. A-ZIP/F-1 mice have virtually no white adipose tissue and low leptin levels,...
Peters, Jeffrey M., Lee, Susanna S. T., Li, Wen, Ward, Jerrold M., Gavrilova, Oksana, Everett, Carrie, ...
To determine the physiological roles of peroxisome proliferator-activated receptor β (PPARβ), null mice were constructed by targeted disruption of the ligand binding domain of the murine PPARβ...
Matsusue, Kimihiko, Haluzik, Martin, Lambert, Gilles, Yim, Sun-Hee, Gavrilova, Oksana, Ward, Jerrold M., ...
To elucidate the function of PPARγ in leptin-deficient mouse (ob/ob) liver, a PPARγ liver-null mouse on an ob/ob background, ob/ob-PPARγ(fl/fl)AlbCre+, was produced using a floxed PPARγ allele,...
Yu, Shuhua, Gavrilova, Oksana, Chen, Hui, Lee, Randy, Liu, Jie, Pacak, Karel, ...
Heterozygous disruption of Gnas, the gene encoding the stimulatory G-protein α subunit (Gsα), leads to distinct phenotypes depending on whether the maternal (m–/+) or paternal (+/p–) allele is...
Life without white fat: a transgenic mouse
Moitra, Jaideep, Mason, Mark M., Olive, Michelle, Krylov, Dmitry, Gavrilova, Oksana, Marcus-Samuels, Bernice, ...
We have generated a transgenic mouse with no white fat tissue throughout life. These mice express a dominant-negative protein, termed A-ZIP/F, under the control of the adipose-specific aP2...
Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice
Gavrilova, Oksana, Marcus-Samuels, Bernice, Graham, David, Kim, Jason K., Shulman, Gerald I., Castle, Arthur L., ...
In lipoatrophic diabetes, a lack of fat is associated with insulin resistance and hyperglycemia. This is in striking contrast to the usual association of diabetes with obesity. To understand the...
Chao, Lily, Marcus-Samuels, Bernice, Mason, Mark M., Moitra, Jaideep, Vinson, Charles, Arioglu, Elif, ...
There is uncertainty about the site(s) of action of the antidiabetic thiazolidinediones (TZDs). These drugs are agonist ligands of the transcription factor PPARγ, which is abundant in adipose tissue...
Alternative Gnas gene products have opposite effects on glucose and lipid metabolism
Chen, Min, Gavrilova, Oksana, Liu, Jie, Xie, Tao, Deng, Chuxia, Nguyen, Annie T., ...
Gnas is an imprinted gene with multiple gene products resulting from alternative splicing of different first exons onto a common exon 2. These products include stimulatory G protein α-subunit...
Chen, Min, Gavrilova, Oksana, Zhao, Wei-Qin, Nguyen, Annie, Lorenzo, Javier, Shen, Laura, ...
The G protein Gsα is essential for hormone-stimulated cAMP generation and is an important metabolic regulator. We investigated the role of liver Gs-signaling pathways by developing mice with...
Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B–null mice
Choi, Young Hun, Park, Sunhee, Hockman, Steven, Zmuda-Trzebiatowska, Emilia, Svennelid, Fredrik, Haluzik, Martin, ...
Cyclic nucleotide phosphodiesterase 3B (PDE3B) has been suggested to be critical for mediating insulin/IGF-1 inhibition of cAMP signaling in adipocytes, liver, and pancreatic β cells. In Pde3b-KO...
Torpor in mice is induced by both leptin-dependent and -independent mechanisms
Gavrilova, Oksana, Leon, Lisa R., Marcus-Samuels, Bernice, Mason, Mark M., Castle, Arthur L., Refetoff, Samuel, ...
We tested the effect of chronic leptin treatment on fasting-induced torpor in leptin-deficient A-ZIP/F-1 and ob/ob mice. A-ZIP/F-1 mice have virtually no white adipose tissue and low leptin levels,...
Peters, Jeffrey M., Lee, Susanna S. T., Li, Wen, Ward, Jerrold M., Gavrilova, Oksana, Everett, Carrie, ...
To determine the physiological roles of peroxisome proliferator-activated receptor β (PPARβ), null mice were constructed by targeted disruption of the ligand binding domain of the murine PPARβ...
Matsusue, Kimihiko, Haluzik, Martin, Lambert, Gilles, Yim, Sun-Hee, Gavrilova, Oksana, Ward, Jerrold M., ...
To elucidate the function of PPARγ in leptin-deficient mouse (ob/ob) liver, a PPARγ liver-null mouse on an ob/ob background, ob/ob-PPARγ(fl/fl)AlbCre+, was produced using a floxed PPARγ allele,...
Yu, Shuhua, Gavrilova, Oksana, Chen, Hui, Lee, Randy, Liu, Jie, Pacak, Karel, ...
Heterozygous disruption of Gnas, the gene encoding the stimulatory G-protein α subunit (Gsα), leads to distinct phenotypes depending on whether the maternal (m–/+) or paternal (+/p–) allele is...
Life without white fat: a transgenic mouse
Moitra, Jaideep, Mason, Mark M., Olive, Michelle, Krylov, Dmitry, Gavrilova, Oksana, Marcus-Samuels, Bernice, ...
We have generated a transgenic mouse with no white fat tissue throughout life. These mice express a dominant-negative protein, termed A-ZIP/F, under the control of the adipose-specific aP2...
Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice
Gavrilova, Oksana, Marcus-Samuels, Bernice, Graham, David, Kim, Jason K., Shulman, Gerald I., Castle, Arthur L., ...
In lipoatrophic diabetes, a lack of fat is associated with insulin resistance and hyperglycemia. This is in striking contrast to the usual association of diabetes with obesity. To understand the...
Chao, Lily, Marcus-Samuels, Bernice, Mason, Mark M., Moitra, Jaideep, Vinson, Charles, Arioglu, Elif, ...
There is uncertainty about the site(s) of action of the antidiabetic thiazolidinediones (TZDs). These drugs are agonist ligands of the transcription factor PPARγ, which is abundant in adipose tissue...
Alternative Gnas gene products have opposite effects on glucose and lipid metabolism
Chen, Min, Gavrilova, Oksana, Liu, Jie, Xie, Tao, Deng, Chuxia, Nguyen, Annie T., ...
Gnas is an imprinted gene with multiple gene products resulting from alternative splicing of different first exons onto a common exon 2. These products include stimulatory G protein α-subunit...
Chen, Min, Gavrilova, Oksana, Zhao, Wei-Qin, Nguyen, Annie, Lorenzo, Javier, Shen, Laura, ...
The G protein Gsα is essential for hormone-stimulated cAMP generation and is an important metabolic regulator. We investigated the role of liver Gs-signaling pathways by developing mice with...
Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B–null mice
Choi, Young Hun, Park, Sunhee, Hockman, Steven, Zmuda-Trzebiatowska, Emilia, Svennelid, Fredrik, Haluzik, Martin, ...
Cyclic nucleotide phosphodiesterase 3B (PDE3B) has been suggested to be critical for mediating insulin/IGF-1 inhibition of cAMP signaling in adipocytes, liver, and pancreatic β cells. In Pde3b-KO...
Lee, Ji-Yeon, Muenzberg, Heike, Gavrilova, Oksana, Reed, Jacquelyn A., Berryman, Darlene, Villanueva, Eneida C., ...
Signal transducers and activators of transcription (STATs) are critical components of cytokine signaling pathways. STAT5A and STAT5B (STAT5), the most promiscuous members of this family, are highly...
A model for obesity and gigantism due to disruption of the Ankrd26 gene
Bera, Tapan K., Liu, Xiu-Fen, Yamada, Masanori, Gavrilova, Oksana, Mezey, Eva, Tessarollo, Lino, ...
Obesity is a major health hazard that is caused by a combination of genetic and behavioral factors. Several models of obesity have been described in mice that have defects in the production of...
Guo, Tingqing, Jou, William, Chanturiya, Tatyana, Portas, Jennifer, Gavrilova, Oksana, McPherron, Alexandra C.
Myostatin (Mstn) is a secreted growth factor expressed in skeletal muscle and adipose tissue that negatively regulates skeletal muscle mass. Mstn−/− mice have a dramatic increase in muscle mass,...
Hypertrophy and/or Hyperplasia: Dynamics of Adipose Tissue Growth
Jo, Junghyo, Gavrilova, Oksana, Pack, Stephanie, Jou, William, Mullen, Shawn, Sumner, Anne E., ...
Adipose tissue grows by two mechanisms: hyperplasia (cell number increase) and hypertrophy (cell size increase). Genetics and diet affect the relative contributions of these two mechanisms to the...
Xie, Tao, Chen, Min, Gavrilova, Oksana, Lai, Edwin W., Liu, Jie, Weinstein, Lee S.
The G protein α-subunit Gsα mediates receptor-stimulated cAMP production and is imprinted with reduced expression from the paternal allele in specific tissues. Disruption of the Gsα maternal (but...
Transduction of rat pancreatic islets with pseudotyped adeno-associated virus vectors
Craig, Anthony T, Gavrilova, Oksana, Dwyer, Nancy K, Jou, William, Pack, Stephanie, Liu, Eric, ...
Gautam, Dinesh, Jeon, Jongrye, Starost, Matthew F., Han, Sung-Jun, Hamdan, Fadi F., Cui, Yinghong, ...
The molecular pathways that promote the proliferation and maintenance of pituitary somatotrophs and other cell types of the anterior pituitary gland are not well understood at present. However, such...
Neumann, Susanne, Huang, Wenwei, Titus, Steve, Krause, Gerd, Kleinau, Gunnar, Alberobello, Anna Teresa, ...
Seven-transmembrane-spanning receptors (7TMRs) are prominent drug targets. However, small-molecule ligands for 7-transmembrane-spanning receptors for which the natural ligands are large,...
Li, Jian Hua, Chou, Chung-Lin, Li, Bo, Gavrilova, Oksana, Eisner, Christoph, Schnermann, Jürgen, ...
X-linked nephrogenic diabetes insipidus (XNDI) is a severe kidney disease caused by inactivating mutations in the V2 vasopressin receptor (V2R) gene that result in the loss of renal...