Olga Pletnikova

Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases (2008)

Tan, Jeanne M.M., Wong, Esther S.P., Kirkpatrick, Donald S., Pletnikova, Olga, Ko, Han Seok, Tay, Shiam-Peng, ...

Although ubiquitin-enriched protein inclusions represent an almost invariant feature of neurodegenerative diseases, the mechanism underlying their biogenesis remains unclear. In particular, whether...

Neurexin 3 polymorphisms are associated with alcohol dependence and altered expression of specific isoforms (2007)

Hishimoto, Akitoyo, Liu, Qing-Rong, Drgon, Tomas, Pletnikova, Olga, Walther, Donna, Zhu, Xu-Guang, ...

Neurexins are cell adhesion molecules that help to specify and stabilize synapses and provide receptors for neuroligins, neurexophilins, dystroglycans and α-latrotoxins. We previously reported...

Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function (2005)

Wang, Cheng, Ko, Han Seok, Thomas, Bobby, Tsang, Fai, Chew, Katherine C.M., Tay, Shiam-Peng, ...

Mutations in parkin are currently recognized as the most common cause of familial Parkinsonism. Emerging evidence also suggests that parkin expression variability may confer a risk for the...

Stress-induced Alterations in Parkin Solubility Promote Parkin Aggregation and Compromise Parkin's Protective Function (2005)

Wang, Cheng, Ko, Han Seok, Thomas, Bobby, Tsang, Fai, Chew, Katherine C.M., Tay, Shiam-Peng, ...

Mutations in parkin are currently recognized as the most common cause of familial Parkinsonism. Emerging evidence also suggest that parkin expression variability may confer a risk for the development...

Aggregation promoting C-terminal truncation of α-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations

Li, Wenxue, West, Neva, Colla, Emanuela, Pletnikova, Olga, Troncoso, Juan C., Marsh, Laura, ...

Abnormal biology of α-synuclein (α-Syn) is directly implicated in the pathogenesis of Parkinson's disease and other α-synucleinopathies. Herein, we demonstrate that C-terminally truncated α-Syn...

Aggregation promoting C-terminal truncation of α-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations

Li, Wenxue, West, Neva, Colla, Emanuela, Pletnikova, Olga, Troncoso, Juan C., Marsh, Laura, ...

Abnormal biology of α-synuclein (α-Syn) is directly implicated in the pathogenesis of Parkinson's disease and other α-synucleinopathies. Herein, we demonstrate that C-terminally truncated α-Syn...

S-nitrosylation of XIAP compromises neuronal survival in Parkinson's disease

Tsang, Anthony H. K., Lee, Yun-IL, Ko, Han Seok, Savitt, Joseph M., Pletnikova, Olga, Troncoso, Juan C., ...

Inhibitors of apoptosis (IAPs) are a family of highly-conserved proteins that regulate cell survival through binding to caspases, the final executioners of apoptosis. X-linked IAP (XIAP) is the most...