Wilkinson, Katalin A, Newton, Sandra M, Stewart, Graham R, Martineau, Adrian R, Patel, Janisha, Sullivan, Susan M, ...
Abstract Background The 19 kDa lipoprotein of Mycobacterium tuberculosis (MTB) is an important target of the innate immune response. To investigate the effect of post-translation modification of this...
Becq, Jennifer, Gutierrez, Maria Cristina, Rosas-Magallanes, Vania, Rauzier, Jean, Gicquel, Brigitte, Neyrolles, Olivier, ...
The contribution of horizontal gene transfer (HGT) to the evolution of Mycobacterium tuberculosis — the main causal agent of tuberculosis in humans — and closely related members of the M....
Promoter Variation in the DC-SIGN–Encoding Gene CD209 Is Associated with Tuberculosis (2006)
Luis B. Barreiro, Olivier Neyrolles, Chantal L. Babb, Ludovic Tailleux, Hélène Quach, Ken McElreavey, ...
Two variants in the gene that encodes DC-SIGN, the major receptor for Mycobacterium tuberculosis on dendritic cells, are associated with susceptibility to TB
Promoter Variation in the DC-SIGN–Encoding Gene CD209 Is Associated with Tuberculosis (2006)
Luis B. Barreiro, Olivier Neyrolles, Chantal L. Babb, Ludovic Tailleux, Hélène Quach, Ken McElreavey, ...
Background Tuberculosis, which is caused by Mycobacterium tuberculosis, remains one of the leading causes of mortality worldwide. The C-type lectin DC-SIGN is known to be the major M. tuberculosis...
Is Adipose Tissue a Place for Mycobacterium tuberculosis Persistence? (2006)
Neyrolles, Olivier, Hernández-Pando, Rogelio, Pietri-Rouxel, France, Fornès, Paul, Tailleux, Ludovic, Payán, Jorge Alberto Barrios, ...
BACKGROUND: Mycobacterium tuberculosis, the etiological agent of tuberculosis (TB), has the ability to persist in its human host for exceptionally long periods of time. However, little is known about...
Is Adipose Tissue a Place for Mycobacterium tuberculosis Persistence? (2006)
Neyrolles, Olivier, Hernández-Pando, Rogelio, Pietri-Rouxel, France, Fornès, Paul, Tailleux, Ludovic, Payán, Jorge Alberto Barrios, ...
BACKGROUND: Mycobacterium tuberculosis, the etiological agent of tuberculosis (TB), has the ability to persist in its human host for exceptionally long periods of time. However, little is known about...
Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis. (2006)
Barreiro, Luis B., Neyrolles, Olivier, Babb, Chantal L., Tailleux, Ludovic, Quach, Hélène, Mcelreavey, Ken, ...
BACKGROUND: Tuberculosis, which is caused by Mycobacterium tuberculosis, remains one of the leading causes of mortality worldwide. The C-type lectin DC-SIGN is known to be the major M. tuberculosis...
Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis. (2006)
Barreiro, Luis B., Neyrolles, Olivier, Babb, Chantal L., Tailleux, Ludovic, Quach, Hélène, Mcelreavey, Ken, ...
BACKGROUND: Tuberculosis, which is caused by Mycobacterium tuberculosis, remains one of the leading causes of mortality worldwide. The C-type lectin DC-SIGN is known to be the major M. tuberculosis...
Horizontal Transfer of a Virulence Operon to the Ancestor of Mycobacterium tuberculosis (2006)
Rosas-Magallanes, Vania, Deschavanne, Patrick, Quintana-Murci, Lluis, Brosch, Roland, Gicquel, Brigitte, Neyrolles, Olivier
The contribution of interspecies horizontal gene transfer (HGT) to the evolution and virulence of Mycobacterium tuberculosis, the agent of tuberculosis in humans, has been barely investigated. Here...
Horizontal Transfer of a Virulence Operon to the Ancestor of Mycobacterium Tuberculosis (2006)
Rosas-Magallanes, Vania, Deschavanne, Patrick, Quintana-Murci, Lluis, Brosch, Roland, Gicquel, Brigitte, Neyrolles, Olivier
The contribution of inter-species horizontal gene transfer (HGT) to the evolution and virulence of Mycobacterium tuberculosis, the agent of tuberculosis in humans, has been barely investigated. Here...
Horizontal Transfer of a Virulence Operon to the Ancestor of Mycobacterium Tuberculosis (2006)
Rosas-Magallanes, Vania, Deschavanne, Patrick, Quintana-Murci, Lluis, Brosch, Roland, Gicquel, Brigitte, Neyrolles, Olivier
The contribution of inter-species horizontal gene transfer (HGT) to the evolution and virulence of Mycobacterium tuberculosis, the agent of tuberculosis in humans, has been barely investigated. Here...
Ludovic Tailleux, Nhan Pham-Thi, Anne Bergeron-Lafaurie, Jean-Louis Herrmann, Patricia Charles, Olivier Schwartz, ...
Alveolar macrophages from patients with TB express higher levels of DC-SIGN compared with controls. Ex-vivo infection induced DC-SIGN in infected and bystander cells, which made the latter more...
Ludovic Tailleux, Nhan Pham-Thi, Anne Bergeron-Lafaurie, Jean-Louis Herrmann, Patricia Charles, Olivier Schwartz, ...
Background Interplays between Mycobacterium tuberculosis, the etiological agent of tuberculosis (TB) in human and host professional phagocytes, namely macrophages (Mϕs) and dendritic cells (DCs),...
Tailleux, Ludovic, Pham-Thi, Nhan, Bergeron-Lafaurie, Anne, Herrmann, Jean-Louis, Charles, Patricia, Schwartz, Olivier, ...
BACKGROUND: Interplays between Mycobacterium tuberculosis, the etiological agent of tuberculosis (TB) in human and host professional phagocytes, namely macrophages (Mphis) and dendritic cells (DCs),...
Tailleux, Ludovic, Pham-Thi, Nhan, Bergeron-Lafaurie, Anne, Herrmann, Jean-Louis, Charles, Patricia, Schwartz, Olivier, ...
BACKGROUND: Interplays between Mycobacterium tuberculosis, the etiological agent of tuberculosis (TB) in human and host professional phagocytes, namely macrophages (Mphis) and dendritic cells (DCs),...
Phase Variations of the Mycoplasma penetrans Main Surface Lipoprotein Increase Antigenic Diversity
Neyrolles, Olivier, Chambaud, Isabelle, Ferris, Stéphane, Prevost, Marie-Christine, Sasaki, Tsuguo, Montagnier, Luc, ...
Mycoplasma penetrans is a recently identified mycoplasma, isolated from urine samples collected from human immunodeficiency virus (HIV)-infected patients. Its presence is significantly associated...
Yu, Jun, Edwards-Jones, Bryn, Neyrolles, Olivier, Kroll, J. Simon
DsbA, a disulfide bond catalyst, is necessary for realization of the pathogenic potential of Shigella flexneri. Sh42, a mutant strain differing from wild-type M90TS solely because it expresses...
Role of Mycobacterium tuberculosis Copper-Zinc Superoxide Dismutase
Dussurget, Olivier, Stewart, Graham, Neyrolles, Olivier, Pescher, Pascale, Young, Douglas, Marchal, Gilles
Superoxide dismutases (SODs) play an important role in protection against oxidative stress and have been shown to contribute to the pathogenicity of many bacterial species. To determine the function...
Post, Frank A., Manca, Claudia, Neyrolles, Olivier, Ryffel, Bernhard, Young, Douglas B., Kaplan, Gilla
Vaccination of mice with Mycobacterium vaccae or M. smegmatis induces some protection against M. tuberculosis challenge. The 19-kDa lipoprotein of M. tuberculosis, expressed in M. vaccae or M....
Stewart, Graham R., Wilkinson, Katalin A., Newton, Sandra M., Sullivan, Susan M., Neyrolles, Olivier, Wain, John R., ...
The 19-kDa lipoprotein of Mycobacterium tuberculosis is an important target of the innate immune response. To investigate the immune biology of this antigen in the context of the whole bacillus, we...
Tailleux, Ludovic, Pham-Thi, Nhan, Bergeron-Lafaurie, Anne, Herrmann, Jean-Louis, Charles, Patricia, Schwartz, Olivier, ...
Alveolar macrophages from patients with TB express higher levels of DC-SIGN compared with controls. Ex-vivo infection induced DC-SIGN in infected and bystander cells, which made the latter more...
Promoter Variation in the DC-SIGN–Encoding Gene CD209 Is Associated with Tuberculosis
Barreiro, Luis B, Neyrolles, Olivier, Babb, Chantal L, Tailleux, Ludovic, Quach, Hélène, McElreavey, Ken, ...
Two variants in the gene that encodes DC-SIGN, the major receptor for Mycobacterium tuberculosis on dendritic cells, are associated with susceptibility to TB
Brodin, Priscille, Majlessi, Laleh, Marsollier, Laurent, De Jonge, Marien I., Bottai, Daria, Demangel, Caroline, ...
The dedicated secretion system ESX-1 of Mycobacterium tuberculosis encoded by the extended RD1 region (extRD1) assures export of the ESAT-6 protein and its partner, the 10-kDa culture filtrate...
Barreiro, Luis B., Patin, Etienne, Neyrolles, Olivier, Cann, Howard M., Gicquel, Brigitte, Quintana-Murci, Lluís
The innate immunity system constitutes the first line of host defense against pathogens. Two closely related innate immunity genes, CD209 and CD209L, are particularly interesting because they...
Pitarque, Sylvain, Herrmann, Jean-Louis, Duteyrat, Jean-Luc, Jackson, Mary, Stewart, Graham R., Lecointe, François, ...
Interactions between dendritic cells and Mycobacterium tuberculosis, the aetiological agent of tuberculosis in humans, are thought to be central to anti-mycobacterial immunity. We have previously...
Phase Variations of the Mycoplasma penetrans Main Surface Lipoprotein Increase Antigenic Diversity
Neyrolles, Olivier, Chambaud, Isabelle, Ferris, Stéphane, Prevost, Marie-Christine, Sasaki, Tsuguo, Montagnier, Luc, ...
Mycoplasma penetrans is a recently identified mycoplasma, isolated from urine samples collected from human immunodeficiency virus (HIV)-infected patients. Its presence is significantly associated...
Yu, Jun, Edwards-Jones, Bryn, Neyrolles, Olivier, Kroll, J. Simon
DsbA, a disulfide bond catalyst, is necessary for realization of the pathogenic potential of Shigella flexneri. Sh42, a mutant strain differing from wild-type M90TS solely because it expresses...
Role of Mycobacterium tuberculosis Copper-Zinc Superoxide Dismutase
Dussurget, Olivier, Stewart, Graham, Neyrolles, Olivier, Pescher, Pascale, Young, Douglas, Marchal, Gilles
Superoxide dismutases (SODs) play an important role in protection against oxidative stress and have been shown to contribute to the pathogenicity of many bacterial species. To determine the function...
Post, Frank A., Manca, Claudia, Neyrolles, Olivier, Ryffel, Bernhard, Young, Douglas B., Kaplan, Gilla
Vaccination of mice with Mycobacterium vaccae or M. smegmatis induces some protection against M. tuberculosis challenge. The 19-kDa lipoprotein of M. tuberculosis, expressed in M. vaccae or M....
Stewart, Graham R., Wilkinson, Katalin A., Newton, Sandra M., Sullivan, Susan M., Neyrolles, Olivier, Wain, John R., ...
The 19-kDa lipoprotein of Mycobacterium tuberculosis is an important target of the innate immune response. To investigate the immune biology of this antigen in the context of the whole bacillus, we...
Barreiro, Luis B., Patin, Etienne, Neyrolles, Olivier, Cann, Howard M., Gicquel, Brigitte, Quintana-Murci, Lluís
The innate immunity system constitutes the first line of host defense against pathogens. Two closely related innate immunity genes, CD209 and CD209L, are particularly interesting because they...
Tailleux, Ludovic, Pham-Thi, Nhan, Bergeron-Lafaurie, Anne, Herrmann, Jean-Louis, Charles, Patricia, Schwartz, Olivier, ...
Alveolar macrophages from patients with TB express higher levels of DC-SIGN compared with controls. Ex-vivo infection induced DC-SIGN in infected and bystander cells, which made the latter more...
Pitarque, Sylvain, Herrmann, Jean-Louis, Duteyrat, Jean-Luc, Jackson, Mary, Stewart, Graham R., Lecointe, François, ...
Interactions between dendritic cells and Mycobacterium tuberculosis, the aetiological agent of tuberculosis in humans, are thought to be central to anti-mycobacterial immunity. We have previously...
Promoter Variation in the DC-SIGN–Encoding Gene CD209 Is Associated with Tuberculosis
Barreiro, Luis B, Neyrolles, Olivier, Babb, Chantal L, Tailleux, Ludovic, Quach, Hélène, McElreavey, Ken, ...
Two variants in the gene that encodes DC-SIGN, the major receptor for Mycobacterium tuberculosis on dendritic cells, are associated with susceptibility to TB
Brodin, Priscille, Majlessi, Laleh, Marsollier, Laurent, De Jonge, Marien I., Bottai, Daria, Demangel, Caroline, ...
The dedicated secretion system ESX-1 of Mycobacterium tuberculosis encoded by the extended RD1 region (extRD1) assures export of the ESAT-6 protein and its partner, the 10-kDa culture filtrate...
Is Adipose Tissue a Place for Mycobacterium tuberculosis Persistence?
Neyrolles, Olivier, Hernández-Pando, Rogelio, Pietri-Rouxel, France, Fornès, Paul, Tailleux, Ludovic, Payán, Jorge Alberto Barrios, ...
Sulzenbacher, Gerlind, Canaan, Stéphane, Bordat, Yann, Neyrolles, Olivier, Stadthagen, Gustavo, Roig-Zamboni, Véronique, ...
Cell envelope lipids play an important role in the pathogenicity of mycobacteria, but the mechanisms by which they are transported to the outer membrane of these prokaryotes are largely unknown....
Rosas-Magallanes, Vania, Stadthagen-Gomez, Gustavo, Rauzier, Jean, Barreiro, Luis B., Tailleux, Ludovic, Boudou, Frédéric, ...
Using signature-tagged transposon mutagenesis, we isolated 23 Mycobacterium tuberculosis mutants, corresponding to 21 genes or genetic regions, attenuated in their ability to parasitize human...
Tailleux, Ludovic, Waddell, Simon J., Pelizzola, Mattia, Mortellaro, Alessandra, Withers, Michael, Tanne, Antoine, ...
DC-SIGN Is the Major Mycobacterium tuberculosis Receptor on Human Dendritic Cells
Tailleux, Ludovic, Schwartz, Olivier, Herrmann, Jean-Louis, Pivert, Elisabeth, Jackson, Mary, Amara, Ali, ...
Early interactions between lung dendritic cells (LDCs) and Mycobacterium tuberculosis, the etiological agent of tuberculosis, are thought to be critical for mounting a protective anti-mycobacterial...
Wilkinson, Katalin A, Newton, Sandra M, Stewart, Graham R, Martineau, Adrian R, Patel, Janisha, Sullivan, Susan M, ...
Evolutionary Dynamics of Human Toll-Like Receptors and Their Different Contributions to Host Defense
Barreiro, Luis B., Ben-Ali, Meriem, Quach, Hélène, Laval, Guillaume, Patin, Etienne, Pickrell, Joseph K., ...
Infectious diseases have been paramount among the threats to health and survival throughout human evolutionary history. Natural selection is therefore expected to act strongly on host defense genes,...