Modelling within-Host Spatiotemporal Dynamics of Invasive Bacterial Disease (2008)
Andrew J. Grant, Olivier Restif, Trevelyan J. McKinley, Mark Sheppard, Duncan J. Maskell, Pietro Mastroeni
Mechanistic determinants of bacterial growth, death, and spread within mammalian hosts cannot be fully resolved studying a single bacterial population. They are also currently poorly understood....
Integrating life history and cross-immunity into the evolutionary dynamics of pathogens
Restif, Olivier, Grenfell, Bryan T
Models for the diversity and evolution of pathogens have branched into two main directions: the adaptive dynamics of quantitative life-history traits (notably virulence) and the maintenance and...
The O Antigen Enables Bordetella parapertussis To Avoid Bordetella pertussis-Induced Immunityâ–¿
Wolfe, Daniel N., Goebel, Elizabeth M., Bjornstad, Ottar N., Restif, Olivier, Harvill, Eric T.
Bordetella pertussis and Bordetella parapertussis are closely related endemic human pathogens which cause whooping cough, a disease that is reemerging in human populations. Despite how closely...
Vaccination and the dynamics of immune evasion
Restif, Olivier, Grenfell, Bryan T
Vaccines exert strong selective pressures on pathogens, favouring the spread of antigenic variants. We propose a simple mathematical model to investigate the dynamics of a novel pathogenic strain...