Selection Acts on DNA Secondary Structures to Decrease Transcriptional Mutagenesis (2009)
Claire Hoede, Erick Denamur, Olivier Tenaillon
Single-stranded DNA is more subject to mutation than double stranded. During transcription, DNA is transiently single stranded and therefore subject to higher mutagenesis. However, if local...
Touchon, Marie, Hoede, Claire, Tenaillon, Olivier, Barbe, Valérie, Baeriswyl, Simon, Bidet, Philippe, ...
The Escherichia coli species represents one of the best-studied model organisms, but also encompasses a variety of commensal and pathogenic strains that diversify by high rates of genetic change. We...
Touchon, Marie, Hoede, Claire, Tenaillon, Olivier, Barbe, Valérie, Baeriswyl, Simon, Bidet, Philippe, ...
The Escherichia coli species represents one of the best-studied model organisms, but also encompasses a variety of commensal and pathogenic strains that diversify by high rates of genetic change. We...
Touchon, Marie, Hoede, Claire, Tenaillon, Olivier, Barbe, Valérie, Baeriswyl, Simon, Bidet, Philippe, ...
The Escherichia coli species represents one of the best-studied model organisms, but also encompasses a variety of commensal and pathogenic strains that diversify by high rates of genetic change. We...
Le Gall, Tony, Clermont, Olivier, Gouriou, Stéphanie, Picard, Bertrand, Nassif, Xavier, Denamur, Erick, ...
The selective pressures leading to the evolution and maintenance of virulence in the case of facultative pathogens are quite unclear. For example, Escherichia coli, a commensal of the gut of...
Understanding the Evolutionary Fate of Finite Populations: The Dynamics of Mutational Effects (2007)
Olin K. Silander, Olivier Tenaillon, Lin Chao
The most consistent result in more than two decades of experimental evolution is that the fitness of populations adapting to a constant environment does not increase indefinitely, but reaches a...
Selection Acts on DNA Secondary Structures to Decrease Transcriptional Mutagenesis (2006)
Claire Hoede, Erick Denamur, Olivier Tenaillon
Single-stranded DNA is more subject to mutation than double stranded. During transcription, DNA is transiently single stranded and therefore subject to higher mutagenesis. However, if local...
Selection Acts on DNA Secondary Structures to Decrease Transcriptional Mutagenesis (2006)
Claire Hoede, Erick Denamur, Olivier Tenaillon
Single stranded DNA is more subject to mutation than double stranded. During transcription DNA is transiently single stranded and therefore subject to higher mutagenesis. However if local...
Evolution of Mutational Robustness in an RNA Virus (2005)
Rebecca Montville, Remy Froissart, Susanna K. Remold, Olivier Tenaillon, Paul E. Turner
RNA phage viruses evolved under high co-infection of host cells are less robust to mutations than those propagated under low co-infection, suggesting that co-infection may be advantageous to RNA...
Evolution of Mutational Robustness in an RNA Virus (2005)
Rebecca Montville, Remy Froissart, Susanna K. Remold, Olivier Tenaillon, Paul E. Turner
Mutational (genetic) robustness is phenotypic constancy in the face of mutational changes to the genome. Robustness is critical to the understanding of evolution because phenotypically expressed...
Selection versus Demography: A Multilocus Investigation of the Domestication Process in Maize (2004)
Tenaillon, Maud I., U'Ren, Jana, Tenaillon, Olivier, Gaut, Brandon S.
The domestication of maize (Zea mays ssp. mays) from its wild ancestor (Zea mays ssp. parviglumis) led to a loss of genetic diversity both through a population bottleneck and through directional...
Selection Versus Demography: A Multilocus Investigation of the Domestication Process in Maize (2004)
Tenaillon, Maud I., U'Ren, Jana, Tenaillon, Olivier, Gaut, Brandon S.
The domestication of maize (Zea mays ssp. mays) from its wild ancestor (Zea mays ssp. parviglumis) led to a loss of genetic diversity both through a population bottleneck and through directional...
Selection versus Demography: A Multilocus Investigation of the Domestication Process in Maize (2004)
Tenaillon, Maud I., U'Ren, Jana, Tenaillon, Olivier, Gaut, Brandon S.
The domestication of maize (Zea mays ssp. mays) from its wild ancestor (Zea mays ssp. parviglumis) led to a loss of genetic diversity both through a population bottleneck and through directional...
FROM METABOLISM TO POLYMORPHISM IN BACTERIAL POPULATIONS: A THEORETICAL STUDY (2001)
Emmanuelle Porcher, Olivier Tenaillon, Bernard Godelle
Stable polymorphisms are commonly observed in experimental bacterial populations grown in homogeneous media. Evidence is accumulating that metabolic interactions might be the main mechanism...
Mutators and sex in bacteria: Conflict between adaptive strategies
Tenaillon, Olivier, Le Nagard, Hervé, Godelle, Bernard, Taddei, François
Bacterial mutation rates can increase and produce genetic novelty, as shown by in vitro and in silico experiments. Despite the cost due to a heavy deleterious mutation load, mutator alleles, which...
Evolution of Mutational Robustness in an RNA Virus
Montville, Rebecca, Froissart, Remy, Remold, Susanna K, Tenaillon, Olivier, Turner, Paul E
Mutational (genetic) robustness is phenotypic constancy in the face of mutational changes to the genome. Robustness is critical to the understanding of evolution because phenotypically expressed...
Charpentier, Charlotte, Nora, Tamara, Tenaillon, Olivier, Clavel, François, Hance, Allan J.
Although recombination during human immunodeficiency virus type 1 (HIV-1) replication in vitro and in vivo has been documented, little information is available concerning the extent that...
Intermediate Mutation Frequencies Favor Evolution of Multidrug Resistance in Escherichia coli
Denamur, Erick, Tenaillon, Olivier, Deschamps, Catherine, Skurnik, David, Ronco, Esthel, Gaillard, Jean Louis, ...
In studying the interplay between mutation frequencies and antibiotic resistance among Escherichia coli natural isolates, we observed that modest modifications of mutation frequency may significantly...
Selection Acts on DNA Secondary Structures to Decrease Transcriptional Mutagenesis
Hoede, Claire, Denamur, Erick, Tenaillon, Olivier
Single-stranded DNA is more subject to mutation than double stranded. During transcription, DNA is transiently single stranded and therefore subject to higher mutagenesis. However, if local...
Mutators and sex in bacteria: Conflict between adaptive strategies
Tenaillon, Olivier, Le Nagard, Hervé, Godelle, Bernard, Taddei, François
Bacterial mutation rates can increase and produce genetic novelty, as shown by in vitro and in silico experiments. Despite the cost due to a heavy deleterious mutation load, mutator alleles, which...
Evolution of Mutational Robustness in an RNA Virus
Montville, Rebecca, Froissart, Remy, Remold, Susanna K, Tenaillon, Olivier, Turner, Paul E
Mutational (genetic) robustness is phenotypic constancy in the face of mutational changes to the genome. Robustness is critical to the understanding of evolution because phenotypically expressed...
Charpentier, Charlotte, Nora, Tamara, Tenaillon, Olivier, Clavel, François, Hance, Allan J.
Although recombination during human immunodeficiency virus type 1 (HIV-1) replication in vitro and in vivo has been documented, little information is available concerning the extent that...
Intermediate Mutation Frequencies Favor Evolution of Multidrug Resistance in Escherichia coli
Denamur, Erick, Tenaillon, Olivier, Deschamps, Catherine, Skurnik, David, Ronco, Esthel, Gaillard, Jean Louis, ...
In studying the interplay between mutation frequencies and antibiotic resistance among Escherichia coli natural isolates, we observed that modest modifications of mutation frequency may significantly...
Selection Acts on DNA Secondary Structures to Decrease Transcriptional Mutagenesis
Hoede, Claire, Denamur, Erick, Tenaillon, Olivier
Single-stranded DNA is more subject to mutation than double stranded. During transcription, DNA is transiently single stranded and therefore subject to higher mutagenesis. However, if local...
Quantifying Organismal Complexity using a Population Genetic Approach
Tenaillon, Olivier, Silander, Olin K., Uzan, Jean-Philippe, Chao, Lin
Understanding the Evolutionary Fate of Finite Populations: The Dynamics of Mutational Effects
Silander, Olin K, Tenaillon, Olivier, Chao, Lin
The most consistent result in more than two decades of experimental evolution is that the fitness of populations adapting to a constant environment does not increase indefinitely, but reaches a...
Nora, Tamara, Charpentier, Charlotte, Tenaillon, Olivier, Hoede, Claire, Clavel, François, Hance, Allan J.
Viral recombination has been postulated to play two roles in the development of human immunodeficiency virus (HIV) resistance to antiretroviral drugs. First, recombination has the capacity to...
Schubert, Sören, Darlu, Pierre, Clermont, Olivier, Wieser, Andreas, Magistro, Giuseppe, Hoffmann, Christiane, ...
Horizontal gene transfer is a key step in the evolution of bacterial pathogens. Besides phages and plasmids, pathogenicity islands (PAIs) are subjected to horizontal transfer. The transfer mechanisms...
Organised Genome Dynamics in the Escherichia coli Species Results in Highly Diverse Adaptive Paths
Touchon, Marie, Hoede, Claire, Tenaillon, Olivier, Barbe, Valérie, Baeriswyl, Simon, Bidet, Philippe, ...
The Escherichia coli species represents one of the best-studied model organisms, but also encompasses a variety of commensal and pathogenic strains that diversify by high rates of genetic change. We...
Gros, Pierre-Alexis, Le Nagard, Hervé, Tenaillon, Olivier
The epistatic interactions among mutations have a large effect on the evolution of populations. In this article we provide a formalism under which epistatic interactions among pairs of mutations have...
Gros, Pierre-Alexis, Tenaillon, Olivier
Genetic robustness is defined as the constancy of a phenotype in the face of deleterious mutations. Overexpression of chaperones, to assist the folding of proteins carrying deleterious mutations, is...