Rhind, Shawn G., Rizoli, Sandro B., Shek, Pang N., Inaba, Kenji, Filips, Dennis, Tien, Homer, ...
Fluid resuscitation can often exacerbate injury sustained during hemorrhagic shock and is associated with altered immuno-inflammatory events. Early monocyte dysregulation and excessive...
Rhind, Shawn G., Rizoli, Sandro B., Shek, Pang N., Inaba, Kenji, Filips, Dennis, Tien, Homer, ...
Fluid resuscitation can often exacerbate injury sustained during hemorrhagic shock and is associated with altered immuno-inflammatory events. Early monocyte dysregulation and excessive...
Rizoli, Sandro B., Rhind, Shawn G., Shek, Pang N., Inaba, Kenji, Filips, Dennis, Tien, Homer, ...
Fluid resuscitation for traumatic hemorrhagic shock remains controversial since current protocols using large-volume crystalloid may exacerbate post-traumatic inflammation and organ dysfunction....
Wells, Carol L., Arland, Loreli A., Simmons, Richard L., Rotstein, Ori D.
Bacteroides fragilis pure-culture abscesses and Bact. fraghs–Escherichia coli mixed- culture abscesses were initiated subcutaneously in mice and intraperiloneally in rats. Within 1 h after...
v-SNARE-dependent secretion is required for phagocytosis
Hackam, David J., Rotstein, Ori D., Sjolin, Carola, Schreiber, Alan D., Trimble, William S., Grinstein, Sergio
Phagosomes are generally believed to form by gradual apposition of the plasma membrane of leukocytes onto the surface of invading microorganisms. The internalization of the encapsulated particle is...
Enhanced Susceptibility to Pulmonary Infection with Burkholderia cepacia in Cftr−/− Mice
Sajjan, Uma, Thanassoulis, George, Cherapanov, Vera, Lu, Annie, Sjolin, Carola, Steer, Brent, ...
Progressive pulmonary infection is the dominant clinical feature of cystic fibrosis (CF), but the molecular basis for this susceptibility remains incompletely understood. To study this problem, we...
Jia, Song Hui, Li, Yue, Parodo, Jean, Kapus, Andras, Fan, Lingzhi, Rotstein, Ori D., ...
Pre–B cell colony-enhancing factor (PBEF) is a highly conserved 52-kDa protein, originally identified as a growth factor for early stage B cells. We show here that PBEF is also upregulated in...
Actin depolymerization-induced tyrosine phosphorylation of cortactin: the role of Fer kinase.
Fan, Lingzhi, Weed, Scott A, Craig, Andrew W B, Greer, Peter A, Rotstein, Ori D, ...
The F-actin-binding protein cortactin is an important regulator of cytoskeletal dynamics, and a prominent target of various tyrosine kinases. Tyrosine phosphorylation of cortactin has been suggested...
Solomkin, Joseph S., Wilson, Samuel E., Christou, Nicholas V., Rotstein, Ori D., Dellinger, E. Patchen, Bennion, Robert S., ...
Solomkin, Joseph S., Yellin, Albert E., Rotstein, Ori D., Christou, Nicolas V., Dellinger, E. Patchen, Tellado, Jose M., ...
v-SNARE-dependent secretion is required for phagocytosis
Hackam, David J., Rotstein, Ori D., Sjolin, Carola, Schreiber, Alan D., Trimble, William S., Grinstein, Sergio
Phagosomes are generally believed to form by gradual apposition of the plasma membrane of leukocytes onto the surface of invading microorganisms. The internalization of the encapsulated particle is...
Enhanced Susceptibility to Pulmonary Infection with Burkholderia cepacia in Cftr−/− Mice
Sajjan, Uma, Thanassoulis, George, Cherapanov, Vera, Lu, Annie, Sjolin, Carola, Steer, Brent, ...
Progressive pulmonary infection is the dominant clinical feature of cystic fibrosis (CF), but the molecular basis for this susceptibility remains incompletely understood. To study this problem, we...
Jia, Song Hui, Li, Yue, Parodo, Jean, Kapus, Andras, Fan, Lingzhi, Rotstein, Ori D., ...
Pre–B cell colony-enhancing factor (PBEF) is a highly conserved 52-kDa protein, originally identified as a growth factor for early stage B cells. We show here that PBEF is also upregulated in...
Actin depolymerization-induced tyrosine phosphorylation of cortactin: the role of Fer kinase.
Fan, Lingzhi, Weed, Scott A, Craig, Andrew W B, Greer, Peter A, Rotstein, Ori D, ...
The F-actin-binding protein cortactin is an important regulator of cytoskeletal dynamics, and a prominent target of various tyrosine kinases. Tyrosine phosphorylation of cortactin has been suggested...
Solomkin, Joseph S., Wilson, Samuel E., Christou, Nicholas V., Rotstein, Ori D., Dellinger, E. Patchen, Bennion, Robert S., ...
Solomkin, Joseph S., Yellin, Albert E., Rotstein, Ori D., Christou, Nicolas V., Dellinger, E. Patchen, Tellado, Jose M., ...
Masszi, András, Fan, Lingzhi, Rosivall, László, McCulloch, Christopher A., Rotstein, Ori D., Mucsi, István, ...
Injury of the tubular epithelium and TGF-β1-induced conversion of epithelial cells to α-smooth muscle actin (SMA)-expressing myofibroblasts are key features of kidney fibrosis. Since injury damages...
Fan, Lingzhi, Sebe, Attila, Péterfi, Zalán, Masszi, András, Thirone, Ana C.P., Rotstein, Ori D., ...
Epithelial-mesenchymal-myofibroblast transition (EMT), a key feature in organ fibrosis, is regulated by the state of intercellular contacts. Our recent studies have shown that an initial injury of...
Powers, Kinga A., Szászi, Katalin, Khadaroo, Rachel G., Tawadros, Patrick S., Marshall, John C., Kapus, András, ...
Oxidative stress generated by ischemia/reperfusion is known to prime inflammatory cells for increased responsiveness to subsequent stimuli, such as lipopolysaccharide (LPS). The mechanism(s)...
Hackam, David J., Rotstein, Ori D., Schreiber, Alan, Zhang, Wei-jian, Grinstein, Sergio
Phagocytosis of bacteria by macrophages and neutrophils is an essential component of host defense against infection. The mechanism whereby the interaction of opsonized particles with Fcγ receptors...
Hackam, David J., Rotstein, Ori D., Zhang, Wei-jian, Gruenheid, Samantha, Gros, Philippe, Grinstein, Sergio
The mechanisms underlying the survival of intracellular parasites such as mycobacteria in host macrophages remain poorly understood. In mice, mutations at the Nramp1 gene (for natural...