Pre- and post-Golgi translocation of glucosylceramide in glycosphingolipid synthesis (2007)
Halter, David, Neumann, Sylvia, Dijk, Suzanne M. Van, Wolthoorn, Jasja, Mazière, Ann M. De, Vieira, Otilia V., ...
Glycosphingolipids are controlled by the spatial organization of their metabolism and by trans port specifi city. Using immunoelectron microscopy, we localize to the Golgi stack the...
Vieira, Otilia V, Gaus, Katharina, Verkade, Paul, Fullekrug, Joachim, Vaz, Winchil L C, Simons, Kai
We have analyzed the role of the phosphatidylinositol-4-phosphate adaptor protein-2 (FAPP2), a component of the apical transport machinery, in cilium formation in polarized Madin-Darby canine kidney...
Modulation of Rab5 and Rab7 Recruitment to Phagosomes by Phosphatidylinositol 3-Kinase
Vieira, Otilia V., Bucci, Cecilia, Harrison, Rene E., Trimble, William S., Lanzetti, Letizia, Gruenberg, Jean, ...
Phagosomal biogenesis is central for microbial killing and antigen presentation by leukocytes. However, the molecular mechanisms governing phagosome maturation are poorly understood. We analyzed the...
Harrison, Rene E., Bucci, Cecilia, Vieira, Otilia V., Schroer, Trina A., Grinstein, Sergio
Nascent phagosomes must undergo a series of fusion and fission reactions to acquire the microbicidal properties required for the innate immune response. Here we demonstrate that this maturation...
Acquisition of Hrs, an Essential Component of Phagosomal Maturation, Is Impaired by Mycobacteria
Vieira, Otilia V., Harrison, Rene E., Scott, Cameron C., Stenmark, Harald, Alexander, David, Liu, Jun, ...
Pathogenic mycobacteria survive within macrophages by precluding the fusion of phagosomes with late endosomes or lysosomes. Because the molecular determinants of normal phagolysosome formation are...
Phagosome maturation: aging gracefully.
Vieira, Otilia V, Botelho, Roberto J, Grinstein, Sergio
Foreign particles and apoptotic bodies are eliminated from the body by phagocytic leucocytes. The initial stage of the elimination process is the internalization of the particles into a plasma...
Modulation of Rab5 and Rab7 Recruitment to Phagosomes by Phosphatidylinositol 3-Kinase
Vieira, Otilia V., Bucci, Cecilia, Harrison, Rene E., Trimble, William S., Lanzetti, Letizia, Gruenberg, Jean, ...
Phagosomal biogenesis is central for microbial killing and antigen presentation by leukocytes. However, the molecular mechanisms governing phagosome maturation are poorly understood. We analyzed the...
Harrison, Rene E., Bucci, Cecilia, Vieira, Otilia V., Schroer, Trina A., Grinstein, Sergio
Nascent phagosomes must undergo a series of fusion and fission reactions to acquire the microbicidal properties required for the innate immune response. Here we demonstrate that this maturation...
Acquisition of Hrs, an Essential Component of Phagosomal Maturation, Is Impaired by Mycobacteria
Vieira, Otilia V., Harrison, Rene E., Scott, Cameron C., Stenmark, Harald, Alexander, David, Liu, Jun, ...
Pathogenic mycobacteria survive within macrophages by precluding the fusion of phagosomes with late endosomes or lysosomes. Because the molecular determinants of normal phagolysosome formation are...
Phagosome maturation: aging gracefully.
Vieira, Otilia V, Botelho, Roberto J, Grinstein, Sergio
Foreign particles and apoptotic bodies are eliminated from the body by phagocytic leucocytes. The initial stage of the elimination process is the internalization of the particles into a plasma...
Vieira, Otilia V., Gaus, Katharina, Verkade, Paul, Fullekrug, Joachim, Vaz, Winchil L. C., Simons, Kai
We have analyzed the role of the phosphatidylinositol-4-phosphate adaptor protein-2 (FAPP2), a component of the apical transport machinery, in cilium formation in polarized Madin–Darby canine...
FAPP2 is involved in the transport of apical cargo in polarized MDCK cells
Vieira, Otilia V., Verkade, Paul, Manninen, Aki, Simons, Kai
Phosphatidylinositol-4-phosphate (PI(4)P) is the main phosphoinositide in the Golgi complex and has been reported to play a pleiotropic role in transport of cargo from the trans-Golgi network to the...
Pre- and post-Golgi translocation of glucosylceramide in glycosphingolipid synthesis
Halter, David, Neumann, Sylvia, Van Dijk, Suzanne M., Wolthoorn, Jasja, De Mazière, Ann M., Vieira, Otilia V., ...
Glycosphingolipids are controlled by the spatial organization of their metabolism and by transport specificity. Using immunoelectron microscopy, we localize to the Golgi stack the...
Vieira, Otilia V., Botelho, Roberto J., Rameh, Lucia, Brachmann, Saskia M., Matsuo, Tsuyoshi, Davidson, Howard W., ...
Phagosomes acquire their microbicidal properties by fusion with lysosomes. Products of phosphatidylinositol 3-kinase (PI 3-kinase) are required for phagosome formation, but their role in maturation...