Vintila, M., Mordenti, G., Van Veldhuisen, D.J., Dobre, D., Poole-Wilson, P.A., Coats, A.J.S., ...
Background The SENIORS trial showed that nebivolol reduced the risk of death or cardiovascular (CV) hospitalization in elderly patients with heart failure (HF). We aimed to assess tolerability and...
Dobre, D., Van Veldhuisen, D.J., Mordenti, G., Vintila, M., Haaijer-Ruskamp, F.M., Coats, A.J.S., ...
Background The SENIORS trial showed that nebivolol reduced the risk of death or cardiovascular (CV) hospitalization in elderly patients with heart failure (HF). We aimed to assess tolerability and...
Dobre, D., Van Veldhuisen, D.J., Mordenti, G., Vintila, M., Haaijer-Ruskamp, F.M., Coats, A.J.S., ...
Background The SENIORS trial showed that nebivolol reduced the risk of death or cardiovascular (CV) hospitalization in elderly patients with heart failure (HF). We aimed to assess tolerability and...
Thum, T., Hoeber, S., Froese, S., Klink, I., Stichtenoth, D.O., Galuppo, P., ...
Aging is associated with an increased risk for atherosclerosis. A possible cause is low numbers and dysfunction of endothelial progenitor cells (EPC) which insufficiently repair damaged vascular...
Moon, J.C.C., De Arenaza, D.P., Elkington, A.G., Taneja, A.K., John, A.S., Wang, D., ...
Objectives The purpose of this study was to determine the pathologic basis of Q-wave (QW) and non-Q-wave (NQW) myocardial infarction (MI). Background: The QW/NQW distinction remains in wide clinical...
Heart failure in a district general hospital: are target doses of beta-blockers realistic? (2004)
Mehta, P.A., McDonagh, S., Poole-Wilson, P.A., Grocott-Mason, R., Dubrey, S.W.
Background: Carvedilol therapy reduces mortality in patients with chronic heart failure. Multi-centre studies suggest a low first dose failure rate and high levels of tolerability to carvedilol....
Clayton, T.C., Pocock, S.J., Henderson, R.A., Poole-Wilson, P.A., Shaw, T.R.D., Knight, R., ...
Aims The RITA 3 trial randomized patients with non-ST-elevation myocardial infarction or unstable angina to strategies of early intervention (angiography followed by revascularization) or...
Who are the enemies? Lack of oxygen (2002)
The most common forms of heart disease are linked to coronary atherosclerosis and a reduction in blood flow to the myocardium, notably under stressful conditions. The lack of oxygen can lead to...
Hospitalization of patients with heart failure. A population-based study (2002)
Cowie, M. R., Fox, K. F., Wood, D. A., Metcalfe, C., Thompson, S. G., Coats, A. J. S., ...
Aims To describe the clinical course of heart failure in a population-based sample of incident cases, and to identify factors predicting hospitalization and mortality. Methods and Results Three...
Massie, B. M., Armstrong, P. W., Cleland, J. G. F., Horowitz, John David, Packer, M., Poole-Wilson, P. A., ...
© 2001 American Medical Association.
Cleland, J. G. F., Thygesen, K., Uretsky, B. F., Armstrong, P. W., Horowitz, John David, Massie, B. M., ...
© 2001 by the European Society of Cardiology.
Massie, B. M., Armstrong, P. W., Cleland, J. G. F., Horowitz, John David, Packer, M., Poole-Wilson, P. A., ...
© 2001 American Medical Association.
Cleland, J. G. F., Thygesen, K., Uretsky, B. F., Armstrong, P. W., Horowitz, John David, Massie, B. M., ...
© 2001 by the European Society of Cardiology.
Coronary artery disease as the cause of incident heart failure in the population (2001)
Fox, K.F, Cowie, M.R, Wood, D.A, Coats, A.J.S, Gibbs, J.S.R, Underwood, S.R, ...
Aims New approaches in the treatment of ischaemic left ventricular dysfunction, including revascularization, make it increasingly important to identify heart failure cases resulting from coronary...
Cleland, J.G.F., Thygesen, K., Uretsky, B.F., Armstrong, P., Horowitz, J.D., Massie, B., ...
Aims To determine the sequence of critical cardiovascular events in the progression of heart failure, and whether aetiology or high-dose vs low-dose lisinopril affected these pathways. Methods and...
Uretsky, B. F., Thygesen, K., Armstrong, P. W., Cleland, J. G. F., Horowitz, J. D., Massie, B. M., ...
Uretsky, B. F., Thygesen, K., Armstrong, P. W., Cleland, J. G. F., Horowitz, J. D., Massie, B. M., ...
Rydén, L, Armstrong, P.W, Cleland, J.G.F, Horowitz, J.D, Massie, B.M, Packer, M, ...
Aims An analysis was designed to determine whether chronic heart failure patients at high cardiovascular risk benefited to the same extent from high-dose lisinopril as the whole ATLAS population....
Leyva, F, Rauchhaus, M, Anker, S.D, Proudler, A.J, Godsland, I.F, Stiefel, P, ...
Background In healthy individuals, insulin administration causes an increase in forearm blood flow which is dependent on the effects of insulin on the vascular endothelium. Glucose, administered as...
Packer, M., Poole-Wilson, P. A., Armstrong, P. W., Cleland, J. G.F., Horowitz, J. D., Massie, B. M., ...
Packer, M., Poole-Wilson, P. A., Armstrong, P. W., Cleland, J. G.F., Horowitz, J. D., Massie, B. M., ...
Anker, S.D., Ponikowski, P.P., Clark, A.L., Leyva, F., Rauchhaus, M., Kemp, M., ...
Background Chronic heart failure is one of a number of disorders associated with the development of a wasting syndrome. The precise mechanisms of this remain unknown, but previous studies have...
Incidence and aetiology of heart failure; a population-based study (1999)
Cowie, M.R., Wood, D.A., Coats, A.J.S., Thompson, S.G., Poole-Wilson, P.A., Suresh, V., ...
Aims To determine the incidence and aetiology of heart failure in the general population. Methods and Results New cases of heart failure were identified from a population of 151000 served by 82...
New perspectives on heart failure due to myocardial ischaemia (1999)
Fox, K.F., Cowie, M.R., Wood, D.A., Coats, A.J.S., Poole-Wilson, P.A., Sutton, G.C.
Uric acid in chronic heart failure: a marker of chronic inflammation (1998)
Leyva, F., Anker, S.D., Godsland, I.F., Teixeira, M., Hellewell, P.G., Kox, W.J., ...
Background Chronic heart failure is associated with hyperuricaemia and elevations in circulating markers of inflammation. Activation of xanthine oxidase, through free radical release, causes...
Mitochondrial DNA in idiopathic cardiomyopathy (1998)
Turner, L.F., Kaddoura, S., Harrington, D., Cooper, J.M., Poole-Wilson, P.A., Schapira, A.H.V.
Aims To investigate the frequency of pathogenic mitochondrial DNA mutations in idiopathic cardiomyopathy. Methods and Results We investigated the occurrence of seven previously reported pathogenic...
The epidemiology of heart failure (1997)
Cowie, M. R., Mosterd, A., Wood, D. A., Deckers, J. W., Poole-Wilson, P. A., Sutton, G. C., ...
Anker, S. D., Swank, J. W., Volterrani, M., Chua, T. P., Clark, A. L., Poole-Wilson, P. A., ...
Background The influence of age, skeletal muscle function and peripheral blood flow on exercise capacity in chronic heart failure patients is controversial, possibly due to variations in skeletal...
Rosano, G. M. C., Kaski, J. C., Arie, S., Pereira, W. I., Collins, P., Pileggi, F., ...
Visual judgment of stenosis severity from cine-film or single-photon emission computed tomographic dipyrida-mole perfusion images was compared to assessment of stenosis severity as measured with...
Histological abnormalities of muscle from limb, thorax and diaphragm in chronic heart failure (1996)
Lindsay, D. C., Lovegrove, C. A., Dunn, M. J., Bennett, J. G., Pepper, J. R., Yacoub, M. H., ...
The aim of the study was to compare histological findings in limb and respiratory muscles from control subjects and patients with heart failure of two different aetiologies. Biopsies of the...
Syndrome X in women is associated with oestrogen deficiency (1995)
ROSANO, G. M. C., COLLINS, P., KASKI, J. C., LINDSAY, D. C., SARREL, P. M., POOLE-WILSON, P. A.
This study was undertaken to ascertain whether gynaecological history or a reduction in ovarian hormones are triggers of angina in menopausal women with a positive exercise test and normal coronary...
Abnormalities of the myocytes in ischaemic cardiomyopathy (1995)
Harding, S. E., MacLeod, K. T., Davies, C. H., Wynne, D. G., Poole-Wilson, P. A.
Acute myocardial ischaemia and subsequent reperfusion result in biochemical and ionic changes in cardiac myocytes which cause contracture of the muscle and a reduced contractile force. Whether...
LINDSAY, D. C., ANAND, I. S., BENNETT, J. G., PEPPER, J. R., YACOUB, M. H., ROTHERY, S. M., ...
Chronic heart failure (CHF) is characterized by increased systemic vascular resistance and diminished blood flow to exercising skeletal muscle. The pathogenesis of the increased resistance is not...
HOLDRIGHT, D. R., CLARKE, D., FOX, K., POOLE-WILSON, P. A., COLLINS, P.
Attenuation of the increase in blood flow caused by acetylcholine in the peripheral vasculature and coronary circulation of patients with heart failure has been interpreted as an impairment of...
Contractile Function and Response to Agonists in Myocytes from Failing Human Heart (1994)
Harding, S. E., Davies, C. H., Wynne, D. G., Poole-Wilson, P. A.
Ventricular myocytes from failing human hearts have a similar maximum contraction amplitude in high Ca2+to those from non-failing heart at low stimulation rates (0.2 Hz, 32°C), but do not exhibit...
The role of calcium antagonists in the treatment of chronic heart failure (1993)
Parameshwar, J., Poole-Wilson, P. A.
Calcium antagonists have been widely used for the treatment of angina and hypertension. Because of vasodilator and anti-ischaemic properties, calcium antagonists might be expected to bring benefit to...
Lindsay, D C, Jiang, C, Brunotte, F, Adamopoulos, S, Coats, A J S, Rajagopalan, B, ...
Objective: The aim was to document the response of aortic rings from a rat model of heart failure to endothelium dependent and endothelium independent vasodilating agents. The effects of an exercise...
DAVIES, S. W., FUSSELL, A. L., JORDAN, S. L., POOLE-WILSON, P. A., LIPKIN, D. P.
Abnormal patterns of diastolic ventricular filling are well recognized in chronic heart failure, but their relationship to the severity of heart failure is not known. The present study evaluates the...
Jiang, C, Crake, T, Poole-Wilson, P A
Study objective – The aim was to determine the effects of barium ions and glibenclamide on the hypoxia induced K+ efflux from rabbit myocardium. Design – Experiments were performed on the...
A possible molecular mechanism for 'stunning' of the myocardium (1991)
Poole-Wilson, P. A., Holmberg, S. R. M., Williams, A. J.
Stunning of the myocardium is mechanical dysfunction that persists after the re-establishment of coronary flow despite the absence of damage and the lack of any evidence for continuing ischaemia....
Relevance of the aetiology of heart failure to drug therapy (1989)
The phrase ‘heart failure’ is used as a shorthand by medical practitoners to describe a wide variety of medical conditions ranging from acute heart failure with pulmonary oedema to terminal...
ANANAD, I.S., VEALL, N., KALRA, G.S., FERRARI, R., SUTTON, G., LIPKIN, D., ...
Body fluid compartments, renal function and plasma hormones were measured in 13 patients with severe chronic heart failure, when the referring physician considered the patient to be appropriately...
The origin of symptoms in patients with chronic heart failure (1988)
Severe shortness of breath is a prominent symptom in acute heart failure (pulmonary oedema) and is related to left atrial pressure. A reduction of this pressure almost always leads to an improvement...
Laser assisted coronary angioplasty (1988)
Bowker, T. J., Cross, F. W., Fox, K. M., Poole-Wilson, P. A., Bown, S. G., Rickards, A. F.
LIPKIN, D. P., BAYLISS, J., POOLE-WILSON, P. A.
We investigated the ability of a submaximal exercise test to predict the maximal aerobic potential and hence exercise capacity of patients with chronic heart failure. Heart rate, oxygen consumption...
Natural history of minor coronary events (1984)
Coronary artery disease is an important potential cause of a sudden event such as myocardial infarction, chest pain or an arrhythmia. These may lead to immediate and unexpected incapacitation of a...
The calcium paradox in isolated frog heart: Ringer revisited (1983)
Ruigrok, T. J. C., Slade, A. M., Poole-Wilson, P. A.
Restoration of a normal calcium concentration in the perfusate of isolated hearts after a short period of calcium-free perfusion may result in irreversible cell damage (calcium paradox). We have...
NAYLER, WINIFRED G., YEPEZ, CARMEN E., POOLE-WILSON, P. A.
Using isolated, Langendorff-perfused, electrically-paced guinea-pig hearts, we have investigated the rise in resting tension that occurs when mammalian heart muscle becomes hypoxic....
Chakrabarti, M K, Cobbe, S M, Loh, L, Poole-Wilson, P A
Respiratory pH oscillations were studied in situ in the aorta and superior vena cava of rabbits, and in the pulmonary vein and aorta of open-chested dogs, using catheter tip pH electrodes....
1. Respiratory and metabolic acid-base changes caused similar steady-state changes in the contractility of cardiac ventricular muscle, but the rate of response was more rapid with the former...
Prevalence of heart failure in three general practices in north west London.
Parameshwar, J, Shackell, M M, Richardson, A, Poole-Wilson, P A, Sutton, G C
There is little recent information on the prevalence of heart failure in the United Kingdom. Assuming that patients with heart failure would be taking diuretic drugs all such patients were identified...
Six minute walking test for assessing exercise capacity in chronic heart failure.
Lipkin, D P, Scriven, A J, Crake, T, Poole-Wilson, P A
Twenty six patients, mean age 58 years (range 36-68), with stable chronic heart failure, New York Heart Association class II-III, and 10 normal subjects of a similar age range were studied. Exercise...
Treatment of chronic heart failure with pirbuterol: acute haemodynamic responses.
Dawson, J R, Canepa-Anson, R, Kuan, P, Whitaker, N H, Carnie, J, Warnes, C, ...
Fifty-nine patients with severe chronic heart failure were given pirbuterol, a beta agonist with vasodilator and positive inotropic properties. The acute haemodynamic responses to both single (20...
Logical approach to lignocaine therapy.
Aps, C, Bell, J A, Jenkins, B S, Poole-Wilson, P A, Reynolds, F
Plasma lignocaine concentrations were measured during and after lignocaine infusions administered for suppressing ventricular dysrhythmias. Twenty-four patients with a primary diagnosis of acute...
Chakrabarti, M K, Cobbe, S M, Loh, L, Poole-Wilson, P A
Respiratory pH oscillations were studied in situ in the aorta and superior vena cava of rabbits, and in the pulmonary vein and aorta of open-chested dogs, using catheter tip pH electrodes....
1. Respiratory and metabolic acid-base changes caused similar steady-state changes in the contractility of cardiac ventricular muscle, but the rate of response was more rapid with the former...
Six minute walking test for assessing exercise capacity in chronic heart failure.
Lipkin, D P, Scriven, A J, Crake, T, Poole-Wilson, P A
Twenty six patients, mean age 58 years (range 36-68), with stable chronic heart failure, New York Heart Association class II-III, and 10 normal subjects of a similar age range were studied. Exercise...
Prevalence of heart failure in three general practices in north west London.
Parameshwar, J, Shackell, M M, Richardson, A, Poole-Wilson, P A, Sutton, G C
There is little recent information on the prevalence of heart failure in the United Kingdom. Assuming that patients with heart failure would be taking diuretic drugs all such patients were identified...
Treatment of chronic heart failure with pirbuterol: acute haemodynamic responses.
Dawson, J R, Canepa-Anson, R, Kuan, P, Whitaker, N H, Carnie, J, Warnes, C, ...
Fifty-nine patients with severe chronic heart failure were given pirbuterol, a beta agonist with vasodilator and positive inotropic properties. The acute haemodynamic responses to both single (20...
Logical approach to lignocaine therapy.
Aps, C, Bell, J A, Jenkins, B S, Poole-Wilson, P A, Reynolds, F
Plasma lignocaine concentrations were measured during and after lignocaine infusions administered for suppressing ventricular dysrhythmias. Twenty-four patients with a primary diagnosis of acute...
Catheter tip pH electrodes were used for continuous recording of coronary sinus and arterial pH during atrial pacing in 20 patients undergoing coronary arteriography for chest pain. An ischaemic...
Bayliss, J, Norell, M, Canepa-Anson, R, Reuben, S R, Poole-Wilson, P A, Sutton, G C
A randomised, within patient comparison was made in patients with severe chronic heart failure, to study the acute haemodynamic effects of oral agents which have inotropic and vasodilator properties....
Coronary sinus potassium concentration recorded during coronary angioplasty.
Webb, S C, Rickards, A F, Poole-Wilson, P A
Coronary sinus potassium concentration was measured continuously in two patients undergoing angioplasty of a significant stenosis of the left anterior descending coronary artery. After each coronary...
Dawson, J R, Canepa-Anson, R, Kuan, P, Reuben, S R, Poole-Wilson, P A, Sutton, G C
An open study of long term treatment with an oral beta 2 agonist (pirbuterol 20 mg three times daily) was undertaken in 63 patients with severe chronic heart failure. During three months of treatment...
Webb, S C, Canepa-Anson, R, Rickards, A F, Poole-Wilson, P A
Glyceryl trinitrate (Tridil) was given by intracoronary injection to a patient who developed coronary artery spasm during angioplasty. Transient exacerbation of chest pain and electrocardiographic...
Respiratory gas exchange in the assessment of patients with impaired ventricular function.
Lipkin, D P, Perrins, J, Poole-Wilson, P A
Respiratory gas exchange on exercise was evaluated as a non-invasive method of assessing patients with heart failure. Twenty four men (age 28-72) with symptomatic chronic stable heart failure (New...
Salbutamol in treatment of heart failure.
Bourdillon, P D, Dawson, J R, Foale, R A, Timmis, A D, Poole-Wilson, P A, Sutton, G C
The haemodynamic effects of oral and intravenous salbutamol were investigated in 22 patients with chronic heart failure. Intravenous salbutamol (13 micrograms/min) increased cardiac index by 53 per...
Salbutamol in cardiogenic shock complicating acute myocardial infarction.
Dawson, J R, Poole-Wilson, P A, Sutton, G C
Intravenous salbutamol (13 microgram/min) has been given to 31 patients with cardiogenic shock complicating acute myocardial infarction. Haemodynamic measurements were made in nine of these patients....
R wave amplitude during exercise. Relation to left ventricular function and coronary artery disease.
Baron, D W, Ilsley, C, Sheiban, I, Poole-Wilson, P A, Rickards, A F
Change in R wave amplitude (mean delta R) was measured sequentially during and after 12 lead maximal treadmill exercise tests in 14 subjects with normal coronary arteries and 62 patients with...
Haemodynamic effects of salbutamol and nitroprusside after cardiac surgery.
Poole-Wilson, P A, Lewis, G, Angerpointer, T, Malcolm, A D, Williams, B T
The haemodynamic effects of a continuous intravenous infusion of salbutamol (15 to 30 microgram/min) and nitroprusside (50 to 100 microgram/min) were compared in 9 patients after cardiac surgical...
Effects of motivation of the patient on indices of exercise capacity in chronic heart failure.
Clark, A. L., Poole-Wilson, P. A., Coats, A. J.
BACKGROUND--Measurement of variables of metabolic gas exchange during exercise is widely used to assess the severity of heart failure. The variables derived however, are potentially dependent on...
Sparrow, J., Parameshwar, J., Poole-Wilson, P. A.
OBJECTIVES--To assess the efficacy of a 9-minute walking test on a self-powered treadmill in a group of patients with various degrees of heart failure, to investigate the reproducibility of the...
Insulin resistance syndrome in postmenopausal women with cardiological syndrome X.
Godsland, I. F., Crook, D., Stevenson, J. C., Collins, P., Rosano, G. M., Lees, B., ...
OBJECTIVE--To determine whether postmenopausal women with cardiological syndrome X (chest pain and abnormal exercise electrocardiogram despite normal coronary angiography) exhibit disturbances in the...
Is aspirin safe for patients with heart failure?
Cleland, J. G., Bulpitt, C. J., Falk, R. H., Findlay, I. N., Oakley, C. M., Murray, G., ...
Elliott, P. M., Rosano, G. M., Gill, J. S., Poole-Wilson, P. A., Kaski, J. C., McKenna, W. J.
OBJECTIVES: The presence of angina pectoris and myocardial scarring in patients with hypertrophic cardiomyopathy (HCM) suggests that myocardial ischemia is a factor in the pathophysiology of the...
Endothelial control of lower limb blood flow in chronic heart failure.
Lindsay, D. C., Holdright, D. R., Clarke, D., Anand, I. S., Poole-Wilson, P. A., Collins, P.
BACKGROUND: Limitation of the blood supply to skeletal muscle in chronic heart failure may contribute to the symptoms of fatigue and diminished exercise capacity. The pathophysiology underlying this...
Ferrari, R., Anand, I. S., Ceconi, C., De Giuli, F., Poole-Wilson, P. A., Harris, P.
OBJECTIVES: Plasma hormones at rest in patients with untreated severe congestive cardiac failure are similar to those occurring during heavy exercise in healthy people. This study examines the...
Relation between serum uric acid and lower limb blood flow in patients with chronic heart failure.
Anker, S. D., Leyva, F., Poole-Wilson, P. A., Kox, W. J., Stevenson, J. C., Coats, A. J.
OBJECTIVE: To determine whether lower limb blood flow is related to serum uric acid concentrations in patients with chronic heart failure, taking into account the hyperuricaemic effects of diuretic...
Comparison of captopril and ibopamine in mild to moderate heart failure.
Dohmen, H. J., Dunselman, P. H., Poole-Wilson, P. A.
OBJECTIVE: To determine the effects of ibopamine 100 mg three times daily compared with captopril 25 mg three times daily on exercise capacity in patients with chronic heart failure. DESIGN: A...
Angiosarcoma of pericardium. Problems in diagnosis and management.
Poole-Wilson, P A, Farnsworth, A, Braimbridge, M V, Pambakian, H
The clinical histories of two patients with angiosarcoma of the pericardium are described. Both were previously well young men who presented with cardiac tamponade caused by haemorrhagic pericardial...
Familial restrictive cardiomyopathy with atrioventricular block and skeletal myopathy.
Fitzpatrick, A P, Shapiro, L M, Rickards, A F, Poole-Wilson, P A
Five generations of an Italian family with an autosomal dominant restrictive cardiomyopathy are described. Members of four generations were examined. Symptoms usually developed in the third or fourth...
Mechanism of the increased ventilatory response to exercise in patients with chronic heart failure.
Buller, N P, Poole-Wilson, P A
Minute ventilation, respiratory rate, and metabolic gas exchange were measured continuously during maximal symptom limited treadmill exercise in 30 patients with stable chronic heart failure. The...
Endothelium dependent and independent responses in coronary artery disease measured at angioplasty.
Holdright, D R, Clarke, D, Poole-Wilson, P A, Fox, K, Collins, P
OBJECTIVE--To investigate the effects of substance P and papaverine, two drugs that increase coronary blood flow by different mechanisms, on vasomotion in stenotic coronary arteries at percutaneous...
Anand, I S, Chandrashekhar, Y, Ferrari, R, Poole-Wilson, P A, Harris, P C
BACKGROUND--Patients with chronic severe anaemia often retain salt and water. Fluid retention in these patients is not caused by heart failure and the exact mechanisms remain unclear. This study was...
Coronary flow reserve in patients with chest pain and normal coronary arteries.
Holdright, D R, Lindsay, D C, Clarke, D, Fox, K, Poole-Wilson, P A, Collins, P
BACKGROUND--Many studies have shown that coronary flow reserve is reduced in patients with chest pain and angiographically normal coronary arteries. The methods used to assess coronary blood flow...
Henein, M. Y., Rosano, G. M., Underwood, R., Poole-Wilson, P. A., Gibson, D. G.
OBJECTIVE--To investigate interrelations between ventricular long axis function, resting electrocardiogram, and myocardial perfusion imaging in a group of patients with syndrome X in order to define...
Factors determining symptoms in heart failure: comparison of fast and slow exercise tests.
Lipkin, D P, Canepa-Anson, R, Stephens, M R, Poole-Wilson, P A
Factors determining the symptoms of breathlessness and fatigue in patients with congestive heart failure were investigated by comparing the response to slow and fast exercise. Symptom limited oxygen...
Perforation thresholds and safety factors in in vivo coronary laser angioplasty.
Bowker, T J, Fox, K M, Cross, F W, Poole-Wilson, P A, Bown, S G, Rickards, A F
Laser angioplasty can cause early (acute perforation) or late (stenosis or aneurysm) complications. To find how much intravascular laser energy can be delivered via a 100 microns core optical fibre...
A new exercise test for the assessment of heart failure: use of a self powered treadmill.
Parameshwar, J, Dambrink, J H, Sparrow, J, Wright, C, Park, A, Tweed, J, ...
Time limited exercise on a self powered treadmill was evaluated as a method of assessing functional capacity in patients with mild heart failure. The characteristics of the treadmill were established...
Diurnal variation of pulmonary artery pressure in chronic heart failure.
Gibbs, J S, Cunningham, D, Shapiro, L M, Park, A, Poole-Wilson, P A, Fox, K M
Variation in pulmonary artery pressure has important consequences for the interpretation of isolated pressure measurements in patients with chronic heart failure. To investigate the nature of diurnal...
Potassium exchange in the human heart during atrial pacing and myocardial ischaemia.
Potassium homoeostasis in the heart was studied during atrial pacing in 20 patients undergoing diagnostic coronary angiography. The potassium concentrations in the coronary sinus and a systemic...
Assessment of regional left ventricular function by magnetic resonance.
Underwood, S R, Rees, R S, Savage, P E, Klipstein, R H, Firmin, D N, Fox, K M, ...
The ability of magnetic resonance to determine regional left ventricular function was investigated in 18 patients--13 with coronary artery disease (nine with previous infarction), one with congestive...
Magnetic resonance assessment of aortic and mitral regurgitation.
Underwood, S R, Klipstein, R H, Firmin, D N, Fox, K M, Poole-Wilson, P A, Rees, R S, ...
Magnetic resonance imaging provides an accurate method for the measurement of left and right ventricular volume. The ratio of left ventricular stroke volume to right ventricular stroke volume was...
Buller, N P, Poole-Wilson, P A
Respiratory gas exchange was measured during maximal treadmill exercise testing in six healthy volunteers and 20 patients with chronic heart failure. A curve of equation y = ax-bx2 was used to model...
Crake, T, Canepa-Anson, R, Shapiro, L, Poole-Wilson, P A
Coronary sinus oxygen saturation was measured continuously during incremental atrial pacing in 34 patients undergoing cardiac catheterisation. In eleven patients with normal coronary arteriograms,...
Crake, T, Crean, P A, Shapiro, L M, Rickards, A F, Poole-Wilson, P A
Coronary sinus pH was measured continuously in eight patients undergoing angioplasty to the left anterior descending coronary artery. A catheter tip pH sensitive electrode with a response time of...
NICE: guessing is not guidance
A preliminary assessment of the extent to which the National Institute for Clinical Excellence (NICE) has achieved its goals within cardiovascular medicine is presented. NICE is a government...
Mode of death in heart failure: findings from the ATLAS trial
Poole-Wilson, P A, Uretsky, B F, Thygesen, K, Cleland, J G F, Massie, B M, Rydén, L
Objective: To investigate markers that predict modes of death in patients with chronic heart failure.
The therapeutic potential of new insights into myocardial excitation–contraction coupling
Scoote, M, Poole-Wilson, P A, Williams, A J
The physiological mechanisms that link myocyte depolarisation and contraction are referred to collectively as excitation–contraction coupling. This important process uses calcium as a second...
Appleyard, W. J., Barbor, P. R. H., Barraclough, M. A., Beeden, A. G., Berger, P., Black, A. J., ...
Canepa-Anson, R, Dawson, J R, Kuan, P, Poole-Wilson, P A, Sutton, G C, Cockrill, B, ...
The metabolic, hormonal and haemodynamic effects of oral pirbuterol, a new beta 2-adrenoceptor agonist, were studied acutely (n = 19) and after 3 months treatment (n = 11) in patients with severe...
Poole-Wilson, P. A., Lipkin, D. P.
1 Left ventricular function was assessed in five patients with coronary artery disease following the infusion of nicardipine 1.5 mg min-1 for 10 min. Patients were atrially paced at a fixed rate and...
The role of digitalis in the future
1 Cardiac glycosides exert an acute positive inotropic effect on the normal and failing heart.
Jiang, C., Poole-Wilson, P. A., Sarrel, P. M., Mochizuki, S., Collins, P., MacLeod, K. T.
1. The effect of 17 beta-oestradiol on cardiac cell contraction, inward Ca2+ current and intracellular free Ca2+ ([free Ca2+]i) was investigated in guinea-pig single, isolated ventricular myocytes....
Endothelium-independent relaxation of rabbit coronary artery by 17 beta-oestradiol in vitro.
Jiang, C. W., Sarrel, P. M., Lindsay, D. C., Poole-Wilson, P. A., Collins, P.
1. We assessed the relaxant effect of 17 beta-oestradiol (10(-7), 10(-6) and 10(-5) M) on rabbit isolated coronary arteries precontracted with prostaglandin F2 alpha (3 x 10(-6) M), high...
Wynne, D. G., Poole-Wilson, P. A., Harding, S. E.
1. The decreased response to beta-adrenoceptor stimulation seen in heart failure may be related to a defect in cyclic AMP production. The inotropic effects of the selective phosphodiesterase (PDE)...
Paradoxical embolism complicating massive pulmonary embolus.
Poole-Wilson, P A, May, A R, Taube, D
Paradoxical embolism is an unusual but well recognized complication of venous thromboembolic disease. This case report of a patient with massive pulmonary embolism, who had a paradoxical embolus...