P. Alexander

Publication List Details

Period

1930 - 2009

Number

161

Co-Authors

A relativistic mixing-layer model for jets in low-luminosity radio galaxies (2009)

Wang, Y., Kaiser, C. R., Laing, R., Alexander, P., Pavlovski, G., Knigge, C.

We present an analytical model for jets in Fanaroff & Riley Class I (FRI) radio galaxies, in which an initially laminar, relativistic flow is surrounded by a shear layer. We apply the appropriate...

Clusters and Large-Scale Structure: the Synchrotron Keys (2009)

Rudnick, L., Alexander, P., Andernach, H., Battaglia, N., Brown, S., Brunetti, Gf., ...

For over four decades, synchrotron-radiating sources have played a series of pathfinding roles in the study of galaxy clusters and large scale structure. Such sources are uniquely sensitive to the...

The star formation history of early-type galaxies as a function of mass and environment (2007)

Clemens, Marcel S., Bressan, Alessandro, Nikolic, B., Alexander, P., Annibali, Francesca, Rampazzo, Roberto

Using the third data release of the Sloan Digital Sky Survey (SDSS) we have rigorously defined a volume limited sample of early-type galaxies in the redshift range z < 0.1. We have defined the...

HI and CO observations of Arp 104: a spiral-elliptical interacting pair (2007)

Cullen, H., Alexander, P., Green, D. A., Sheth, K.

We present data probing the spatial and kinematical distribution of both the atomic (HI) and molecular (CO) gas in NGC 5218, the late-type barred spiral galaxy in the spiral-elliptical interacting...

Giant Metrewave Radio Telescope limits on cool HI in galaxy groups (2006)

Green, D. A., Clemens, M. S., Alexander, P., Cullen, H., Nikolic, B.

We present Giant Metrewave Radio Telescope 21-cm HI observations towards a sample of compact radio sources behind galaxy groups, to search for cool HI. The results -- from high dynamic range spectra...

The unusual distribution of molecular gas and star formation in Arp 140 (2006)

Cullen, H., Alexander, P., Green, D. A., Clemens, M., Sheth, K.

We investigate the atomic and molecular interstellar medium and star formation of NGC 275, the late-type spiral galaxy in Arp 140, which is interacting with NGC 274, an early-type system. The atomic...

The hot, warm and cold gas in Arp 227 – an evolving poor group (2006)

Rampazzo, R., Alexander, P., Carignan, C., Clemens, M. S., Cullen, H., Garrido, O., ...

Arp 227 represents a prototypical example of an interacting mixed pair of galaxies located in a low-density environment. We investigate the gas properties of the pair in the X-ray, Hα, H i and CO...

The star formation history of early-type galaxies as a function of mass and environment (2006)

Clemens, M. S., Bressan, A., Nikolic, B., Alexander, P., Annibali, F., Rampazzo, R.

Using the third data release of the Sloan Digital Sky Survey (SDSS) we have rigorously defined a volume limited sample of early-type galaxies in the redshift range z < 0.1. We have defined the...

A Simple Model For Mid-Infrared Emission from Normal Galaxies (2006)

Nikolic, B., Alexander, P., Ford, D.

We have combined up-to-date stellar population synthesis models, a simple radiative transfer approach, and a fully comprehensive dust model with the aim of developing a simple but quantitative way of...

Star Formation in Close Pairs Selected from the Sloan Digital Sky Survey (2004)

Nikolic, B., Cullen, H., Alexander, P.

The effect of galaxy interactions on star formation has been investigated using Data Release 1 of the Sloan Digital Sky Survey (SDSS). Both the imaging and spectroscopy data products have been used...

Multifrequency radio continuum observations of NGC 1569: Evidence for a convective wind (2004)

Lisenfeld, U., Wilding, T., Pooley, G. G., Alexander, P.

We present high-sensitivity radio continuum observations with the VLA and Ryle Telescope at 1.5, 4.9, 8.4 and 15.4 GHz of the dwarf irregular galaxy NGC 1569. The radio data show an extended,...

Defining a formal coalgebraic semantics for the rosetta specification language (2003)

Kong, C., Alexander, P., Menon, Catherine

Rosetta is a systems level design language that allows algebraic specification of systems through facets. The usual approach to formally describe a specification is to define an algebra that...

Defining a formal coalgebraic semantics for the rosetta specification language (2003)

Kong, C., Alexander, P., Menon, Catherine

Rosetta is a systems level design language that allows algebraic specification of systems through facets. The usual approach to formally describe a specification is to define an algebra that...

The long-term effect of radio sources on the ICM (2002)

Basson, J. F., Alexander, P.

We have performed 3D hydrodynamical simulations of FR-II radio sources in beta-profile cooling-flow clusters. The effects of cooling of the cluster gas were incorporated into a modified version of...

On the interaction of FR-II radio sources with the intracluster medium (2002)

Alexander, P.

The effect of the expansion of powerful FR-II radio sources into a cluster environment is discussed. The analysis considers both the thermal and temporal evolution of the ICM which has passed through...

Air Traffic Control Experimentation and Evaluation with the NASA ATS-6 Satellite. Volume V. Multipath Channel Characterization Test. (2002)

Thompson,A. D., Burreson,B. J., Rieder,P. F., Alexander,P.

Results of aeronautical L-band multipath channel characterization tests are given. All tests were conducted between September 1974 and April 1975 as part of the U.S. DOT aeronautical technology test...

The SCUBA Local Universe Galaxy Survey I: First Measurements of the Submillimetre Luminosity and Dust Mass Functions (2000)

Dunne, L., Eales, S. A., Edmunds, M. G., Ivison, R. J., Alexander, P., Clements, D. L.

We have used SCUBA to observe a complete sample of 104 galaxies selected at 60 microns from the IRAS BGS and we present here the 850 micron measurements. Fitting the 60,100 and 850 micron fluxes with...

Western Grey Kangaroos, Macropus fuliginosus, In The South Australian Pastoral Zone: Populations At The Edge Of Their Range (2000)

Cairns, S. C., Grigg, G. C., Beard, L. A., Pople, A. R., Alexander, P.

As part of a large-scale monitoring program linked to the management of kangaroos in the South Australian pastoral zone, the western grey kangaroo populations have been surveyed annually with...

Trends In The Numbers Of Red Kangaroos And Emus On Either Side Of The South Australian Dingo Fence: Evidence For Predator Regulation? (2000)

Pople, A. R., Grigg, G. C., Cairns, S. C., Beard, L. A., Alexander, P.

Most of Australia's sheep rangelands are enclosed by a dingo-proof fence. Within these rangelands, where dingoes (Canis lupus dingo) are rare, red kangaroos (Macropus rufus) are considered to be food...

Western Grey Kangaroos, Macropus fuliginosus, In The South Australian Pastoral Zone: Populations At The Edge Of Their Range (2000)

Cairns, S. C., Grigg, G. C., Beard, L. A., Pople, A. R., Alexander, P.

As part of a large-scale monitoring program linked to the management of kangaroos in the South Australian pastoral zone, the western grey kangaroo populations have been surveyed annually with...

Trends In The Numbers Of Red Kangaroos And Emus On Either Side Of The South Australian Dingo Fence: Evidence For Predator Regulation? (2000)

Pople, A. R., Grigg, G. C., Cairns, S. C., Beard, L. A., Alexander, P.

Most of Australia's sheep rangelands are enclosed by a dingo-proof fence. Within these rangelands, where dingoes (Canis lupus dingo) are rare, red kangaroos (Macropus rufus) are considered to be food...

Trends in the numbers of red kangaroos and emus on either side of the South Australian dingo fence: evidence for predator regulation? (2000)

Alexander, P, Beard, LA, Cairns, SC, Grigg, GC, Pople, AR

Most of Australia's sheep rangelands are enclosed by a dingo-proof fence. Within these rangelands, where dingoes (Canis lupus dingo) are rare, red kangaroos (Macropus rufus) are considered to be food...

A study of phase-steepened Alfvén waves in a high-speed stream at 0.29 AU (2000)

Alexander, P.

This work performs a search of phase-steepened Alfvén waves under a priori ideal conditions: a high-speed solar wind stream observed in one of the closest approaches to the Sun by any spacecraft...

A study of phase-steepened Alfvén waves in a high-speed stream at 0.29 AU (2000)

Alexander, P.

This work performs a search of phase-steepened Alfvén waves under a priori ideal conditions: a high-speed solar wind stream observed in one of the closest approaches to the Sun by any spacecraft...

Western Grey Kangaroos, Macropus fuliginosus, In The South Australian Pastoral Zone: Populations At The Edge Of Their Range (2000)

Cairns, S. C., Grigg, G. C., Beard, L. A., Pople, A. R., Alexander, P.

As part of a large-scale monitoring program linked to the management of kangaroos in the South Australian pastoral zone, the western grey kangaroo populations have been surveyed annually with...

Trends In The Numbers Of Red Kangaroos And Emus On Either Side Of The South Australian Dingo Fence: Evidence For Predator Regulation? (2000)

Pople, A. R., Grigg, G. C., Cairns, S. C., Beard, L. A., Alexander, P.

Most of Australia's sheep rangelands are enclosed by a dingo-proof fence. Within these rangelands, where dingoes (Canis lupus dingo) are rare, red kangaroos (Macropus rufus) are considered to be food...

The heating of the ICM by powerful radio sources (1999)

Kaiser, C. R., Alexander, P.

We present a model for the compression and heating of the ICM by powerful radio galaxies and quasars. Based on a self-similar model of the dynamical evolution of FRII-type objects we numerically...

Aerial Survey Of Kangaroos In South Australia 1918-1998: A Brief Report Focusing On Methodology (1999)

Grigg, G. C., Beard, L. A., Alexander, P., Pople, A. R., Cairns, S. C.

Twenty-one surveys have been conducted using a Cessna 182 in the pastoral zone of South Australia, covering the twenty year period 1978 to 1998, flying the same transects and using the same method....

Aerial Survey Of Kangaroos In South Australia 1918-1998: A Brief Report Focusing On Methodology (1999)

Grigg, Gordon C., Beard, L. A., Alexander, P., Pople, A. R., Cairns, S. C.

Twenty-one surveys have been conducted using a Cessna 182 in the pastoral zone of South Australia, covering the twenty year period 1978 to 1998, flying the same transects and using the same method....

Aerial Survey Of Kangaroos In South Australia 1918-1998: A Brief Report Focusing On Methodology (1999)

Grigg, Gordon C., Beard, L. A., Alexander, P., Pople, A. R., Cairns, S. C.

Twenty-one surveys have been conducted using a Cessna 182 in the pastoral zone of South Australia, covering the twenty year period 1978 to 1998, flying the same transects and using the same method....

FRII radio galaxies with z (1998)

Hardcastle, M. J., Alexander, P., Pooley, G. G., Riley, J. M.

In a previous paper we presented measurements of the properties of jets and cores in a large sample of FRII radio galaxies with z

Symbol Designs for the Graphic Symbol Subset of the ASCII, (1998)

Shurtleff,D. A., Alexander,P.

Symbols in the Graphic Symbol subset of the ASCII were designed for use on AWACS(Airbone Waring And Control Systems) displays. These graphic symbol designs also are recommended for use in other...

Cosmic ray propagation and star formation history of NGC 1961 (1998)

Lisenfeld, U., Alexander, P., Pooley, G. G., Wilding, T.

We present new radio continuum data at 4 frequencies on the supermassive, peculiar galaxy NGC 1961. These observations allow us to separate the thermal and the nonthermal radio emission and to...

FR II radio galaxies with z (1998)

Hardcastle, M. J., Alexander, P., Pooley, G. G., Riley, J. M.

In previous papers we have discussed high-resolution observations of a large sample of powerful radio galaxies with z

The jets in 3C 296 (1997)

Hardcastle, M. J., Alexander, P., Pooley, G. G., Riley, J. M.

We present observations made with the VLA at 1.5 and 8.4 GHz of the nearby FRI radio galaxy 3C296. The most recent models of FRI radio galaxies suggest that substantial deceleration must take place...

A self-similar model for extragalactic radio sources (1997)

Kaiser, C.R., Alexander, P.

An analytical model for extragalactic radio sources with pressure-confined jets is presented. We show that the properties of the bow shock and of the gas surrounding these objects force the sources...

Evolutionary tracks of FRII sources through the P-D diagram (1997)

Kaiser, C.R., Dennett-Thorpe, J., Alexander, P.

This is the second in a series of papers presenting an analytical model for the evolution of Fanaroff-Riley II radio sources. In this paper we evaluate the expected radio emission from a radio source...

High resolution observations at 3.6 cm of seventeen FR II radio galaxies with . . . (1997)

M.J. Hardcastle, P. Alexander, G. G. Pooley, J.M. Riley

We present high-resolution VLA observations at 8.4 GHz of the seventeen FRII radio galaxies with 0:15 ! z ! 0:30 and ` LAS ! 190 arcsec from the sample of Laing, Riley & Longair (1983), together...

Constraints on Cosmic Ray propagation from Radio Continuum data of NGC 2146 (1996)

Lisenfeld, U., Alexander, P., Pooley, G. G., Wilding, T.

We present high-sensitivity multi-frequency radio continuum observations of the starburst galaxy NGC~2146. We have fitted these data with a three-dimensional diffusion model. The model can describe...

Trends in Numbers and Changes in the Distribution of Feral Goats (Capra hircus) in the South Australian Pastoral Zone (1996)

Pople, A.R., Grigg, G. C., Cairns, S. C., Alexander, P., Beard, L. A., Henzell, R. P.

Trends in numbers and changes in the distribution of feral goats in the South Australian pastoral zone (217,300 km2) during 1978-94 were determined by winter aerial surveys. Only the presence or...

Trends in Numbers and Changes in the Distribution of Feral Goats (Capra hircus) in the South Australian Pastoral Zone (1996)

Pople, A.R., Grigg, G. C., Cairns, S. C., Alexander, P., Beard, L. A., Henzell, R. P.

Trends in numbers and changes in the distribution of feral goats in the South Australian pastoral zone (217,300 km2) during 1978-94 were determined by winter aerial surveys. Only the presence or...

Trends in Numbers and Changes in the Distribution of Feral Goats (Capra hircus) in the South Australian Pastoral Zone (1996)

Pople, A.R., Grigg, G. C., Cairns, S. C., Alexander, P., Beard, L. A., Henzell, R. P.

Trends in numbers and changes in the distribution of feral goats in the South Australian pastoral zone (217,300 km2) during 1978-94 were determined by winter aerial surveys. Only the presence or...

Electricity from photovoltaic solar cells: Flat-Plate Solar Array Project final report. Volume V: Process development (1986)

Gallagher, B., Alexander, P., Burger, D.

The Flat-Plate Solar Array (FSA) Project, funded by the U.S. Government and managed by the Jet Propulsion Laboratory, was formed in 1975 to develop the module/array technology needed to attain...

Spin-23/2- Isomer of Lu177 (1964)

Alexander, P., Boehm, F., Kankeleit, E.

Investigations of the decay of the three-particle state in Lu177 with spin 23/2- performed with the crystal diffraction technique revealed evidence for three-particle states in Hf177 and rotational...

Gene for an immunoglobulin-binding protein from a group G streptococcus.

Fahnestock, S R, Alexander, P, Nagle, J, Filpula, D

The gene (spg) for an immunoglobulin G (IgG)-binding protein from a Streptococcus clinical isolate of Lancefield group G was cloned and expressed in Escherichia coli. The complete nucleotide sequence...

Autoimmunization with Irradiated Tumour Cells in Human Malignant Melanoma

Ikonopisov, R. L., Lewis, M. G., Hunter-Craig, I. D., Bodenham, D. C., Phillips, T. M., Cooling, C. I., ...

Thirteen patients have been immunized with their own irradiated melanoma cells on one or more occasions. Following these autografts tumour-specific cytotoxic antibodies were produced, the longest...

Gene for an immunoglobulin-binding protein from a group G streptococcus.

Fahnestock, S R, Alexander, P, Nagle, J, Filpula, D

The gene (spg) for an immunoglobulin G (IgG)-binding protein from a Streptococcus clinical isolate of Lancefield group G was cloned and expressed in Escherichia coli. The complete nucleotide sequence...

Autoimmunization with Irradiated Tumour Cells in Human Malignant Melanoma

Ikonopisov, R. L., Lewis, M. G., Hunter-Craig, I. D., Bodenham, D. C., Phillips, T. M., Cooling, C. I., ...

Thirteen patients have been immunized with their own irradiated melanoma cells on one or more occasions. Following these autografts tumour-specific cytotoxic antibodies were produced, the longest...

Role of Plasma Carcinoembryonic Antigen in Diagnosis of Gastrointestinal, Mammary, and Bronchial Carcinoma

Laurence, D. J. R., Stevens, U., Bettelheim, R., Darcy, D., Leese, C., Turberville, C., ...

Our studies have confirmed that raised plasma levels of carcinoembryonic antigen (C.E.A.) occur with many but not all malignant tumours, particularly those of the gastrointestinal tract, breast, and...

Role of macrophages in tumour immunity: I. Co-operation between macrophages and lymphoid cells in syngeneic tumour immunity

Evans, R., Alexander, P.

Macrophages from DBA/2 mice hyperimmunized with irradiated syngeneic L5178Y or SL2 lymphoma cells inhibited the growth of these cells in vitro and killed them within 48 hours of culture. The reaction...

Role of macrophages in tumour immunity: II. Involvement of a macrophage cytophilic factor during syngeneic tumour growth inhibition*

Evans, R., Alexander, P.

Growth inhibition by immune or armed macrophages of target L5178Y or SL2 (DBA/2) lymphoma cells leading to their death required an immunologically specific cell-to-cell contact, and was not mediated...

Rat tumour allografts evoke anaphylactic antibody responses.

Broom, B C, Alexander, P

In vitro assays of release of histamine from peritoneal mast cells showed that Wistar rats produced anaphylactic antibody in response to a single immunization with an allogeneic sarcoma. The response...

Recognition of Leukaemia Cells as Foreign before and after Autoimmunization

Powles, R. L., Balchin, L. A., Fairley, G. Hamilton, Alexander, P.

Leukaemia cells in the peripheral blood of nine patients with acute leukaemia were removed and stored. When the patients had been brought into haematological remission these leukaemia cells were...

Aerial Survey Of Kangaroos In South Australia 1918-1998: A Brief Report Focusing On Methodology

Grigg, G. C., Beard, L. A., Alexander, P., Pople, A. R., Cairns, S. C.

Twenty-one surveys have been conducted using a Cessna 182 in the pastoral zone of South Australia, covering the twenty year period 1978 to 1998, flying the same transects and using the same method....

Trends in Numbers and Changes in the Distribution of Feral Goats (Capra hircus) in the South Australian Pastoral Zone

Pople, A.R., Grigg, G. C., Cairns, S. C., Alexander, P., Beard, L. A., Henzell, R. P.

Trends in numbers and changes in the distribution of feral goats in the South Australian pastoral zone (217,300 km2) during 1978-94 were determined by winter aerial surveys. Only the presence or...

Trends In The Numbers Of Red Kangaroos And Emus On Either Side Of The South Australian Dingo Fence: Evidence For Predator Regulation?

Pople, A. R., Grigg, G. C., Cairns, S. C., Beard, L. A., Alexander, P.

Most of Australia's sheep rangelands are enclosed by a dingo-proof fence. Within these rangelands, where dingoes (Canis lupus dingo) are rare, red kangaroos (Macropus rufus) are considered to be food...

Western Grey Kangaroos, Macropus fuliginosus, In The South Australian Pastoral Zone: Populations At The Edge Of Their Range

Cairns, S. C., Grigg, G. C., Beard, L. A., Pople, A. R., Alexander, P.

As part of a large-scale monitoring program linked to the management of kangaroos in the South Australian pastoral zone, the western grey kangaroo populations have been surveyed annually with...

Inability to demonstrate lytic antibodies to autologous leukaemia cells in the sera from remission patients with acute myelogenous leukaemia treated with active specific immunotherapy.

Chapuis, B J, Powles, R, Alexander, P

The sera from seven patients with acute myelogenous leukaemia (AML) who had achieved a clinical remission and who were being maintained by weekly immunotherapy using irradiated allogeneic AML cells...

Tumour-specific Antibodies in Human Malignant Melanoma and their Relationship to the Extent of the Disease

Lewis, M. G., Ikonopisov, R. L., Nairn, R. C., Phillips, T. M., Fairley, G. Hamilton, Bodenham, D. C., ...

Biopsy specimens and sera were obtained from 103 melanoma patients. Autoantibodies were demonstrated by (1) complement-dependent cytotoxicity of autologous melanoma cells in short-term culture; (2)...

THYMOCYTES FROM MICE IMMUNIZED AGAINST AN ALLOGRAFT RENDER BONE-MARROW CELLS SPECIFICALLY CYTOTOXIC

Grant, C. K., Currie, G. A., Alexander, P.

Thymocytes from C57BL mice immunized with the DBA/2 lymphoma L5178Y exert in vitro an immunologically specific cytotoxic action against the target cells in the presence of bone-marrow cells. Neither...

THYMUS-DERIVED LYMPHOCYTES PRODUCE AN IMMUNOLOGICALLY SPECIFIC MACROPHAGEARMING FACTOR

Evans, R., Grant, C. K., Cox, Helen, Steele, Kathleen, Alexander, P.

Spleen cells from mice immunized with an allogeneic tumor when cultured with the specific tumor cells release into the supernatant a specific macrophage-arming factor(s) (SMAF) which binds...

Urinary epidermal growth factor (hEGF) levels in patients with carcinomas of the breast, colon and rectum.

Sweetenham, J. W., Davies, D. E., Warnes, S., Alexander, P.

A specific two-site ELISA for human epidermal growth factor (hEGF) has been used to measure urinary hEGF/creatinine ratios in 30 normal subjects, 30 hospital in-patients with breast cancer and 30...

Similarities of the Anti-tumour Actions of Endotoxin, Lipid A and Double-stranded RNA

Parr, I., Wheeler, E., Alexander, P.

Double stranded RNA (dsRNA) whether isolated from a fungal virus or prepared synthetically (i.e., Poly I Poly C) and endotoxin were found to exert very similar effects on syngeneic murine lymphomata...

The Presence of Tumour Specific Membrane Antigen in the Serum of Rats with Chemically Induced Sarcomata

Thomson, D. M. P., Steele, K., Alexander, P.

Antibodies to the tumour-specific transplantation type antigen (TSTA) of a transplanted methylcholanthrene-induced sarcoma (MC-1) in syngeneic rats were studied using the techniques of indirect...

A Cross-Reacting Embryonic Antigen in the Membrane of Rat Sarcoma Cells which is Immunogenic in the Syngeneic Host

Thomson, D. M. P., Alexander, P.

An analysis of the constituents of the plasma membrane of a methylcholanthrene-induced sarcoma (the MC1 tumour) in a hooded rat revealed four tumour-associated macromolecules. Two of these were...

Radioimmunoassay of Tumour Specific Transplantation Antigen of a Chemically Induced Rat Sarcoma: Circulating Soluble Tumour Antigen in Tumour Bearers

Thomson, D. M. P., Sellens, V., Eccles, S., Alexander, P.

The tumour specific transplantation antigen (TSTA) from a chemically induced rat sarcoma has been isolated as an electrophoretically homogeneous soluble material by affinity chromatography using a...

Immunotherapy for Acute Myelogenous Leukaemia

Powles, R. L., Crowther, D., Bateman, C. J. T., Beard, M. E. J., McElwain, T. J., Russell, J., ...

One hundred and seven untreated patients with acute myelogenous leukaemia (AML) were admitted to St Bartholomew's Hospital between 10 October 1970 and 31 January 1973. Before receiving drugs to...

Antibodies and Soluble Tumour-specific Antigens in Blood and Lymph of Rats with Chemically Induced Sarcomata

Thomson, D. M. P., Eccles, S., Alexander, P.

In confirmation of other studies it has been shown that antibody directed against the tumour specific transplantation-type antigens (TSTAs) cannot be detected in rats with a tumour growing...

Sequestration of Macrophages in Growing Tumours and its Effect on the Immunological Capacity of the Host

Eccles, S. A., Alexander, P.

The effects of rat tumours of various macrophage contents on the syngeneic host's ability to produce either: (1) an inflammatory exudate in response to intraperitoneal oyster glycogen or (2) a...

Failure of suckling to transfer immunity to a syngeneic rat sarcoma.

Eccles, S. A., Alexander, P.

Young born to and suckled by mothers rendered immune to a syngeneic sarcoma showed no acquired resistance to challenge with tumour. Whilst other workers had found that allograft immunity could be...

Immunity as the predominant factor determining metastasis by murine lymphomas.

Davey, G. C., Currie, G. A., Alexander, P.

The metastatic behaviour of the L5178E (non-M) lymphoma and a highly metastatic subline L51787ES (M) were studied in syngeneic DBA2 mice. The non-M tumour rarely metastasizes in intact syngeneic...

Spontaneous regression of human acute myeloid leukaemia xenografts and phenotypic evidence for maturation.

Palú, G., Selby, P., Powles, R., Alexander, P.

A population of human AML cells which have a characteristic karyotypic marker was cryopreserved and then grown in short-term liquid culture for 2 weeks, during which time the cells increased about...

Patterns of maturation in short-term culture of human acute myeloid leukaemic cells.

Palú, G., Powles, R., Selby, P., Summersgill, B. M., Alexander, P.

Leukaemic cells taken from the blood of patients with acute myelogenous leukaemia (AML) frequently proliferate in suspension culture without the addition of growth factors for a limited period only....

Effect of cyclosporin A on the growth and spontaneous metastasis of syngeneic animal tumours.

Eccles, S. A., Heckford, S. E., Alexander, P.

Cyclosporin A (Cy A), a novel immunosuppressive agent with apparently selective inhibitory effects on T lymphocytes and little myelotoxicity, was tested for its effects on a variety of syngeneic...

Mechanism by which antibodies to non-AgB antigens mediate rejection of rat leukaemia cells.

Denham, S., Hooton, J. W., Barfoot, R. K., Alexander, P., Mayol, R., Wrathmell, A. B.

The August and Hooded rat strains are compatible at the major histocompatibility locus (both are AgB5 or Rtlc). Antisera against the minor histocompatibility antigens of Hooded rats were raised by...

Failure to detect autologous antibodies in the remission sera of patients with AML: complications introduced by the presence of rheumatoid factor.

James, S. E., Dean, C. J., Alexander, P.

Sera were collected from patients with acute myelogenous leukaemia (AML) at various times during remission induced by chemotherapy, but after cessation of all immunosupressive treatment. These sera...

Failure of short-term treatment with flurbiprofen to enhance the therapeutic effect of cyclophosphamide against rodent sarcomas and a leukaemia.

Heckford, S. E., Eccles, S. A., Powles, T. J., Alexander, P.

Animals bearing metastatic fibrosarcomas were treated with cyclophosphamide (CY) alone or in combination with flurbiprofen (FP), an inhibitor of prostaglandin synthesis. FP did not affect local...

2nd Gordon Hamilton Fairley Lecture*: Need for new approaches to the treatment of patients in clinical remission, with special reference to acute myeloid leukaemia

Alexander, P.

A serious limitation of chemotherapy for acute myeloid leukaemia (AML), Hodgkins disease and some classes of breast cancer is that, even when clinically evident disease responds well, the same...

Effect of cyclosporin A on the anti-leukaemia action associated with graft-versus-host disease.

Denham, S., Attridge, S., Barfoot, R. K., Alexander, P.

Graft-versus-host disease (GVHD) was induced in Hooded (Rt1c) strain rats by means of high dose total body irradiation (TBI) and subsequent reconstitution with allogeneic bone marrow and spleen cells...

Role of "lymphotoxin" in the local anti-tumour action associated with inflammation caused by delayed hypersensitivity responses or intralesional BCG. I. Variations in response of different syngeneic mouse tumours.

Parr, I. B., Jackson, L. E., Alexander, P.

The anti-tumour effect induced by a delayed hypersensitivity response (DHSR) unrelated to the tumour or by intra-tumoural inoculation of BCG was studied with 6 syngeneic mouse tumours. The growth of...

Spontaneous shedding and antibody induced modulation of histocompatibility antigens on murine lymphomata: Correlation with metastic capacity.

Davey, G. C., Currie, G. A., Alexander, P.

The lability of cell surface histocompatibility antigens of 2 murine lymphomata was examined. These 2 tumours differ greatly in their capacity to metastasize in syngeneic hosts. Cells of the...

Estimation in sera by radioimmunoassay of a specific membrane antigen associated with a murine lymphoma.

Wolf, A., Steele, K. A., Alexander, P.

Material with a molecular weight of less than 10(5) daltons has been isolated and partially purified from the ascitic fluid of DBA2 mice bearing a syngeneic lymphoma (SL2). This substance inhibits...

Cross reactivity of an alloantigen present on normal cells with the tumour-specific transplantation-type antigen of the acute myeloid leukaemia (SAL) of rats.

Wrathmell, A. B., Gauci, C. L., Alexander, P.

Resistance can be induced in the syngeneic host (August rats) to a myelogeneous leukaemia of spontaneous origin, called SAL, by immunization with allogeneic cells derived form both normal and...

Immunogenicity of a rat leukaemia of spontaneous origin (SAL).

Wrathmell, A. B., Alexander, P.

The SAL rat leukaemia, which resembles acute myeloblastic leukaemia, appeared initially to be non-immunogenic since resistance to an i.p. challenge with as few as 100 cells could not be obtained...

Trapping and destruction of blood-borne syngeneic leukaemia cells in lung, liver and spleen of normal and leukaemic rats.

Sadler, T. E., Alexander, P.

Leukaemic cells from rats with a lymphoid (HRL) or myeloid (SAL) leukaemia were labelled with 125IUDR and injected i.v. into either normal or leukaemic syngeneic recipients. The fate of the injected...

Monocytosis associated with the growth of transplanted syngeneic rat sarcomata differing in immunogenicity.

Eccles, S. A., Bandlow, G., Alexander, P.

The effect of the growth of two syngeneic transplanted sarcomata of widely differing biological properties on the number of monocytes in the blood of rats was measured (1) by binding of a specific...

Further evidence of response by leukaemia patients in remission to antigen(s) related to acute myelogenous leukaemia.

Cocks, P., Powles, R. L., Chapuis, B., Alexander, P.

Fifteen patients with acute myelogenous leukaemia were studied to determine if their remission blood leucocytes could be stimulated into taking up [3H] thymidine after in vitro culture with their own...

Immunotherapy for acute myelogenous leukaemia: a controlled clinical study 2 1/2 years after entry of the last patient.

Powles, R. L., Russell, J., Lister, T. A., Oliver, T., Whitehouse, J. M., Malpas, J., ...

One hundred and thirty-nine untreated patients with acute myelogenous leukaemia (AML) were admitted between August 1970 and December 1973 and allocated into two remission treatment regimens: one to...

Non-specific cytotoxicity of spleen cells in mice bearing transplanted chemically induced fibrosarcomas.

Mantovani, A., Evans, R., Alexander, P.

Spleen cells collected from mice bearing transplanted chemically induced syngeneic fibrosarcomas non-specifically inhibited DNA synthesis of sarcoma and lymphoma target cells in vitro. Splenocytes...

Contribution of host-derived growth factors to in vivo growth of a transplantable murine mammary carcinoma.

Davies, D. E., Farmer, S., White, J., Senior, P. V., Warnes, S. L., Alexander, P.

The contribution of host-derived growth factors to tumour growth in vivo was studied using the transplantable murine mammary carcinoma, MT1, grown in syngeneic mice. Promotion of growth of the...

Preferential growth of bloodborne cancer cells in colonic anastomoses.

Skipper, D., Jeffrey, M. J., Cooper, A. J., Taylor, I., Alexander, P.

Intracardiac injection, in hooded Lister rats, of syngeneic MC28 sarcoma cells never induced tumour growth in normal bowel. Tumour growth occurred at the site of a colonic anastomosis if surgery...

Mechanisms of organ selective tumour growth by bloodborne cancer cells.

Murphy, P., Alexander, P., Senior, P. V., Fleming, J., Kirkham, N., Taylor, I.

The sites of tumour development for 6 rat tumours injected into syngeneic rats via different vascular routes was determined. Xenografts of human tumours were also injected intra-arterially (i.a.)...