First-pass metabolism of cyclosporin by the gut (1991)
Kolars, Joseph C., Watkins, P. B., Merion, Robert M., Awni, W. M.
Cyclosporin is thought to be exclusively metabolised in the liver. We instilled cyclosporin into the small bowel of 2 patients during the anhepatic phase of liver transplantation; cyclosporin...
Omeprazole and aryl hydrocarbon hydroxylases: Should we be worried? (1991)
Kolars, Joseph C., Turgeon, D. K., Watkins, P. B.
Diaz and colleagues have carefully studied the effects of omeprazole on the expression of cytochrome P-450 in primary cultures of human hepatocytes. When omeprazole was added to the culture medium in...
Cyclosporin toxicity at therapeutic blood levels and cytochrome P-450 IIIA (1990)
Lucey, Michael R., Kolars, Joseph C., Merion, Robert M., Campbell, Darrell A., Aldrich, M., Watkins, P. B.
A 40-year-old male liver allograft recipient had neurological dysfunction and renal failure while his cyclosporin blood levels were in the therapeutic range; these features recurred on rechallenge....
Watkins, P B, Murray, S A, Winkelman, L G, Heuman, D M, Wrighton, S A, Guzelian, P S
The major P-450IIIA gene family member present in human liver is HLp which, like its rat liver orthologue P-450p, is inducible by glucocorticoids and catalyzes erythromycin N-demethylation. To...
Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver.
Molowa, D T, Schuetz, E G, Wrighton, S A, Watkins, P B, Kremers, P, Mendez-Picon, G, ...
HLp is a human liver cytochrome P-450 that is immunochemically related to the glucocorticoid-inducible liver cytochrome P-450p in the rat and its homologue in the rabbit, P-450 LM3c. To investigate...
Identification of an inducible form of cytochrome P-450 in human liver.
Watkins, P B, Wrighton, S A, Maurel, P, Schuetz, E G, Mendez-Picon, G, Parker, G A, ...
It has not yet been determined whether human liver contains inducible cytochromes P-450 similar to those that catalyze the oxidative metabolism of foreign substances in animals. We carried out...
Wrighton, S A, Thomas, P E, Willis, P, Maines, S L, Watkins, P B, Levin, W, ...
Among characterized forms of liver microsomal cytochromes P-450 in rats are four related isozymes (P-450f-i) notable for their lack of inducibility. Immunoblot analyses demonstrated that human livers...
Watkins, P B, Wrighton, S A, Schuetz, E G, Molowa, D T, Guzelian, P S
We used monoclonal antibodies and complementary DNAs (cDNAs) to glucocorticoid-inducible liver cytochromes P-450 in rats (P-450p) and in man (HLp) to search for related cytochromes in intestinal...
Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes.
Kolars, J C, Schmiedlin-Ren, P, Schuetz, J D, Fang, C, Watkins, P B
Enzymes within the P450IIIA (CYP3A) subfamily appear to account for significant "first pass" metabolism of some drugs in the intestine. To identify which of the known P450IIIA genes are expressed in...
Lown, K S, Bailey, D G, Fontana, R J, Janardan, S K, Adair, C H, Fortlage, L A, ...
The increase in oral availability of felodipine and other commonly used medications when taken with grapefruit juice has been assumed to be due to inhibition of CYP3A4, a cytochrome P450 that is...
Watkins, P B, Murray, S A, Winkelman, L G, Heuman, D M, Wrighton, S A, Guzelian, P S
The major P-450IIIA gene family member present in human liver is HLp which, like its rat liver orthologue P-450p, is inducible by glucocorticoids and catalyzes erythromycin N-demethylation. To...
Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver.
Molowa, D T, Schuetz, E G, Wrighton, S A, Watkins, P B, Kremers, P, Mendez-Picon, G, ...
HLp is a human liver cytochrome P-450 that is immunochemically related to the glucocorticoid-inducible liver cytochrome P-450p in the rat and its homologue in the rabbit, P-450 LM3c. To investigate...
Identification of an inducible form of cytochrome P-450 in human liver.
Watkins, P B, Wrighton, S A, Maurel, P, Schuetz, E G, Mendez-Picon, G, Parker, G A, ...
It has not yet been determined whether human liver contains inducible cytochromes P-450 similar to those that catalyze the oxidative metabolism of foreign substances in animals. We carried out...
Wrighton, S A, Thomas, P E, Willis, P, Maines, S L, Watkins, P B, Levin, W, ...
Among characterized forms of liver microsomal cytochromes P-450 in rats are four related isozymes (P-450f-i) notable for their lack of inducibility. Immunoblot analyses demonstrated that human livers...
Watkins, P B, Wrighton, S A, Schuetz, E G, Molowa, D T, Guzelian, P S
We used monoclonal antibodies and complementary DNAs (cDNAs) to glucocorticoid-inducible liver cytochromes P-450 in rats (P-450p) and in man (HLp) to search for related cytochromes in intestinal...
Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes.
Kolars, J C, Schmiedlin-Ren, P, Schuetz, J D, Fang, C, Watkins, P B
Enzymes within the P450IIIA (CYP3A) subfamily appear to account for significant "first pass" metabolism of some drugs in the intestine. To identify which of the known P450IIIA genes are expressed in...
Lown, K S, Bailey, D G, Fontana, R J, Janardan, S K, Adair, C H, Fortlage, L A, ...
The increase in oral availability of felodipine and other commonly used medications when taken with grapefruit juice has been assumed to be due to inhibition of CYP3A4, a cytochrome P450 that is...
Blood gene expression signatures predict exposure levels
Bushel, P. R., Heinloth, A. N., Li, J., Huang, L., Chou, J. W., Boorman, G. A., ...
To respond to potential adverse exposures properly, health care providers need accurate indicators of exposure levels. The indicators are particularly important in the case of acetaminophen (APAP)...