Barry, A. L., Fuchs, P. C., Allen, S. D., Brown, S. D., Jorgensen, J. H., Tenover, F. C.
The l-isomer of ofloxacin (levofloxacin) was twice as active as ofloxacin and the d-isomer was inactive against 654 Streptococcus pneumoniae isolates. For disc susceptibility tests of pneumococci, 5...
Fuchs, P. C., Barry, A. L., Tenover, F. C., Allen, S. D., Jorgensen, J. H., Murray, P. R.
Proposed quality control (QC) parameters for susceptibility testing of Streptococcus pneumoniae to cefdinir were developed following the procedure recommended by the National Committee for Clinical...
McLaughlin, J. C., Barry, A. L., Fuchs, P. C., Gerlach, E. H., Hardy, D. J., Pfaller, M. A.
Susceptibility tests were performed on 2402 of consecutive isolates of Enterobacteriaceae and 254 strains of Pseudomonas aeruginosa in five separate medical centres. Five β-lactams were evaluated...
Barry, A. L., Fuchs, P. C., Citron, D. M., Allen, S. D., Wexler, H. M.
The susceptibility of anaerobic bacteria to two new fluoroquinolones, PD 131628 (the bioactive form of PD 131112 or CI-990) and clinafloxacin (CI-960 or PD 127391), was determined with the agar...
Desacetylcefotaxime--another broad spectrum cephalosporin? (1989)
FUCHS, P. C., JONES, R. N., BARRY, A. L., ALLEN, S. D., AYERS, L. W., PFALLER, M.
Cefpiramide: comparative in-vitro activity and {beta}-lactamase stability (1985)
Barry, A. L., Jones, R. N., Thornsberry, C., Fuchs, P. C., Ayers, L. W., Gavan, T. L., ...
Cefpiramide is a new Pseudomonas-active cephalosporin with a broad spectrum of antibacterial activity. Like cefoperazone, cefpiramide was moderately susceptible to hydrolysis by a variety of...
Barry, A. L., Jones, R. N., Thornsberry, C., Fuchs, P. C., Gerlach, E. H., Sommers, H. M.
Ceftizoxime is a 7-aminothiazolyl α-methoxyimino cephalosporin, a new ‘third-generation’ cephalosporin. A collaborative study was undertaken to document its in vitro activity, β-lactamase...
Barry, A. L., Fuchs, P. C., Brown, S. D.
Four different compounds belonging to the macrolide-lincosamide-streptogramin B (MLSb) class of antimicrobial agents were tested against 611 Streptococcus pneumoniae strains. The ketolide (HMR 3647,...
Barry, A. L., Pfaller, M. A., Rennie, R. P., Fuchs, P. C., Brown, S. D.
Interpretive agreements among the results of fluconazole broth microdilution tests, Etests, and disk diffusion tests were documented by evaluating 495 Candida spp. Microdilution reference test...
Broth microdilution tests were carried out with 2,671 respiratory tract isolates from 19 medical centers throughout the continental United States. The tests compared a streptogramin (RP59500) to...
Fuchs, P C, Barry, A L, Sewell, D L
The in vitro antimicrobial activity of an oral penem, WY-49605, was compared with those of six other oral antimicrobial agents against 598 bacterial isolates representing 51 different species....
Fuchs, P C, Barry, A L, Brown, S D
More than 3,000 consecutive clinical bacterial isolates from 10 U.S. medical centers were subjected to standard broth microdilution and disk diffusion tests to determine their susceptibilities to...
Barry, A L, Fuchs, P C, Brown, S D
Ciprofloxacin, clinafloxacin, PD 131628, sparfloxacin, and trovafloxacin were tested against 236 strains of Streptococcus pneumoniae, most of which were resistant to other agents. Resistance to...
Fuchs, P C, Jones, R N, Barry, A L
E1040 is a new parenteral cephalosporin which was tested against 690 clinical isolates and compared with cefpirome and ceftazidime. E1040 had the best activity of the three drugs against Pseudomonas...
In vitro antimicrobial activity of tigemonam, a new orally administered monobactam.
Fuchs, P C, Jones, R N, Barry, A L
At five geographically separate medical centers, over 6,000 clinical bacterial isolates were tested for their susceptibility to tigemonam by the broth microdilution method. The antimicrobial spectrum...
Multicenter in vitro evaluation of SM-7338, a new carbapenem.
Jones, R N, Aldridge, K E, Allen, S D, Barry, A L, Fuchs, P C, Gerlach, E H, ...
A new carbapenem, SM-7338, was compared with imipenem, cefotaxime, and ceftazidime at five medical centers. Nearly 6,000 strains were tested by reference methods of the National Committee for...
Evaluation of the in vitro activity of BMY-28142, a new broad-spectrum cephalosporin.
Fuchs, P C, Jones, R N, Barry, A L, Thornsberry, C
The in vitro activity of BMY-28142, a new cephalosporin, was tested by a broth microdilution system and compared with those of cefotaxime, ceftazidime, cefoperazone, moxalactam, and HR 810 against...
Jones, R N, Baker, C, Barry, A L, Fuchs, P C
A new oral cephalosporin, LY164846 (Eli Lilly & Co., Indianapolis, Ind.), was found to have a unique antimicrobial spectrum confined to methicillin-susceptible Staphylococcus spp., streptococci...
Jones, R N, Fuchs, P C, Barry, A L, Ayers, L W, Gerlach, E H, Gavan, T L
Susceptibility testing of 7,775 recent clinical isolates from four medical centers showed Ro 15-8074 to be 2-to greater than 8-fold more active than either cefaclor or cefuroxime against the...
Mezlocillin: tentative interpretive standards for disk diffusion susceptibility testing.
Fuchs, P C, Barry, A L, Thornsberry, C, Jones, R N, Gerlack, E H
The susceptibility of 447 clinical bacterial isolates to mezlocillin and carbenicillin was tested by standardized agar disk diffusion and reference broth micro-dilution methods. Tentative...
Fuchs, P C, Barry, A L, Thornsberry, C, Gavan, T L, Jones, R N
Augmentin (Beecham Laboratories, Bristol, Tenn.), a combination drug consisting of two parts amoxicillin to one part clavulanic acid and a potent beta-lactamase inhibitor, was evaluated in vitro in...
In vitro activity of ticarcillin plus clavulanic acid against 632 clinical isolates.
Fuchs, P C, Barry, A L, Thornsberry, C, Jones, R N
A total of 632 clinical bacterial isolates were tested for susceptibility to twofold dilutions of ticarcillin alone and in combination with 1, 2, and 4 micrograms of clavulanic acid (CA) (Timentin)...
Ayers, L W, Jones, R N, Barry, A L, Thornsberry, C, Fuchs, P C, Gavan, T L, ...
Cefotetan is a new, potent, 7 alpha-methoxy cephalosporin (cephamycin). The in vitro activity of cefotetan tested in a multiphasic, collaborative study against 12,260 consecutive clinical isolates...
Barry, A L, Fuchs, P C, Pfaller, M A
In in vitro studies we evaluated the susceptibilities of beta-lactamase-producing and -nonproducing, ampicillin-resistant strains of Haemophilus influenzae and compared them with those of...
Pfaller, M A, Barry, A L, Fuchs, P C
Ro 40-6890, the active metabolite of Ro 41-3399, was tested against 391 gram-negative and gram-positive clinical isolates. Ro 40-6890 was active against members of the family Enterobacteriaceae,...
Barry, A L, Fuchs, P C, Gerlach, E H, Hardy, D J, McLaughlin, J C, Pfaller, M A
A five-laboratory coordinated study was undertaken to determine whether ticarcillin and ticarcillin-clavulanic acid disk susceptibility tests could accurately detect resistance among enteric bacilli....
Barry, A L, Fuchs, P C, Allen, S D, Tenover, F C, Jorgensen, J H, Reller, L B
For testing bacterial susceptibility to PD131628, a 5-micrograms disk and the following tentative interpretive criteria may be used: > or = 19 mm for susceptible (MIC, < or = 1.0 micrograms/ml), 16...
Methods for predicting susceptibility of Streptococcus pneumoniae to cefixime.
Among 698 Streptococcus pneumoniae isolates, 475 were penicillin susceptible and > 99% of those were susceptible to 0.5 microgram of cefixime per ml; other pneumococci were tentatively assumed to be...
Cefotaxime- and ceftriaxone-resistant Streptococcus pneumoniae is now appearing in some medical centers, but 30-micrograms cefotaxime or 30-micrograms ceftriaxone disks are not reliable for detecting...
Fuchs, P C, Barry, A L, Brown, S D
Two hundred twenty-eight strains of Haemophilus influenzae and 234 strains of Streptococcus pneumoniae were tested by broth microdilution and disk diffusion methods for susceptibility to trimethoprim...
Fuchs, P C, Stickel, S, Anderson, P H, Barry, A L, Shilling, S
At clinically achievable levels (e.g., 25 micrograms/ml), sulbactam exerted no effect on aminoglycoside concentrations when incubated together in pooled serum at 37 degrees C for up to 24 h....
Fuchs, P C, Barry, A L, Pfaller, M A, Allen, S D, Gerlach, E H
The in vitro activities of three new quinolones (sparfloxacin, CI-960, and PD 131,628) were compared with that of ciprofloxacin against 5,252 routine clinical aerobic and facultatively anaerobic...
In vitro activities of sparfloxacin, tosufloxacin, ciprofloxacin, and fleroxacin.
The in vitro activity of sparfloxacin was compared with those of tosufloxacin, ciprofloxacin, and fleroxacin against 730 bacterial isolates representing 49 different species. Sparfloxacin and...
Barry, A L, Fuchs, P C, Jorgensen, J H, Tenover, F C, Allen, S D, Hardy, D J, ...
In vitro studies evaluated methods for testing the susceptibility of Haemophilus influenzae to piperacillin-tazobactam combinations. Ampicillin-resistant beta-lactamase-nonproducing strains of H....
One hundred fifty isolates of Haemophilus influenzae (including 30 beta-lactamase-positive strains and 23 beta-lactamase-negative, ampicillin-resistant strains) were tested for susceptibilities to...
Barry, A L, Cohen, M A, Sesnie, J C, Fuchs, P C, Washington, J A, Murray, P R, ...
For testing the susceptibility of Neisseria gonorrhoeae to enoxacin, a proposed susceptibility category includes strains for which MICs are less than or equal to 0.5 micrograms/ml and zones of...
Fuchs, P C, Barry, A L, Baker, C, Murray, P R, Washington, J A
A multilaboratory study designed to determine the in vitro susceptibility criteria and quality control parameters for ofloxacin against Neisseria gonorrhoeae was conducted according to the guidelines...
Fuchs, P C, Barry, A L, Baker, C N, Murray, P R, Washington, J A
To support future clinical studies, in vitro susceptibility tests were examined to determine whether Neisseria gonorrhoeae could be tested reliably against two beta-lactam-clavulanate combinations....
Levofloxacin disk potency and tentative interpretive criteria for susceptibility tests.
Pfaller, M A, Barry, A L, Fuchs, P C
Levofloxacin disk susceptibility test criteria were evaluated by testing 350 bacterial isolates. Either 5- or 10-micrograms disks could be used satisfactorily. A 5-micrograms levofloxacin disk with...
Ramoplanin susceptibility testing criteria.
Barry, A L, Pfaller, M A, Fuchs, P C
Ramoplanin and mupirocin are two antimicrobial agents that may be applied topically. They had similar potencies against susceptible gram-positive cocci, but they differed in their spectra of...
Tentative interpretive criteria for disk diffusion susceptibility testing of sparfloxacin.
Fuchs, P C, Barry, A L, Pfaller, M A
Susceptibility to sparfloxacin was tested simultaneously by the agar dilution and disk diffusion methods. For tests with 5-micrograms sparfloxacin disks, we propose that the breakpoints for the...
Barry, A L, Fuchs, P C, Allen, S D, Jorgensen, J H, Tenover, F C, Murray, P R, ...
Sparfloxacin and levofloxacin were evaluated against 150 Haemophilus influenzae isolates and 149 Neisseria gonorrhoeae isolates in order to define susceptibility testing parameters....
Quality control limits for microdilution susceptibility tests with norfloxacin.
Barry, A L, Gavan, T L, Ayers, L W, Fuchs, P C, Gerlach, E H, Thornsberry, C
A multilaboratory study was designed to define quality control limits for microdilution susceptibility tests with norfloxacin. The following limits were proposed: for Escherichia coli ATCC 25922,...
Hartstein, A I, Valvano, M A, Morthland, V H, Fuchs, P C, Potter, S A, Crosa, J H
We compared a disk diffusion antimicrobic susceptibility panel with plasmid DNA profiles as tests for identity of 106 isolates of coagulase-negative staphylococci cultured from the blood of 45...
Fuchs, P C, Barry, A L, Jones, R N
A total of 97 anaerobic bacteria were tested for susceptibility to ampicillin, ampicillin-sulbactam, and amoxicillin-clavulanic acid by broth microdilution and disk elution methods, the results of...
Fuchs, P C, Jones, R N, Barry, A L
There are at least four different existing or proposed interpretive criteria for the disk diffusion susceptibility testing of ticarcillin and ticarcillin plus clavulanic acid (T/C). To assess these...
Jones, R N, Gavan, T L, Thornsberry, C, Fuchs, P C, Gerlach, E H, Knapp, J S, ...
A six-laboratory study developed a standardized method for determining the susceptibilities of Neisseria gonorrhoeae strains to penicillin, tetracycline, spectinomycin, and ceftriaxone. Three quality...
Fuchs, P C, Jones, R N, Barry, A L, Gavan, T L
The susceptibilities of 221 clinical isolates to ofloxacin were tested simultaneously by broth microdilution and disk diffusion methods with commercially prepared 5-micrograms ofloxacin disks. The...
Zabransky, R J, Bobey, D G, Barry, A L, Allen, S D, Fuchs, P C, Gerlach, E H, ...
Reference values for quality control of in vitro susceptibility tests with cefotetan against anaerobic bacteria were determined in two independent multilaboratory studies with the approved National...
Barry, A L, Fuchs, P C, Allen, S D, Thornsberry, C, Gerlach, E H, Jones, R N
Multilaboratory studies were performed to develop MIC quality control limits for the National Committee for Clinical Laboratory Standards reference agar dilution method for anaerobic susceptibility...
Proposed disk diffusion susceptibility criteria for ofloxacin.
Fuchs, P C, Barry, A L, Jones, R N, Thornsberry, C
Disk diffusion zone diameter breakpoint criteria for ofloxacin were tentatively established by correlating MICs with 1-, 3-, and 5-micrograms disk inhibitory zone diameters for 638 bacterial isolates...
Tentative disk diffusion susceptibility interpretive criteria for BMY-28142, a new cephalosporin.
Fuchs, P C, Jones, R N, Barry, A L, Thornsberry, C
A total of 750 bacterial isolates, including 37 different species, were tested for susceptibility to BMY-28142 by standardized broth microdilution and disk diffusion tests. The zone diameter...
Selection of a reference lot of Mueller-Hinton agar.
Pollock, H M, Barry, A L, Gavan, T L, Fuchs, P C, Hansen, S, Thornsberry, C L, ...
A collaborative study was undertaken to evaluate the performance of currently marketed Mueller-Hinton agars from seven manufacturers by replicate disk diffusion tests with standard quality control...
Jones, R N, Barry, A L, Fuchs, P C, Thornsberry, C
The 15-micrograms erythromycin disk was twice evaluated for interpretive accuracy against 417 and then 266 strains of gram-positive cocci, Neisseria meningitidis, and Haemophilus influenzae by using...
Tentative disk diffusion susceptibility interpretive criteria for pefloxacin.
Fuchs, P C, Barry, A L, Jones, R N, Thornsberry, C
Standardized broth microdilution and disk diffusion susceptibility tests for pefloxacin were performed on 585 clinical isolates. The 5-micrograms pefloxacin disk is recommended, and the following...
Cefixime disk susceptibility test criteria.
Fuchs, P C, Barry, A L, Jones, R N
A total of 583 bacterial isolates was tested for susceptibility to cefixime by broth microdilution and by disk agar diffusion with 5-, 10-, and 30-microgram disks. At MIC breakpoints of less than or...
Jones, R N, Barry, A L, Fuchs, P C, Thornsberry, C
Cefmetazole, formerly CS-1170, was found to have antimicrobial activity slightly superior to that of cefoxitin but a clinically usable antimicrobial spectrum that should be considered identical to...
Interpretive criteria for disk diffusion susceptibility testing of mupirocin, a topical antibiotic.
Fuchs, P C, Jones, R N, Barry, A L
Five hundred gram-positive clinical bacterial isolates were tested for susceptibility to mupirocin by broth microdilution and disk diffusion methods (5- and 10-micrograms disks). All but 1 of 330...
Fuchs, P C, Barry, A L, Baker, C, Murray, P R, Washington, J A
Ciprofloxacin was subjected to a multilaboratory study designed to determine its in vitro susceptibility criteria for Neisseria gonorrhoeae and its quality control parameters for both agar dilution...
Barry, A L, Jorgensen, J H, Hardy, D J, Allen, S D, Baker, C N, Fuchs, P C, ...
Haemophilus influenzae isolates were uniformly susceptible to enoxacin, ofloxacin, and temafloxacin. Zone diameter and MIC interpretive criteria were proposed to define susceptible populations so...
Disk diffusion susceptibility testing of ticarcillin plus clavulanic acid.
Fuchs, P C, Jones, R N, Barry, A L, Thornsberry, C
Disk diffusion susceptibility testing of ticarcillin plus the beta-lactamase inhibitor clavulanic acid was performed on 489 clinical isolates, and the results were compared with reference broth...
Jones, R N, Thornsberry, C, Barry, A L, Ayers, L, Brown, S, Daniel, J, ...
HR810 is a new, very broad-spectrum cephalosporin with significant activity against members of the family Enterobacteriaceae, pseudomonads, gram-positive cocci, and anaerobes that is generally...
Cefotiam susceptibility testing criteria.
Fuchs, P C, Barry, A L, Jones, R N, Thornsberry, C
Interpretive zone size breakpoints for diffusion tests with 30-micrograms cefotiam disks are diameters of greater than or equal to 18 mm for susceptible and less than or equal to 14 mm for resistant...
Gavan, T L, Jones, R N, Barry, A L, Fuchs, P C, Gerlach, E H, Matsen, J M, ...
A multilaboratory in vitro study was carried out to determine disk diffusion susceptibility testing quality control limits for two new semisynthetic penicillins, mezlocillin and piperacillin....
Jones, R N, Fuchs, P C, Barry, A L, Gavan, T L, Sommers, H M, Gerlach, E H
The in vitro activity of cefoperazone (T-1551) against almost 9,000 recent clinical isolates at six institutions was tested and compared with that of cephalothin and gentamicin. The modal minimum...
Jones, R N, Fuchs, P C, Sommers, H M, Gavan, T L, Barry, A L, Gerlach, E H
Moxalactam (LY127935) exhibited greater in vitro activity than cefamandole and tobramycin against clinical isolates of Enterobacteriaceae, Aeromonas hydrophila, and Pseudomonas maltophilia. The...
Cefotaxime: in vitro activity and tentative interpretive standards for disk susceptibility testing.
Fuchs, P C, Barry, A L, Thornsberry, C, Jones, R N, Gavan, T L, Gerlach, E H, ...
Tested against 9,412 recent clinical isolates, cefotaxime exhibited 8 to 64 times greater activity against the Enterobacteriaceae than did cephalothin and two to four times greater activity against...
In vitro susceptibility testing procedures for fosfomycin tromethamine.
Fosfomycin tromethamine (previously fosfomycin trometamol) is an orally administered fosfomycin which may be used for single-dose therapy of uncomplicated urinary tract infections. Fosfomycin...
Barry, A L, Pfaller, M A, Fuchs, P C, Packer, R R
Clinical isolates of Haemophilus influenzae, Streptococcus pneumoniae, Streptococcus pyogenes, and Moraxella catarrhalis were gathered from 19 different clinical laboratories throughout the...
Jones, R N, Barry, A L, Fuchs, P C, Gavan, T L, Sommers, H M, Gerlach, E H
The susceptibility of 11,840 clinical bacterial isolates to fortimicin A was determined by agar dilution or broth microdilution methods and compared with their susceptibility to amikacin and...
In Vitro Antimicrobial Activity of Cinoxacin Against 2,968 Clinical Bacterial Isolates
Cinoxacin demonstrated effective in vitro antimicrobial activity against the Enterobacteriaceae, but negligible activity against Pseudomonas aeruginosa and gram-positive cocci. The activity of...
Cefuroxime, an in vitro Comparison with Six Other Cephalosporins
Barry, A L, Thornsberry, C, Jones, R N, Fuchs, P C, Gavan, T L, Gerlach, E H
Barry, A. L., Fuchs, P. C., Brown, S. D.
Four different compounds belonging to the macrolide-lincosamide-streptogramin B (MLSb) class of antimicrobial agents were tested against 611 Streptococcus pneumoniae strains. The ketolide (HMR 3647,...
Barry, A. L., Pfaller, M. A., Rennie, R. P., Fuchs, P. C., Brown, S. D.
Interpretive agreements among the results of fluconazole broth microdilution tests, Etests, and disk diffusion tests were documented by evaluating 495 Candida spp. Microdilution reference test...
Broth microdilution tests were carried out with 2,671 respiratory tract isolates from 19 medical centers throughout the continental United States. The tests compared a streptogramin (RP59500) to...
Fuchs, P C, Barry, A L, Sewell, D L
The in vitro antimicrobial activity of an oral penem, WY-49605, was compared with those of six other oral antimicrobial agents against 598 bacterial isolates representing 51 different species....
Fuchs, P C, Barry, A L, Brown, S D
More than 3,000 consecutive clinical bacterial isolates from 10 U.S. medical centers were subjected to standard broth microdilution and disk diffusion tests to determine their susceptibilities to...
Barry, A L, Fuchs, P C, Brown, S D
Ciprofloxacin, clinafloxacin, PD 131628, sparfloxacin, and trovafloxacin were tested against 236 strains of Streptococcus pneumoniae, most of which were resistant to other agents. Resistance to...
Fuchs, P C, Jones, R N, Barry, A L
E1040 is a new parenteral cephalosporin which was tested against 690 clinical isolates and compared with cefpirome and ceftazidime. E1040 had the best activity of the three drugs against Pseudomonas...
In vitro antimicrobial activity of tigemonam, a new orally administered monobactam.
Fuchs, P C, Jones, R N, Barry, A L
At five geographically separate medical centers, over 6,000 clinical bacterial isolates were tested for their susceptibility to tigemonam by the broth microdilution method. The antimicrobial spectrum...
Multicenter in vitro evaluation of SM-7338, a new carbapenem.
Jones, R N, Aldridge, K E, Allen, S D, Barry, A L, Fuchs, P C, Gerlach, E H, ...
A new carbapenem, SM-7338, was compared with imipenem, cefotaxime, and ceftazidime at five medical centers. Nearly 6,000 strains were tested by reference methods of the National Committee for...
Evaluation of the in vitro activity of BMY-28142, a new broad-spectrum cephalosporin.
Fuchs, P C, Jones, R N, Barry, A L, Thornsberry, C
The in vitro activity of BMY-28142, a new cephalosporin, was tested by a broth microdilution system and compared with those of cefotaxime, ceftazidime, cefoperazone, moxalactam, and HR 810 against...
Jones, R N, Baker, C, Barry, A L, Fuchs, P C
A new oral cephalosporin, LY164846 (Eli Lilly & Co., Indianapolis, Ind.), was found to have a unique antimicrobial spectrum confined to methicillin-susceptible Staphylococcus spp., streptococci...
Jones, R N, Fuchs, P C, Barry, A L, Ayers, L W, Gerlach, E H, Gavan, T L
Susceptibility testing of 7,775 recent clinical isolates from four medical centers showed Ro 15-8074 to be 2-to greater than 8-fold more active than either cefaclor or cefuroxime against the...
Mezlocillin: tentative interpretive standards for disk diffusion susceptibility testing.
Fuchs, P C, Barry, A L, Thornsberry, C, Jones, R N, Gerlack, E H
The susceptibility of 447 clinical bacterial isolates to mezlocillin and carbenicillin was tested by standardized agar disk diffusion and reference broth micro-dilution methods. Tentative...
Fuchs, P C, Barry, A L, Thornsberry, C, Gavan, T L, Jones, R N
Augmentin (Beecham Laboratories, Bristol, Tenn.), a combination drug consisting of two parts amoxicillin to one part clavulanic acid and a potent beta-lactamase inhibitor, was evaluated in vitro in...
In vitro activity of ticarcillin plus clavulanic acid against 632 clinical isolates.
Fuchs, P C, Barry, A L, Thornsberry, C, Jones, R N
A total of 632 clinical bacterial isolates were tested for susceptibility to twofold dilutions of ticarcillin alone and in combination with 1, 2, and 4 micrograms of clavulanic acid (CA) (Timentin)...
Ayers, L W, Jones, R N, Barry, A L, Thornsberry, C, Fuchs, P C, Gavan, T L, ...
Cefotetan is a new, potent, 7 alpha-methoxy cephalosporin (cephamycin). The in vitro activity of cefotetan tested in a multiphasic, collaborative study against 12,260 consecutive clinical isolates...
Barry, A L, Fuchs, P C, Pfaller, M A
In in vitro studies we evaluated the susceptibilities of beta-lactamase-producing and -nonproducing, ampicillin-resistant strains of Haemophilus influenzae and compared them with those of...
Pfaller, M A, Barry, A L, Fuchs, P C
Ro 40-6890, the active metabolite of Ro 41-3399, was tested against 391 gram-negative and gram-positive clinical isolates. Ro 40-6890 was active against members of the family Enterobacteriaceae,...
Barry, A L, Fuchs, P C, Gerlach, E H, Hardy, D J, McLaughlin, J C, Pfaller, M A
A five-laboratory coordinated study was undertaken to determine whether ticarcillin and ticarcillin-clavulanic acid disk susceptibility tests could accurately detect resistance among enteric bacilli....
Barry, A L, Fuchs, P C, Allen, S D, Tenover, F C, Jorgensen, J H, Reller, L B
For testing bacterial susceptibility to PD131628, a 5-micrograms disk and the following tentative interpretive criteria may be used: > or = 19 mm for susceptible (MIC, < or = 1.0 micrograms/ml), 16...
Methods for predicting susceptibility of Streptococcus pneumoniae to cefixime.
Among 698 Streptococcus pneumoniae isolates, 475 were penicillin susceptible and > 99% of those were susceptible to 0.5 microgram of cefixime per ml; other pneumococci were tentatively assumed to be...
Cefotaxime- and ceftriaxone-resistant Streptococcus pneumoniae is now appearing in some medical centers, but 30-micrograms cefotaxime or 30-micrograms ceftriaxone disks are not reliable for detecting...
Fuchs, P C, Barry, A L, Brown, S D
Two hundred twenty-eight strains of Haemophilus influenzae and 234 strains of Streptococcus pneumoniae were tested by broth microdilution and disk diffusion methods for susceptibility to trimethoprim...
Fuchs, P C, Stickel, S, Anderson, P H, Barry, A L, Shilling, S
At clinically achievable levels (e.g., 25 micrograms/ml), sulbactam exerted no effect on aminoglycoside concentrations when incubated together in pooled serum at 37 degrees C for up to 24 h....
Fuchs, P C, Barry, A L, Pfaller, M A, Allen, S D, Gerlach, E H
The in vitro activities of three new quinolones (sparfloxacin, CI-960, and PD 131,628) were compared with that of ciprofloxacin against 5,252 routine clinical aerobic and facultatively anaerobic...
In vitro activities of sparfloxacin, tosufloxacin, ciprofloxacin, and fleroxacin.
The in vitro activity of sparfloxacin was compared with those of tosufloxacin, ciprofloxacin, and fleroxacin against 730 bacterial isolates representing 49 different species. Sparfloxacin and...
Barry, A L, Fuchs, P C, Jorgensen, J H, Tenover, F C, Allen, S D, Hardy, D J, ...
In vitro studies evaluated methods for testing the susceptibility of Haemophilus influenzae to piperacillin-tazobactam combinations. Ampicillin-resistant beta-lactamase-nonproducing strains of H....
One hundred fifty isolates of Haemophilus influenzae (including 30 beta-lactamase-positive strains and 23 beta-lactamase-negative, ampicillin-resistant strains) were tested for susceptibilities to...
Barry, A L, Cohen, M A, Sesnie, J C, Fuchs, P C, Washington, J A, Murray, P R, ...
For testing the susceptibility of Neisseria gonorrhoeae to enoxacin, a proposed susceptibility category includes strains for which MICs are less than or equal to 0.5 micrograms/ml and zones of...
Fuchs, P C, Barry, A L, Baker, C, Murray, P R, Washington, J A
A multilaboratory study designed to determine the in vitro susceptibility criteria and quality control parameters for ofloxacin against Neisseria gonorrhoeae was conducted according to the guidelines...
Fuchs, P C, Barry, A L, Baker, C N, Murray, P R, Washington, J A
To support future clinical studies, in vitro susceptibility tests were examined to determine whether Neisseria gonorrhoeae could be tested reliably against two beta-lactam-clavulanate combinations....
Levofloxacin disk potency and tentative interpretive criteria for susceptibility tests.
Pfaller, M A, Barry, A L, Fuchs, P C
Levofloxacin disk susceptibility test criteria were evaluated by testing 350 bacterial isolates. Either 5- or 10-micrograms disks could be used satisfactorily. A 5-micrograms levofloxacin disk with...
Ramoplanin susceptibility testing criteria.
Barry, A L, Pfaller, M A, Fuchs, P C
Ramoplanin and mupirocin are two antimicrobial agents that may be applied topically. They had similar potencies against susceptible gram-positive cocci, but they differed in their spectra of...
Tentative interpretive criteria for disk diffusion susceptibility testing of sparfloxacin.
Fuchs, P C, Barry, A L, Pfaller, M A
Susceptibility to sparfloxacin was tested simultaneously by the agar dilution and disk diffusion methods. For tests with 5-micrograms sparfloxacin disks, we propose that the breakpoints for the...
Barry, A L, Fuchs, P C, Allen, S D, Jorgensen, J H, Tenover, F C, Murray, P R, ...
Sparfloxacin and levofloxacin were evaluated against 150 Haemophilus influenzae isolates and 149 Neisseria gonorrhoeae isolates in order to define susceptibility testing parameters....
Quality control limits for microdilution susceptibility tests with norfloxacin.
Barry, A L, Gavan, T L, Ayers, L W, Fuchs, P C, Gerlach, E H, Thornsberry, C
A multilaboratory study was designed to define quality control limits for microdilution susceptibility tests with norfloxacin. The following limits were proposed: for Escherichia coli ATCC 25922,...
Hartstein, A I, Valvano, M A, Morthland, V H, Fuchs, P C, Potter, S A, Crosa, J H
We compared a disk diffusion antimicrobic susceptibility panel with plasmid DNA profiles as tests for identity of 106 isolates of coagulase-negative staphylococci cultured from the blood of 45...
Fuchs, P C, Barry, A L, Jones, R N
A total of 97 anaerobic bacteria were tested for susceptibility to ampicillin, ampicillin-sulbactam, and amoxicillin-clavulanic acid by broth microdilution and disk elution methods, the results of...
Fuchs, P C, Jones, R N, Barry, A L
There are at least four different existing or proposed interpretive criteria for the disk diffusion susceptibility testing of ticarcillin and ticarcillin plus clavulanic acid (T/C). To assess these...
Jones, R N, Gavan, T L, Thornsberry, C, Fuchs, P C, Gerlach, E H, Knapp, J S, ...
A six-laboratory study developed a standardized method for determining the susceptibilities of Neisseria gonorrhoeae strains to penicillin, tetracycline, spectinomycin, and ceftriaxone. Three quality...
Fuchs, P C, Jones, R N, Barry, A L, Gavan, T L
The susceptibilities of 221 clinical isolates to ofloxacin were tested simultaneously by broth microdilution and disk diffusion methods with commercially prepared 5-micrograms ofloxacin disks. The...
Zabransky, R J, Bobey, D G, Barry, A L, Allen, S D, Fuchs, P C, Gerlach, E H, ...
Reference values for quality control of in vitro susceptibility tests with cefotetan against anaerobic bacteria were determined in two independent multilaboratory studies with the approved National...
Barry, A L, Fuchs, P C, Allen, S D, Thornsberry, C, Gerlach, E H, Jones, R N
Multilaboratory studies were performed to develop MIC quality control limits for the National Committee for Clinical Laboratory Standards reference agar dilution method for anaerobic susceptibility...
Proposed disk diffusion susceptibility criteria for ofloxacin.
Fuchs, P C, Barry, A L, Jones, R N, Thornsberry, C
Disk diffusion zone diameter breakpoint criteria for ofloxacin were tentatively established by correlating MICs with 1-, 3-, and 5-micrograms disk inhibitory zone diameters for 638 bacterial isolates...
Tentative disk diffusion susceptibility interpretive criteria for BMY-28142, a new cephalosporin.
Fuchs, P C, Jones, R N, Barry, A L, Thornsberry, C
A total of 750 bacterial isolates, including 37 different species, were tested for susceptibility to BMY-28142 by standardized broth microdilution and disk diffusion tests. The zone diameter...
Selection of a reference lot of Mueller-Hinton agar.
Pollock, H M, Barry, A L, Gavan, T L, Fuchs, P C, Hansen, S, Thornsberry, C L, ...
A collaborative study was undertaken to evaluate the performance of currently marketed Mueller-Hinton agars from seven manufacturers by replicate disk diffusion tests with standard quality control...
Jones, R N, Barry, A L, Fuchs, P C, Thornsberry, C
The 15-micrograms erythromycin disk was twice evaluated for interpretive accuracy against 417 and then 266 strains of gram-positive cocci, Neisseria meningitidis, and Haemophilus influenzae by using...
Tentative disk diffusion susceptibility interpretive criteria for pefloxacin.
Fuchs, P C, Barry, A L, Jones, R N, Thornsberry, C
Standardized broth microdilution and disk diffusion susceptibility tests for pefloxacin were performed on 585 clinical isolates. The 5-micrograms pefloxacin disk is recommended, and the following...
Cefixime disk susceptibility test criteria.
Fuchs, P C, Barry, A L, Jones, R N
A total of 583 bacterial isolates was tested for susceptibility to cefixime by broth microdilution and by disk agar diffusion with 5-, 10-, and 30-microgram disks. At MIC breakpoints of less than or...
Jones, R N, Barry, A L, Fuchs, P C, Thornsberry, C
Cefmetazole, formerly CS-1170, was found to have antimicrobial activity slightly superior to that of cefoxitin but a clinically usable antimicrobial spectrum that should be considered identical to...
Interpretive criteria for disk diffusion susceptibility testing of mupirocin, a topical antibiotic.
Fuchs, P C, Jones, R N, Barry, A L
Five hundred gram-positive clinical bacterial isolates were tested for susceptibility to mupirocin by broth microdilution and disk diffusion methods (5- and 10-micrograms disks). All but 1 of 330...
Fuchs, P C, Barry, A L, Baker, C, Murray, P R, Washington, J A
Ciprofloxacin was subjected to a multilaboratory study designed to determine its in vitro susceptibility criteria for Neisseria gonorrhoeae and its quality control parameters for both agar dilution...
Barry, A L, Jorgensen, J H, Hardy, D J, Allen, S D, Baker, C N, Fuchs, P C, ...
Haemophilus influenzae isolates were uniformly susceptible to enoxacin, ofloxacin, and temafloxacin. Zone diameter and MIC interpretive criteria were proposed to define susceptible populations so...
Disk diffusion susceptibility testing of ticarcillin plus clavulanic acid.
Fuchs, P C, Jones, R N, Barry, A L, Thornsberry, C
Disk diffusion susceptibility testing of ticarcillin plus the beta-lactamase inhibitor clavulanic acid was performed on 489 clinical isolates, and the results were compared with reference broth...
Jones, R N, Thornsberry, C, Barry, A L, Ayers, L, Brown, S, Daniel, J, ...
HR810 is a new, very broad-spectrum cephalosporin with significant activity against members of the family Enterobacteriaceae, pseudomonads, gram-positive cocci, and anaerobes that is generally...
Cefotiam susceptibility testing criteria.
Fuchs, P C, Barry, A L, Jones, R N, Thornsberry, C
Interpretive zone size breakpoints for diffusion tests with 30-micrograms cefotiam disks are diameters of greater than or equal to 18 mm for susceptible and less than or equal to 14 mm for resistant...
Gavan, T L, Jones, R N, Barry, A L, Fuchs, P C, Gerlach, E H, Matsen, J M, ...
A multilaboratory in vitro study was carried out to determine disk diffusion susceptibility testing quality control limits for two new semisynthetic penicillins, mezlocillin and piperacillin....
Jones, R N, Fuchs, P C, Barry, A L, Gavan, T L, Sommers, H M, Gerlach, E H
The in vitro activity of cefoperazone (T-1551) against almost 9,000 recent clinical isolates at six institutions was tested and compared with that of cephalothin and gentamicin. The modal minimum...
Jones, R N, Fuchs, P C, Sommers, H M, Gavan, T L, Barry, A L, Gerlach, E H
Moxalactam (LY127935) exhibited greater in vitro activity than cefamandole and tobramycin against clinical isolates of Enterobacteriaceae, Aeromonas hydrophila, and Pseudomonas maltophilia. The...
Cefotaxime: in vitro activity and tentative interpretive standards for disk susceptibility testing.
Fuchs, P C, Barry, A L, Thornsberry, C, Jones, R N, Gavan, T L, Gerlach, E H, ...
Tested against 9,412 recent clinical isolates, cefotaxime exhibited 8 to 64 times greater activity against the Enterobacteriaceae than did cephalothin and two to four times greater activity against...
In vitro susceptibility testing procedures for fosfomycin tromethamine.
Fosfomycin tromethamine (previously fosfomycin trometamol) is an orally administered fosfomycin which may be used for single-dose therapy of uncomplicated urinary tract infections. Fosfomycin...
Barry, A L, Pfaller, M A, Fuchs, P C, Packer, R R
Clinical isolates of Haemophilus influenzae, Streptococcus pneumoniae, Streptococcus pyogenes, and Moraxella catarrhalis were gathered from 19 different clinical laboratories throughout the...
Jones, R N, Barry, A L, Fuchs, P C, Gavan, T L, Sommers, H M, Gerlach, E H
The susceptibility of 11,840 clinical bacterial isolates to fortimicin A was determined by agar dilution or broth microdilution methods and compared with their susceptibility to amikacin and...
In Vitro Antimicrobial Activity of Cinoxacin Against 2,968 Clinical Bacterial Isolates
Cinoxacin demonstrated effective in vitro antimicrobial activity against the Enterobacteriaceae, but negligible activity against Pseudomonas aeruginosa and gram-positive cocci. The activity of...