Population differences in the international multi-centre ADHD gene project (2008)
Neale, B.M., Sham, P.C., Purcell, S., Banaschewski, T., Buitelaar, J., Franke, B., ...
The International Multi-Centre ADHD Gene sample consists of 674 families from eight countries (Belgium, England, Germany, Holland, Ireland, Israel, Spain, and Switzerland) ascertained from clinics...
Tomlinson, I.P.M., Webb, E., Carvajal-Carmona, L., Broderick, P., Howarth, K., Pittman, A.M., ...
To identify colorectal cancer (CRC) susceptibility alleles, we conducted a genome-wide association study. In phase 1, we genotyped 550,163 tagSNPs in 940 familial colorectal tumor cases (627 CRC, 313...
MaGIC: a program to generate targeted marker sets for genome-wide association studies (2004)
Simpson, C.L., Hansen, V.K., Sham, P.C., Collins, A., Powell, J.F., Al-Chalabi, A.
High-throughput genotyping technologies such as DNA pooling and DNA microarrays mean that whole-genome screens are now practical for complex disease gene discovery using association studies. Because...
Purcell, S., Cherny, S. S., Sham, P. C.
Summary: A website for performing power calculations for the design of linkage and association genetic mapping studies of complex traits.Availability: The package is made available...
Chumakov I, Blumenfeld M, Guerassimenko O, Cavarec L, Palicio M, Abderrahim H, ...
A map of 191 single-nucleotide polymorphism (SNPs) was built across a 5-Mb segment from chromosome 13q34 that has been genetically linked to schizophrenia. DNA from 213 schizophrenic patients and 241...
Equivalence between Haseman-Elston and Variance-Components Linkage Analyses for Sib Pairs
The Haseman-Elston regression method offers a simpler alternative to variance-components (VC) models, for the linkage analysis of quantitative traits. However, even the “revisited” method, which...
Sham, P C, Cherny, S S, Purcell, S, Hewitt, J K
Optimal design of quantitative-trait loci (QTL) mapping studies requires a precise understanding of the power of QTL linkage versus QTL association analysis, under a range of different conditions. In...
Power comparison of parametric and nonparametric linkage tests in small pedigrees.
Sham, P C, Lin, M W, Zhao, J H, Curtis, D
When the mode of inheritance of a disease is unknown, the LOD-score method of linkage analysis must take into account uncertainties in model parameters. We have previously proposed a parametric...
Combined linkage and association sib-pair analysis for quantitative traits.
Fulker, D W, Cherny, S S, Sham, P C, Hewitt, J K
An extension to current maximum-likelihood variance-components procedures for mapping quantitative-trait loci in sib pairs that allows a simultaneous test of allelic association is proposed. The...
Joint linkage of multiple loci for a complex disorder.
MacLean, C J, Sham, P C, Kendler, K S
Many investigators who have been searching for linkage to complex diseases have by now accumulated a drawer full of negative results. If disease is actually caused by genes at several loci, these...
Equivalence between Haseman-Elston and Variance-Components Linkage Analyses for Sib Pairs
The Haseman-Elston regression method offers a simpler alternative to variance-components (VC) models, for the linkage analysis of quantitative traits. However, even the “revisited” method, which...
Combined linkage and association sib-pair analysis for quantitative traits.
Fulker, D W, Cherny, S S, Sham, P C, Hewitt, J K
An extension to current maximum-likelihood variance-components procedures for mapping quantitative-trait loci in sib pairs that allows a simultaneous test of allelic association is proposed. The...
Sham, P C, Cherny, S S, Purcell, S, Hewitt, J K
Optimal design of quantitative-trait loci (QTL) mapping studies requires a precise understanding of the power of QTL linkage versus QTL association analysis, under a range of different conditions. In...
Power comparison of parametric and nonparametric linkage tests in small pedigrees.
Sham, P C, Lin, M W, Zhao, J H, Curtis, D
When the mode of inheritance of a disease is unknown, the LOD-score method of linkage analysis must take into account uncertainties in model parameters. We have previously proposed a parametric...
Joint linkage of multiple loci for a complex disorder.
MacLean, C J, Sham, P C, Kendler, K S
Many investigators who have been searching for linkage to complex diseases have by now accumulated a drawer full of negative results. If disease is actually caused by genes at several loci, these...
Model-free linkage analysis using likelihoods.
Misspecification of transmission model parameters can produce artifactually negative lod scores at small recombination fractions and in multipoint analysis. To avoid this problem, we have tried to...