Providing infertility treatment in resource-poor countries (2009)
Pennings, Guido, De Wert, G., Shenfield, F., Cohen, J., Tarlatzis, B., Devroey, P.
Recently, several initiatives were started to introduce medically assisted reproduction in developing countries. Infertility is a major problem in these countries and causes extensive social and...
Providing infertility treatment in resource-poor countries (2009)
Pennings, G., De Wert, G., Shenfield, F., Cohen, J., Tarlatzis, B., ...
Recently, several initiatives were started to introduce medically assisted reproduction in developing countries. Infertility is a major problem in these countries and causes extensive social and...
Mild ovarian stimulation for IVF (2009)
Verberg, M.F.G., Macklon, N.S., Nargund, G., Frydman, R., Devroey, P., Broekmans, F.J., ...
BACKGROUND Mild ovarian stimulation for in vitro fertilization (IVF) aims to achieve cost-effective, patient-friendly regimens which optimize the balance between outcomes and risks of treatment. ...
An in vivo culture system for human embryos using an encapsulation technology: a pilot study (2009)
Blockeel, C., Mock, P., Verheyen, G., Bouche, N., Le Goff, Ph., Heyman, Y., ...
BACKGROUND Animal studies have demonstrated better embryo development in vivo than in vitro. This pilot study tested the feasibility of using a novel in utero culture system (IUCS) to obtain normal...
Devroey, P., Leader, A., Boime, I., Baird, D.T.
BACKGROUND Recombinant DNA technologies have been used to develop longer-acting therapeutic proteins. One approach is to introduce sequences containing additional glycosylation sites. Using this...
Approaches to improve the diagnosis and management of infertility (2009)
BACKGROUND Recent advances in our understanding of the causes of infertility and of assisted reproductive technology (ART) have led to the development of complex diagnostic tools, prognostic models...
Kyrou, D., Popovic-Todorovic, B., Fatemi, H.M., Bourgain, C., Haentjens, P., Van Landuyt, L., ...
BACKGROUND The purpose of this prospective observational study was to evaluate the association between estradiol (E2) levels on the day of human chorionic gonadotrophin (hCG) administration and...
Blockeel, C., De Vos, M., Verpoest, W., Stoop, D., Haentjens, P., Devroey, P.
BACKGROUND GnRH-antagonist protocols shorten the treatment period and reduce inconvenience for IVF patients. This randomised controlled trial (RCT) further explored whether low-dose hCG can be used...
Verpoest, W., Haentjens, P., De Rycke, M., Staessen, C., Sermon, K., Bonduelle, M., ...
BACKGROUND Couples undergoing preimplantation genetic diagnosis (PGD) have a different background and set of treatment characteristics to couples undergoing regular IVF or ICSI. The aim of this study...
The incidence of monozygotic twinning following PGD is not increased (2009)
Verpoest, W., Van Landuyt, L., Desmyttere, S., Cremers, A., Devroey, P., Liebaers, I.
BACKGROUND Monozygotic (MZ) twin pregnancies are associated with increased perinatal mortality and morbidity, and risk of congenital anomalies. The causes of MZ twinning in humans are unclear but the...
De Vos, A., Staessen, C., De Rycke, M., Verpoest, W., Haentjens, P., Devroey, P., ...
BACKGROUND Human embryo biopsy is performed for preimplantation genetic diagnosis (PGD). The impact of 1- or 2-cell removal at cleavage-stage on future embryo development and implantation capacity is...
Devroey, P., Boostanfar, R., Koper, N.P., IJzerman-Boon, P.C., ...
BACKGROUND Corifollitropin alfa, a fusion protein lacking LH activity, has a longer elimination half-life and extended time to peak levels than recombinant FSH (rFSH). A single injection of...
Cross-border reproductive care in Belgium (2009)
Pennings, G., Autin, C., Decleer, W., Delbaere, A., Delbeke, L., Delvigne, A., ...
BACKGROUND Cross-border reproductive care indicates the cross-border movements made by patients to obtain infertility treatment they cannot obtain at home. The problem at present is that empirical...
Genetic aspects of female reproduction (2008)
Collins, J., Diedrich, K., Franks, S., Geraedts, J.P.M., Jacobs, P.A., Karges, B., ...
BACKGROUND: Sexual reproduction provides the means for preserving genetic identity and in turn, genetic variability may affect the ability to reproduce. This review aims to summarize current research...
ESHRE Task Force on Ethics and Law 14: Equity of access to assisted reproductive technology (2008)
Pennings, Guido, DE WERT, G, SHENFIELD, F, COHEN, J, TARLATZIS, B, DEVROEY, P
ESHRE task force on ethics and law 15: Cross-border reproductive care (2008)
Pennings, Guido, De Wert, G., Shenfield, F., Cohen, J., Tarlatzis, B., Devroey, P.
This paper analyses the ethical aspects of cross-border reproductive care. Ethical questions are raised by some of the main reasons of cross-border travelling, i.e. law evasion and unequal access to...
De Vos, A., Van Landuyt, L., Van Ranst, H., Vandermonde, A., DHaese, V., Sterckx, J., ...
BACKGROUND The enzyme hyaluronidase from bovine origin is commonly used for oocyte–cumulus cell removal in ICSI. A recombinant human hyaluronidase (rHuPH20) has been introduced as a...
Ovarian stimulation is applied in the clinic to restore mono-ovulatory cycles in anovulatory women (ovulation induction) or to induce the development of multiple dominant follicles for assisted...
ESHRE Task Force on Ethics and Law 14: Equity of access to assisted reproductive technology (2008)
Pennings, G., De Wert, G., Shenfield, F., Cohen, J., Tarlatzis, B., ...
Justice and access are among the most urgent questions for medically assisted reproduction. This paper analyses this question not only for people suffering from infertility, but also for people who...
Four years of IVF/ICSI experience in Kampala (Uganda) (2008)
Platteau, P., Desmet, B., Odoma, G., Albano, C., Devroey, P., Sali, E. Tamale
We all know that starting and running an ART clinic is not so easy as some people might perceive from outside. Doing the same thing in the middle of Africa is even more challenging as some evidences...
Verpoest, W., De Rademaeker, M., Sermon, K., De Rycke, M., Seneca, S., Papanikolaou, E., ...
BACKGROUND This study aimed to analyse the reproductive outcome of a large cohort of myotonic dystrophy type 1 (DM1) patients undergoing ICSI and PGD. The secondary outcome parameter of this study...
Staessen, C., Verpoest, W., Donoso, P., Haentjens, P., Liebaers, I., ...
BACKGROUND Single-embryo transfer is a well-accepted strategy to avoid multiple pregnancies in an assisted reproductive technology (ART) programme. Besides the morphological quality and embryo...
ESHRE Task Force on Ethics and Law 15: Cross-border reproductive care (2008)
Pennings, G., De Wert, G., Shenfield, F., Cohen, J., Tarlatzis, B., Devroey, P.
This paper analyses the ethical aspects of cross-border reproductive care. Ethical questions are raised by some of the main reasons of cross-border travelling, i.e. law evasion and unequal access to...
Belva, F., Henriet, S., Camus, M., Devroey, P., ...
BACKGROUND To evaluate the safety of cryopreservation in combination with IVF and ICSI, prenatal diagnosis and neonatal outcome were investigated in children conceived from frozen-thawed ICSI embryos...
Chromosomal aneuploidy in embryos conceived with unstimulated cycle IVF (2008)
Verpoest, W., Fauser, B.C., Papanikolaou, E., Staessen, C., Van Landuyt, L., Donoso, P., ...
There is an ever increasing trend in reproductive medicine to reduce the intensity of ovarian stimulation for in vitro fertilization (IVF) and to restrict the number of embryos that are transferred...
Pennings, G., De Wert, G., Shenfield, F., Cohen, J., Tarlatzis, B., ...
The analysis of the welfare of the child in the context of medically assisted reproduction is divided in two parts: the first part addresses the risks associated with the would-be parent(s), the...
Venetis, C.A., Kolibianakis, E.M., Papanikolaou, E., Bontis, J., Devroey, P., Tarlatzis, B.C.
The role of progesterone elevation on in vitro fertilization (IVF) outcome has remained a debatable issue for several years. The aim of this systematic review and meta-analysis was to evaluate...
The role of the endometrium and embryo in human implantation (2007)
Diedrich, K., Devroey, P., Griesinger, G.
Despite many advances in assisted reproductive technologies (ART), implantation rates are still low. The process of implantation requires a reciprocal interaction between blastocyst and endometrium,...
ESHRE Task Force on Ethics and Law 12: Oocyte donation for non-reproductive purposes (2007)
Pennings, G., De Wert, G., Shenfield, F., Cohen, J., Tarlatzis, B., ...
The present paper focuses on oocyte donation for non-reproductive purposes, i.e. research and future therapy. The general principles of research ethics apply to these interventions. The...
Fatemi, H.M., Bourgain, C., Donoso, P., Blockeel, C., Papanikolaou, E.G., Popovic-Todorovic, B., ...
BACKGROUND We aimed to explore the endometrial histology and endocrine profiles on day 21 of an artificial cycle in patients with premature ovarian failure (POF) treated with oral dydrogesterone (DG)...
Kosmas, I.P., Janssens, R., De Munck, L., Al Turki, H., Tournaye, H., ...
BACKGROUND Ultrasound-guided embryo transfer (ET) is widely suggested as a standard clinical practice that improves overall embryo implantation and pregnancy rates. Various studies of this issue...
Single embryo transfer in preimplantation genetic diagnosis cycles for women (2007)
Donoso, P., Verpoest, W., Papanikolaou, E.G., Liebaers, I., Fatemi, H.M., Sermon, K., ...
BACKGROUND The Belgian legislation imposes single embryo transfer (SET) on women of
ESHRE Task Force on Ethics and Law 12: Oocyte donation for non-reproductive purposes (2007)
Pennings, Guido, DE WERT, G, SHENFIELD, F, COHEN, J, TARLATZIS, B, DEVROEY, P
Current value of preimplantation genetic aneuploidy screening in IVF (2007)
Donoso, P., Staessen, C., Devroey, P.
Preimplantation genetic aneuploidy screening (PGS) has been performed during the last decade as a way of enhancing embryo selection in patients with an increased incidence of embryonic numerical...
Smitz, J., Andersen, A.N., Devroey, P.
BACKGROUND: Highly purified menotrophin (HP-hMG) has been associated with fewer oocytes retrieved and a higher proportion of top-quality embryos compared with recombinant FSH (rFSH). METHODS: A...
Single embryo transfer in preimplantation genetic diagnosis cycles for women (2007)
Donoso, P., Verpoest, W., Papanikolaou, E.G., Liebaers, I., Fatemi, H.M., Sermon, K., ...
BACKGROUND: The Belgian legislation imposes single embryo transfer (SET) on women of
Fatemi, H.M., Bourgain, C., Donoso, P., Blockeel, C., Papanikolaou, E.G., Popovic-Todorovic, B., ...
BACKGROUND We aimed to explore the endometrial histology and endocrine profiles on day 21 of an artificial cycle in patients with premature ovarian failure (POF) treated with oral dydrogesterone (DG)...
Kosmas, I.P., Janssens, R., De Munck, L., Al Turki, H., Tournaye, H., ...
BACKGROUND Ultrasound-guided embryo transfer (ET) is widely suggested as a standard clinical practice that improves overall embryo implantation and pregnancy rates. Various studies of this issue...
ESHRE Task Force on Ethics and Law 12: Oocyte donation for non-reproductive purposes (2007)
Pennings, G., De Wert, G., Shenfield, F., Cohen, J., Tarlatzis, B., ...
The present paper focuses on oocyte donation for non-reproductive purposes, i.e. research and future therapy. The general principles of research ethics apply to these interventions. The...
Single embryo transfer in preimplantation genetic diagnosis cycles for women (2007)
Donoso, P., Verpoest, W., Papanikolaou, E.G., Liebaers, I., Fatemi, H.M., Sermon, K., ...
BACKGROUND: The Belgian legislation imposes single embryo transfer (SET) on women of
Fatemi, H.M., Bourgain, C., Donoso, P., Blockeel, C., Papanikolaou, E.G., Popovic-Todorovic, B., ...
BACKGROUND We aimed to explore the endometrial histology and endocrine profiles on day 21 of an artificial cycle in patients with premature ovarian failure (POF) treated with oral dydrogesterone (DG)...
Kosmas, I.P., Janssens, R., De Munck, L., Al Turki, H., Tournaye, H., ...
BACKGROUND Ultrasound-guided embryo transfer (ET) is widely suggested as a standard clinical practice that improves overall embryo implantation and pregnancy rates. Various studies of this issue...
ESHRE Task Force on Ethics and Law 12: Oocyte donation for non-reproductive purposes (2007)
Pennings, G., De Wert, G., Shenfield, F., Cohen, J., Tarlatzis, B., ...
The present paper focuses on oocyte donation for non-reproductive purposes, i.e. research and future therapy. The general principles of research ethics apply to these interventions. The...
How successful is repeat testicular sperm extraction in patients with azoospermia? (2006)
Verheyen, G, Van Steirteghem, A, Devroey, P, Tournaye, H
BACKGROUND: Little is known about the extraction rate in repeated sperm retrieval procedures in azoospermic patients. This study aimed to assess the feasibility of repeated sperm recovery in these...
Nutrition and reproduction in women (2006)
Baird, D. T., Cnattingius, S., Collins, J., Evers, J. L. H., Glasier, A., Heitmann, B. L., ...
© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.
Nutrition and reproduction in women (2006)
Baird, D. T., Cnattingius, S., Collins, J., Evers, J. L. H., Glasier, A., Heitmann, B. L., ...
© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.
ESHRE task force on ethics and law 11: Posthumous assisted reproduction (2006)
Pennings, Guido, DE WERT, G, SHENFIELD, F, COHEN, J, DEVROEY, P, TARLATZIS, B
GnRH antagonists in ovarian stimulation for IVF (2006)
Tarlatzis, B.C., Fauser, B.C., Kolibianakis, E.M., Diedrich, K., Devroey, P.
The present review describes, on the basis of the currently available evidence, the consensus reached by a group of experts on the use of gonadotropin-releasing hormone (GnRH) antagonists in ovarian...
Reply: 'GnRH agonist trigger: looking for the coin under the lamp post?' (2006)
Kolibianakis, E.M., Devroey, P., Diedrich, K., Griesinger, G.
ESHRE Task Force on Ethics and Law 11: Posthumous assisted reproduction (2006)
Pennings, G., De Wert, G., Shenfield, F., Cohen, J., Devroey, P., ...
This article analyses the different ethical aspects of posthumous assisted reproduction. Two situations are distinguished: cases in which the gametes or embryos are used by the surviving partner and...
How successful is repeat testicular sperm extraction in patients with azoospermia? (2006)
Vernaeve, Valérie, Verheyen, G., Goossens, A., Steirteghem, A. Van, Devroey, P., Tournaye, H.
BACKGROUND: Little is known about the extraction rate in repeated sperm retrieval procedures in azoospermic patients. This study aimed to assess the feasibility of repeated sperm recovery in these...
Fatemi, H.M., Kolibianakis, E.M., Camus, M., Tournaye, H., Donoso, P., Papanikolaou, E., ...
BACKGROUND: The role of progesterone for luteal support in stimulated cycles for IVF is well established. However, controversy still surrounds the benefit of additional supplementation with estradiol...
Donoso, P., Platteau, P., Papanikolaou, E.G., Staessen, C., Van Steirteghem, A., Devroey, P.
BACKGROUND: An increased incidence of aneuploid embryos has been recently described from azoospermic men. The aim of this study was to assess if embryo selection on day 5, based on morphological...
ESHRE Task Force on Ethics and Law 11: Posthumous assisted reproduction (2006)
Pennings, G., De Wert, G., Shenfield, F., Cohen, J., Devroey, P., ...
This article analyses the different ethical aspects of posthumous assisted reproduction. Two situations are distinguished: cases in which the gametes or embryos are used by the surviving partner and...
How successful is repeat testicular sperm extraction in patients with azoospermia? (2006)
Vernaeve, Valérie, Verheyen, G., Goossens, A., Van Steirteghem, A., Devroey, P., Tournaye, H.
BACKGROUND: Little is known about the extraction rate in repeated sperm retrieval procedures in azoospermic patients. This study aimed to assess the feasibility of repeated sperm recovery in these...
Kolibianakis, E.M., Collins, J., Tarlatzis, B.C., Devroey, P., Diedrich, K., Griesinger, G.
This systematic review and meta-analysis aimed to answer the following clinical question: among patients treated for IVF with gonadotrophins and GnRH analogues, is the probability of live birth per...
Donoso, P., Platteau, P., Papanikolaou, E.G., Staessen, C., Van Steirteghem, A., Devroey, P.
BACKGROUND: An increased incidence of aneuploid embryos has been recently described from azoospermic men. The aim of this study was to assess if embryo selection on day 5, based on morphological...
Mateizel, I., De Temmerman, N., Ullmann, U., Cauffman, G., Sermon, K., ...
BACKGROUND: Human embryonic stem (hES) cells are pluripotent cells usually derived from the inner cell mass (ICM) of blastocysts. Because of their ability to differentiate into all three embryonic...
Kolibianakis, E.M., Collins, J., Tarlatzis, B., Papanikolaou, E., Devroey, P.
The aim of this systematic review was to evaluate, among women with normal ovulation or World Health Organization (WHO) II oligoanovulation who undergo ovarian stimulation for IVF using GnRH...
Brugnon, F., Van Assche, E., Verheyen, G., Sion, B., Boucher, D., Pouly, J.L., ...
BACKGROUND: To try to explain the infertility of chromosomal translocation carrier patients, we compared the expression of two markers of apoptosis in the sperm of patients and of fertile donors, and...
GnRH antagonists in ovarian stimulation for IVF (2006)
Tarlatzis, B.C., Fauser, B.C., Kolibianakis, E.M., Diedrich, K., Devroey, P.
The present review describes, on the basis of the currently available evidence, the consensus reached by a group of experts on the use of gonadotropin-releasing hormone (GnRH) antagonists in ovarian...
GnRH antagonists in ovarian stimulation for IVF (2006)
Tarlatzis, B.C., Fauser, B.C., Kolibianakis, E.M., Diedrich, K., Devroey, P.
The present review describes, on the basis of the currently available evidence, the consensus reached by a group of experts on the use of gonadotropin-releasing hormone (GnRH) antagonists in ovarian...
Reply: Agonist trigger in the context of OHSS prevention: primum non nocere (2006)
Griesinger, G., Diedrich, K., Devroey, P., Kolibianakis, E.M.
Kolibianakis, E.M., Collins, J., Tarlatzis, B.C., Devroey, P., Diedrich, K., Griesinger, G.
This systematic review and meta-analysis aimed to answer the following clinical question: among patients treated for IVF with gonadotrophins and GnRH analogues, is the probability of live birth per...
Current value of preimplantation genetic aneuploidy screening in IVF (2006)
Donoso, P., Staessen, C., Devroey, P.
Preimplantation genetic aneuploidy screening (PGS) has been performed during the last decade as a way of enhancing embryo selection in patients with an increased incidence of embryonic numerical...
Griesinger, G., Diedrich, K., Devroey, P., Kolibianakis, E.M.
Triggering final oocyte maturation with GnRH agonist during ovarian stimulation is feasible when inhibition of premature LH surge is performed with GnRH antagonists, and we aimed to systematically...
Fatemi, H.M., Kolibianakis, E.M., Camus, M., Tournaye, H., Donoso, P., Papanikolaou, E., ...
BACKGROUND: The role of progesterone for luteal support in stimulated cycles for IVF is well established. However, controversy still surrounds the benefit of additional supplementation with estradiol...
How successful is repeat testicular sperm extraction in patients with azoospermia? (2006)
Vernaeve, Valérie, Verheyen, G., Goossens, A., Steirteghem, A. Van, Devroey, P., Tournaye, H.
BACKGROUND: Little is known about the extraction rate in repeated sperm retrieval procedures in azoospermic patients. This study aimed to assess the feasibility of repeated sperm recovery in these...
Fatemi, H.M., Kolibianakis, E.M., Camus, M., Tournaye, H., Donoso, P., Papanikolaou, E., ...
BACKGROUND: The role of progesterone for luteal support in stimulated cycles for IVF is well established. However, controversy still surrounds the benefit of additional supplementation with estradiol...
Donoso, P., Platteau, P., Papanikolaou, E.G., Staessen, C., Van Steirteghem, A., Devroey, P.
BACKGROUND: An increased incidence of aneuploid embryos has been recently described from azoospermic men. The aim of this study was to assess if embryo selection on day 5, based on morphological...
ESHRE Task Force on Ethics and Law 11: Posthumous assisted reproduction (2006)
Pennings, G., De Wert, G., Shenfield, F., Cohen, J., Devroey, P., ...
This article analyses the different ethical aspects of posthumous assisted reproduction. Two situations are distinguished: cases in which the gametes or embryos are used by the surviving partner and...
ESHRE Task Force on Ethics and Law 10: Surrogacy (2005)
SHENFIELD, F, Pennings, Guido, COHEN, J, DEVROEY, P, DE WERT, G, TARLATZIS, B
ESHRE Task Force on Ethics and Law 10: Surrogacy (2005)
Shenfield, F., Pennings, G., Cohen, J., Devroey, P., De Wert, G., ...
This 10th statement of the Task Force on Ethics and Law considers ethical questions specific to varied surrogacy arrangements. Surrogacy is especially complex as the interests of the intended...
Kolibianakis, E.M., Schultze-Mosgau, A., Schroer, A., Van Steirteghem, A., Devroey, P., Diedrich, K., ...
BACKGROUND: Eliciting an endogenous LH surge by GnRH-agonist for the induction of final oocyte maturation may be more physiological compared with the administration of HCG. However, the efficacy of...
Papanikolaou, E.G., Vernaeve, V., Kolibianakis, E., Assche, E.Van, Bonduelle, M., Liebaers, I., ...
BACKGROUND: There is no agreement about the frequency of chromosomal abnormalities (CAs) in the female partner of an infertile couple and therefore there is no evidence base for determining whether...
Preimplantation genetic diagnosis for neurofibromatosis type 1 (2005)
Spits, C., De Rycke, M., Van Ranst, N., Joris, H., Verpoest, W., Lissens, W., ...
PGD is an alternative to prenatal diagnosis that circumvents therapeutic abortion. Diagnosis is carried out on single cells obtained from three-day-old embryos, and only those that are free of the...
Preimplantation genetic diagnosis for neurofibromatosis type 1 (2005)
Spits, C., De Rycke, M., Van Ranst, N., Joris, H., Verpoest, W., Lissens, W., ...
PGD is an alternative to prenatal diagnosis that circumvents therapeutic abortion. Diagnosis is carried out on single cells obtained from three-day-old embryos, and only those that are free of the...
Shenfield, F., Pennings, G., Cohen, J., Devroey, P., Tarlatzis, B.
This 9th statement of the ESHRE Taskforce on Ethics and Law considers ethical questions and specific dilemmas concerning preimplantation genetic diagnosis for human leukocyte antigen typing of...
ESHRE Task Force on Ethics and Law 10: Surrogacy (2005)
Shenfield, F., Pennings, G., Cohen, J., Devroey, P., De Wert, G., ...
This 10th statement of the Task Force on Ethics and Law considers ethical questions specific to varied surrogacy arrangements. Surrogacy is especially complex as the interests of the intended...
Kolibianakis, E.M., Schultze-Mosgau, A., Schroer, A., Van Steirteghem, A., Devroey, P., Diedrich, K., ...
BACKGROUND: Eliciting an endogenous LH surge by GnRH-agonist for the induction of final oocyte maturation may be more physiological compared with the administration of HCG. However, the efficacy of...
Papanikolaou, E.G., Vernaeve, V., Kolibianakis, E., VanAssche, E., Bonduelle, M., Liebaers, I., ...
BACKGROUND: There is no agreement about the frequency of chromosomal abnormalities (CAs) in the female partner of an infertile couple and therefore there is no evidence base for determining whether...
Mateizel, I., De Temmerman, N., Ullmann, U., Cauffman, G., Sermon, K., ...
BACKGROUND: Human embryonic stem (hES) cells are pluripotent cells usually derived from the inner cell mass (ICM) of blastocysts. Because of their ability to differentiate into all three embryonic...
Mateizel, I., Temmerman, N. De, Ullmann, U., Cauffman, G., Sermon, K., De Velde, H. Van, ...
BACKGROUND: Human embryonic stem (hES) cells are pluripotent cells usually derived from the inner cell mass (ICM) of blastocysts. Because of their ability to differentiate into all three embryonic...
Brugnon, F., Assche, E. Van, Verheyen, G., Sion, B., Boucher, D., Pouly, J.L., ...
BACKGROUND: To try to explain the infertility of chromosomal translocation carrier patients, we compared the expression of two markers of apoptosis in the sperm of patients and of fertile donors, and...
Reply to Comments on Staessen et al. (2004) (2005)
Staessen, C., Platteau, P., Van Assche, E., Michiels, A., Tournaye, H., Camus, M., ...
Taskforce 8: Ethics of medically assisted fertility treatment for HIV positive men and women (2004)
SHENFIELD, F, Pennings, Guido, COHEN, J, DEVROEY, P, TARLATZIS, B, SUREAU, C
Kolibianakis, E.M., Zikopoulos, K., Schiettecatte, J., Smitz, J., Tournaye, H., Camus, M., ...
BACKGROUND: The significance of suppressed LH levels in GnRH antagonist cycles for IVF outcome is currently unknown. The purpose of this study was to evaluate prospectively the association between LH...
Kolibianakis, E.M., Zikopoulos, K., Verpoest, W., Camus, M., Joris, H., Van Steirteghem, A.C., ...
BACKGROUND: The aim of this study was to compare ongoing pregnancy rates per started cycle between patients randomized at consultation to have embryo transfer either on day 3 or on day 5 of in-vitro...
Kolibianakis, E.M., Zikopoulos, K., Smitz, J., Camus, M., Tournaye, H., Van Steirteghem, A.C., ...
BACKGROUND: The objective of this prospective study was to assess the impact of elevated serum progesterone levels on day 2 of the cycle on pregnancy rates in patients treated by IVF using GnRH...
Platteau, P., Staessen, C., Michiels, A., Tournaye, H., Van Steirteghem, A., Liebaers, I., ...
BACKGROUND: The use of ICSI has been a major breakthrough in the treatment of male infertility. Even azoospermic patients with focal spermatogenesis in the testis (not sufficient to spill over into...
Verheyen, G., Vernaeve, V., Van Landuyt, L., Tournaye, H., Devroey, P., Van Steirteghem, A.
BACKGROUND: This was a retrospective study to determine if diagnostic testicular biopsy followed by cryopreservation should be the procedure of choice for all patients with testicular failure....
A review of ten years experience of ICSI (2004)
Devroey, P., Van Steirteghem, A.
This review summarizes the introduction of ICSI in the early 1990s as an assisted fertilization procedure in couples with severe male factor infertility, who could not be helped by conventional IVF....
Vernaeve, V., Staessen, C., Verheyen, G., Van Steirteghem, A., Devroey, P., Tournaye, H.
BACKGROUND: Contradictory results are available regarding prediction of testicular sperm extraction in 47,XXY patients. This study, therefore, aimed at assessing the availability of testicular sperm...
Georgiou, I., De Rycke, M., Schots, R., Sermon, K., Lissens, W., ...
BACKGROUND: β‐Thalassaemia results from co‐inheritance of two mutant β‐globin alleles. Allogeneic cord blood cell transplantation (CBT) from an HLA‐identical sibling donor is an...
Georgiou, I., De Rycke, M., Schots, R., Sermon, K., Lissens, W., ...
BACKGROUND: β-Thalassaemia results from co-inheritance of two mutant β-globin alleles. Allogeneic cord blood cell transplantation (CBT) from an HLA-identical sibling donor is an excellent treatment...
Vernaeve, V., Staessen, C., Verheyen, G., Van Steirteghem, A., Devroey, P., Tournaye, H.
BACKGROUND: Contradictory results are available regarding prediction of testicular sperm extraction in 47,XXY patients. This study, therefore, aimed at assessing the availability of testicular sperm...
Kolibianakis, E.M., Zikopoulos, K., Smitz, J., Camus, M., Tournaye, H., Van Steirteghem, A.C., ...
BACKGROUND: The objective of this prospective study was to assess the impact of elevated serum progesterone levels on day 2 of the cycle on pregnancy rates in patients treated by IVF using GnRH...
Platteau, P., Staessen, C., Michiels, A., Tournaye, H., Van Steirteghem, A., Liebaers, I., ...
BACKGROUND: The use of ICSI has been a major breakthrough in the treatment of male infertility. Even azoospermic patients with focal spermatogenesis in the testis (not sufficient to spill over into...
Vernaeve, V., Krikilion, A., Verheyen, G., Van Steirteghem, A., Devroey, P., Tournaye, H.
BACKGROUND: Little is known about sperm recovery and ICSI using testicular sperm from men with non-obstructive azoospermia who had a previous orchidopexy. We therefore studied the sperm recovery in...
Kolibianakis, E.M., Zikopoulos, K., Verpoest, W., Camus, M., Joris, H., Van Steirteghem, A.C., ...
BACKGROUND: The aim of this study was to compare ongoing pregnancy rates per started cycle between patients randomized at consultation to have embryo transfer either on day 3 or on day 5 of in-vitro...
Taskforce 8: Ethics of medically assisted fertility treatment for HIV positive men and women (2004)
Shenfield, F., Pennings, G., Cohen, J., Devroey, P., Tarlatzis, B., ...
In this 8th statement of the ESHRE Taskforce on Ethics and Law, the focus is on the ethical issues raised by (assisted) reproduction for HIV positive men and women. Due to treatment improvements,...
Kolibianakis, E.M., Zikopoulos, K., Schiettecatte, J., Smitz, J., Tournaye, H., Camus, M., ...
BACKGROUND: The significance of suppressed LH levels in GnRH antagonist cycles for IVF outcome is currently unknown. The purpose of this study was to evaluate prospectively the association between LH...
Verheyen, G., Vernaeve, V., Van Landuyt, L., Tournaye, H., Devroey, P., Van Steirteghem, A.
BACKGROUND: This was a retrospective study to determine if diagnostic testicular biopsy followed by cryopreservation should be the procedure of choice for all patients with testicular failure....
Devroey, P, Liebaers, I, Van Steirteghem, A
Background: Zona pellucida opening for blastomere removal can be done by mechanical or chemical means, or by laser. So far, only limited data on the use of laser systems for zona drilling in cases of...
Osmanagaoglu, K, Camus, M, Bonduelle, M, Liebaers, I, ...
Objective: To compare pregnancy outcome after prenatal genetic testing by chorionic villus sampling (CVS) or amniocentesis in singleton pregnancies achieved by intracytoplasmic sperm injection (ICSI).
6. Ethical issues related to multiple pregnancies in medically assisted procreation (2003)
SHENFIELD, F, Pennings, Guido, COHEN, J, DEVROEY, P, SUREAU, C, TARLATZIS, B
Taskforce 5: preimplantation genetic diagnosis (2003)
SHENFIELD, F, Pennings, Guido, DEVROEY, P, SUREAU, C, TARLATZIS, B, COHEN, J
Taskforce 5: preimplantation genetic diagnosis (2003)
Shenfield, F., Pennings, G., Devroey, P., Sureau, C., Tarlatzis, B., Cohen, J., ...
The European Society of Human Reproduction and Embryology (ESHRE) Ethics Task Force sets out a recommended multidisciplinary approach to the application of preimplantation genetic diagnosis (PGD)....
Bonduelle, M., Ponjaert, I., Steirteghem, A.Van, Devroey, P., Liebaers, I.
BACKGROUND: Since the introduction of ICSI in 1991, medical outcome studies on ICSI children have been performed, but few have addressed developmental outcome. Hence, this outcome was assessed by...
PGD in 47,XXY Klinefelter's syndrome patients (2003)
Staessen, C., Tournaye, H., Van Assche, E., Michiels, A., Van Landuyt, L., Devroey, P., ...
The use of ICSI has been a major breakthrough in the treatment of male infertility. Even azoospermic patients with focal spermatogenesis in the testis, may benefit from the ICSI technique in order to...
Preimplantation genetic diagnosis for Charcot-Marie-Tooth disease type 1A (2003)
De Vos, A., Sermon, K., De Rijcke, M., Goossens, V., Henderix, P., Van Ranst, N., ...
Charcot–Marie–Tooth (CMT) disease is the ‘common’ name for a range of hereditary peripheral neuropathies. CMT1 is the most common form and is transmitted in an autosomal dominant manner....
Joris, H., De Vos, A., Janssens, R., Devroey, P., Liebaers, I., Van Steirteghem, A.
BACKGROUND: Zona pellucida opening for blastomere removal can be done by mechanical or chemical means, or by laser. So far, only limited data on the use of laser systems for zona drilling in cases of...
Goossens, V., Sermon, K., Lissens, W., De Rycke, M., Saerens, B., De Vos, A., ...
Cystic fibrosis (CF) is an autosomal recessive disease characterized by obstruction and chronic infection of the respiratory tract and pancreatic insufficiency. The first preimplantation genetic...
Preimplantation genetic diagnosis for Huntington's disease with exclusion testing (2002)
De Rijcke, M, Lissens, W, De Vos, A, Platteau, P, Bonduelle, M, ...
Huntington's disease is an autosomal dominant, late-onset disorder, for which the gene and the causative mutation have been known since 1993. Some at-risk patients choose for presymptomatic testing...
Alternative approaches in IVF (2002)
Fauser, B.C., Bouchard, P., Coelingh Bennink, H.J., Collins, J.A., Devroey, P., Evers, J.L., ...
Various new developments in clinical and basic science which may impact on IVF in the near or distant future will be discussed in this review. These key areas include the regulation of early follicle...
III. Gamete and embryo donation (2002)
SHENFIELD, F, Pennings, Guido, SUREAU, C, COHEN, J, DEVROEY, P, TARLATZIS, B
Engel, J.B., Ludwig, M., Felberbaum, R., Albano, C., Devroey, P., Diedrich, K.
BACKGROUND: With the recently introduced GnRH antagonists, soft stimulation protocols on the basis of clomiphene pretreatment should be possible as the pituitary remains fully sensitive at the...
Estimation of spontaneous pregnancies in patients after unsuccessful ICSI treatment (2002)
Osmanagaoglu, K., Kolibianakis, E., Tournaye, H., Devroey, P.
Follow-up of children born after ICSI (2002)
Van Steirteghem, A., Bonduelle, M., Devroey, P., Liebaers, I.
The comparison of outcome of assisted reproductive technology (ART) children and naturally conceived children may be hampered by the difference in characteristics of the infertile patients such as...
Vernaeve, V., Tournaye, H., Schiettecatte, J., Verheyen, G., Steirteghem, A.Van, Devroey, P.
BACKGROUND: Serum inhibin B, a direct product of the Sertoli cells, may serve as a marker of spermatogenesis. The present retrospective study aimed at evaluating the predictive value of inhibin B for...
Prevention of twin pregnancies after IVF/ICSI by single embryo transfer. (2001)
COETSIER, T, DEVROEY, P, Dhont, Marc, EDWARDS, RG, EVERS, H, HAGGLUND, L, ...
I. The moral status of the pre-implantation embryo (2001)
SHENFIELD, F, Pennings, Guido, SUREAU, C, COHEN, J, DEVROEY, P, TARLATZIS, B
II. The cryopreservation of human embryos (2001)
SHENFIELD, F, Pennings, Guido, SEREAU, C, COHE, J, DEVROEY, P, TARLATZIS, B, ...
Comment on the debate article: Embryo implantation: the Rubicon for GnRH antagonists (2001)
Diedrich, K., Frydman, R., Devroey, P., Felberbaum, R., Schally, A.V., Reissmann, T., ...
The Brussels' experience of more than 5 years of clinical preimplantation genetic diagnosis (2000)
Staessen, C, Sermon, K, Van Assche, E, ...
This paper describes the 5 years' experience of preimplantation genetic diagnosis (PGD) at the Brussels Free University. Our first PGD was carried out in February 1993. Up to October 1998, we carried...
The moral value of reproductive agreements in the context of medically assisted reproduction (2000)
Pennings, Guido, HEURCKMANS, N, SABBE, K, RIGO, A, PONJAERT-KRISTOFFERSEN, I, GULDIX, E, ...
Attitude towards the acceptability of controversial groups as recipients and donors of sperm (2000)
PONJAERT-KRISTOFFERSEN, I, HEURCKMANNS, N, Pennings, Guido, SABBE, K, BAETENS, P, RIGO, A, ...
The Brussels' experience of more than 5 years of clinical preimplantation genetic diagnosis (2000)
Vandervorst, M., Staessen, C., Sermon, K., De Vos, A., Van Assche, E., ...
This paper describes the 5 years' experience of preimplantation genetic diagnosis (PGD) at the Brussels Free University. Our first PGD was carried out in February 1993. Up to October 1998, we carried...
Tavaniotou, A., Smitz, J., Bourgain, C., Devroey, P.
Different routes of natural progesterone supplementation have been tried as luteal phase support in infertility treatments. Orally administered progesterone is rapidly metabolized in the...
Romàn, E., Aytoz, A., Smitz, J.E.J., Faguer, B., Camus, M., Van Steirteghem, A.C., ...
This study was designed to determine the effects of a vaginal micronized progesterone preparation on bleeding patterns and pregnancy outcomes after in-vitro fertilization and intracytoplasmic sperm...
Felberbaum, R.E., Albano, C., Ludwig, M., Riethmüller-Winzen, H., Grigat, M., Devroey, P., ...
A total of 346 women with normal ovulatory function was stimulated with human menopausal gonadotrophins (HMG) to attain ovarian stimulation for IVF or intracytoplasmic sperm injection (ICSI)....
Baetens, P., Devroey, P., Camus, M., Van Steirteghem, A.C., Ponjaert-Kristoffersen, I.
In order to avoid a long waiting period, the Centre for Reproductive Medicine of the Free University of Brussels suggests that couples in need of donor oocytes search for a donor among family and...
Albano, C., Felberbaum, R.E., Smitz, J., Riethmüller-Winzen, H., Engel, J., Diedrich, K., ...
In this prospective and randomized study, 188 patients received the luteinizing hormone-releasing hormone (LHRH) antagonist cetrorelix, and 85 patients the LHRH agonist buserelin to prevent...
Seven years of intracytoplasmic sperm injection and follow-up of 1987 subsequent children (1999)
Camus, M, Staessen, C, Tournaye, H, Van Assche, E, ...
Intracytoplasmic sperm injection (ICSI) with ejaculated, epididymal or testicular spermatozoa was first successful in 1992 and has since become the widely accepted treatment for couples with severe...
The influence of the social context on the meaning of sperm donation (1999)
Pennings, Guido, BAETENS, P, KRISTOFFERSEN, I, DEVROEY, P, VAN STEIRTEGHAM, A, STUY, J
Kol, S., Lightman, A., Hillensjo, T., Devroey, P., Fauser, B., Tarlatzis, B., ...
The clinical application of gonadotrophin-releasing hormone (GnRH) antagonists instead of GnRH agonists, to prevent spontaneous premature luteinizing hormone surge during ovarian stimulation for...
Albano, C., Smitz, J., Tournaye, H., Riethmüller-Winzen, H., Van Steirteghem, A., Devroey, P.
The luteal phase hormonal profile and the clinical outcome of 69 patients undergoing in-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) after ovarian stimulation with human...
Liebaers, I, Sermon, K, Staessen, C, ...
The inheritance pattern of monogenic inheritable disorders influences the proportion of unaffected embryos after preimplantation genetic diagnosis (PGD), We aimed to investigate the influence of the...
Motile organisms in the epididymis? [In Process Citation] (1998)
Pierard, D, Janssenswillen, C, Tournaye, H, Devroey, P, Van Steirteghem, A
Hysteroscopic septum resection in patients with recurrent abortions or infertility (1998)
Grimbizis, G, Camus, M, Clasen, K, Tournaye, H, De Munck, L, Devroey, P
Preparation of endometrium for egg donation (1998)
Nowadays oocyte donation is a well established method of assisted reproduction and offers the unique opportunity to treat patients with various clinical indications, with or without ovarian function,...
Verheyen, G, Nagy, P, Ubaldi, F, Silber, S, ...
Recovery of testicular spermatozoa from azoospermic patients with testicular failure followed by intracytoplasmic sperm injection (ICSI) is a recent advance in the treatment of male infertility. This...
Oocyte donors: helping out family and friends (1997)
BAETENS, P, DESAEDELEER, V, Pennings, Guido, DEVROEY, P, VANSTEIRTEGHEM, AC, PONJAERTKRISTOFFERSEN, I
Microsurgical epididymal sperm aspiration with motile trophozoite cells but no spermatozoa (1997)
Janssenswillen, C, Tournaye, H, Pierard, D, Devroey, P, Van Steirteghem, A
Patients with absolutely immotile spermatozoa and intracytoplasmic sperm injection (1997)
Vandervorst, M, Tournaye, H, Camus, M, Nagy, ZP, Van Steirteghem, A, Devroey, P
Viability of partially damaged human embryos after cryopreservation (1997)
Camus, M, Van Waesberghe, L, Devroey, P, Van Steirteghem, AC
Tournaye, H, Silber, S, Van Steirteghem, A C, Devroey, P
OBJECTIVE: To describe two cases with testicular seminoma incidentally discovered at the time of successful testicular sperm extraction for intracytoplasmic sperm injection (ICSI)> DESIGN: Report of...
Nagy, P Z, Camus, M, Silber, S, ...
A comprehensive study is presented of a series of 124 infertile men undergoing testicular sperm retrieval for intracytoplasmic sperm injection (ICSI). In this study we correlated the histological...
Albano, C., Smitz, J., Camus, M., Bennink, H.Coelingh, Van Steirteghem, A.C., Devroey, P.
We report a case of an allergic reaction to i.m. injections of urinary human menopausal gonadotrophin (HMG) and a successful management of the problem by using recombinant follicle stimulating...
Tournaye, H., Liu, J., Nagy, P.Z., Camus, M., Goossens, A., Silber, S., ...
A comprehensive study is presented of a series of 124 infertile men undergoing testicular sperm retrieval for intracytoplasmic sperm injection (ICSI). In this study we correlated the histological...
Cystic fibrosis, Duchenne muscular dystrophy and preimplantation genetic disorders (1996)
Liu, J, Lissens, W, Devroey, P, Liebaers, I, Van Steirteghem, A
Cystic fibrosis (CF) is the most common genetic disease among Caucasians. Duchenne muscular dystrophy (DMD) is one of the most common X-linked genetic disorders. The CF and DMD genes were discovered...
Female age predicts embryonic implantation after ICSI: a case-controlled study (1996)
Devroey, P., Godoy, H., Smitz, J., Camus, M., Tournaye, H., Derde, M.P., ...
From 1 October 1991 until 31 December 1993, 1270 cycles for intracytoplasmic sperm injection were performed. Of these, 71 (5.6%) were carried out in women ≥40 years of age. The semen...
Prospective follow-up study of 423 children born after intracytoplasmic sperm injection (1996)
Bonduelle, M., Legein, J., Buysse, A., Van Assche, E., Wisanto, A., Devroey, P., ...
In order to evaluate the safety of the intracytoplasmic sperm injection (ICSI) procedure, a prospective follow-up study of 423 children born after ICSI was carried out. The aim of this study was to...
Devroey, P., Nagy, P., Toumaye, H., Liu, J., Silber, S., Van Steirteghem, A.
From 1 August 1993 until 30 September 1994, 69 couples suffering from azoospermia underwent testicular sperm extraction and intracytoplasmic sperm injection. In 50 couples with obstructive...
Albano, C., Smitz, J., Camus, M., Riethmüller-Winzen, H., Siebert-Weigel, M., Diedrich, K., ...
A third-generation gonadotrophin-releasing hormone antagonist (Cetrorelix) was used during ovarian stimulation in 32 patients undergoing assisted reproduction, in order to prevent the premature...
Recent concepts in the management of infertility because of non-obstructive azoospermia (1995)
Camus, M, Liu, J, Nagy, P, Silber, S, ...
Testicular biopsy has been widely used for the diagnosis of male infertility. Since the introduction of intracytoplasmic sperm injection (ICSI), spermatozoa recovered from a testicular biopsy...
Obstetric outcome of 424 pregnancies after intracytoplasmic sperm injection (1995)
Wisanto, A., Magnus, M., Bonduelle, M., Liu, J., Camus, M., Tournaye, H., ...
An evaluation of the outcome of pregnancies resulting from intracytoplasmic sperm injection for severe male factor infertility was conducted by analysing the data obtained from the patients...
Lesbian mothers who conceived after donor insemination: a follow-up study (1995)
Brewaeys, A., Devroey, P., Helmerhorst, F.M., Hall, E.V. Van, Ponjaert, I.
This study investigated the development of family relationships in lesbian families who conceived after donor insemination (DI). The main characteristics of this unknown family structure were...
Ubaldi, F., Smitz, J., Wisanto, A., Joris, H., Schiettecatte, J., Derde, M.P., ...
The effect of elevated serum progesterone concentrations (>1 ng/1) on or before the day of human chorionic gonadotrophin (HCG) injection on the outcome of women receiving gonadotrophin-releasing...
Nagy, Z.P., Liu, J., Joris, G., Bocken, G., Desmet, B., Van Ranst, A., ...
The aims of this study were to examine, in a prospective, controlled way, the effect of the sperm deposition site in the oocyte and the mode of oolemma breakage in intracytoplasmic sperm injection...
Staessen, C., Nagy, Z.P., Liu, J., Janssenswillen, C., Camus, M., Devroey, P., ...
High incidences of multiple pregnancies, after transferring a maximum of three embryos, were observed after in-vitro fertilization (IVF) treatment. In a randomized study, it was demonstrated that,...
Bonduelle, M., Legein, J., Buysse, A., Schietecatte, J., Wisanto, A., ...
The safety of intracytoplasmic sperm injection (ICSI) as a novel procedure of assisted fertilization may be assessed by the health of the children born. In a prospective followup study of children...
Devroey, P., Tjandraprawira, K., Mannaerts, B., Bennink, H.Coelingh, Smitz, J., Bonduelle, M., ...
A randomized, assessor-blind, group-comparative study was performed to compare the efficacy of Normegon® [75 IU follicle stimulating hormone (FSH) and 25 IU luteinizing hormone (LH)] and Metrodin®...
Comparison of four mechanical methods to retrieve spermatozoa from testicular tissue (1995)
Verheyen, G., De Croo, I., Tournaye, H., Pletincx, I., Devroey, P., Van Steirteghem, A.C.
To maximize the total number of spermatozoa which can be retrieved from a testicular biopsy, four mechanical methods for preparation were compared. In all, 17 biopsies were divided into four equal...
Silber, S.J., Van Steirteghem, A.C., Liu, J., Nagy, Z., Tournaye, H., Devroey, P.
In cases requiring microsurgical epididymal sperm aspiration (MESA) for congenital absence of the vas deferens (CAVD) or irreparable obstructive azoospermia, often no spermatozoa can be retrieved...
Chedid, S., Camus, M., Smitz, J., Van Steirteghem, A.C., Devroey, P.
The objective of our study was to establish the most adequate ovarian stimulation regimen for assisted procreation in endometriotic patients. It consisted of a retrospective analysis comparing the...
Nagy, Z.P., Verheyen, G., Liu, J., Joris, H., Janssenswillen, C., Wisanto, A., ...
Antisperm antibodies present in the semen can be a primary cause of infertility. If the proportion of spermatozoa carrying antisperm antibodies is very high, then usually a poor result ensues in...
Small diameter laparoscopy using a microlaparoscope (1995)
Bauer, O., Devroey, P., Wisanto, A., Gerling, W., Kaisi, M., Diedrich, K.
In order to determine the suitability of new microlaparoscopes of
Ethics and society: Artificial insemination by donor: an alternative for single women (1995)
Baetens, P., Ponjaert-Kristoffersen, I., Devroey, P., Van Steirteghem, A.C.
Artificial insemination using donor spermatozoa (AID) has been known as a treatment for heterosexual couples where the husband has been found to be infertile. The first woman without a male partner...
Devroey, P, Liu, J, Nagy, Z, Goossens, A, Tournaye, H, Camus, M, ...
Nagy, Z.P., Liu, J., Joris, H., Verheyen, G., Tournaye, H., Camus, M., ...
High success rates have been reported for the use of intracytoplasmic sperm injection (ICSI) in alleviating essentially andrological infertility. However, neither the relationship between any of the...
The evolution and outcome of pregnancies from oocyte donation (1994)
Pados, G., Camus, M., Van Steirteghem, A., Bonduelle, M., Devroey, P.
A total of 199 patients participated in the oocyte donation programme in 336 replacement cycles in whom 69 clinical pregnancies were achieved, of which 53 reached term and delivery. Data concerning...
Nagy, Z.P., Liu, J., Joris, H., Devroey, P., Van Steirteghem, A.
Knowledge of the timing of the stages of fertilization in humans is still limited because the time of gamete fusion is not known when pre-ovulatory or in-vitro matured cumulus-enclosed oocytes are...
Bonduelle, M., Desmyttere, S., Buysse, A., Van Assche, E., Schietecatte, J., Devroey, P., ...
In 163 couples referred for assisted fertilization, pregnancy was established by subzonal insemination (SUZI), intracytoplasmic sperm injection (ICSI) or a combination of both techniques. These...
Devroey, P., Mannaerts, B., Smitz, J., Bennink, H.Coelingh, Van Steirteghem, A.
In total, 50 couples participated in a pilot study evaluating the efficacy of various regimens of gonadotrophin-releasing hormone agonist (GnRHa) in association with recombinant human...
Verheyen, G., Tournaye, H., Laurier, K., Devroey, P., Van Steirteghem, A.
Selection of antibody-free spermatozoa by immunobead adsorption was performed as a preliminary test in order to check probable recovery before introducing the procedure in an in-vitro fertilization...
Bourgain, C., Smitz, J., Camus, M., Erard, P., Devroey, P., Van Steirteghem, A.C., ...
In human cycles stimulated for ovulation with gonadotrophin–releasing hormone (GnRH) agonists and human menopausal gonadotrophin (HMG), a luteal phase defect has been described. To evaluate the...
Staessen, C., Van Abbeel, E.den, Janssenswillen, C., Devroey, P., Van Steirteghem, A.C.
In order to optimize the in-vitro fertilization (IVF) procedure and to avoid the batch-to-batch fluctuations of in-house culture medium, we investigated the use of a commercially available medium. In...
Staessen, C., Janssenswillen, C., Devroey, P., Van Steirteghem, A.C.
Attempts to increase the probability of a successful pregnancy in in-vitro fertilization (IVF) treatment by increasing the number of embryos transferred automatically also increase the probability of...
Nagy, Z.P., Joris, H., Liu, J., Staessen, C., Devroey, P., Van Steirteghem, A.C.
Although the average fertilization rate in most in-vitro fertilization (IVF) centres is ∼60–70%, there are cases of complete or virtually complete fertilization failures. The aim of our...
Comparison of two local anaesthetics in transvaginal ultrasound-guided oocyte retrieval (1993)
Godoy, H., Erard, P., De Munck, L., Camus, M., Gepts, E., Van Steirteghem, A.C., ...
Transvaginal ultrasound-guided oocyte retrieval is an accepted procedure in most in-vitro fertilization programmes. In order to simplify the anaesthetic procedure into a minimally invasive one, we...
Staessen, C., Janssenswillen, C., Devroey, P., Steirteghem, A.C.Van
At 16–18 h after insemination, 5.5% of the inseminated oocytes displayed only one pronucleus. The incidence of single-pronucleated oocytes was not correlated with the age of the patient....
Smitz, J., Bourgain, C., Van Waesberghe, L., Camus, M., Devroey, P., Van Steirteghem, A.C.
A prospective randomized study was conducted to evaluate the use of adding oestradiol valerate 6 mg per os daily to intravaginal micronized progesterone (600 mg daily) as luteal supplements. The...
Smitz, J., Abbeel, E. Van Den, Bollen, N., Camus, M., Devroey, P., Tournaye, H., ...
Sixty-three normo-ovulatory infertile women were randomly divided into two groups. All women were first desensitized with the gonadotrophin-releasing hormone agonist (GnRHa), buserelin. Thereafter,...
Oocyte and embryo donation: evaluation of 412 consecutive trials (1992)
Pados, G., Camus, M., Van Waesberghe, L., Liebaers, I., Van Steirteghem, A., Devroey, P.
A total of 199 patients (412 consecutive cycles) were treated by oocyte-embryo donation in 336 replacement cycles. Of these, 296 involved intra-uterine embryo transfers, 38 zygote intra-Fallopian...
Laparoscopic application of Interceed (TC7) (1992)
Pados, G., Camus, M., De Munck, L., Devroey, P.
Interceed (TC7) is a surgical adjuvant which has been shown to be efficacious in reducing adhesion formation in gynaecological pelvic surgery by laparotomy. In view of the increasing number of...
Smitz, J., Devroey, P., Faguer, B., Bourgain, C., Camus, M., Steirteghem, A.C. Van
A luteal phase defect has been demonstrated in cycles stimulated using a protocol including a gonadotrophin releasing hormone agonist (GnRHa). We have conducted a randomized prospective study of...
Induction of acrosome reaction in human spermatozoa used for subzonal insemination (1992)
Palermo, G., Joris, H., Devroey, P., Van Steirteghem, A.C.
Human spermatozoa were injected into the perivitelline space of oocytes from 43 couples (44 cycles) in whom fertilization had failed in conventional in-vitro fertilization (IVF). The spermatozoa were...
Smitz, J., Erard, P., Camus, M., Devroey, P., Tournaye, H., Wisanto, A., ...
Pituitary gonadotrophin reserve and basal gonadotrophin secretion were tested during the luteal phase in women superovulated with buserelin/human menopausal gonadotrophin (HMG) in a...
{beta}-N-acetylhexosaminidase activity in human oocytes and preimplantation embryos (1992)
Sermon, K., Lissens, W., Tarlatzis, B., Braude, P.R., Devroey, P., Van Steirteghem, A., ...
β-N-acetylhexosaminidase is a lysosomal enzyme, which has two isoenzymes: β-Hex A, a trimer consisting of one α-chain and two β-chains (αβ2) and β-Hex B, a tetramer formed of four β-chains...
Smitz, J., Camus, M., Devroey, P., Bollen, N., Tournaye, H., Van Steirteghem, A.C.
Buserelin was inadvertently administered during 13 early pregnancies in 12 women with long-standing infertility, who had started the GnRHI-agonist for gonadotrophin desensitization prior to ovarian...
Smitz, J., Camus, M., Devroey, P., Erard, P., Wisanto, A., Van Steirteghem, A.C.
In 1673 treatment cycles stimulated with buserelin and HMG, for IVF, GIFT or ZIFT, the severe ovarian hyperstimulation syndrome (OHSS) occurred in 10 cycles (0.6%). Eight patients were...
Bourgain, C., Devroey, P., Waeshberghe, L.Van, Smitz, J., Steirteghem, A.C.Van
In 43 patients without ovaries, endometrial biopsies at day 21 of 75 substituted cycles were studied by Light and electron microscopy. The morphology of the endometrium was compared after oral,...
Smitz, J., Bollen, N., Camus, M., Devroey, P., Wisanto, A., Steirteghem, A.C.Van
Ten endocrinologically normal women were injected subcutaneously with 500 μg D-Ser(TBU)6-EA10-LHRH (buserelin) on days 3,4 and 5 after the start of the menses. Two types of response were observed....
Endocrinology in luteal phase and implantation (1990)
Smitz, J, Devroey, P, Van Steirteghem, A C
The normality of the luteal phase after superovulation depends on the method and adequacy of the stimulation regimen. In comparison with natural cycles, the luteinisation of multiple follicles...
Counselling and selection of homosexual couples in fertility treatment (1989)
Brewaeys, A., Olbrechts, H., Devroey, P., Van Steirteghem, A.C.
Artificial insemination with anonymous donor sperm (AID) is a widespread practice for heterosexual couples in which the male partner appears to be infertile. The Centre for Reproductive Medicine of...
Zygote intra-Fallopian transfer as an alternative treatment for male infertility (1989)
Palermo, G., Devroey, P., Camus, M., De Grauwe, E., Khan, I., Staessen, C., ...
The results of 42 zygote intra-Fallopian transfer cycles in 37 couples with persistent male infertility are reported. Of 396 retrieved oocytes, 39.1% fertilized normally and 63 zygotes were replaced...
Oocyte donation in patients without ovarian function (1988)
Devroey, P., Wisanto, A., Camus, M., Waesberghe, L.Van, Bourgain, Cl., Liebaers, I., ...
The clinical, hormonal and cytogenetic findings in 36 women with primary ovarian failure, referred for oocyte or embryo donations are reported. Fifteen women were suffering from ovarian dysgenesis...
Verbessem, D., Camu, F., Devroey, P, Steirteghem, A.Van
The effects of different insufflation media gases for pneumoperitoneum on the acidity of follicular fluid and blood acid-base balance were studied in two groups of patients during laparoscopic oocyte...
Deschacht, J., Devroey, P., Camus, M., Khan, I., Smitz, J., Staessen, C., ...
When previous attempts at in-vitro fertilization using semen from the husband failed, a subsequent IVF attempt was performed using husband and donor sperm in order to compare fertilization and embryo...
The luteal phase after in-vitro fertilization and related procedures (1988)
Steirteghem, A.C.Van, Smitz, J., Camus, M., Waesberghe, L. Van, Deschacht, J., Khan, I., ...
To evaluate any beneficial effect of progesterone supplemen–tation during the luteal phase of GIFT or IVF cycles stimulated by clomiphene citrate and HMG, two random prospective studies were...
Hens, L., Bonduelle, M., Liebaers, I., Devroey, P.
Cytogenetic studies were performed in 500 couples referred for in-vitro fertilization or gamete (zygote) intra-Fallopian transfer. Thirteen individuals (1.3%) with chromosomal abnormalities were...
Smitz, J., Devroey, P., Camus, M., Deschacht, J., Khan, I., Staessen, C., ...
Endometrial biopsies showing inadequate development were observed after ovarian stimulation with the GnRH agonist Buserelin and HMG for IVF or GIFT when luteal supplementation was omitted. Ninety-one...
Effects of etomidate on ovarian steroidogenesis (1987)
Heytens, L., Devroey, P., Camu, F., Van Steirteghem, A.C.
The present study investigated the influence of two i.v. induction agents, etomidate (0.25 mg/kg) and thiopental (4 mg/kg) followed by isofluorane anaesthesia on the venous blood...
Gamete intra-Fallopian transfer: evaluation of 100 consecutive attempts (1987)
Braeckmans, P., Devroey, P., Camus, M., Khan, I., Staessan, C., Smitz, J., ...
The results of 100 gamete intra-Fallopian transfer (GIFT) procedures to treat persistent infertility are reported. Twenty-four pregnancies were achieved, of these six aborted, two were extra-uterine,...
Van Steirteghem, A.C., Camus, M., Van Waesberghe, L., Braeckmans, P., Khan, I., ...
During a one-year period 636 excess embryos obtained after in-vitro fertilization and gamete intra-Fallopian transfer combined with in-vitro fertilization were cryopreserved using two different...
Smitz, J., Devroey, P., Braeckmans, P., Camus, M., Khan, I., Staessen, C., ...
The addition of the gonadotrophin rrleasing hormone (GnRH) agonist Buserelin to human menopausal gonadotrophin/human chorioaic gonadotrophin (HMG/MCG) during ovarian stimulation was evaluated...
Endocrine profiles in early pregnancies with delayed implantation (1986)
Naaktgeboren, N., Devroey, P., Wisanto, A., Traey, E., Van Steirteghem, A.C.
Delayed implantation in cycles with ovarian stimulation and ovulation induction was observed in eight patients. Endocrinological evidence for ovulation during pregnancy is presented in three cases;...
Hyperthyroidism after gonadotrophic ovarian stimulation
Noppen, M, Velkeniers, B, Buydens, P, Devroey, P, Van Steirteghem, A, Vanhaelst, L
Hyperthyroidism after gonadotrophic ovarian stimulation
Noppen, M, Velkeniers, B, Buydens, P, Devroey, P, Van Steirteghem, A, Vanhaelst, L