Long-term outcome following total knee arthroplasty: a controlled longitudinal study (2009)
Cushnaghan, J., Bennett, J., Reading, I., Croft, P., Byng, P., Cox, K., ...
Objectives: to assess long-term outcome and predictors of prognosis following total knee arthroplasty (TKA) for osteoarthritis. Methods: we followed-up 325 patients from 3 English health districts...
Developing and evaluating complex interventions: the new Medical Research Council guidance (2008)
Craig , P., Dieppe, P., Macintyre, S., Michie, S., Nazareth, I., Petticrew, M.
Hawker, GA, Davis, AM, French, MR, Cibere, J, Jordan, JM, March, L, ...
OBJECTIVE: To evaluate the measurement properties of a new osteoarthritis (OA) pain measure. METHODS: The new tool, comprised of 12 questions on constant vs intermittent pain was administered by...
Long-term outcome following total knee arthroplasty: a controlled longitudinal study (2008)
Cushnaghan, J., Bennett, J., Reading, I., Croft, P., Byng, P., Cox, K., ...
Objectives: To assess long-term outcome and predictors of prognosis following total knee arthroplasty (TKA) for osteoarthritis. Methods: We followed-up 325 patients from three English health...
Stone, M. A., Pomeroy, E., Keat, A., Sengupta, R., Hickey, S., Dieppe, P., ...
Objectives. Many AS patients report periods of perceived higher disease activity (flares). This pilot study aims to document disease activity patterns reported by AS patients and examine associations...
Turning evidence into recommendations: protocol of a study guideline development groups (2007)
Michie, S., Berentson-Shaw, J., Pilling, S., Feder, G., Dieppe, P., Raine, R., ...
Background: Health care practice based on research evidence requires that evidence is synthesised, and that recommendations based on this evidence are implemented. It also requires an intermediate...
Long-term outcome following total hip arthroplasty: A controlled longitudinal study (2007)
Cushnaghan, J., Coggon, D., Reading, I., Croft, P., Byng, P., Cox, K., ...
OBJECTIVE: To assess long-term outcome and predictors of prognosis following total hip arthroplasty (THA) for osteoarthritis (OA). METHODS: We studied 282 patients from 2 English health districts...
Adamson, J., Ebrahim, S., Dieppe, P., Hunt, K.
Objective: To examine the association between three modifiable risk factors (obesity, smoking, and alcohol consumption) and reported joint pain. Methods: Cross sectional data were collected on 858...
What is successful ageing and who should define it? (2005)
The substantial increases in life expectancy at birth achieved over the previous century, combined with medical advances, escalating health and social care costs, and higher expectations for older...
Is it time for more rheumatologists to embrace osteoarthritis? (2005)
Birrell, F., Arden, N.K., Conaghan, P.G., Cooper, C., Dieppe, P., Doherty, M.
Is it time for more rheumatologists to embrace osteoarthritis? (2005)
Birrell, F., Arden, N. K., Conaghan, P. G., Cooper, C., Dieppe, P., Doherty, M.
Is it time for more rheumatologists to embrace osteoarthritis? (2005)
Birrell, F., Arden, N. K., Conaghan, P. G., Cooper, C., Dieppe, P., Doherty, M.
Jordan, K.M., Arden, N.K., Doherty, M., Bannwarth, B., Bijlsma, J.W., Dieppe, P., ...
Objectives: To update the EULAR recommendations for management of knee osteoarthritis (OA) by an evidence based medicine and expert opinion approach. Methods: The literature search and guidelines...
Population requirement for primary knee replacement surgery: a cross-sectional study (2003)
Juni, P., Dieppe, P., Donovan, J., Peters, T., Eachus, J., Pearson, N., ...
Objectives. To determine the population requirement for total knee replacement (TKR) in England Methods. Population-based study using an age/sex-stratified random sample of 28 080 individuals aged 35...
Population requirement for primary knee replacement surgery: a cross-sectional study (2003)
Juni, P., Dieppe, P., Donovan, J., Peters, T., Eachus, J., Pearson, N., ...
Objectives. To determine the population requirement for total knee replacement (TKR) in England Methods. Population‐based study using an age/sex‐stratified random sample...
Population requirement for primary knee replacement surgery: a cross-sectional study (2003)
Juni, P., Dieppe, P., Donovan, J., Peters, T., Eachus, J., Pearson, N., ...
Objectives. To determine the population requirement for total knee replacement (TKR) in England Methods. Population-based study using an age/sex-stratified random sample of 28 080 individuals aged 35...
The utilization of synovial fluid analysis in the UK (2001)
Amer, H., Swan, A., Dieppe, P.
Objective. To ascertain what use is being made of synovial fluid analysis in the UK, who is carrying out polarized light microscopy (PLM), and what confidence clinicians have in the...
Recommendations for the registration of drugs used in the treatment of osteoarthritis. (1996)
DOUGADOS, M, DEVOGELAER, JP, ANNEFELDT, M, AVOUAC, B, BOUVENOT, G, COOPER, C, ...
Training in Rheumatology (1996)
BLAKE, D., DIEPPE, P., EMERY, P., MADDISON, P., NUKI, G., PANAYI, G. S., ...
OSTEOARTHRITIS OF THE SCAPHO-TRAPEZIAL JOINT (1994)
In a cohort of 199 patients with OA we studied the prevalence of radiographic scapho-trapezial joint osteoarthritis (STJOA) and its clinical features. The prevalence of STJ OA was 38%. Lone...
ACUTE INFLAMMATORY POLYARTHRITIS IN ASSOCIATION WITH TAMOXIFEN (1994)
CREAMER, P., LIM, K., GEORGE, E., DIEPPE, P.
The antioestrogen drug tamoxifen is widely used to treat breast carcinoma. We report three cases in which its use was temporally related to the development of an acute inflammatory polyarthritis...
THE EXPRESSION OF RHEUMATOID ARTHRITIS IN MALAYSIAN AND BRITISH PATIENTS: A COMPARATIVE STUDY (1993)
VEERAPEN, K., MANGAT, G., WATT, I., DIEPPE, P.
Seventy consecutive patients with definite or classical RA attending a University Hospital Rheumatology Clinic in Malaysia, were compared with an age, sex, disease duration matched group of RA...
DIEPPE, P., CUSHNAGHAN, J., JASANI, M. K., MCCRAE, F., WATT, I.
Eighty-nine patients with established OA of the knee joint, already on regular NSAIDs for joint pain, were randomly allocated to receive lOOmg/day of slow release diclofenac (45 patients) or...
INCREASING AWARENESS OF ARTHRITIS--THE PUBLIC'S RESPONSE (1993)
Six hundred and fifty telephone calls in response to a television programme about arthritis have been analysed for their content. Social and psychological isolation, lack of pain control and fears of...
PYROPHOSPHATE ARTHROPATHY: A PROSPECTIVE STUDY (1993)
DOHERTY, M., DIEPPE, P., WATT, I.
One hundred and four consecutive patients with pyrophosphate arthropathy were followed prospectively and re-studied at a mean of 4.6 years. Sixty-four patients (43F, 21M; mean age at review 71.2...
VEERAPEN, K., WATT, I., DIEPPE, P.
Four patients with mild CREST syndrome and extensive subcutaneous calcification have been studied over a 5-year period. There was no correlation between mineral deposition and other features of the...
APPARENT BONE EROSIONS IN PAINFUL REGIONAL OSTEOPOROSIS (1980)
DOHERTY, M., WATT, I., DIEPPE, P.
A case of painful regional osteoporosis of the foot is described. The radiographs show apparent erosions of bone, which resolved completely as bone density improved. The significance of erosions...
Seegmiller, J E, Dixon, R M, Kemp, G J, Angus, P W, McAlindon, T E, Dieppe, P, ...
The hyperuricemia responsible for the development of gouty arthritis results from a wide range of environmental factors and underlying genetically determined aberrations of metabolism. 31P magnetic...
Evidence for altered synthesis of type II collagen in patients with osteoarthritis.
Nelson, F, Dahlberg, L, Laverty, S, Reiner, A, Pidoux, I, Ionescu, M, ...
There is evidence to suggest that the synthesis of type II collagen is increased in osteoarthritis (OA). Using an immunoassay, we show that the content of the C-propeptide of type II procollagen...
The effects of serum and human albumin on calcium hydroxyapatite crystal growth.
The effects of potential serum inhibitors upon the growth of calcium hydroxyapatite (HAP) crystals were studied in vivo using a pH-stat system. Whole serum caused a marked decrease in crystal growth...
Seegmiller, J E, Dixon, R M, Kemp, G J, Angus, P W, McAlindon, T E, Dieppe, P, ...
The hyperuricemia responsible for the development of gouty arthritis results from a wide range of environmental factors and underlying genetically determined aberrations of metabolism. 31P magnetic...
Evidence for altered synthesis of type II collagen in patients with osteoarthritis.
Nelson, F, Dahlberg, L, Laverty, S, Reiner, A, Pidoux, I, Ionescu, M, ...
There is evidence to suggest that the synthesis of type II collagen is increased in osteoarthritis (OA). Using an immunoassay, we show that the content of the C-propeptide of type II procollagen...
The effects of serum and human albumin on calcium hydroxyapatite crystal growth.
The effects of potential serum inhibitors upon the growth of calcium hydroxyapatite (HAP) crystals were studied in vivo using a pH-stat system. Whole serum caused a marked decrease in crystal growth...
Osteoarthritis and articular chondrocalcinosis in the elderly.
Wilkins, E, Dieppe, P, Maddison, P, Evison, G
One hundred consecutive admissions to an acute geriatric unit were examined for clinical and radiographic evidence of osteoarthritis (OA) and articular chondrocalcinosis (ACC). Thirty-four patients...
Five hundred and sixty intact skeletons and several thousand disarticulated vertebrae have been examined with special reference to spinal fusion. In period they ranged from a 21st dynasty Egyptian...
A reappraisal of 'analgesic hip'.
Doherty, M, Holt, M, MacMillan, P, Watt, I, Dieppe, P
Nineteen patients with hip radiographs typical of 'analgesic hip' (rapidly destructive, atrophic arthropathy involving both femoral and acetabular components) have been studied. Women predominated...
Regressive systemic sclerosis.
Black, C, Dieppe, P, Huskisson, T, Hart, F D
Systemic sclerosis is a disease which usually progresses or reaches a plateau with persistence of symptoms and signs. Regression is extremely unusual. Four cases of established scleroderma are...
Detection of crystals in synovial fluids by light microscopy: sensitivity and reliability.
Polarised light microscopy of synovial fluid is an established diagnostic technique widely regarded as reliable for the detection of crystals. The threshold concentration of crystals which can be...
Osteoarthritis of the knee joint: an eight year prospective study.
Massardo, L, Watt, I, Cushnaghan, J, Dieppe, P
Thirty one patients (25 women, six men, mean age 71.7 years) with established osteoarthritis (OA) of the knee were examined clinically and radiologically on two occasions, eight years apart. Four...
Clinical assessment of osteoarthritis of the knee.
Cushnaghan, J, Cooper, C, Dieppe, P, Kirwan, J, McAlindon, T, McCrae, F
The repeatability of physical signs used to assess osteoarthritis of the knee has not been systematically examined. The within and between observer variation of 10 commonly used physical signs to...
Five hundred subjects with symptomatic limb joint osteoarthritis, who had been referred to a rheumatologist, were enrolled into a continuing study. They comprised 342 women (mean age 65.3) and 158...
Scintigraphic assessment of osteoarthritis of the knee joint.
McCrae, F, Shouls, J, Dieppe, P, Watt, I
Clinical, radiographic, and scintigraphic abnormalities of the knee joint have been correlated in a cross sectional study of 100 patients with osteoarthritis. The group comprised 73 women and 27 men...
Dieppe, P, Cushnaghan, J, Young, P, Kirwan, J
OBJECTIVES--To test the hypothesis that bone scintigraphy will predict the outcome of osteoarthritis (OA) of the knee joint. METHODS--Ninety four patients (65 women, 29 men; mean age 64.2 years) with...
Occupational activity and osteoarthritis of the knee.
Cooper, C, McAlindon, T, Coggon, D, Egger, P, Dieppe, P
OBJECTIVES--To test the hypothesis that specific occupational physical activities are risk factors for knee osteoarthritis (OA). METHODS--A population-based case-control study of knee osteoarthritis...
Submicroscopic crystals in osteoarthritic synovial fluids.
Swan, A, Chapman, B, Heap, P, Seward, H, Dieppe, P
OBJECTIVES--To investigate the hypothesis that synovial fluid (SF) from patients with osteoarthritis (OA) may contain calcium phosphate crystals that are either too small, or too few in number to be...
Is tibiofemoral osteoarthritis in the knee joint a new disease?
OBJECTIVES--To compare the prevalence of osteoarthritis (OA) of the hip, tibiofemoral and patellofemoral joints in a skeletal population. METHODS--A total of 785 adult English skeletons (695 Saxon or...
Absence of Mycobacterium tuberculosis DNA in synovial fluid from patients with rheumatoid arthritis.
Jalal, H, Millar, M, Linton, C, Dieppe, P
OBJECTIVES--To determine whether Mycobacterium tuberculosis DNA can be detected in synovial fluid of patients with rheumatoid arthritis (RA). METHODS--The polymerase chain reaction was applied to...
Swan, A, Heywood, B, Chapman, B, Seward, H, Dieppe, P
OBJECTIVE--To investigate any relationship between the nature, size, and numbers of synovial fluid (SF) calcium pyrophosphate dihydrate (CPPD) crystals, and attacks of pseudogout. METHODS--Knee SF...
Doherty, M, Dacre, J, Dieppe, P, Snaith, M
The locomotor system is complex and difficult to examine. A selective clinical process to detect important locomotor abnormalities and functional disability could prove valuable. A screen based on a...
Bone formers: osteophyte and enthesophyte formation are positively associated
Rogers, J., Shepstone, L., Dieppe, P.
OBJECTIVE—To test the hypothesis that enthesophyte formation and osteophyte growth are positively associated and to look for associations between bone formation at different sites on the skeleton...
Creamer, P, Keen, M, Zananiri, F, Waterton, J, Maciewicz, R, Oliver, C, ...
OBJECTIVES—To investigate the potential of quantitative magnetic resonance imaging (MRI) to differentiate between therapeutically induced changes in inflammation and synovial proliferation in...
Sharif, M, Shepstone, L, Elson, C, Dieppe, P, Kirwan, J
OBJECTIVE—Raised serum C reactive protein (CRP) and hyaluronate (HA) concentrations predict the progression of knee osteoarthritis (OA) in the long term but the consistency of these relations with...
Pendleton, A, Arden, N, Dougados, M, Doherty, M, Bannwarth, B, Bijlsma, J, ...
BACKGROUND—Osteoarthritis (OA) is the most common joint disease encountered throughout Europe. A task force for the EULAR Standing Committee for Clinical Trials met in 1998 to determine the...
Kessler, S, Dieppe, P, Fuchs, J, Sturmer, T, Gunther, K
OBJECTIVE—The hands are often involved in the osteoarthritic disease process. A radiological grading scale is presented, derived from a published atlas, to assess the prevalence of hand...
Epidemiology of research into interventions for the treatment of osteoarthritis of the knee joint
Chard, J., Tallon, D., Dieppe, P.
OBJECTIVE—To assess the published research base for interventions for osteoarthritis of the knee, and to identify areas in need of further research. METHODS—Literature searches were conducted...
The value of synovial fluid assays in the diagnosis of joint disease: a literature survey
Objective: To carry out a critical appraisal of the literature in an attempt to assess the current value of synovial fluid (SF) analysis in the diagnosis of joint disease.
Jordan, K, Arden, N, Doherty, M, Bannwarth, B, Bijlsma, J, Dieppe, P, ...
Objectives: To update the EULAR recommendations for management of knee osteoarthritis (OA) by an evidence based medicine and expert opinion approach.
Adamson, J., Ebrahim, S., Dieppe, P., Hunt, K.
Objective: To examine the association between three modifiable risk factors (obesity, smoking, and alcohol consumption) and reported joint pain. Methods: Cross sectional data were collected on 858...
Trends in hip and knee joint replacement: socioeconomic inequalities and projections of need
Dixon, T, Shaw, M, Ebrahim, S, Dieppe, P
Objectives: To examine trends in primary and revision joint (hip and knee) replacement in England between 1991 and 2000.
Pham, T, Le Henanff, A, Ravaud, P., Dieppe, P, Paolozzi, L, Dougados, M
Objective: To evaluate long term efficacy of three iterative courses of three weekly intra-articular (IA) injections of NRD101 in the treatment of symptomatic knee osteoarthritis (OA).
Adamson, J., Ebrahim, S., Dieppe, P., Hunt, K.
Objective: To examine the association between three modifiable risk factors (obesity, smoking, and alcohol consumption) and reported joint pain. Methods: Cross sectional data were collected on 858...
Campbell, R, Evans, M, Tucker, M, Quilty, B, Dieppe, P, Donovan, J
STUDY OBJECTIVES—To understand reasons for compliance and non-compliance with a home based exercise regimen by patients with osteoarthritis of the knee. DESIGN—A qualitative study, nested...
Taping the patella medially: a new treatment for osteoarthritis of the knee joint?
Cushnaghan, J., McCarthy, C., Dieppe, P.
OBJECTIVE--To test the hypothesis that medial taping of the patella reduces the symptoms of osteoarthritis of the knee when the patellofemoral joint is affected. DESIGN--Randomised, single blind,...