Bailey, C. L., Berendt, R. F., Brown, J. L., Bunner, D. L., Canonico, P. G.
A report of progress on the research program of the U.S. Army Medical Research Institute of Infectious Diseases on Medical Defense Against Biological Agents (U) for Fiscal Year 1981 is presented.
Chemotherapy for 'Exotic' RNA Viruses (2006)
Canonico, P. G., Jahrling, P. B.
In-vitro screening programmes have identified a number of compounds with broad-spectrum antiviraloactivity against 'Exotic' RNA viruses. Among these, ribavirin has been the most extensively evaluated...
Annual Progress Report - Fiscal Year 1982 (2003)
Bailey, C. L., Berendt, R. F., Bunner, D. L., Canonico, P. G., Crumrine, M. H.
A report on the research program of the U.S. Army Medical Research Institute of Infectious Diseases on Medical Defense Against Biological Agent (U) for Fiscal Year 1982 is presented. The formal...
Effects of Ribavirin on Red Blood Cells, (2002)
Canonico,P. G., Kastello,M. D., Spears,C. T., Brown,J. R., Jackson,E. A.
Hematological and Bone Marrow Effects of Ribavirin in Rhesus Monkeys, (2002)
Canonico,P. G., Kastello,M. D., Cosgriff,T. M., Donovan,J. C., Ross,P. E.
Kende,M., Alving,C. R., Rill,W. L., Canonico,P. G.
Administration of liposome-encapsulated ribavirin to mice led to ribavirin concentrations in the liver, the primary site of Rift Valley fever virus proliferation, that were fivefold greater than...
Macrophage Biochemistry, Activation and Function, (1998)
Kastello,M. D., Canonico,P. G.
Supersedes report dated 5 Nov 80, AD-A095 995.
Treatment of Experimental Viral Infections with Immunomodulators, (1998)
Kende, M., Lupton, H. W., Canonico, P. G.
The prophylactic or therapeutic antiviral activity of selected immunomodulators was evaluated against bunya, flavi, and arenavirus infections. CL-246.738 an acridine hydrochloride derivative (AD)...
Typescript.
Kende, M, Lupton, H W, Rill, W L, Levy, H B, Canonico, P G
The therapeutic efficacy of polyriboinosinic-polyribocytidylic acid stabilized with poly-L-lysine and carboxymethyl cellulose [poly(ICLC)] given alone or in combination with ribavirin was evaluated...
Kende, M, Lupton, H W, Rill, W L, Gibbs, P, Levy, H B, Canonico, P G
The prophylactic efficacy of poly(ICLC) (stabilized, synthetic, double-stranded polyriboinosinic-polyribocytidylic acid) against Rift Valley fever virus infection in Swiss-Webster mice was dependent...
Huggins, J W, Robins, R K, Canonico, P G
Binary combinations of the N-nucleoside ribavirin (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide) and the C-nucleoside analog selenazofurin (2-beta-D-ribofuranosylselenazole-4-carboxamide) or...
Kende, M, Alving, C R, Rill, W L, Swartz, G M, Canonico, P G
Administration of liposome-encapsulated ribavirin to mice led to ribavirin concentrations in the liver, the primary site of Rift Valley fever virus proliferation, that were fivefold greater than...
Kenyon, R H, Canonico, P G, Green, D E, Peters, C J
Subcutaneous injections of ribavirin into guinea pigs infected intraperitoneally or intracerebrally with Junin virus significantly increased the mean time to death but did not enhance survival of the...
Kirsi, J J, North, J A, McKernan, P A, Murray, B K, Canonico, P G, Huggins, J W, ...
The relative in vitro antiviral activities of three related nucleoside carboxamides, ribavirin (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide), tiazofurin...
Antibody response to Rocky Mountain spotted fever.
Kenyon, R H, Canonico, P G, Sammons, L S, Bagley, L R, Pedersen, C E
Various techniques were compared to determine the most sensitive method for detection of rocky Mountain spotted fever antibody. A radiometabolic technique for detection of Rocky Mountain spotted...
Phagocytosis of Francisella tularensis by Rhesus monkey peripheral leukocytes.
Proctor, R A, White, J D, Ayala, E, Canonico, P G
Phagocytosis of Francisella tularensis by rhesus monkey peripheral neutrophils (PMN, was assessed by autoradiography, electron microscopy, and biochemical techniques. PMN, in contrast to mononuclear...
Canonico, P G, McManus, A T, Mangiafico, J A, Sammons, L S, McGann, V G, Dangerfield, H G
The burst in oxidative metabolism that is mediated through activation of the hexose monophosphate shunt and accompanies particle ingestion by polymorphonuclear leukocytes was used as the indicator in...
Canonico, P G, Powanda, M C, Cockerell, G L, Moe, J B
A temporal study is reported of the febrile responses, tissue bacterial contents, and serum concentration of the lysosomal enzymes, beta-glucuronidase and lysozyme, in nonimmune rats inoculated with...
Characterization of monkey peripheral neutrophil granules during infection.
Rhesus monkey (Macaca mulatta) neutrophils were shown to contain the azurophilic granule maker enzymes myeloperoxidase and beta-glucuronidase but were deficient in the specific granule markers...
Kishimoto, R A, Veltri, B J, Canonico, P G, Shirey, F G, Walker, J S
An electron microscopic study was conducted to explore the interaction between normal guinea pig peritoneal macrophages and phase I and II Coxeilla burnetii previously treated with either normal or...
Berendt, R F, Long, G G, Abeles, F B, Canonico, P G, Elwell, M R, Powanda, M C
Gram-negative bacterial pneumonias have been increasingly important as nosocomial infections. The following model was developed to study the pathogenesis and evaluate therapy of such infections....
Fat of Coxiella burnetti in macrophages from immune guinea pigs.
Kishimoto, R A, Veltri, B J, Shirey, F G, Canonico, P G, Walker, J S
The interaction between Coxiella burnetii and peritoneal macrophages obtained from immune guinea pigs was studied by transmission electron microscopy. Phagocytosis and subsequent fate of ingested...
Little, J S, Kishimoto, R A, Canonico, P G
The inactivation of Coxiella burnetii in suspension or in cultures of guinea pig peritoneal macrophages by ultraviolet (UV) light was studied. The effect of UV treatment on the activity of macrophage...
Canonico, P G, Little, J S, Powanda, M C, Bostian, K A, Beisel, W R
Streptococcus pneumoniae infection leads to multifold increases in sialyltransferase, galactosyltransferase, alpha 2-fucosyltransferase, and alpha 3-fucosyltransferase activity of rat liver. Such...
Kende, M, Lupton, H W, Rill, W L, Levy, H B, Canonico, P G
The therapeutic efficacy of polyriboinosinic-polyribocytidylic acid stabilized with poly-L-lysine and carboxymethyl cellulose [poly(ICLC)] given alone or in combination with ribavirin was evaluated...
Kende, M, Lupton, H W, Rill, W L, Gibbs, P, Levy, H B, Canonico, P G
The prophylactic efficacy of poly(ICLC) (stabilized, synthetic, double-stranded polyriboinosinic-polyribocytidylic acid) against Rift Valley fever virus infection in Swiss-Webster mice was dependent...
Huggins, J W, Robins, R K, Canonico, P G
Binary combinations of the N-nucleoside ribavirin (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide) and the C-nucleoside analog selenazofurin (2-beta-D-ribofuranosylselenazole-4-carboxamide) or...
Kende, M, Alving, C R, Rill, W L, Swartz, G M, Canonico, P G
Administration of liposome-encapsulated ribavirin to mice led to ribavirin concentrations in the liver, the primary site of Rift Valley fever virus proliferation, that were fivefold greater than...
Kenyon, R H, Canonico, P G, Green, D E, Peters, C J
Subcutaneous injections of ribavirin into guinea pigs infected intraperitoneally or intracerebrally with Junin virus significantly increased the mean time to death but did not enhance survival of the...
Kirsi, J J, North, J A, McKernan, P A, Murray, B K, Canonico, P G, Huggins, J W, ...
The relative in vitro antiviral activities of three related nucleoside carboxamides, ribavirin (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide), tiazofurin...
Antibody response to Rocky Mountain spotted fever.
Kenyon, R H, Canonico, P G, Sammons, L S, Bagley, L R, Pedersen, C E
Various techniques were compared to determine the most sensitive method for detection of rocky Mountain spotted fever antibody. A radiometabolic technique for detection of Rocky Mountain spotted...
Phagocytosis of Francisella tularensis by Rhesus monkey peripheral leukocytes.
Proctor, R A, White, J D, Ayala, E, Canonico, P G
Phagocytosis of Francisella tularensis by rhesus monkey peripheral neutrophils (PMN, was assessed by autoradiography, electron microscopy, and biochemical techniques. PMN, in contrast to mononuclear...
Canonico, P G, McManus, A T, Mangiafico, J A, Sammons, L S, McGann, V G, Dangerfield, H G
The burst in oxidative metabolism that is mediated through activation of the hexose monophosphate shunt and accompanies particle ingestion by polymorphonuclear leukocytes was used as the indicator in...
Canonico, P G, Powanda, M C, Cockerell, G L, Moe, J B
A temporal study is reported of the febrile responses, tissue bacterial contents, and serum concentration of the lysosomal enzymes, beta-glucuronidase and lysozyme, in nonimmune rats inoculated with...
Characterization of monkey peripheral neutrophil granules during infection.
Rhesus monkey (Macaca mulatta) neutrophils were shown to contain the azurophilic granule maker enzymes myeloperoxidase and beta-glucuronidase but were deficient in the specific granule markers...
Kishimoto, R A, Veltri, B J, Canonico, P G, Shirey, F G, Walker, J S
An electron microscopic study was conducted to explore the interaction between normal guinea pig peritoneal macrophages and phase I and II Coxeilla burnetii previously treated with either normal or...
Berendt, R F, Long, G G, Abeles, F B, Canonico, P G, Elwell, M R, Powanda, M C
Gram-negative bacterial pneumonias have been increasingly important as nosocomial infections. The following model was developed to study the pathogenesis and evaluate therapy of such infections....
Fat of Coxiella burnetti in macrophages from immune guinea pigs.
Kishimoto, R A, Veltri, B J, Shirey, F G, Canonico, P G, Walker, J S
The interaction between Coxiella burnetii and peritoneal macrophages obtained from immune guinea pigs was studied by transmission electron microscopy. Phagocytosis and subsequent fate of ingested...
Little, J S, Kishimoto, R A, Canonico, P G
The inactivation of Coxiella burnetii in suspension or in cultures of guinea pig peritoneal macrophages by ultraviolet (UV) light was studied. The effect of UV treatment on the activity of macrophage...
Canonico, P G, Little, J S, Powanda, M C, Bostian, K A, Beisel, W R
Streptococcus pneumoniae infection leads to multifold increases in sialyltransferase, galactosyltransferase, alpha 2-fucosyltransferase, and alpha 3-fucosyltransferase activity of rat liver. Such...