Evaluation of cardioplegia in coronary artery bypass graft surgery (2005)
Brower, R.W., Jong, J.W. De, Simoons, M.L., Bos, A. Van De, Hugenholtz, P.G., Haalebos, M., ...
Abizaid, A., Sousa, J.E., Costa, M.A., Centemero, M., Abizaid, A.S., Serruys, P.W., ...
BACKGROUND: Our aims were to compare coronary artery bypass grafting (CABG) and stenting for the treatment of diabetic patients with multivessel coronary disease enrolled in the Arterial...
Recommendations on stent manufacture, implantation and utilization (1997)
Balcon, R., Beyar, R., Chierchia, S., De Scheerder, I., Hugenholtz, P. G., Kiemeneij, F., ...
Percutaneous transluminal coronary angioplasty for unstable angina (1991)
Feyter, P.J. De, Hugenholtz, P.G.
Coronary angioplasty is an effective treatment for patients with angina at rest, either refractory or initially stabilized but returning despite pharmacologic treatment, and with early postinfarction...
Restenosis after coronary angioplasty: new standards for clinical studies (1990)
With the high initial success rates for coronary angioplasty that are reported regularly, it has become increasingly difficult to demonstrate methods or techniques that are able to provide more...
Myocardial release of hypoxanthine and lactate during coronary angioplasty (1990)
Piscione, F., Wijns, W., Hegge, J.A.J., Harmsen, E., Brand, M. Van Den, ...
Ejection filling and diastasis during transluminal occlusion in man (1990)
Piscione, F., Wijns, W., Slager, C., Feyter, P.J. De, Brand, M. Van Den, ...
Suryapranata, H., Piscione, F., Harmsen, E., Brand, M. Van Den, Feyter, P.J. De, ...
The response of myocardial lactate and hypoxanthine metabolism during percutaneous transluminal coronary angioplasty was studied in a series of 15 patients undergoing this procedure. A minimum of 4...
Actions of nisoldipine in cardiovascular disease (1989)
Duncker, D.J., Woerkens, L.J. Van, Hugenholtz, P.G., Verdouw, P.D.
The potent systemic and coronary vasodilatory properties of nisoldipine have been demonstrated in several studies in patients with cardiovascular disease. The increase in cardiac output results from...
Acute consequences of ischemic myocardial damage (1989)
Hugenholtz, P.G., Simoons, M.L., Vermeer, F.
The current revolution in the treatment of acute myocardial infarction by means of thrombolytic therapy has as its underlying strategy three aims: early restoration of the blood flow in order to...
Multicentre european trials: their design, execution and relevance (1989)
Multicentre randomized clinical trials in Europe over the past decade have made a major contribution to the practice of cardiology and will increasingly do so when the Single Europe Act becomes a...
LAIRD-MEETER, K., ERDMAN, R. A. M., VAN DOMBURG, R., AZAR, A. J., DE FEYTER, P. J., BOS, E., ...
To examine whether coronary angioplasty has a different effect on work resumption than has coronary artery bypass surgery, we studied the work status of patients before and at least 1 year after...
Beatt, K.J., Feyter, P.J. De, Brand, M. Van Den, Verdouw, P.D., Hugenholtz, P.G.
Animal studies have demonstrated that synchronised coronary sinus retroperfusion with arterial blood can provide effective perfusion of ischaemic myocardium. Preliminary clinical studies have shown...
Luijten, H.E., Beatt, K.J., Geuskens, R., Feyter, P.J. De, Brand, M. Van Den, ...
Data from experimental, clinical, and pathologic studies have suggested that the process of restenosis begins very early after coronary angioplasty. The present study was performed to determine...
Coronary vasodilatory action after a single dose of nicorandil (1988)
Suryapranata, H., Feyter, P.J. De, Verdouw, P.D., Hugenholtz, P.G.
Coronary hemodynamics and vasodilatory effects on major epicardial arteries were investigated after a single dose of nicorandil in 22 patients undergoing cardiac catheterization for suspected...
Vermeer, F., Simoons, M.L., Bär, F.W., Suryapranata, H., Fioretti, P., ...
Immediate PTCA following thrombolysis with streptokinase was performed in 46 out of 533 patients enrolled in a multicentre randomized trial of early reperfusion in patients with acute myocardial...
Indications for coronary angioplasty in acute myocardial ischemic syndromes (1988)
Feyter, P.J. De, Hugenholtz, P.G.
The role of coronary angioplasty for the treatment of patients with evolving myocardial infarction, unstable angina, and early postinfarction unstable angina is discussed. It has been shown that...
Feyter, P.J. De, Suryapranata, H., Beatt, K., Domburg, R. Van, Brand, M. Van Den, ...
Two hundred patients (mean age 56 years, range 36 to 74) with unstable angina (chest pain at rest, associated with ST-T changes) underwent coronary angioplasty. In 65 patients with multivessel...
VERMEER, F., SIMOONS, M. L., DE FEYTER, P. I., BÄR, F. W., SURYAPRANATA, H., FIORETTI, P., ...
Immediate PTCA following thrombolysis with streptokinase was performed in 46 out of 533 patients enrolled in a multicentre randomized trial of early reperfusion in patients with acute myocardial...
Piscione, F., Hugenholtz, P.G.
The effects of brief periods of major coronary artery occlusion on global and regional peak left ventricular (LV) filling rates were studied during angioplasty in 10 patients. No patient had had a...
Beat-by-beat analysis of left ventricular haemodynamic variables (1987)
Meester, G.T., Brand, M. Van Den, Meij, S., Hugenholtz, P.G.
Pop, G., Piscione, F., Feyter, P.J. De, Brand, M. Van Den, Huizer, T., ...
Twelve patients with proximal stenosis of the left anterior descending artery, normal myocardial wall motion but without angiographically demonstrable collateral circulation, were studied during...
Thrombolytic therapy for acute coronary thrombosis (1987)
Simoons, M.L., Lubsen, J., Hugenholtz, P.G.
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Suryapranata, H., Vermeer, F., Feyter, P.J. De, Brand, M. Van Den, Simoons, M.L., ...
A total of 533 patients with acute myocardial infarction of less than 4-h duration were enrolled in the multicenter randomized trial of intracoronary thrombolysis compared to conventional treatment....
Deckers, J.W., Luijten, H.E., Reiber, J.H.C., Tijssen, J.G.P., Chadha, D., ...
The vasodilatory action of molsidomine was studied by intracoronary injection of its active metabolite, Sin 1. In 10 patients repeat coronary angiography in multiple projections was performed before...
Feyter, P.J. De, Suryapranata, H., Beatt, K., Brand, M. Van Den, Hugenholtz, P.G.
Sixty-eight patients (58 men, 10 women, mean age 56.3 years, range 31 to 72) with unstable angina pectoris, either initially stabilized with or refractory to optimal pharmacologic treatment, were...
Thrombolysetherapie beim frischen Myokardinfarkt (1987)
Hugenholtz, P.G., Simoons, M.L., Suryapranata, H., Vermeer, F., Lubsen, J.
In this overview the characteristics have been defined of those patients with acute myocardial infarction to whom early thrombolytic therapy would offer a major benefit. However, this concerns only...
Survival at 5 to 10 years after aorto-coronary bypass operations in 1041 consecutive patients (1987)
LAIRD-MEETER, K., VAN DOMBURG, R., BOS, E., HUGENHOLTZ, P. G.
To evaluate longterm survival, 1041 consecutive patients with aorto-coronary bypass operations were followed for a mean of 7.5 years (range 5 to 14.5). The peri-operative mortality was 12 (1.2%). Of...
Early cardiac valve replacement in infective endocarditis; a 10-year experience (1987)
SURYAPRANATA, H., ROELANDT, J., HAALEBOS, M., DEGENER, J., BOS, E., HUGENHOLTZ, P. G.
Thirty one patients underwent early valve replacement for infective endocarditis during a 10-year period (between September 1973 and December 1983). Intractable heart failure, persistent infection...
Unstable angina pectoris (1987)
Tijssen, J. G. P., Simoons, M. L., De Feijter, P. J., Hugenholtz, P. G., Lubsen, J.
SERRUYS, P. W., DECKERS, J. W., LUUTEN, H. E., REIBER, J. H. C., TUSSEN, J. G. P., CHADHA, D., ...
The vasodilatory action of molsidomine was studied by intracoronary injection of its active metabolite, Sin 1. In 10 patients repeat coronary angiography in multiple projections was performed before...
Thrombolytic therapy for acute coronary thrombosis (1987)
Simoons, M. L., Lubsen, J., Serruys, P. W., Hugenholtz, P. G.
ST 567 (alinidine) in stable angina: a comparison with metoprolol (1987)
Balakumaran, K., Jovanovic, A., Fels, W., Van Es, G. A., Bokslag, M., Lubsen, J., ...
Alinidine, a drug which reduces heart rate without depressing myocardial function was compared against metoprolol, a beta-blocking drug, in the treatment of stable angina pectoris in a double-blind...
Quantitative assessment of regional left ventricular motion using endocardial landmarks (1986)
Slager, C.J., Hooghoudt, T.E.H., Schuurbiers, J.C.H., Reiber, J.H.C., Meester, G.T., ...
In this study the hypothesis is tested that the motion pattern of small anatomic landmarks, recognizable at the left ventricular endocardial border in the contrast angiocardiogram, reflects the...
Wijns, W., Slager, C.J., Grimm, J., Krayenbuehl, H.P., Hugenholtz, P.G., ...
The effect of repeated (3 to 10 second) and transient (15 to 75 second) abrupt coronary occlusion on the global and regional chamber stiffness was studied in nine patients undergoing angioplasty of a...
Simoons, M.L., Suryapranata, H., Vermeer, F., Wijns, W., Brand, M. Van Den, ...
The effect of early myocardial reperfusion (within 4 hours after onset of symptoms) on regional left ventricular function in patients with acute myocardial infarction has been quantitated by analysis...
Thrombolytic therapy for acute coronary obstruction: status in 1986 (1986)
Hugenholtz, P.G., Simoons, M.L., Lubsen, J.
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Jaski, B., Wijns, W., Piscione, F., Ten Kate, F., Feyter, P.J. De, ...
Epicardial wall motion, myocardial wall thickness and segmental wall motion during percutaneous transluminal coronary angioplasty, a situation which resembles the experimental abrupt occlusion of a...
Rational management following diagnosis of myocardial ischemia (1986)
Hugenholtz, P.G., Laird-Meeter, K., Fioretti, P.
Assuming one knows that myocardial ischemia is present, rational management will first require a careful history to assess the severity of symptoms, such as angina, the lifestyle of the patient,...
Hoe heroperatie te voorkomen bij een reeds bestaande bypass op een coronaire bypass (1986)
Feyter, P.J. De, Brand, M. Van Den, Luijten, H.E., Hugenholtz, P.G.
Feyter, P.J. De, Arnold, A., Simoons, M.L., Wijns, W., Geuskens, R., ...
This study is a retrospective analysis of the efficacy of percutaneous transluminal coronary angioplasty of the ischaemia-related vessel in patients with unstable angina. Forty-three patients had...
Zijlstra, F., Hugenholtz, P.G.
A potent, short-acting vasodilator that induces a maximal hyperemic response of the coronary vascular bed is needed to determine coronary flow reserve. In 12 patients, we measured coronary sinus...
Revascularization as a means of reducing sudden death (1986)
Hugenholtz, P.G., Laird-Meeter, K., Roelandt, J.
From this brief overview the arguments have become clear why further studies are needed to verify that the problem of unnecessary sudden cardiac death can best be tackled by a strategy aimed at early...
Hugenholtz, P.G., Fioretti, P.M., Simoons, M.L.
Right after the first signs and symptoms of acute myocardial infarctions the prognosis is determined by the interventions which are carried out at that time. Preservation of as much myocardial tissue...
Hugenholtz, P.G., Fioretti, P., Simoons, M.L., Lubsen, J.
Immediately after the first signs and symptoms of acute myocardial infarction are detected, its prognosis is determined by the size of the area at risk, the availability of collaterals and the time...
Which patients benefit most from early thrombolytic therapy with intracoronary streptokinase? (1986)
Vermeer, F., Simoons, M.L., Bär, F.W., Tijssen, J.G.P., Domburg, R.T. Van, ...
The effect of thrombolysis in acute myocardial infarction on enzymatic infarct size, left ventricular function, and early mortality was studied in subsets of patients in a randomized trial. Early...
Coronary angioplasty for early postinfarction unstable angina (1986)
Feyter, P.J. De, Soward, A., Brand, M. Van Den, Bos, E., Hugenholtz, P.G.
Coronary angioplasty was performed in 53 patients in whom unstable angina had reoccurred after 48 hr and within 30 days after sustained myocardial infarction. Single-vessel disease was present in 64%...
Thrombolytic therapy for acute coronary obstruction: status in 1986 (1986)
Hugenholtz, P.G., Simoons, M.L., Lubsen, J.
The effect of thrombolysis in acute myocardial infarction on enzymatic infarct size, left ventricular function, and early mortality was studied in subsets of patients in a randomized trial at The...
Soward, A.L., Feyter, P.J. De, Hugenholtz, P.G.
Systemic and hemodynamic effects of nisoldipine, administered as a 4.5-micrograms/kg intravenous bolus over 3 minutes followed immediately by an infusion of 0.2 microgram/kg/min over 30 minutes, were...
Coronary and systemic hemodynamic effects of intravenous nisoldipine (1986)
Soward, A.L., Feyter, P.J. De, Hugenholtz, P.G.
Systemic and coronary hemodynamic effects of the new dihydropyridine calcium antagonist nisoldipine were studied over a 30-minute period in 12 patients with angina pectoris. Previously instituted...
DE FEYTER, P. J., SERRUYS, P. W., ARNOLD, A., SIMOONS, M. L., WIJNS, W., GEUSKENS, R., ...
This study is a retrospective analysis of the efficacy of percutaneous transluminal coronary angioplasty of the ischaemia-related vessel in patients with unstable angina. Forty-three patients had...
On a possible role for calcium antagonists in atherosclerosis. A personal view (1986)
HUGENHOLTZ, P.G., LICHTLEN, P., BECKER, A.E., NAYLER, W.G., FLECKENSTEIN, A., ...
An overview is provided of current thinking regarding the origin(s) of atherosclerosis on the basis of clinical evidence, experimental models and pharmacological investigations with calcium...
Coronary Angioplasty in Early Post-Infarction Angina (1986)
De Feyter, P.J., Serruys, P.W., Hugenholtz, P.G.
Coronary angioplasty was performed in 23 patients in whom within 10 days after acute myocardial infarction severe angina recurred despite continuing maximal pharmacological therapy. Initial success...
Reiber, J.H.C., Kooijman, C.J., Slager, C.J., Gerbrands, J.J., Schuurbiers, J.C.H., Boer, A. Den, ...
A computer-assisted technique has been developed to assess absolute coronary arterial dimensions from 35 mm cineangiograms. The boundaries of optically magnified and video-digitized coronary segments...
Wijns, W., Reiber, J.H.C., Brand, M. Van Den, Simoons, M.L., Kooijman, C.J., ...
To evaluate, during cardiac catheterization, what constitutes a physiologically significant obstruction to blood flow in the human coronary system, computer-based quantitative analysis of coronary...
Wijns, W., Simoons, M.L., Brand, M. Van Den, Feyter, P.J. De, Reiber, J.H.C., ...
Restenosis of the dilated vessel after percutaneous transluminal coronary angioplasty can be detected by non-invasive procedures but their ability to predict later restenosis soon after a successful...
Wijns, W., Reiber, J.H.C., Feyter, P.J. De, Brand, M. Van Den, Simoons, M.L., ...
The value of exercise testing and thallium scintigraphy in predicting recurrence of angina pectoris and restenosis after a primary successful transluminal coronary angioplasty (PTCA) was...
Umans, V., Heyndrickx, G.R., Brand, M. Van Den, Feyter, P.J. De, Wijns, W., ...
Of 652 consecutive patients referred for coronary angioplasty between September 1980 and March 1984, 49 patients presented with total or functional 'occlusion' of the involved vessel. Total vessel...
Intracoronary streptokinase in acute myocardial infarction. A review (1985)
Hugenholtz, P.G., Simoons, M.L., Brand, M. Van Den
The attempt to salvage myocardium threatened by ischemia during temporary or permanent occlusion of one or more of the nutrient arteries, is based on the observation that the major determinant of...
Late results of reperfusion with intracoronary streptokinase (1985)
Hugenholtz, P.G., Simoons, M.L., Feyter, P.J. De, Brand, M. Van Den, Fioretti, P.
Intracoronary streptokinase was infused to 152 randomly selected patients after acute myocardial infarction (MI). Control group consisted of 150 randomly selected patients after MI who were treated...
Feyter, P.J. De, Brower, R.W., Brand, M. Van Den, Katen HJ Ten, Hugenholtz, P.G., ...
During a follow-up period of 3 years, among a consecutive series of 423 patients who gave informed consent for recatheterization both 1 and 3 years after coronary artery bypass grafting, the...
Emergency coronary angioplasty in refractory unstable angina (1985)
Feyter, P.J. De, Brand, M. Van Den, Balakumaran, K., Mochtar, B., Soward, A.L., ...
We performed percutaneous transluminal coronary angioplasty as an emergency procedure in 60 patients with unstable angina pectoris that was refractory to treatment with maximally tolerated doses of...
Bos, R.J., Brower, R.W., Katen, H.J. Ten, Vanhaleweyk, G., Hugenholtz, P.G.
15 patients, 1 to 3 year after coronary bypass surgery, underwent symptom limited supine bicycle exercise tests without nifedipine and after acute and chronic (3 months) administration of the drug....
Pharmakologische Untersuchungen mit Tredalat (1985)
Hugenholtz, P.G., Jong, J.W. De, Verdouw, P.D., Simoons, M.L., Ten Kate, L., ...
Cardioprotection during transluminal angioplasty (1985)
Brand, M. Van De, Feyter, P.J. De, Jong, J.W. De, Hugenholtz, P.G.
Suryapranata, H., Planellas, J., Wijns, W., Vanhaleweyk, G., Jaski, B.E., ...
The hemodynamic effects of diltiazem were investigated in 15 patients with suspected coronary artery disease undergoing routine cardiac catheterization. Diltiazem was given in a high dose of 500...
Simoons, M.L., Feyter, P.J. De, Suryapranata, H., Wijns, W., Brand, M. Van Den, ...
The effect of myocardial reperfusion on regional left ventricular function has been quantitated by analysis of segmental wall motion in 185 patients enrolled in a randomized trial comparing...
Wijns, W., Reiber, J.H.C., Feyter, P.J. De, Brand, M. Van Den, Piscione, F., ...
The pressure gradient across coronary stenoses is measured routinely during angioplasty. Due to the finite size of the angioplasty catheter within the stenotic cross section, the remaining luminal...
Surgery, angioplasty or drugs? (1985)
Hugenholtz, P.G., Brand, M. Van Den, Laird-Meeter, K., Bos, E.
Late results of reperfusion with intracoronary streptokinase (1985)
Hugenholtz, P.G., Simoons, M.L., Feyter, P.J. De, Brand, M. Van Den, Fioretti, P.
Acute coronary hemodynamic effects of equihypotensive doses of nisoldipine and diltiazem (1985)
Suryapranata, H., Soward, A.L., Planellas, J., Vanhaleweyk, G., Hugenholtz, P.G.
The hemodynamic effects of nisoldipine and diltiazem were investigated in two groups of patients undergoing investigation for suspected coronary artery disease. Emphasis was placed on the coronary...
Suryapranata, H., Planellas, J., Wijns, W., Vanhaleweyk, G.L.J., Soward, A., ...
The hemodynamic effects of nisoldipine were investigated in 16 patients with suspected coronary artery disease who underwent routine cardiac catheterization. Nisoldipine was given intravenously in a...
SERRUYS, P. W., UMANS, V., HEYNDRICKX, G. R., BRAND, M. V. D., DE FEYTER, P. J., WIJNS, W., ...
Of 652 consecutive patients referred for coronary angioplasty between September 1980 and March 1984, 49 patients presented with total or functional ‘occlusion’ of the involved vessel. Total...
Serruys, P. W., Wijns, W., Simmons, M. L., Suryapranata, H., Planellas, J., Van Domburg, R., ...
To answer the question whether intracoronary thrombolysis in patients with acute myocardial infarction is beneficial, a randomised trial was started in June 1981 at the Thoraxcenter: so far, 167...
Surgery, Angioplasty or Drugs? (1985)
Hugenholtz, P. G., Serruys, P. W., Laird-Meeter, K., Bos, E.
It is argued that the dilemma posed in the title is an artificial one. In fact, the three therapeutic modalities, coronary artery bypass grafting, percutaneous transluminal angioplasty and...
BOS, R. J., SERRUYS, P. W., BROWER, R. W., TEN KATEN, H. J., VANHALEWEYK, G., HUGENHOLTZ, P. G.
15 patients, 1 to 3 year after coronary bypass surgery, underwent symptom limited supine bicycle exercise tests without nifedipine and after acute and chronic (3 months) administration of the drug....
FIORETTI, P., SCLAVO, M., BROWER, R. W., SIMOONS, M. L., HUGENHOLTZ, P. G.
The extent to which patients with low peak serum creatine kinase (CK) at their first myocardial infarction differ from patients with high CK levels in terms of risk for subsequent ischaemic events...
Haemodynamic effects of encainide, flecainide, lorcainide and tocainide (1984)
Vanhaleweyk, G., Hugenholtz, P.G.
The haemodynamic effects of encainide, flecainide, lorcainide and tocainide in man are reviewed. Most of the investigations discussed are acute intervention studies after intravenous administration...
Reiber, J.H.C., Wijns, W., Brand, M. Van Den, Kooijman, C.J., Katen HJ Ten, ...
Cineangiograms of 138 patients who underwent percutaneous transluminal coronary angioplasty (PTCA) were analyzed with a computer-based coronary angiography analysis system. The results before and...
Wijns, W., Brand, M. Van Den, Mey, S., Slager, C., Schuurbiers, J.C.H., ...
The response of left ventricular function, was studied in a series of patients undergoing percutaneous transluminal coronary angioplasty (PTCA). From 4 to 6 balloon inflations procedures per patient...
Reiber, J.H.C., Kooijman, C.J., Slager, C.J., Gerbrands, J.J., Schuurbiers, J.C.H., Boer, A. Den, ...
Survival in 1041 patients with consecutive aorto-coronary bypass operations (1984)
LAIRD-MEETER, K., HAALEBOS, M.M.P., Van DOMBURG, R., LUBSEN, J., BOS, E., ...
The first 1041 patients who underwent an isolated aorto-coronary bypass operation in the same institution since it opened in 1971, were followed for up to 10 years to determine their prognosis. The...
Haemodynamic effects of encainide, flecainide, lorcainide and tocainide (1984)
Vanhaleweyk, G., Serruys, P. W., Hugenholtz, P. G.
The haemodynamic effects of encainide, flecainide, lorcainide and tocainide in man are reviewed. Most of the investigations discussed are acute intervention studies after intravenous administration...
GUSSENHOVEN, W.J., DE VILLENEUVE, V.H., HUGENHOLTZ, P.G., LIGTVOET, C.M., BECKER, A.E.
In 23 patients with Ebstein's anomaly of the tricuspid valve, the functional class of the patients has been related to the echocardiographic parameters generally used to diagnose this disorder. These...
Flecainide: one-year efficacy in patients with chronic ventricular arrhythmias (1984)
VANHALEWEYK, G., BALAKUMARAN, K., LUBSEN, J., CATE, F. J. TEN, JOVANOVIC, A., HAGEMEIJER, F., ...
During a one-week short-term in-hospital period, 60 patients with chronic ventricular arrhythmias were treated with 200 mg flecainide twice a day. Flecainide reduced premature ventricular complexes...
Ventricular free wall rupture: sudden, subacute, slow, sealed and stabilized varieties (1984)
BALAKUMARAN, K., VERBAAN, C. J., ESSED, C. E., NAUTA, J., BOS, E., HAALEBOS, M.M.P., ...
Six cases of acute myocardial infarction with blood in the pericardial sac are described. In one case rapid death followed myocardial rupture leaving no time for the possibility of intervention. Of...
Stoel, I., Hugenholtz, P.G., Leeuw PW De, Vliet HHDM Van, ...
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Vanhaleweyk, G.L.J., Hugenholtz, P.G.
Nitrates and beta-blockers have been the mainstay in the therapy of chronic stable angina pectoris for many years. Since an important number of patients remains symptomatic, new potent anti-ischemic...
Lablanche, J.M., Reiber, J.H.C., Bertrand, M.E., Hugenholtz, P.G.
The hypothesis has been developed that increased coronary artery vasomotor tone superimposed on a preexisting obstruction is a possible mechanism responsible for resting and exertional angina. In 18...
Fioretti, P., Roelandt, J., Bos, R.J., Meltzer, R.S., Hoogenhuijze D Van, ...
To determine whether a ventricular (LV) end-systolic dimension (ESD) greater than or equal to 55 mm and LV left fractional shortening less than 25% are risk factors for aortic valve replacement (AVR)...
Hooghoudt, T.E.H., Reiber, J.H.C., Clager, C., Brouwer, R.W., Hugenholtz, P.G.
The effect of intracoronary nifedipine on regional and global left ventricular performance, coronary vasomotility, and myocardial oxygen consumption is reported. Left ventricular pressures and volume...
Intracoronary platelet release in patients with and without coronary artery disease (1983)
Verheugt, F.W., Vliet H Van, Spijkers, A., Hugenholtz, P.G.
Intracoronary platelet release of beta-thromboglobulin (BTG) was measured in 18 patients with a history of chest pain by analysis of aortic and coronary sinus blood samples in rest and during atrial...
Wijns, W., Brand, M. Van Den, Ribeiro, V., Fioretti, P., Simoons, M.L., ...
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Simoons, M.L., Fioretti, P., Brand, M. Van Den, Hugenholtz, P.G.
Treatment of a patient with myocardial infarction might include opiates and sedatives to reduce pain and anxiety, heparin, antiarrhythmic drugs, diuretics which aim at improvement of myocardial...
Laird-Meeter, K., Brand, M. Van Den, Haalebos, M.M.P., Bos, E., ...
Of 1041 patients with consecutive aortocoronary bypass operations, 53 (5.1%) underwent reoperation during a mean follow-up time of three and a half years. The operative mortality of first operations...
Vanhaleweyk, G., Brand, M. Van Den, Verdouw, P., Lubsen, J., Hugenholtz, P.G.
Flecainide acetate has been shown to be a potent antiarrhythmic agent which is active for more than 8 h, whether given intravenously or orally. However, the negative inotropic effect demonstrated in...
The management of unstable angina pectoris (1983)
Hugenholtz, P.G., Michels, H.R., Balakumaran, K., Haalebos, M.
Angina pectoris, one to 10 years after aortocoronary bypass surgery (1983)
Laird-Meeter, K., Katen HJ Ten, Brower, R.W., Brand, M. Van Den, Haalebos, M.M.P., ...
The incidence of angina pectoris (AP) after bypass surgery was assessed in 1041 patients operated on consecutively between 1971 and 1980. Of the 977 survivors, 920 (94%) participated in the study...
Nifedipine for angina and acute myocardial ischemia (1983)
Hugenholtz, P.G., Jong, J.W. De, Verdouw, P.D.
This paper reviews the mechanisms believed to be responsible for myocardial ischaemia and the mode of action of calcium antagonist drugs. The clinical management of patients with myocardial ischaemia...
The value of contrast echocardiography in atrial septal defects (1983)
Santoso, T., Meltzer, R.S., Rahman, A.M., Trishnohadi, H.B., Abdurahman, N., ...
Serruys, P. W., Brower, R. W., Hugenholtz, P. G.
The influx of calcium ions into the myocardial cell sets in motion a series of steps which end with contraction. Reduced intracellular calcium activity diminishes the contractile and mechanical...
Nifedipine is a calcium antagonist with established anti-vasospastic action in man and. possibly cardioprotective effects during ischaemia. Although it is regularly used in the treatment of acute...
Angina pectoris, one to 10 years after aorto-coronary bypass surgery (1983)
LAIRD-MEETER, K., KATEN, H. J. TEN, BROWER, R. W., SERRUYS, P. W., HAALEBOS, M. M. P., ...
The incidence of angina pectoris (AP) after bypass surgery was assessed in 1041 patients operated on consecutively between 1971 and 1980. Of the 977 survivors, 920 (94%) participated in the study...
Molsidomine, an effective long-acting anti-anginal drug (1983)
BALAKUMARAN, K., HUGENHOLTZ, P. G., TIJSSEN, J. G. P., CHADHA, DEV R.
Molsidomine was compared with propranolol for anti-anginal efficacy in a double-blind, cross-over, fixed-dose clinical trial, involving 39 patients with moderate, stable angina pectoris, and...
Vanhaleweyk, G. L. J., Serruys, P. W., Hugenholtz, P. G.
Nitrates and beta-blockers have been the mainstay in the therapy of chronic stable angina pectoris for many years. Since an important number of patients remains symptomatic, new potent anti-ischemic...
Simoons, M. L., Serruys, P. W., Fioretti, P., Hugenholtz, P. G.
Treatment of a patient with myocardial infarction might include opiates and sedatives to reduce pain and anxiety, heparine, antiarrhythmic drugs, diuretics which aim at improvement of myocardial...
Analysis of drug effects on left ventricular isovolumic contraction during atrial pacing (1982)
Brower, R.W., Lubsen, J., Brand, M. Van Den, Meester, G.T., Hugenholtz, P.G.
Coronary recanalization in acute myocardial infarction: immediate results and potential risks (1982)
Brand, M. Van Den, Hooghoudt, T.E.H., Simoons, M.L., Fioretti, P., Ruiter, J., ...
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From unstable angina pectoris to impending infarction: a challenge to intensive care (1982)
Hugenholtz, P.G., Michiels, H.R., Balakumaran, K., Haalebos, M.
Potential risks of intracoronary streptokinase during acute myocardial infarction (1982)
Brand, M. Van Den, Hooghoudt, T.E.H., Simoons, M.L., Fioretti, P., Ruiter, J., ...
The management of unstable angina (1982)
Hugenholtz, P.G., Simoons, M.L., Michels, R., Balakumaran, K.
What is preferable in unstable angina, beta-blockade or calcium inhibition? (1982)
Hugenholtz, P.G., Michels, H.R., Simoons, M.L.
Nifedipine is a strong calcium antagonist; it blocks the excitation-contraction coupling, yet at therapeutic dosage levels it has few side effects. It is said that a single molecule of nifedipine can...
Coronary recanalization in acute myocardial infarction: immediate results and potential risks (1982)
SERRUYS, P. W., HOOGHOUDT, T. E. H., SIMOONS, M. L., FIORETTI, P., RUITER, J., ...
Between September 1980 and March 1982, 83 patients were catheterized during the acute phase of their myocardial infarction with the intention to recanalize their infarct-related vessel (IRV); of...
HOOGHOUDT, T. E. H., SERRUYS, P. W., REIBER, J. H. C., SLAGER, C. J., HUGENHOLTZ, P. G.
In 20 patients with acute myocardial infarction a left ventriculogram was obtained within 6 h after the onset of chest pain and again during a follow-up study, 2–3 weeks later. In 17 patients the...
FIORETTI, P., SIMOONS, M. L., SERRUYS, P. W., BRAND, M. VAN DEN, FELS, P. W., HUGENHOLTZ, P. G.
Immediate results and follow-up are reported on 118 patients with a diagnosis of myocardial infarction who were included in studies on intracoronary thrombolysis at the Thoraxcenter. Pilot studies...
SIMOONS, M. L., WIJNS, W., BALAKUMARAN, K., SERRUYS, P. W., FIORETTI, P., ...
In order to evaluate the effect of coronary recanalization in acute myocardial infarction, thallium scintigrams were made on admission in 23 patients in whom thrombolysis was attempted and in 27...
Meester, G. T., Brower, R. W., Hugenholtz, P. G.
Left ventricular wall mass was studied within the framework of the Cooperative Study in The Netherlands for the evaluation of the effects of CBS on left ventricular function. Normal values,...
Effets hémodynamiques de la nifédipine après injection intraveineuse ou intracoronarienne (1981)
Brower, R.W., Brand, M. Van Den, Michels, R., Hugenholtz, P.G.
Cardiac catheterization under echocardiographic control in a pregnant woman (1981)
Meltzer, R.S., McGhie, J., Hugenholtz, P.G., Roelandt, J.
A 22 year old woman had signs of rheumatic mitral and aortic valve disease early in pregnancy. Cardiac catheterization was performed during her third month of pregnancy under two-dimensional...
Diagnosis of tricuspid regurgitation by contrast echocardiography (1981)
Meltzer, R.S., Hoogenhuyze D Van, Haalebos, M.M.P., Hugenholtz, P.G., Roelandt, J.
Verdouw, P.D., Hartog, J.M., Cate, F.J. Ten, Schamhardt, H.C., Bastiaans, O.L., Bremen, R.H. Van, ...
Intravenous carbon dioxide as an echocardiographic contrast agent (1981)
Meltzer, R.S., Hugenholtz, P.G., Roelandt, J.
Intravenous carbon dioxide (CO2) was employed to cause echocardiographic contrast in 40 patients. One to 3 cc of medically pure CO2 were agitated with 5 to 8 cc of 5% dextrose in water and rapidly...
Methode voor objectieve en kwantitatieve analyse van coronaircine-angiogrammen (1981)
Reiber, J.H.C., Booman, F., Gerbrands, J.J., Slager, C.J., Schuurbiers, J.C.H., ...
Nifedipine in the treatment of unstable angina, coronary spasm and myocardial ischemia (1981)
Hugenholtz, P.G., Michels, H.R., Brower, R.W.
The effects of nifedipine, a potent calcium antagonist, were studied in patients with unstable angina, coronary spasm and myocardial ischemia. Data from two separate groups of patients studied in the...
Unstable angina pectoris and coronary arterial vasomotion: which role for nifedipine? (1981)
Stewart, R., Booman, F., Michels, R., Reiber, J.C.H., Hugenholtz, P.G.
Management of unstable Angina Pectoris (1981)
Michels, R., Hugenholtz, P.G., Haalebos, M., Brand, M. Van Den, Balakumaran, K.
WOLLFFENBUTTEL, B. H. R., VERDOUW, P. D., HUGENHOLTZ, P.G.
One hundred and thirty-two patients with acute myocardial infarction (AMI) within the preceding 24 h were followed over a two year period. The non-invasive prognostic indices of Norris and Peel were...
Can unstable angina pectoris be due to increased coronary vasomotor tone? (1980)
Steward, R., Booman, F., Michels, R., Reiber, J.H.C., Hugenholtz, P.G.
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The effect of coronary artery bypass graft (CBG) on left ventricular performance was evaluated by analysing preoperative (preop) and postoperative (postop) pressure-derived measurements from tip...
Intra aortic balloon pumping in myocardial infarction and unstable angina (1980)
Michels, R., Haalebos, M., Kint, P.P., Hagemeijer, F., Balakumaran, K., Brand, M. Van Den, ...
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Can unstable angina pectoris be due to increased coronary vasomotor tone? (1980)
Serruys, P.W., Steward, R., Booman, F., Michels, R., Reiber, J.H.C., Hugenholtz, P.G.
In this study it is argued that the clinical manifestations of unstable angina pectoris, with at its extreme end impending myocardial infarction, may be due to increased coronary arterial vasomotion...
Hugenholtz, P.G., Brower, R.W.
In 56 patients operated on for coronary artery bypass grafting the relation between regional epicardial shortening, bypass flow, reactive hyperemia, and time postoperative was determined. Regional...
Early myocardial depression after coronary artery bypass surgery (1979)
Brower, R.W., Katen, H.J. Ten, Brand, M. Van Den, Hugenholtz, P.G.
Intra-aortic balloon pumping in coronary artery disease (1979)
Michels, R., Kint, P.P., Hagemeijer, F., Haalebos, M., Brand, M. Van Den, ...
Cardiogenic shock and severe left ventricular failure after acute myocardial infarction, refractory angina pectoris at rest either of new onset or superimposed on stable angina pectoris, or occurring...
Intracoronary use of nifedipine in coronary spasm, is it rational? (1979)
Brower, R.W., Brand, M. Van Den, Verdouw, P., Reiber, H., Hugenholtz, P.G.
Current methods of assessment of cardiac function in coronary artery disease (1978)
Hugenholtz, P.G., Bos, E., Brand, M. Van Den, Brower, R.W., Meester, G.T., Prakash, O., ...
VERDOUW, P. D., REMME, W. J., HUGENHOLTZ, P. G.
The effect of intravenously administered aprindine (AC 1802) as a prophylactic agent against ventricular arrhythmias was studied in pigs. During the first 30 min of ischaemia 5 of the 22 untreated...
Thrombolytic Therapy for Acute Coronary Obstruction: Status in 1986
Hugenholtz, P.G., Serruys, P.W., Simoons, M.L., Lubsen, J.
The effect of thrombolysis in acute myocardial infarction on enzymatic infarct size, left ventricular function, and early mortality was studied in subsets of patients in a randomized trial at The...
Thrombolytic Therapy for Acute Coronary Obstruction: Status in 1986
Hugenholtz, P.G., Serruys, P.W., Simoons, M.L., Lubsen, J.
The effect of thrombolysis in acute myocardial infarction on enzymatic infarct size, left ventricular function, and early mortality was studied in subsets of patients in a randomized trial at The...
Serruys, P W, Hooghoudt, T E, Reiber, J H, Slager, C, Brower, R W, Hugenholtz, P G
The effect of intracoronary nifedipine on regional and global left ventricular performance, coronary vasomotility, and myocardial oxygen consumption is reported. Left ventricular pressures and volume...
Laird-Meeter, K, Van Den Brand, M J, Serruys, P W, Penn, O C, Haalebos, M M, Bos, E, ...
Of 1041 patients with consecutive aortocoronary bypass operations, 53 (5.1%) underwent reoperation during a mean follow-up time of three and a half years. The operative mortality of first operations...
Wolffenbuttel, B H, Verdouw, P D, Scheffer, M G, Bom, H P, Bijleveld, R E, Hugenholtz, P G
In order to assess the value of haemodynamic monitoring in the coronary care unit for long term prognosis after recovery of an acute myocardial infarction, the records of two groups of consecutive...
Fioretti, P, Brower, R W, Simoons, M L, Das, S K, Bos, R J, Wijns, W, ...
The relative merits of resting ejection fraction measured by radionuclide angiography and predischarge exercise stress testing were compared for predicting prognosis in hospital survivors of...
Wijns, W, Serruys, P W, Simoons, M L, De Feijter, P J, Reiber, J H, ...
Restenosis of the dilated vessel after percutaneous transluminal coronary angioplasty can be detected by non-invasive procedures but their ability to predict later restenosis soon after a successful...
Fioretti, P, Brower, R W, Lazzeroni, E, Simoons, M L, Wijns, W, Reiber, J H, ...
The value of a QRS scoring system derived from 12 lead electrocardiograms to estimate left ventricular ejection fraction was assessed in a prospective study of 285 hospital survivors of myocardial...
Surgical versus non-surgical management of patients soon after acute myocardial infarction.
Brower, R W, Fioretti, P, Simoons, M, Haalebos, M, Rulf, E N, Hugenholtz, P G
Of 510 patients admitted to hospital with acute myocardial infarction, 34 had coronary artery bypass grafting before discharge (6-43 days (median 20) after infarction). The patients who were given...
Effect of nicotine on production of prostacyclin in human umbilical artery.
Stoel, I, Vd Giessen, W J, Zwolsman, E, Verheugt, F W, Ten Hoor, F, Quadt, F J, ...
The influence of nicotine on the production of prostacyclin was studied in umbilical arteries from newborn infants of mothers who were smokers and those who were non-smokers. Thirteen umbilical cords...
Wenting, G J, Man In't Veld, A J, Woittiez, A J, Boomsma, F, Laird-Meeter, K, Simoons, M L, ...
The angiotensin-converting enzyme inhibitor, captopril, was given to 19 patients with severe heart failure. Seven patients had acute myocardial infarction and the remainder had chronic myocardial...
Multidimensional echocardiography. An appraisal of its clinical usefulness.
Roelandt, J, Kloster, F E, Ten Cate, F J, Van Dorp, W G, Honkoop, J, Bom, N, ...
Beatt, K J, Serruys, P W, De Feyter, P, Verdouw, P D, Hugenholtz, P G
Animal studies have demonstrated that synchronised coronary sinus retroperfusion with arterial blood can provide effective perfusion of ischaemic myocardium. Preliminary clinical studies have shown...
Fioretti, P, Tijssen, J G, Azar, A J, Lazzeroni, E, Brower, R W, Ten Katen, H J, ...
The prognostic value of QRS score (Selvester), ST depression, ST elevation, extrasystoles, P terminal force in V1, and QTc derived from the predischarge 12 lead electrocardiogram was assessed after...
Incidence, risk, and outcome of reintervention after aortocoronary bypass surgery.
Laird-Meeter, K, Van Domburg, R, Van Den Brand, M J, Lubsen, J, Bos, E, Hugenholtz, P G
Reintervention was required in 123 (12%) individuals during a follow up (mean 7.5 years, range 5-14.5) of 1041 patients with consecutive, isolated, first aortocoronary bypass operations. In 89...
The haemodynamic effect of intravenous flecainide acetate in patients with coronary artery disease.
Serruys, P W, Vanhaleweyk, G, Verdouw, P, Lubsen, J, Hugenholtz, P G
Flecainide acetate has been shown to be a potent antiarrhythmic agent which is active for more than 8 h, whether given intravenously or orally. However, the negative inotropic effect demonstrated in...
Duncker, D. J., Hartog, J. M., Hugenholtz, P. G., Saxena, P. R., Verdouw, P. D.
The effects of the 1,4-dihydropyridine derivative nisoldipine, infused intravenously (i.v.) at 3 different rates (0.25, 0.5 and 1.0 microgram kg-1 min-1), were studied in anaesthetized pigs on...