Albano, F, Cambrin, G R, Quarta, G, Fabbiano, F, ...
Six patients with de novo acute myeloid leukemia (AML) and a t(2;3)(p15-21;q26-27) were identified among approximately 1000 cases enrolled in the GIMEMA trial. The t(2;3) was the sole anomaly in...
Mandalà, M., Curigliano, G., Bucciarelli, P., Ferretti, G., Mannucci, P. M., Colleoni, M., ...
Background: To analyze the influence of the prothrombotic gene mutation factor V G1691A (factor V Leiden) and prothrombin G20210A on the risk of a first episode of catheter-related deep venous...
Human chromosome 7: DNA sequence and biology (2003)
Scherer, S.W., Cheung, J., MacDonald, J.R., Osborne, L.R., Nakabayashi, K., ...
DNA sequence and annotation of the entire human chromosome 7, encompassing nearly 158 million nucleotides of DNA and 1917 gene structures, are presented. To generate a higher order description,...
Göttlicher, M., Minucci, S., Zhu, P., Krämer, O.H., Schimpf, A., Giavara, S., ...
43.Frühjahrstagung der Deutschen Gesellschaft für experimentelle und klinische Pharmakologie und Toxikologie (DGPT), Mainz, 12.-14.März 2002
Göttlicher, M., Minucci, S., Zhu, P., Krämer, O.H., Schimpf, A., Giavara, S., ...
93rd Annual Meeting of the American Association for Cancer Research, San Francisco, Calif., April 6-10, 2002
ALK+ lymphoma: clinico-pathological findings and outcome (1999)
Pileri, S, Zinzani, P L, Carbone, A, Zagonel, V, Wolf-Peeters, C, ...
A distinct pathologic entity (ALK+ lymphoma) that is characterized by expression of the anaplastic lymphoma kinase (ALK) protein has recently emerged within the heterogeneous group of CD30(+)...
The acute promyelocytic leukaemia-associated PML gene is induced by interferon. (1995)
Lavau, C., Marchio, A., Fagioli, M., Jansen, J., Falini, B., Lebon, P., ...
The PML protein concentrates within discrete nuclear structures known as nuclear bodies, also called NDs or PODs, which contain several proteins including the interferon (IFN)-inducible SP100...
Targeted disruption of the PML gene of acute promyelocytic leukemia. (1993)
Pandolfi, P.P., Bygrave, A., Lindenbaum, M., Pelicci, P.G., Luzzatto, L., Grosveld, F.G.
Wong, W T, Schumacher, C, Salcini, A E, Romano, A, Castagnino, P, Pelicci, P G, ...
In this report we structurally and functionally define a binding domain that is involved in protein association and that we have designated EH (for Eps15 homology domain). This domain was identified...
Expression pattern of the RAR alpha-PML fusion gene in acute promyelocytic leukemia.
Alcalay, M, Zangrilli, D, Fagioli, M, Pandolfi, P P, Mencarelli, A, Lo Coco, F, ...
Two chimeric genes, PML-RAR alpha and RAR alpha-PML, are formed as a consequence of the acute promyelocytic leukemia (APL)-specific reciprocal translocation of chromosomes 15 and 17 [t(15;17)]....
Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases.
McGlade, J, Cheng, A, Pelicci, G, Pelicci, P G, Pawson, T
The mammalian shc gene encodes two overlapping proteins of 46 and 52 kDa, each with a C-terminal Src homology 2 (SH2) domain and an N-terminal glycine/proline-rich sequence, that induce malignant...
Constitutive phosphorylation of eps8 in tumor cell lines: relevance to malignant transformation.
Matoskova, B, Wong, W T, Salcini, A E, Pelicci, P G, Di Fiore, P P
eps8, a recently identified tyrosine kinase substrate, has been shown to augment epidermal growth factor (EGF) responsiveness, implicating it in EGF receptor (EGFR)-mediated mitogenic signaling. We...
Lotti, L V, Lanfrancone, L, Migliaccio, E, Zompetta, C, Pelicci, G, Salcini, A E, ...
The intracellular localization of Shc proteins was analyzed by immunofluorescence and immunoelectron microscopy in normal cells and cells expressing the epidermal growth factor receptor or the...
Ruthardt, M, Testa, U, Nervi, C, Ferrucci, P F, Grignani, F, Puccetti, E, ...
Fusion proteins involving the retinoic acid receptor alpha (RAR alpha) and the PML or PLZF nuclear protein are the genetic markers of acute promyelocytic leukemias (APLs). APLs with the PML-RAR alpha...
Pelicci, P G, Knowles, D M, Magrath, I, Dalla-Favera, R
We have examined the position of the chromosomal breakpoint relative to the human c-myc gene (MYC) and the presence of other structural alterations of the same locus in 19 fresh samples of Burkitt...
Pannuti, A, Lanfrancone, L, Pascucci, A, Pelicci, P G, La Mantia, G, Lania, L
The finger motif is a tandemly repeated DNA-binding domain recently identified in the primary structure of several eukaryotic transcriptional regulatory proteins. It was first described for Xenopus...
Human leukemia cells synthesize and secrete proteins related to platelet-derived growth factor.
Pantazis, P, Lanfrancone, L, Pelicci, P G, Dalla-Favera, R, Antoniades, H N
Human leukemia cells in culture (HL-60) synthesize and secrete proteins that are recognized by antiserum to human platelet-derived growth factor (PDGF). The molecular mass of the intracellular...
Knowles, D M, Neri, A, Pelicci, P G, Burke, J S, Wu, A, Winberg, C D, ...
The lineage and clonality of Hodgkin's disease (HD) were investigated by analyzing the organization of the immunoglobulin and T-cell receptor beta-chain (T beta) gene loci in 18 cases of HD, and for...
Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway.
Puil, L, Liu, J, Gish, G, Mbamalu, G, Bowtell, D, Pelicci, P G, ...
The cytosolic 185 and 210 kDa Bcr-Abl protein tyrosine kinases play important roles in the development of Philadelphia chromosome positive (Ph+) chronic myelogenous leukemia (CML) and acute...
Pantazis, P, Pelicci, P G, Dalla-Favera, R, Antoniades, H N
Immunoprecipitation of proteins extracted from metabolically labeled human glioblastoma and fibrosarcoma cells with antiserum to platelet-derived growth factor (PDGF) showed that these cells express...
T-cell receptor gene rearrangements as markers of lineage and clonality in T-cell neoplasms.
Flug, F, Pelicci, P G, Bonetti, F, Knowles, D M, Dalla-Favera, R
Ig gene rearrangements represent markers of lineage, clonality, and differentiation of B cells, allowing a molecular diagnosis and immunogenotypic classification of B-cell neoplasms. We sought to...
Chen, Y, Grall, D, Salcini, A E, Pelicci, P G, Pouysségur, J
The serine protease thrombin activates G protein signaling systems that lead to Ras activation and, in certain cells, proliferation. Whereas the steps leading to Ras activation by G protein-coupled...
Grignani, F, Testa, U, Rogaia, D, Ferrucci, P F, Samoggia, P, Pinto, A, ...
The block of terminal differentiation is a prominent feature of acute promyelocytic leukemia (APL) and its release by retinoic acid correlates with disease remission. Expression of the APL-specific...
Testa, U, Grignani, F, Samoggia, P, Zanetti, C, Riccioni, R, Lo Coco, F, ...
We investigated the effect of the acute promyelocytic leukemia (APL) specific PML/RARalpha fusion protein on the sensitivity to TNF-alpha-mediated apoptosis. The U937 leukemia cell line was...
Migliaccio, E, Mele, S, Salcini, A E, Pelicci, G, Lai, K M, Superti-Furga, G, ...
Shc proteins are targets of activated tyrosine kinases and are implicated in the transmission of activation signals to Ras. The p46shc and p52shc isoforms share a C-terminal SH2 domain, a proline-...
Recognition specificity of individual EH domains of mammals and yeast.
Paoluzi, S, Castagnoli, L, Lauro, I, Salcini, A E, Coda, L, Fre', S, ...
The Eps homology (EH) domain is a recently described protein binding module that is found, in multiple or single copies, in several proteins in species as diverse as human and yeast. In this work, we...
Wong, W T, Schumacher, C, Salcini, A E, Romano, A, Castagnino, P, Pelicci, P G, ...
In this report we structurally and functionally define a binding domain that is involved in protein association and that we have designated EH (for Eps15 homology domain). This domain was identified...
Expression pattern of the RAR alpha-PML fusion gene in acute promyelocytic leukemia.
Alcalay, M, Zangrilli, D, Fagioli, M, Pandolfi, P P, Mencarelli, A, Lo Coco, F, ...
Two chimeric genes, PML-RAR alpha and RAR alpha-PML, are formed as a consequence of the acute promyelocytic leukemia (APL)-specific reciprocal translocation of chromosomes 15 and 17 [t(15;17)]....
Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases.
McGlade, J, Cheng, A, Pelicci, G, Pelicci, P G, Pawson, T
The mammalian shc gene encodes two overlapping proteins of 46 and 52 kDa, each with a C-terminal Src homology 2 (SH2) domain and an N-terminal glycine/proline-rich sequence, that induce malignant...
Constitutive phosphorylation of eps8 in tumor cell lines: relevance to malignant transformation.
Matoskova, B, Wong, W T, Salcini, A E, Pelicci, P G, Di Fiore, P P
eps8, a recently identified tyrosine kinase substrate, has been shown to augment epidermal growth factor (EGF) responsiveness, implicating it in EGF receptor (EGFR)-mediated mitogenic signaling. We...
Lotti, L V, Lanfrancone, L, Migliaccio, E, Zompetta, C, Pelicci, G, Salcini, A E, ...
The intracellular localization of Shc proteins was analyzed by immunofluorescence and immunoelectron microscopy in normal cells and cells expressing the epidermal growth factor receptor or the...
Ruthardt, M, Testa, U, Nervi, C, Ferrucci, P F, Grignani, F, Puccetti, E, ...
Fusion proteins involving the retinoic acid receptor alpha (RAR alpha) and the PML or PLZF nuclear protein are the genetic markers of acute promyelocytic leukemias (APLs). APLs with the PML-RAR alpha...
Pelicci, P G, Knowles, D M, Magrath, I, Dalla-Favera, R
We have examined the position of the chromosomal breakpoint relative to the human c-myc gene (MYC) and the presence of other structural alterations of the same locus in 19 fresh samples of Burkitt...
Pannuti, A, Lanfrancone, L, Pascucci, A, Pelicci, P G, La Mantia, G, Lania, L
The finger motif is a tandemly repeated DNA-binding domain recently identified in the primary structure of several eukaryotic transcriptional regulatory proteins. It was first described for Xenopus...
Human leukemia cells synthesize and secrete proteins related to platelet-derived growth factor.
Pantazis, P, Lanfrancone, L, Pelicci, P G, Dalla-Favera, R, Antoniades, H N
Human leukemia cells in culture (HL-60) synthesize and secrete proteins that are recognized by antiserum to human platelet-derived growth factor (PDGF). The molecular mass of the intracellular...
Knowles, D M, Neri, A, Pelicci, P G, Burke, J S, Wu, A, Winberg, C D, ...
The lineage and clonality of Hodgkin's disease (HD) were investigated by analyzing the organization of the immunoglobulin and T-cell receptor beta-chain (T beta) gene loci in 18 cases of HD, and for...
Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway.
Puil, L, Liu, J, Gish, G, Mbamalu, G, Bowtell, D, Pelicci, P G, ...
The cytosolic 185 and 210 kDa Bcr-Abl protein tyrosine kinases play important roles in the development of Philadelphia chromosome positive (Ph+) chronic myelogenous leukemia (CML) and acute...
Pantazis, P, Pelicci, P G, Dalla-Favera, R, Antoniades, H N
Immunoprecipitation of proteins extracted from metabolically labeled human glioblastoma and fibrosarcoma cells with antiserum to platelet-derived growth factor (PDGF) showed that these cells express...
T-cell receptor gene rearrangements as markers of lineage and clonality in T-cell neoplasms.
Flug, F, Pelicci, P G, Bonetti, F, Knowles, D M, Dalla-Favera, R
Ig gene rearrangements represent markers of lineage, clonality, and differentiation of B cells, allowing a molecular diagnosis and immunogenotypic classification of B-cell neoplasms. We sought to...
Chen, Y, Grall, D, Salcini, A E, Pelicci, P G, Pouysségur, J
The serine protease thrombin activates G protein signaling systems that lead to Ras activation and, in certain cells, proliferation. Whereas the steps leading to Ras activation by G protein-coupled...
Grignani, F, Testa, U, Rogaia, D, Ferrucci, P F, Samoggia, P, Pinto, A, ...
The block of terminal differentiation is a prominent feature of acute promyelocytic leukemia (APL) and its release by retinoic acid correlates with disease remission. Expression of the APL-specific...
Testa, U, Grignani, F, Samoggia, P, Zanetti, C, Riccioni, R, Lo Coco, F, ...
We investigated the effect of the acute promyelocytic leukemia (APL) specific PML/RARalpha fusion protein on the sensitivity to TNF-alpha-mediated apoptosis. The U937 leukemia cell line was...
Migliaccio, E, Mele, S, Salcini, A E, Pelicci, G, Lai, K M, Superti-Furga, G, ...
Shc proteins are targets of activated tyrosine kinases and are implicated in the transmission of activation signals to Ras. The p46shc and p52shc isoforms share a C-terminal SH2 domain, a proline-...
Recognition specificity of individual EH domains of mammals and yeast.
Paoluzi, S, Castagnoli, L, Lauro, I, Salcini, A E, Coda, L, Fre', S, ...
The Eps homology (EH) domain is a recently described protein binding module that is found, in multiple or single copies, in several proteins in species as diverse as human and yeast. In this work, we...
Flenghi, L., Bigerna, B., Fizzotti, M., Venturi, S., Pasqualucci, L., Pileri, S., ...
The human BCL-6 gene, which is rearranged in approximately 30% of diffuse large B cell lymphomas, encodes a 706-amino-acid nuclear protein of the Kruppel-type zinc finger transcription factors mainly...
Gambacorta, M., Flenghi, L., Fagioli, M., Pileri, S., Leoncini, L., Bigerna, B., ...
The RING-finger promyelocytic leukemia (PML) protein is the product of the PML gene that fuses with the retinoic acid receptor-alpha gene in the t(15; 17) translocation of acute promyelocytic...
Knowles, D. M., Dodson, L., Burke, J. S., Wang, J. M., Bonetti, F., Pelicci, P. G., ...
The authors performed immunophenotypic, functional, and molecular analysis of the neoplastic cells from 20 cases of SIg-, E-("null-cell") non-Hodgkin's lymphoma (NHL) in order to determine their...