P. Herrlich

Publication List Details

Period

1979 - 2008

Number

593

Co-Authors

A five-amino-acid peptide blocks Met and Ron dependent cell migration. (2005)

Matzke, A., Herrlich, P., Ponta, H., Orian-Rousseau, V.

ELSO Meeting (European Life Scientist Organization), Dresden, September 3-6, 2005

CD44v6 is a co-receptor for another member of the c-Met family, RON. (2004)

Matzke, A., Herrlich, P., Ponta, H., Orian-Rousseau, V.

2nd Internat.DFG Symp.'Cell Migration in Development and Disease', Karlsruhe, October 10-13, 2004

Antagonistic signaling pathways regulate alternative splicing of CD44 in T cells. (2003)

Weg-Remers, S., Ponta, H., Herrlich, P., König, H.

Cell Signalling, Transcription and Translation as Therapeutic Targets, Luxembourg, L, January 30 - February 2, 2002

CD44 and ERM proteins in the regulation of invasiveness. (2003)

Herrlich, P.

Internat.Symp.WIS-ULP 'The Biology of Cancer', Strasbourg, F,January 13-15, 2003

Biomedizinische Forschung am Forschungszentrum Karlsruhe. (2002)

Herrlich, P.

Nachrichten - Forschungszentrum Karlsruhe, 34(2002) S.5-10

CD44 and ERM proteins in the regulation of invasiveness. (2002)

Herrlich, P.

Meeting on Mechanisms of Invasion and Metastasis, Madrid, E, November 18-20, 2002

Identification of novel factors involved in AP-1 repression. (2001)

Schneider, S., Heilbock, C., Göttlicher, M., Herrlich, P.

Keystone Symp.on Mechanisms of Eukaryotic Transcriptional Regulation, Keystone, Colo., February 26 - March 4, 2001

Two sides of one and the same molecule, CD44: tumor metastasis promotion and suppression. (2001)

Herrlich, P., Morrison, H., Linfeng, C., Orian-Rousseau, V., Ponta, H.

2001 Annual Scientific Conf.of the General Motors Cancer Research Foundation (GMCRF), 'Mechanisms of Metastasis', Bethesda, Md., June 5-6, 2001

Antagonistic signaling pathways regulate alternative splicing of CD44 in T cells. (2001)

Weg-Remers, S., Ponta, H., Herrlich, P., König, H.

3rd Cold Spring Harbor Meeting on Eukaryotic mRNA Processing, Cold Spring Harbor, N.Y., August 22-26, 2001

Redox regulation in mammalian signal transduction. (2001)

Herrlich, P., Klöhn, P.C., Göttlicher, M., Böhmer, F.

Workshop on Redox Signalling in Proliferate Disorders, Roma, I, June 21, 2001

Redox regulation of signal transduction in mammalian cells. (2001)

Göttlicher, M., Böhmer, F.D., Herrlich, P.

21st World Congress of Pathology and Laboratory Medicine, Düsseldorf, November 20-23, 2001

Two opposite functions of CE44 in cancer. (2001)

Orian-Rousseau, V., Morrison, H., Linfeng, C., Ponta, H., Herrlich, P.

6th World Congress on Advances in Oncology, Creta Maris, GR, October 18-20, 2001

Regulated alternative splicing of CD44. (2000)

König, H., Weg-Remers, S., Marx, M., Matter, N., Ponta, H., Herrlich, P.

24.Jahrestagung der Deutschen Gesellschaft für Zellbiologie, Karlsruhe, 26.-30.März 2000

The Merlin CD44 connection in contact-inhibition. (2000)

Ponta, H., Morrison, H., Herrlich, P.

24.Jahrestagung der Deutschen Gesellschaft für Zellbiologie, Karlsruhe, 26.-30.März 2000

A mechanism for contact inhibition. (2000)

Morrison, H., Sherman, L., Legg, J., Isacke, C., Ponta, H., Herrlich, P.

EMBL/SALK/EMBO Conf.on Oncogenes and Growth Control, Heidelberg, May 13-17, 2000

Tin alkyl compounds as signal molecules. The induction of programmed cell death. (2000)

Krug, H.F., Klöhn, P.C., Göttlicher, M., Herrlich, P.

Herbsttagung der Gesellschaft für Biochemie und Molekulare Biologie (GBM), München, 10.-13.Oktober 2000

The Merlin-CD44 connection. (2000)

Herrlich, P.

9th ESPR Meeting, Pigment Cell Research 2000 : Perspectives for the 3rd Millenium, Ulm, September 27 - October 1, 2000

CD44 acts both as a growth- and invasiveness-promoting molecule and as a tumor-suppressing cofactor. (2000)

Herrlich, P., Morrison, H., Sleeman, J., Orian-Rousseau, V., König, H., Weg-Remers, S., ...

Colorectal Cancer: New Aspects of Molecular Biology and Immunology and Their Clinical Applications, Berlin, October 8-9, 2000

Ligand-independent Fas receptor activation by tributyltin. (2000)

Klöhn, P.C., Krug, H.F., Meixner, S., Göttlicher, M., Herrlich, P.

Meeting on Signal Transduction: Receptors, Mediators and Genes, Berlin, November 2-4, 2000

Analysis of genes implicated in the process of metastasis. (2000)

Novac, N., Müller, T., Nestl, A., Stein, O.von, Thies, W., Zatloukal, K., ...

8th Internat.Congress of the Metastasis Research Society, London, September 24-27, 2000

Radiation-induced signal transduction. (1999)

Göttlicher, M., Bender, K., Knebel, A., Krug, H., Böhmer, F., Herrlich, P.

27th Annual Meeting of the American Society for Photobiology, Washington, D.C., July 10-15, 1999

Activity regulation of the neurofibromatosis type 2 protein (Merlin). (1999)

Morrison, H., Sherman, L., Duttu, V., Isacke, C., Herrlich, P.

Beatson Internat.Cancer Conf.'Invasion and Metastasis', Glasgow, GB, June 27-30, 1999

Oncogenic signaling pathways upregulate inclusion of CD44 variant exons. (1999)

Weg-Remers, S., Ponta, H., Stallmach, A., Zeitz, M., Herrlich, P., König, H.

7.KBF-Symp., Common Mechanisms in Development and Disease, Karlsruhe, September 8-10, 1999

Molecular functions of the tumor progression protein CD44. (1998)

Ponta, H., Sleeman, J., Sherman, L., Moll, J., Herrlich, P.

Congress 'Biological Therapy of Cancer', München, June 11-14, 1997

Regulation of inducible alternative splicing of pre-mRNA and its significance in cancer. (1998)

König, H., Ponta, H., Herrlich, P.

2nd Internat.Symp.on Regulatory Structures of Nucleic Acids and Proteins, Berlin, January 23-26, 1998

UV induced signal transduction. (1998)

Bender, K., Knebel, A., Böhmer, F., Rahmsdorf, H., Herrlich, P.

26th Annual Meeting of the American Society for Photobiology, Snowbird, Utah, July 11-15, 1998

Radiation-induced signal transduction. (1998)

Herrlich, P., Knebel, A., Bender, K., Gross, S., Rahmsdorf, H.J., Böhmer, F.D.

Academie des Sciences de l'Institut de France: Carcinogenic Risks due to Ionizing Radiation, Paris, F, May 14-16, 1998

Molecules in focus: the CD44 protein family. (1998)

Ponta, H., Wainwright, D., Herrlich, P.

The International Journal of Biochemistry and Cell Biology, 30(1998) S.299-305

Primary targets for UV-induced signal transduction. (1998)

Herrlich, P.

Innovationskolleg Zellspezialisierung, Martin-Luther-Universität, Halle-Wittenberg, 10.-13.Dezember 1998

CD44 expression is aberrant in benign Schwann cell tumors possessing mutations in the neurofibromatosis type 2, but not type 1, gene. (1997)

Sherman, L, Jacoby, L B, Lampe, J, Pelton, P, Aguzzi, A, Herrlich, P, ...

Atypical expression of CD44 splice variants has been implicated in the progression of numerous tumors. This abnormal CD44 expression is presumed to result from gene alterations that cause tumorigenic...

Primary targets of UV induced expression in mammalian cells. (1997)

Herrlich, P.

Seminar, Department of Plant Biology, Section of Plant Physiology, Lund University, Lund, S, January 23, 1997

Adhesion molecules in metastatic cancer. (1997)

Herrlich, P., Sleeman, J., Moll, J., Sherman, L.

5.Deutsch-Koreanisches Symp., Würzburg, 23.-27.Juli 1997

Molecular functions of the tumor progression protein CD44. (1997)

Ponta, H., Sleeman, J., Sherman, L., Moll, J., Herrlich, P.

American Association for Cancer Research (AACR) Special Conf.: Cell Signaling and Cancer Treatment, Telfs, A, February 23-28, 1997

Multiple sensors for toxic agents in the genetic stress response. (1997)

Herrlich, P., Rahmsdorf, H.J., Knebel, A., Krug, H., Zaucke, F., Bender, K., ...

7th Internat.Conf.on Environmental Mutagens, Toulouse, F, September 7-12, 1997

Molecular steps in metastasis formation. (1997)

Herrlich, P., Ponta, H., Hofmann, M., Stein, O.von, Sherman, L., Sleeman, H.

19th Symp.of the Internat.Association for Comparative Research on Leukemia and Related Disorders, Mannheim/Heidelberg, July 13-18, 1997

Hyaluronic acid stimulates hemopoiesis in vitro. (1997)

Khaldoyanidi, S., Kharakhanova, S., Moll, J., Herrlich, P., Ponta, H.

19th Symp.of the Internat.Assoc.for Comparative Research on Leukemia and Related Deseases, Mannheim/Heidelberg, July 13-18, 1997

Organ specific hemopoietic repopulation is influenced by CD44 variant proteins. (1997)

Kharakhanova, S., Khaldoyanidi, S., Moll, J., Herrlich, P., Ponta, H.

19th Symp.of the Internat.Assoc.for Comparative Research on Leukemia and Related Deseases, Mannheim/Heidelberg, July 13-18, 1997

UV-induced signal transduction. (1997)

Bender, K., Blattner, C., Knebel, A., Iordanov, M., Herrlich, P., Rahmsdorf, H.J.

Journal of Photochemistry and Photobiology B, 37(1997) S.1-17

An essential role for CD44 variant isoforms in epidermal Langerhans cell and dendritic cell function. (1997)

Weiss, J.M., Sleeman, J., Dittmar, H., Termeer, C.C., Renkl, A.C., Howells, N., ...

2nd Amsterdam 'Zoo' Meeting - Cell Adhesion and Migration in Inflammation and Cancer, Amsterdam, NL, October 22-25, 1997

Mechanisms of radiation-induced gene expression. (1997)

Herrlich, P.

Vortr.: Paul Scherrer Institut, Villigen, CH, 10.Juni 1997

Molecular mechanism of tumor progression. (1997)

Herrlich, P., Ponta, H., Sleeman, J., Stein, O.von, Wainwright, D.

7th Charles Heidelberger Meeting, Cancer: Genesis - Detection - Therapy, Ulm, July 2-5, 1997

Coupling of signal transduction to alternative splicing by an inducible splice enhancer in a CD44 variant exon. (1997)

König, H., Ponta, H., Herrlich, P.

Cold Spring Harbor Laboratory Meeting: Eukaryotic mRNA Processing, Cold Spring Harbor Laboratory, N.Y., August 20-24, 1997

The CD44 family of proteins: glycosaminoglycan binding and growth factor presentation. (1997)

Herrlich, P., Sleeman, J., Sherman, L., Wainwright, D., Ponta, H.

2nd Amsterdam 'Zoo' Meeting - Cell Adhesion and Migration in Inflammation and Cancer, Amsterdam, NL, October 22-25, 1997

The CD44 family of proteins: glycosaminoglycan binding and growth factor presentation. (1997)

Herrlich, P., Sleeman, J., Sherman, L., Wainwright, D., Ponta, H.

European Science Foundation Research Conf.'Molecular Biology of Cellular Interactions: Cell Adhesion Molecules and Receptor Cross-Talk', Granada, E, October 31 - November 5, 1997

Genetik im Forschungszentrum Karlsruhe. (1997)

Herrlich, P.

Nachrichten - Forschungszentrum Karlsruhe, 29(1997) S.197-99

CD44 in colon cancer. (1996)

Herrlich, P., Pals, S.T., Ponta, H.

European Journal of Cancer, 31A(1995) S.1110-12

Adhesion molecules in growth control and signal transduction. (1996)

Moll, J., Sleeman, J., Khaldoyanidi, S., Ponta, H., Herrlich, P.

10th GIF Meeting on Cell Biology of Protein Interactions, Signalling Translocation and Degradation, Dead Sea, IL, March 10-15, 1996

Umweltschadstoffe und biologische Systeme. (1996)

Dertinger, H., Herrlich, P.

Umweltschonende Hochtechnologien - Forschung und Anwendung

The hyaluronan binding of CD44 variants is not required for metastasis of tumor cells. (1996)

Sleeman, J., Arming, S., Moll, J., Herrlich, P., Ponta, H.

12th Internat.Conf.on Lymphoid Tissues and Germinal Centers in Immune Reactions, Graz, A, July 1-5, 1996

The dephosphorylation of receptor tyrosine kinases is modulated by oxidants, UV and antioxidants. (1996)

Knebel, A., Sachsenmaier, C., Rahmsdorf, H.J., Ullrich, A., Herrlich, P.

Oxidative Stress and Redox Regulation: Cellular Signaling, Aids, Cancer and other Diseases, Institut Pasteur, Paris, F, May 21-24, 1996

Signal transduction and DNA damage. (1996)

Blattner, C., Knebel, A., Bender, K., Herrlich, P., Rahmsdorf, H.J.

The UK Environmental Mutagen Society Annual Meeting, Birmingham, GB, July 15-17, 1996

The casein I, casein II and DNA-dependent protein kinase sites are not involved in the stabilization of p53 after DNA damage. (1996)

Blattner, C., Herrlich, P., Rahmsdorf, H.J.

Cold Spring Harbor Laboratory Meeting on Cancer Genetics and Tumor Suppressor Genes, Cold Spring Harbor, N.Y., August 14-18, 1996

The role of adhesion molecules in determining genetic programs. (1996)

Herrlich, P., Sleeman, J., Sherman, L., Ponta, H., Moll, J.

Internat.Summer School on Mechanisms in Eukaryotic Gene Regulation, Spetses, GR, September 2-12, 1996

Signal transduction to transcription factors. (1996)

Herrlich, P., Heck, S., Göttlicher, M., Knebel, A., Rahmsdorf, H.J.

Internat.Summer School on Mechanisms in Eukaryotic Gene Regulation, Spetses, GR, September 2-12, 1996

Ligand-independent activation of receptor tyrosine kinases. (1996)

Herrlich, P., Knebel, A., Bender, K., Blattner, C., Wilhelm, D., Rahmsdorf, H.J.

35th National Scientific Conf.of the Australian Society for Medical Research, Gold Coast, AUS, November 24-27, 1996

Radiation-induced signal transduction. (1995)

Rahmsdorf, H.J., Sachsenmaier, C., Radler-Pohl, A., Blattner, C., Van Dam, H., Herrlich, P.

McGill Cancer Centre 'Gene Induction and Adaptive Responses in Irradiated Cells: Mechanisms and Clinical Implications', Montreal, CDN, June 3-4, 1994

Dissociation of positively and negatively regulating functions of nuclear receptors. (1995)

Göttlicher, M., Heck, S., Herrlich, P., Cato, A.C.B.

EMBO Workshop: Structure and Function of Steroid and Nuclear Receptors, Porto Conte, I, April 27-30, 1995

CD44 proteins in embryonic development and human cancer. (1995)

Sherman, L., Dall, P., Ponta, H., Herrlich, P., Pals, S.T.

Tumor Microenvironment - Progression, Therapy and Prevention, Tiberias, IL, May 14-18, 1995

Regulation of P53 after DNA-damage. (1995)

Blattner, C., Herrlich, P., Rahmsdorf, H.J.

Conf.on Cancer Genetics and Tumor Supressor Genes, Frederick, Md., June 14-17, 1995

Gene regulatory pathways triggered by chemical and physical carcinogens. (1995)

Iordanov, M., Knebel, A., Wilhelm, D., Angel, P., Rahmsdorf, H.J., Herrlich, P.

6th Charles Heidelberger Conf.'Control of Cell Proliferation and Differentiation: Molecular Targets in Carcinogenesis and Cancer Therapy', Essen, July 9-13, 1995

Characteristics of the transrepression functions of the glucocorticoid receptor. (1995)

Heck, S., Wade, E., Herrlich, P., Cato, A.C.B.

5th Internat.Congress: Hormones and Cancer, Quebec, CDN, September 16-20, 1995

Regulation of AP-1 activity and of AP-1-dependent target genes. (1995)

Iordanov, M., Wade, E., Knebel, A., Angel, P., Rahmsdorf, H.J., Wilhelm, D., ...

5th Internat.Congress: Hormones and Cancer, Quebec, CDN, September 16-20, 1995

A family of adhesion molecules expressed in the embryo and in cancer cells during progression. (1995)

Herrlich, P.

The Translation of Advances in Basic Science to Human Therapy, Les Treilles, F, July 23-27, 1995

Regulation of AP-1 transcription factor activity. (1995)

Herrlich, P., Angel, P., Wilhelm, D., Tuckermann, J., Knebel, A., Rahmsdorf, H.J., ...

Symp.on Cell Proliferation, Innsbruck, A, November 30 - December 1, 1995

UV signaling through the plasma membrane. (1995)

Sachsenmaier, C., Knebel, A., Rahmsdorf, H.J., Herrlich, P.

Symp.on Cell Proliferation, Innsbruck, A, November 30 - December 1, 1995

Participation of immediate early genes in steroid hormone mediated responses. (1994)

Cato, A.C.B., Angel, P., Herrlich, P.

Keystone Symp.on Molecular and Cellular Biology, Taos, N.M., February 7-13, 1994

Ultraviolet light induced rapid signalling from plasma membrane to nucleus. (1994)

Sachsenmaier, C., Radler-Pohl, A., Knebel, A., Herrlich, P., Rahmsdorf, H.J.

Internat.Symp.'Ozone - Sun - Cancer, Molecular and Cellular Mechanisms, Prevention', Paris, F, May 17-20, 1994

Tumor metastasis formation: surface epitopes for diagnosis and treatment of human cancer. (1994)

Dall, P., Hekele, A., Heider, K.H., Ponta, H., Herrlich, P.

Meeting of the American Association for Cancer Research, Interlaken, CH, March 5-11, 1994

Growth factor receptor activation is an obligatory step in UVC-induced gene transcription. (1994)

Sachsenmaier, C., Radler-Pohl, A., Herrlich, P., Rahmsdorf, H.J.

Internat.Symp.on Ozone-Sun-Cancer: Molecular and Cellular Mechanisms, Prevention, Paris, F, May 17-20, 1994

Variants of CD44 trigger metastasis formation. (1994)

Ponta, H., Dall, P., Hekele, A., Heider, K.H., Sleeman, J., Pals, S.T., ...

13th Meeting of the European Association for Cancer Research, Berlin, September 25-28, 1994

Signal transduction following DNA damage. (1994)

Herrlich, P., Sachsenmaier, C., Radler-Pohl, A., Blattner, C., Rahmsdorf, H.J.

11th Internat.Symp.on ADP-Ribosylation, Strasbourg, F, September 17-21, 1994

CD44, a family of surface proteins of proliferating and migrating cells. (1994)

Sherman, L., Gack, S., Blum, M., Vallon, R., Angel, P., Ponta, H., ...

Arolla Workshop 1994, Cell Differentiation and Gene Expression, Zürich, CH, August 21-28, 1994

Overexpression of c-fos increases recombination frequency in human osteosarcoma cells (1993)

Rahmsdorf, H.J., Herrlich, P., Kaina, B.

We have shown previously that overexpression of c-Ha-ras, v-mos or c-fos increases the spontaneous level of chromosomal aberrations and gene mutations in NIH 3T3 cells, and that reduction of the Fos...

Entdeckung eines Metastasen-Gens. (1993)

Ponta, H., Zoeller, M., Herrlich, P.

Spektrum der Wissenschaft, (1993) Nr. 1, S.21-26

Involvement of oncogenes in mutagenesis. (1993)

Rahmsdorf, H.J., Herrlich, P., Kaina, B.

The Molecular Basis of Chromosomal Aberrations, Castlemaine, AUS, February 17-20, 1993

Carcinogen induced regulation of immediate early genes. (1993)

Herrlich, P., Sachsenmaier, C., Gebel, S., Radler-Pohl, A., Auer, H.P., Kraemer, M., ...

2nd Biannual ISREC Conf.on Genetic Damage and Escape from Proliferation Control, Lausanne, CH, January 14-15, 1993

UV-C induced immediate activation of MAP-2 kinase and c-Jun phosphorylation. (1993)

Radler-Pohl, A., Sachsenmaier, C., Gebel, S., Herrlich, P., Rahmsdorf, H.J.

Keystone Symp.'Transcription Factors, Regulation and Differentiation', Keystone, Colo., January 17-24, 1993

Oncogene overexpression affects genomic instability. (1993)

Rahmsdorf, H.J., Herrlich, P., Kaina, B.

23rd Annual Meeting of the European Environmental Mutagen Society, Barcelona, E, September 27 - October 2, 1993

CD44 V6 - marker for metastatic human tumors and aggressive lymphomas. (1993)

Herrlich, P., Ponta, H., Heider, K.H., Kaufmann, M., Sinn, H.P., Pals, S.T., ...

12th Meeting of the Internat.Society of Haematology, Wien, A, August 28 - September 3, 1993

CD44 splice variants in tumor metastasis. (1993)

Kaufmann, M., Heider, K.H., Sinn, H.P., Sleeman, J., Kondo, K., Ponta, H., ...

Cell Adhesion Meeting 'Cell Adhesion - Regulation and Clinical Prospects', Amsterdam, NL, October 13-16, 1993

UV-C induced signal transduction. (1993)

Sachsenmaier, C., Radler-Pohl, A., Blattner, C., Fritz, E., Rahmsdorf, H.J., Herrlich, P.

9th Internat.Symp.on Cellular Endocrinology 'Cell Signalling and the Molecular Stress Response' Lake Placid, N.Y., September 23-26, 1993

Expression of variant exon v6 of the surface glycoprotein CD44 - a prognostic marker in human mammary carcinomas. (1993)

Heider, K.H., Sinn, H.P., Adolf, G.R., Minckwitz, G., Kaufmann, M., Ponta, H., ...

AACR (American Association for Cancer Research) Special Conf.in Cancer Research 'Molecular Approaches to Cancer Immunotherapy', Asheville, N.C., November 7-11, 1993

Expression of variant exon v6 of the surface glycoprotein CD44 in mammary tumors correlates with poor survival. (1993)

Heider, K.H., Sinn, H.P., Kaufmann, M., Ponta, H., Herrlich, P.

The Netherlands Cancer Institute: Cell Adhesion Regulation and Clinical Prospects, Amsterdam, NL, October 13-16, 1993

Interleukin 1 induction of the c-jun promoter. (1993)

Muegge, K., Vila, M., Gusella, G.I., Musso, T., Herrlich, P., Stein, B., ...

Proceedings of the National Academy of Science of the USA, 90(1993) S.7054-58

A new prognostic surface marker for survival of patients with breast cancer. (1993)

Heider, K.H., Kaufmann, M., Sleeman, J., Arch, R., Zoeller, M., Ponta, H., ...

24th Internat.Symp.of the Princess Takamatsu Cancer Research Fund, Tokyo, J, November 9-11, 1993

CD44 splice variants in tumor metastasis. A mutational analysis. (1993)

Sleeman, J., Kondo, K., Moll, J., Zoeller, M., Arch, R., Rudy, W., ...

XI. Congresso ABCD (Cell Biology and Development Association), Milano, I, September 16-19, 1993

Metastatic behavior of cancer cells, a challenge to molecular biologists and clinicians alike. (1993)

Moll, J., Heider, K.H., Sleeman, J., Kaufmann, M., Zoeller, M., Adolf, G.R., ...

Annual Meeting of the Society for Histochemistry, Gargellen, A, September 29 - October 2, 1993

CD44 and CD44 splice variants in normal differentiation and in tumor progression. (1993)

Herrlich, P., Hofmann, M., Zoeller, M., Rudy, W., Arch, R., Heider, K.H., ...

Keystone Symp.on Cell Adhesion Mechanisms in Leukocyte Traffic, Keystone, Colo., January 24-31, 1993

Mechanismus der Tumormetastasenbildung. (1992)

Zoeller, M., Hofmann, M., Herrlich, P.

Deutscher Krebskongress, Berlin, 16.-20.Maerz 1992

Transcriptional regulation of genes in response to photon absorption. (1992)

Herrlich, P., Kraemer, M., Gebel, S., Sachsenmaier, Ch., Stein, B., Rahmsdorf, H.J.

Symp.on Activation of Cellular and Viral Genes by Optical Photons, 20th Annual Meeting of the American Society for Photobiology, Marco Island, Fla., June 21-25, 1992

The DNA binding domain of c-jun is a target for repression of AP1 activity by E1A. (1992)

Angel, P., Hagmeyer, B., Oehler, T., Herr, I., Koenig, H., ...

Keystone Symp.on Molecular and Cellular Biology, Copper Mountain, Colo., March 28 - April 4, 1992

Cross-talk between transcription factors. (1992)

Angel, P., Cato, A.C.B., Gebel, S., Koenig, H., Ponta, H., Herrlich, P.

Cytokines and Growth Factors in Cancer: From Basic Research to Clinical Application, Innsbruck, A, March 11-14, 1992

Crosstalk between transcription factors. (1992)

Herrlich, P.

Vortr.: Sonderforschungsbereich 322, Universitaet Ulm, 16.Maerz 1992

Metastatic tumor cells mimic lymphocytes. (1992)

Herrlich, P.

98.Tagung der Deutschen Gesellschaft fuer Innere Medizin, Wiesbaden, 26.-29.April 1992

Tumorprogression mediated by isoforms of the surface-glycoprotein CD44. (1992)

Rudy, W., Hofmann, M., Schwartz-Albiez, R., Zoeller, M., Heider, K.H., Ponta, H., ...

3rd Meeting on the Molecular Basis of Human Cancer, Frederick, Md., June 18-21, 1992

AP1: multiple mechanisms to regulate its activity. (1992)

Angel, P., Oehler, T., Hagmeyer, B., Gebel, S., Koenig, H., Herr, I., ...

2nd Internat.Symp.on Molecular Hematology, Freiburg, June 18-20, 1992

Interactions of hormone receptors with the Fos/Jun complex. (1992)

Herrlich, P., Cato, A.C.B., Koenig, H., Nebl, G., Ponta, H.

Zinc-Finger Proteins in Oncogenesis: DNA Binding and Gene Regulation, Leeuwenhorst, NL, September 6-9, 1992

Transcription factor interactions. (1992)

Ponta, H., Cato, A.C.B., Koenig, H., Nebl, G., Herrlich, P.

17th European Symp.on Hormones and Cell Regulation, Strasbourg, F, September 25-28, 1992

Cellular responses to carcinogens. (1992)

Herrlich, P., Radler-Pohl, A., Rahmsdorf, H.J., Sachsenmaier, Ch.

AACR Special Conf. Chemicals, Mutations and Cancer, Banff, CDN, December 7-12, 1992

Regulation of gene expression by steroid hormones. (1992)

Cato, A.C.B., Ponta, H., Herrlich, P.

Progress in Nucleic Acid Research and Molecular Biology

Inducible effects of DNA damage. (1991)

Herrlich, P., Kraemer, M., Gebel, S., Luecke-Huhle, C., Mai, S., Fritz, G., ...

Workshop on DNA Repair, Noordwijkerhout, NL, April 14-19, 1991

Dominant and recessive metastasis genes. (1991)

Herrlich, P., Ponta, H., Hofmann, M., Guenthert, U., Zoeller, M.

Soviet-German (West European) Molecular Biology Meeting, Konstanz, June 18-21, 1991

Mechanism of interference between glucocorticoid hormone receptor and the transcription factor AP-1. (1991)

Herrlich, P.

1st Joint Conf.of the American Association for Cancer Research and European Association for Cancer Research, Santa Margarita, I, November 6-9, 1991

Mechanism of interference between glucocorticoid hormone receptor and the transcription factor AP-1. (1991)

Koenig, H., Gebel, S., Hagmeyer, B., Van Dam, H., Angel, P., Ponta, H., ...

11th Biennial Meeting of the European Association for Cancer Research, Genova, I, November 3-6, 1991

Die Wirkung krebserregender Substanzen in der Tumorpromotion. (1991)

Rahmsdorf, H.J., Ponta, H., Herrlich, P.

Umwelt und Krebs : Tagung der AGF, Bonn-Bad Godesberg, 13.-14.Dezember 1990 Berichtsband

The interference between pathway specific transcription factors. (1991)

Koenig, H., Cato, A.C.B., Ponta, H., Rahmsdorf, H.J., Herrlich, P.

4th Internat.Congress on Hormones and Cancer, Amsterdam, NL, September 15-19, 1991

Regulation and function of metastasis-specific cell surface molecules. (1991)

Guenthert, U., Hofmann, M., Zoeller, M., Herrlich, P.

1st Joint Conf.of the American Association for Cancer Research and European Association for Cancer Research, Santa Margarita, I, November 6-9, 1991

Damage induced signal transduction in mammalian cells. (1990)

Mai, S., Stein, B., Rahmsdorf, H.J., Kaina, B., Luecke-Huhle, C., Herrlich, P.

Conf.on Ionizing Radiation Damage to DNA: Molecular Aspects, Lake Tahoe, Calif., January 13-28, 1990

Inhibition of AP1 by adenovirus E1A: a novel function for CR1. (1990)

Timmers, H.Th.M., Offringa, R., Van Dam, H., Zantema, A., Bos, J.L., Herrlich, P., ...

UCLA Symp.on Molecular and Cellular Biology 'Transcriptional Control of Cell Growth', Keystone, Colo., January 27 - February 2, 1990

Stress-induced genetic changes in mammalian cells. (1990)

Kaina, B., Mai, S., Luecke-Huhle, C., Fritz, G., Rahmsdorf, H.J., ...

Fruehjahrstagung der Deutschen Gesellschaft fuer Zellbiologie, Bremen, 19.-22.Maerz

F9 terracarcinoma cells loose the ability of damage-induced DHFR amplification upon retinoic acid induced endodermal differentiation. (1990)

Luecke-Huhle, C., Herrlich, P.

Workshop Molekulare Strahlenbiologie: DNS-Schaeden, ihre Reparatur und biologische Bedeutung, Muenchen-Neuherberg, 21.-23.Maerz 1990

Primary interactions of adverse environmental agents are transduced into genetic consequences by cellular mechanisms: an analysis into the molecular components of the response. (1990)

Kraemer, M., Kaina, B., Herrlich, P., Rahmsdorf, H.J.

Jahrestagung der Gesellschaft fuer Umwelt- und Mutationsforschung, Die zukuenftige Nutzung der Molekularbiologie in der Mutagenitaetspruefung, Westerland, 3.-4.Mai 1990

Metastasis-associated expression of surface proteins. (1990)

Guenthert, U., Hofmann, M., Rudy, W., Herrlich, P., Zoeller, M., Matzku, S., ...

Hoppe-Seylers Herbsttagung der Gesellschaft fuer Biologische Chemie, Konstanz, 17.-19.September 1990

Negative control of AP-1 activity by glucocorticoid hormone requires a novel function of the specific receptor molecule. (1989)

Jonat, C., Rahmsdorf, H.J., Ponta, H., Cato, A.C.B., Kraemer, M., Offringa, R., ...

8th Cold Spring Harbor Conf.on Cancer Cells 'Regulation of Eukaryotic mRNA Transcription', Cold Spring Harbor, N.Y., September 6-10, 1989

The mammalian UV response. (1989)

Mai, S., Rahmsdorf, H.J., Ponta, H., Stein, B., Kaina, B., ...

NICHD Workshop on Genetic Response to Environmental Adversity, Airlie, USA, April 23-26, 1989

Mechanism of the UV response in mammalian cells. (1989)

Herrlich, P., Mai, S., Waldstein, E., Kaina, B., Lavi, S., ...

UKEMS/DNA Repair Network Meeting, Brighton, GB, April 3-7, 1989

Adenovirus Ela represses the activity of the TPA responsive element while inducing the c-jun gene. (1989)

Offringa, R., Gebel, S., Smits, L., Van Dam, H., Zwart, R., Bos, J.L., ...

8th Cold Spring Harbor Conf.on Cancer Cells 'Regulation of Eukaryotic mRNA Transcription', Cold Spring Harbor, N.Y., September 6-10, 1989

Regulatorische Elemente induzierbarer Gene. (1989)

Herrlich, P.

10.Krebskongress der DDR, Berlin, DDR, 4.-7.Dezember 1989

Modulation of expression of stress-related genes. (1989)

Jonat, C., Gebel, S., Cato, A.C.B., Rahmsdorf, H.J., Ponta, H., Herrlich, P.

3rd Internat.Conf.on Anticarcinogenesis and Radiation Protection, Dubrovnik, YU, October 15-21, 1989

Genotoxic agents and the control of gene expression and amplification. (1989)

Herrlich, P., Mai, S., Stein, B., Rahmsdorf, H.J., Luecke-Huhle, C., Ponta, H., ...

Falk Symp.No. 55 'Proteins in the Regulation of Hepatic Genes' Basel, CH, October 15-17, 1989

Mechanisms of the mammalian UV response. (1988)

Herrlich, P., Stein, B., Schoenthal, A., Gebel, S., Buescher, M., Vanetti, M., ...

NATO-Advanced Workshop 'DNA Repair Mechanisms' Fontevraud, F, October 2-7, 1988

The ultraviolet light induced signal pathways to specific genes. (1988)

Rahmsdorf, H.J., Stein, B., Buescher, M., Vanetti, M., Schoenthal, A., Ponta, H., ...

10th Internat.Congress on Photobiology, Jerusalem, IL, October 30 - November 4, 1988

Metallothionein overexpression protects from MNNG-induced alkylation death. (1988)

Kaina, B., Lohrer, H., Karin, M., Herrlich, P.

NATO-Advanced Workshop 'DNA Repair Mechanisms' Fontevraud, F, October 2-7, 1988

Cis-acting elements for UV and TPA induced c-fos expression. (1987)

Buescher, M., Rahmsdorf, H.J., Herrlich, P.

Tagung der Gesellschaft fuer Genetik, Martinsried, 28.-30.Mai 1987

Signal transduction genes induced by carcinogenic agents. (1987)

Herrlich, P.

Vortr.: Friedrich-Miescher-Institut, Basel, CH, 17.Juni 1987

DNA damage inducible responses in mammalian cells. (1987)

Herrlich, P., Imagawa, M., Angel, P., Buescher, M., Karin, M., Rahmsdorf, H.J., ...

British Association for Cancer Research Annual General Meeting, Univ.of Newcastle upon Tyne, GB, April 5-8, 1987

An XPA cell clone with intermediate UV sensitivity following transfection with genomic mouse DNA. (1987)

Blum, M., Lohrer, H., Herrlich, P.

ASM Conf.on DNA Replication and Mutagenesis, Marco Island, USA, November 8-12, 1987

A 'UV response' in mammalian cells. (1987)

Herrlich, P.

ASM Conf.on DNA Replication and Mutagenesis, Marco Island, USA, November 8-12, 1987

Preformed regulatory proteins as targets of carcinogen action. (1987)

Herrlich, P., Stein, B., Rahmsdorf, H.J., Buescher, M., Schoenthal, A., Angel, P., ...

Japanese-German Workshop on 'Molecular Aspects of Cacinogenesis', Essen, October 1-3, 1987

Radiation-induced amplification of viral DNA sequences integrated in the genome of Chinese hamster embryo cells. (1986)

Luecke-Huhle, C., Herrlich, P.

19th Annual Meeting of the European Society for Radiation Biology, Praha, CS, August 26 - 30, 1985

Analysis of the metastatic phenotype of rat metastasizing tumor cells. (1986)

Giles, M., Guenthert, U., Herrlich, P., Matzku, S., Ponta, H.

Internat.Conf.on Biological and Therapeutic Aspects of Cancer Metastasis, Vitoria, E, April 14-17, 1986

Genes and gene products identified as part of the mammalian genetic stress response. (1986)

Rahmsdorf, H.J., Angel, P., Schorpp, M., Luecke-Huhle, C., Herrlich, P.

UCLA-Symp.on Growth Factors, Tumor Promoters and Cancer Genes, Steamboat Springs, Colo., April 2-16, 1986

The metallothionein gene reveals a general stress sensing mechanism. (1985)

Herrlich, P., Karin, M., Rahmsdorf, H.J., Angel, P., Cato, A.C.B.

11th EMBO Annual Symp. 'Growth Factors, Receptors and Oncogenes', Heidelberg, September 16-19, 1985

Mammalian stress response, its genetic components and possible function. (1985)

Herrlich, P., Angel, P., Luecke-Huhle, C., Harth, N., Eades, A., Rahmsdorf, H.J.

24th Internat.Symp., on Regulation of Enzyme Activity, Indianapolis, Ind., September 30 - October 1, 1985

Proliferation-controlled genes in primary human fibroblasts. (1984)

Angel, P., Poeting, A., Rahmsdorf, H.J., Mallick, U., Herrlich, P.

6th Conf.on Macromolecular Synthesis Gene Expression, Hamburg, May 30 - June 3, 1984

Alpha radiation induced gene amplification in Chinese hamster cells. (1984)

Luecke-Huhle, C., Herrlich, P.

18th Annual Meeting European Society for Radiation Biology, Zuerich, CH, September 9-13, 1984

An UV inducible factor regulates carcinogen and carcinogen dependent gene expression. (1984)

Angel, P., Schorpp, M., Poeting, A., Rahmsdorf, H.J., Mallick, U., Herrlich, P.

Cold Spring Harbor Meeting Cell Proliferation and Cancer: Growth Factors and Transformation, Cold Spring Harbor, N.Y., September 19-23, 1984

Biologische Wirkung von Strahlung: Neue Ergebnisse und Entwicklungen. (1984)

Rahmsdorf, H.J., Herrlich, P., Schorpp, M., Angel, P., Luecke-Huhle, C., Poeting, A., ...

Strahlung und Radionuklide in der Umwelt: Tagung der Arbeitsgemeinschaft der Grossforschungseinrichtungen, Bonn, 8.-9.November 1984

Alpha radiation induces changes of gene expression. (1983)

Herrlich, P., Hieber, L., Luecke-Huhle, C., Mallick, U.

Biological Effects of Low-Level Radiation : Proc.of an Internat.Symp.on the Effects of Low-Level Radiation with Special Regard to Stochastic and Non-Stochastic Effects, Venezia, I, April 11-15, 1983

Gene and genome amplification in mammalian cells following exposure to 3.4 MeV alpha particles. (1983)

Luecke-Huhle, C., Hieber, L., Kennedy, N., Herrlich, P.

UCLA Symp.on the Repair of Genomic Damage in Living Tissue, Keystone, Colo., April 10-15, 1983

Ionisierende Strahlung aktiviert Gene. (1982)

Herrlich, P., Rahmsdorf, H.J., Hieber, L., Luecke-Huhle, C., Ponta, H., Mallick, U.

Wissenschaftliche Vortragsveranstaltung der Arbeitsgemeinschaft der Grossforschungseinrichtungen, Wissenschaftszentrum, Bonn, 4.-5.November 1982

Arresting replication induces Ia associated invariant chain synthesis in proliferating B cells. (1982)

Rahmsdorf, H.J., Mallick, U., Herrlich, P., Koch, N.

Joint Meeting of the Nordic Biochemical Society and the Gesellschaft fuer Biologische Chemie, Damp/Kiel, September 27-29, 1982

DNA mediated transfer and fate of a proviral gene of mouse mammary tumor virus in cultured cells. (1982)

Hynes, N., Rahmsdorf, U., Kennedy, N., Herrlich, P., Hohn, B., Groner, B.

Burger, M.M. [Hrsg.]: Embryonic Development: 9.Congress of the Internat.Society of Developmental Biologists, Basel, CH, August 28 - September 1, 1981. - New York: Liss. (Progress in Clinical and...

B lymphocyte specific nuclear proteins are induced by mutagenic treatment. (1982)

Herrlich, P., Rahmsdorf, H.J., Ponta, H., Mallick, U.

Special FEBS-Meeting (Federation of European Biochemical Societies), Athinai, GR, April 25-29, 1982

The endogenous proviral mouse mammary tumor virus genes of the GR mouse are not identical and only one corresponds to the exogenous virus (1981)

Herrlich, P., Hynes, N.E., Ponta, H., Rahmsdorf, U., Kennedy, N., Groner, B.

The endogenous proviral copies of mouse mammary tumor virus (MMTV) were selected from a gene library of GR mouse DNA. We obtained five different λ.MMTV recombinant clones. Four of them correspond to...

Hormone responsive expression of a cloned mouse mammary tumor virus gene in transfected L cells. (1981)

Groner, B., Kennedy, N., Rahmsdorf, U., Herrlich, P., Hynes, N.

1st Symp.of the Section of Experimental Cancer Research (SEK) of the German Cancer Society, Heidelberg, March 11-13, 1981

An inducible DNA-binding protein in mammalian cells. (1981)

Mallick, U., Rahmsdorf, H.J., Ponta, H., Herrlich, P.

10th Annual ICN-UCLA Symp. 'Molecular and Cellular Biology', Keystone, Colo., February 8 - March 20, 1981

TPA-inducible proteins are synthesized at elevated rate in Bloom's syndrome. (1981)

Mallick, U., Rahmsdorf, H.J., Yamamoto, N., Ponta, H., Herrlich, P.

Meeting of the Internat.Soc.of Developmental Biologists, Basel, CH, August 28 - September 1, 1981

Regulation eines Tumorgens. (1981)

Herrlich, P.

Festkolloquium aus Anlass des 25-jaehrigen Bestehens des Kernforschungszentrums Karlsruhe, Kernforschungszentrum Karlsruhe, 11.Juni 1981

Different DNA repair capacity in various differentiated cells. (1980)

Rahmsdorf, H.J., Ponta, H., Mallick, U., Weibezahn, K.F., Herrlich, P.

2nd Internat.Congress on Cell Biology, Berlin, August 31 - September 5, 1980.

Two mechanisms of antirestriction. (1980)

Spoerel, N., Litfin, F., Herrlich, P.

EMBO Workshop on Protein-DNA Interactions in Bacteriophages. Salamanca, E, June 30 - July 5, 1980

Virus T7: a probe of cellular control mechanisms. (1979)

Herrlich, P., Schweiger, M., Rahmsdorf, H.J., Ponta, H., Spoerel, N., Pfennig-Yeh, M.L., ...

Rosenthal, S., Bielka, H. (u.a.Hrsg.): Gene functions. Oxford,New York,N.Y.: Pergamon Pr.1979. (FEBS Federation of European Biochemical Societies, 12th meeting, Dresden 1978. Vol.51.) S.337-346

Gen-Manipulation. (1979)

Herrlich, P.

KfK-Nachrichten, 11(1979) No 4, S.49

Interleukin 1 induction of the c-jun promoter.

Muegge, K, Vila, M, Gusella, G L, Musso, T, Herrlich, P, Stein, B, ...

Interleukin 1 (IL-1) induces pleiotropic effects in many cell types during inflammation and immunity. We have recently shown how the IL-1 signal is transmitted to the nucleus: In T cells and in...

Overexpressed human metallothionein IIA gene protects Chinese hamster ovary cells from killing by alkylating agents.

Kaina, B, Lohrer, H, Karin, M, Herrlich, P

Experiments were designed to detect survival advantages that cells gain by overexpressing metallothionein (MT). Chinese hamster ovary K1-2 cells and an x-ray-sensitive derivative were transfected...

UV-induced transcription from the human immunodeficiency virus type 1 (HIV-1) long terminal repeat and UV-induced secretion of an extracellular factor that induces HIV-1 transcription in nonirradiated cells.

Stein, B, Krämer, M, Rahmsdorf, H J, Ponta, H, Herrlich, P

UV irradiation, but not visible sunlight, induces the transcription of human immunodeficiency virus type 1 (HIV-1). Chimeric constructs carrying all or parts of the HIV-1 long terminal repeat linked...

Splicing choice from ten variant exons establishes CD44 variability.

Tölg, C, Hofmann, M, Herrlich, P, Ponta, H

The enormous heterogeneity of the surface protein designated CD44 is in part due to posttranslational modification, and in part due to differential splicing. Alternative splicing occurs within one...

The endogenous proviral mouse mammary tumor virus genes of the GR mouse are not identical and only one corresponds to the exogenous virus.

Herrlich, P, Hynes, N E, Ponta, H, Rahmsdorf, U, Kennedy, N, Groner, B

The endogenous proviral copies of mouse mammary tumor virus (MMTV) were selected from a gene library of GR mouse DNA. We obtained five different lambda. MMTV recombinant clones. Four of them...

A new cAMP response element in the transcribed region of the human c-fos gene.

Härtig, E, Loncarević, I F, Büscher, M, Herrlich, P, Rahmsdorf, H J

In NIH 3T3 cells the c-fos gene is induced rapidly and transiently by cAMP. As shown by the analysis of 3T3 cells stably transfected with promoter mutants of the human c-fos gene this induction does...

Posttranscriptional regulation of c-fos mRNA expression.

Rahmsdorf, H J, Schönthal, A, Angel, P, Litfin, M, Rüther, U, Herrlich, P

The transient induction of c-fos mRNA and protein suggests that regulation occurs not only by transcriptional activation but also at the level of turnover of the gene product. Here we present...

12-O-tetradecanoylphorbol 13-acetate-inducible proteins are synthesized at an increased rate in Bloom syndrome fibroblasts.

Mallick, U, Rahmsdorf, H J, Yamamoto, N, Ponta, H, Wegner, R D, Herrlich, P

A set of proteins, which in normal fibroblasts were barely, if at all, detectable, were synthesized at an increased rate in fibroblasts from patients with Bloom syndrome (BS). The same set of...

Differential effects of the adenovirus E1A oncogene on members of the AP-1 transcription factor family.

Van Dam, H, Offringa, R, Meijer, I, Stein, B, Smits, A M, Herrlich, P, ...

The adenovirus early region 1A (E1A) oncogene interferes with the expression level and activity of the AP-1 transcription factor family. E1A abolished the transactivating function of AP-1 (Jun/Fos),...

Infection with the intracellular protozoan parasite Theileria parva induces constitutively high levels of NF-kappa B in bovine T lymphocytes.

Ivanov, V, Stein, B, Baumann, I, Dobbelaere, D A, Herrlich, P, Williams, R O

The intracellular protozoan parasite Theileria parva causes a lymphoproliferative disease of T cells in cattle and uncontrolled lymphocyte proliferation in culture. We have identified and...

UV-induced early-domain binding factor as the limiting component of simian virus 40 DNA amplification in rodent cells.

Lücke-Huhle, C, Mai, S, Herrlich, P

UV radiation and other carcinogenic agents induce an increase in DNA-binding activity to the early domain of the simian virus 40 (SV40) minimal origin in both SV40-permissive and SV40-nonpermissive...

UV-induced DNA damage is an intermediate step in UV-induced expression of human immunodeficiency virus type 1, collagenase, c-fos, and metallothionein.

Stein, B, Rahmsdorf, H J, Steffen, A, Litfin, M, Herrlich, P

UV irradiation of human and murine cells enhances the transcription of several genes. Here we report on the primary target of relevant UV absorption, on pathways leading to gene activation, and on...

12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region.

Angel, P, Baumann, I, Stein, B, Delius, H, Rahmsdorf, H J, Herrlich, P

Genomic clones coding for human fibroblast collagenase were isolated. By constructing and transfecting mutants with 5' and 3' deletion mutations of the 5' control region of the gene into human or...

Induction of metallothionein and other mRNA species by carcinogens and tumor promoters in primary human skin fibroblasts.

Angel, P, Pöting, A, Mallick, U, Rahmsdorf, H J, Schorpp, M, Herrlich, P

We used nucleic acid hybridization and cDNA cloning techniques to isolate human sequences that respond to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). These clones were used as...

Protein Kinase Induction in Escherichia coli by Bacteriophage T7

Rahmsdorf, H. J., Pai, S. H., Ponta, P., Herrlich, P., Roskoski, R., Schweiger, M., ...

After bacteriophage T7 infection, a protein kinase (EC 2.7.1.37; ATP:protein phosphotransferase) activity can be demonstrated in E. coli in vivo by sodium dodecyl sulfate-polyacrylamide gel...

Translational Control Induced by Bacteriophage T7

Herrlich, P., Rahmsdorf, H. J., Pai, S. H., Schweiger, M.

Phage T7 discontinues host gene expression by translational and transcriptional control mechanisms. Translational control is exerted by the T7 translational-repressor. This protein inhibits the...

Subfragments of the large terminal repeat cause glucocorticoid-responsive expression of mouse mammary tumor virus and of an adjacent gene.

Hynes, N, Van Ooyen, A J, Kennedy, N, Herrlich, P, Ponta, H, Groner, B

After transfection of mouse mammary tumor virus (MMTV) proviral DNA into cultured cells, the DNA is transcribed in a glucocorticoid-sensitive fashion. The large terminal repeat (LTR) region of MMTV...

A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1.

Heck, S, Kullmann, M, Gast, A, Ponta, H, Rahmsdorf, H J, Herrlich, P, ...

Steroid receptors activate and repress genes. An important class of genes that they repress is controlled by the transcription factor AP-1. The activity of AP-1 is inhibited by the receptor, a...

ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents.

Van Dam, H, Wilhelm, D, Herr, I, Steffen, A, Herrlich, P, Angel, P

The major regulators of the c-jun promoter are ATF-2 and c-Jun. They act as pre-bound heterodimers on two 'AP-1-like' sites, and are preferentially addressed by different types of extracellular...

Autoregulation of fos: the dyad symmetry element as the major target of repression.

König, H, Ponta, H, Rahmsdorf, U, Büscher, M, Schönthal, A, Rahmsdorf, H J, ...

Fos and Jun co-operatively repress the fos promoter. Removal of all putative Fos/Jun binding sites from the fos promoter neither obliterates the repression by Fos/Jun in transient cotransfection...

Regulation of synthesis of a major outer membrane protein: cyclic AMP represses Escherichia coli protein III synthesis.

Mallick, U, Herrlich, P

Cyclic AMP is the effector molecule for both positive and negative control of synthesis of several Escherichia coli proteins. Among the latter is the major outer membrane protein III. The control...

Export without proteolytic processing of inner and outer membrane proteins encoded by F sex factor tra cistrons in Escherichia coli minicells.

Achtman, M, Manning, P A, Edelbluth, C, Herrlich, P

Most tra proteins encoded by the Escherichia coli F sex factor are incorporated into the minicell envelope. We have now assigned the tra proteins to cytoplasm (TraIp and 2b), inner membrane (TraEp,...

Heterodimer formation of cJun and ATF-2 is responsible for induction of c-jun by the 243 amino acid adenovirus E1A protein.

Van Dam, H, Duyndam, M, Rottier, R, Bosch, A, Herrlich, P, ...

The adenovirus E1A proteins differentially regulate AP-1-responsive genes. Collagenase and stromelysin are repressed by E1A, whereas the expression of c-jun is elevated. Inhibition of collagenase has...

UV-induced activation of AP-1 involves obligatory extranuclear steps including Raf-1 kinase.

Radler-Pohl, A, Sachsenmaier, C, Gebel, S, Auer, H P, Bruder, J T, Rapp, U, ...

Irradiation of cells with ultraviolet light (UV) leads to modifications of c-Jun resembling those elicited by phorbol esters or oncogenes, and to enhanced transcription of AP-1-dependent genes. The...

Adenovirus E1A negatively and positively modulates transcription of AP-1 dependent genes by dimer-specific regulation of the DNA binding and transactivation activities of Jun.

Hagmeyer, B M, König, H, Herr, I, Offringa, R, Zantema, A, ...

Adenovirus E1A proteins inhibit expression of the collagenase gene but activate expression of the c-jun gene. Both effects are mediated by TPA-responsive elements (TREs), the binding sites for...

Cross-coupling of the NF-kappa B p65 and Fos/Jun transcription factors produces potentiated biological function.

Stein, B, Baldwin, A S, Ballard, D W, Greene, W C, Angel, P, Herrlich, P

NF-kappa B and AP-1 represent distinct mammalian transcription factors that target unique DNA enhancer elements. The heterodimeric NF-kappa B complex is typically composed of two DNA binding...

Nitrofurans, a group of synthetic antibiotics, with a new mode of action: discrimination of specific messenger RNA classes.

Herrlich, P, Schweiger, M

Nitrofurans, a class of antibacterial drugs in extensive use, interferes with gene expression in a highly specific manner. While in the low dose range (0.5-25 mug/ml),...

Trans-acting factors regulate the expression of CD44 splice variants.

Konig, H, Moll, J, Ponta, H, Herrlich, P

Variant isoforms of the cell surface glycoprotein CD44 (CD44v) are expressed during development, in selected adult tissues and in certain metastatic tumor cells. CD44v differ from the standard...

Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents.

Knebel, A, Rahmsdorf, H J, Ullrich, A, Herrlich, P

Several non-physiologic agents such as radiation, oxidants and alkylating agents induce ligand-independent activation of numerous receptor tyrosine kinases (RTKs) and of protein tyrosine kinases at...

Two different functions for CD44 proteins in human myelopoiesis.

Moll, J, Khaldoyanidi, S, Sleeman, J P, Achtnich, M, Preuss, I, Ponta, H, ...

CD44 is important during myelopoiesis, although the contributions of variant CD44 proteins are unclear. We show here that in human long-term bone marrow culture antibodies recognizing a CD44...

Regulation of MHC class II invariant chain expression: induction of synthesis in human and murine plasmocytoma cells by arresting replication.

Rahmsdorf, H J, Koch, N, Mallick, U, Herrlich, P

The expression of the H2 Ia-associated invariant chain (Ii) has been determined by pulse labeling cells with [35S]methionine and resolving the proteins. Expression is maximal in noncycling peripheral...

Interference between pathway-specific transcription factors: glucocorticoids antagonize phorbol ester-induced AP-1 activity without altering AP-1 site occupation in vivo.

König, H, Ponta, H, Rahmsdorf, H J, Herrlich, P

Phorbol esters stimulate and glucocorticoid hormones down-regulate a variety of promoters such as that of the collagenase gene through the transcription factor AP-1 (Fos/Jun). We now show by genomic...

Comparison of human stromelysin and collagenase by cloning and sequence analysis.

Whitham, S E, Murphy, G, Angel, P, Rahmsdorf, H J, Smith, B J, Lyons, A, ...

A comparison of the cDNA-derived amino acid sequences of human stromelysin and collagenase with the N-terminal sequences of purified enzymes reveals that these metalloproteinases are highly conserved...

CREB is activated by UVC through a p38/HOG-1-dependent protein kinase.

Iordanov, M, Bender, K, Ade, T, Schmid, W, Sachsenmaier, C, Engel, K, ...

Changes in environmental conditions such as the addition of growth factors or irradiation of cells in culture first affect immediate response genes. We have shown previously that short wavelength UV...

I kappaB alpha-independent downregulation of NF-kappaB activity by glucocorticoid receptor.

Heck, S, Bender, K, Kullmann, M, Göttlicher, M, Herrlich, P, Cato, A C

I kappaB alpha is an inhibitor protein that prevents nuclear transport-and activation of the transcription factor NF-kappaB. In acute inflammation, NF-kappaB is activated and increases the expression...

Coupling of signal transduction to alternative pre-mRNA splicing by a composite splice regulator.

König, H, Ponta, H, Herrlich, P

Alternative splicing of pre-mRNA is a fundamental mechanism of differential gene expression in that it can give rise to functionally distinct proteins from a single gene, according to the...

Sequential DNA damage-independent and -dependent activation of NF-kappaB by UV.

Bender, K, Göttlicher, M, Whiteside, S, Rahmsdorf, H J, Herrlich, P

NF-kappaB activation in response to UV irradiation of HeLa cells or of primary human skin fibroblasts occurs with two overlapping kinetics but totally different mechanisms. Although both mechanisms...

Interleukin 1 induction of the c-jun promoter.

Muegge, K, Vila, M, Gusella, G L, Musso, T, Herrlich, P, Stein, B, ...

Interleukin 1 (IL-1) induces pleiotropic effects in many cell types during inflammation and immunity. We have recently shown how the IL-1 signal is transmitted to the nucleus: In T cells and in...

Overexpressed human metallothionein IIA gene protects Chinese hamster ovary cells from killing by alkylating agents.

Kaina, B, Lohrer, H, Karin, M, Herrlich, P

Experiments were designed to detect survival advantages that cells gain by overexpressing metallothionein (MT). Chinese hamster ovary K1-2 cells and an x-ray-sensitive derivative were transfected...

UV-induced transcription from the human immunodeficiency virus type 1 (HIV-1) long terminal repeat and UV-induced secretion of an extracellular factor that induces HIV-1 transcription in nonirradiated cells.

Stein, B, Krämer, M, Rahmsdorf, H J, Ponta, H, Herrlich, P

UV irradiation, but not visible sunlight, induces the transcription of human immunodeficiency virus type 1 (HIV-1). Chimeric constructs carrying all or parts of the HIV-1 long terminal repeat linked...

Splicing choice from ten variant exons establishes CD44 variability.

Tölg, C, Hofmann, M, Herrlich, P, Ponta, H

The enormous heterogeneity of the surface protein designated CD44 is in part due to posttranslational modification, and in part due to differential splicing. Alternative splicing occurs within one...

The endogenous proviral mouse mammary tumor virus genes of the GR mouse are not identical and only one corresponds to the exogenous virus.

Herrlich, P, Hynes, N E, Ponta, H, Rahmsdorf, U, Kennedy, N, Groner, B

The endogenous proviral copies of mouse mammary tumor virus (MMTV) were selected from a gene library of GR mouse DNA. We obtained five different lambda. MMTV recombinant clones. Four of them...

A new cAMP response element in the transcribed region of the human c-fos gene.

Härtig, E, Loncarević, I F, Büscher, M, Herrlich, P, Rahmsdorf, H J

In NIH 3T3 cells the c-fos gene is induced rapidly and transiently by cAMP. As shown by the analysis of 3T3 cells stably transfected with promoter mutants of the human c-fos gene this induction does...

Posttranscriptional regulation of c-fos mRNA expression.

Rahmsdorf, H J, Schönthal, A, Angel, P, Litfin, M, Rüther, U, Herrlich, P

The transient induction of c-fos mRNA and protein suggests that regulation occurs not only by transcriptional activation but also at the level of turnover of the gene product. Here we present...

12-O-tetradecanoylphorbol 13-acetate-inducible proteins are synthesized at an increased rate in Bloom syndrome fibroblasts.

Mallick, U, Rahmsdorf, H J, Yamamoto, N, Ponta, H, Wegner, R D, Herrlich, P

A set of proteins, which in normal fibroblasts were barely, if at all, detectable, were synthesized at an increased rate in fibroblasts from patients with Bloom syndrome (BS). The same set of...

Differential effects of the adenovirus E1A oncogene on members of the AP-1 transcription factor family.

Van Dam, H, Offringa, R, Meijer, I, Stein, B, Smits, A M, Herrlich, P, ...

The adenovirus early region 1A (E1A) oncogene interferes with the expression level and activity of the AP-1 transcription factor family. E1A abolished the transactivating function of AP-1 (Jun/Fos),...

Infection with the intracellular protozoan parasite Theileria parva induces constitutively high levels of NF-kappa B in bovine T lymphocytes.

Ivanov, V, Stein, B, Baumann, I, Dobbelaere, D A, Herrlich, P, Williams, R O

The intracellular protozoan parasite Theileria parva causes a lymphoproliferative disease of T cells in cattle and uncontrolled lymphocyte proliferation in culture. We have identified and...

UV-induced early-domain binding factor as the limiting component of simian virus 40 DNA amplification in rodent cells.

Lücke-Huhle, C, Mai, S, Herrlich, P

UV radiation and other carcinogenic agents induce an increase in DNA-binding activity to the early domain of the simian virus 40 (SV40) minimal origin in both SV40-permissive and SV40-nonpermissive...

UV-induced DNA damage is an intermediate step in UV-induced expression of human immunodeficiency virus type 1, collagenase, c-fos, and metallothionein.

Stein, B, Rahmsdorf, H J, Steffen, A, Litfin, M, Herrlich, P

UV irradiation of human and murine cells enhances the transcription of several genes. Here we report on the primary target of relevant UV absorption, on pathways leading to gene activation, and on...

12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region.

Angel, P, Baumann, I, Stein, B, Delius, H, Rahmsdorf, H J, Herrlich, P

Genomic clones coding for human fibroblast collagenase were isolated. By constructing and transfecting mutants with 5' and 3' deletion mutations of the 5' control region of the gene into human or...

Induction of metallothionein and other mRNA species by carcinogens and tumor promoters in primary human skin fibroblasts.

Angel, P, Pöting, A, Mallick, U, Rahmsdorf, H J, Schorpp, M, Herrlich, P

We used nucleic acid hybridization and cDNA cloning techniques to isolate human sequences that respond to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). These clones were used as...

Protein Kinase Induction in Escherichia coli by Bacteriophage T7

Rahmsdorf, H. J., Pai, S. H., Ponta, P., Herrlich, P., Roskoski, R., Schweiger, M., ...

After bacteriophage T7 infection, a protein kinase (EC 2.7.1.37; ATP:protein phosphotransferase) activity can be demonstrated in E. coli in vivo by sodium dodecyl sulfate-polyacrylamide gel...

Translational Control Induced by Bacteriophage T7

Herrlich, P., Rahmsdorf, H. J., Pai, S. H., Schweiger, M.

Phage T7 discontinues host gene expression by translational and transcriptional control mechanisms. Translational control is exerted by the T7 translational-repressor. This protein inhibits the...

Subfragments of the large terminal repeat cause glucocorticoid-responsive expression of mouse mammary tumor virus and of an adjacent gene.

Hynes, N, Van Ooyen, A J, Kennedy, N, Herrlich, P, Ponta, H, Groner, B

After transfection of mouse mammary tumor virus (MMTV) proviral DNA into cultured cells, the DNA is transcribed in a glucocorticoid-sensitive fashion. The large terminal repeat (LTR) region of MMTV...

A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1.

Heck, S, Kullmann, M, Gast, A, Ponta, H, Rahmsdorf, H J, Herrlich, P, ...

Steroid receptors activate and repress genes. An important class of genes that they repress is controlled by the transcription factor AP-1. The activity of AP-1 is inhibited by the receptor, a...

ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents.

Van Dam, H, Wilhelm, D, Herr, I, Steffen, A, Herrlich, P, Angel, P

The major regulators of the c-jun promoter are ATF-2 and c-Jun. They act as pre-bound heterodimers on two 'AP-1-like' sites, and are preferentially addressed by different types of extracellular...

Autoregulation of fos: the dyad symmetry element as the major target of repression.

König, H, Ponta, H, Rahmsdorf, U, Büscher, M, Schönthal, A, Rahmsdorf, H J, ...

Fos and Jun co-operatively repress the fos promoter. Removal of all putative Fos/Jun binding sites from the fos promoter neither obliterates the repression by Fos/Jun in transient cotransfection...

Regulation of synthesis of a major outer membrane protein: cyclic AMP represses Escherichia coli protein III synthesis.

Mallick, U, Herrlich, P

Cyclic AMP is the effector molecule for both positive and negative control of synthesis of several Escherichia coli proteins. Among the latter is the major outer membrane protein III. The control...

Export without proteolytic processing of inner and outer membrane proteins encoded by F sex factor tra cistrons in Escherichia coli minicells.

Achtman, M, Manning, P A, Edelbluth, C, Herrlich, P

Most tra proteins encoded by the Escherichia coli F sex factor are incorporated into the minicell envelope. We have now assigned the tra proteins to cytoplasm (TraIp and 2b), inner membrane (TraEp,...

Heterodimer formation of cJun and ATF-2 is responsible for induction of c-jun by the 243 amino acid adenovirus E1A protein.

Van Dam, H, Duyndam, M, Rottier, R, Bosch, A, Herrlich, P, ...

The adenovirus E1A proteins differentially regulate AP-1-responsive genes. Collagenase and stromelysin are repressed by E1A, whereas the expression of c-jun is elevated. Inhibition of collagenase has...