Almroth, G, Lindell, Å, Åselius, H, Sörén, L, Svensson, L, Hultman, P, ...
We studied history, renal histopathology and microbiology of an epidemic of acute glomerulonephritis associated with throat infections and uncommon culture results in four neighbour families.A...
Xenobiotic acceleration of idiopathic systemic autoimmunity in lupus-prone bxsb mice.
Pollard, K M, Pearson, D L, Hultman, P, Deane, T N, Lindh, U, Kono, D H
The diverse genetic backgrounds of lupus-prone murine models, which produce both quantitative and qualitative differences in disease expression, may be a valuable resource for studying the influence...
Lupus-prone mice as models to study xenobiotic-induced acceleration of systemic autoimmunity.
Pollard, K M, Pearson, D L, Hultman, P, Hildebrandt, B, Kono, D H
The linkage between xenobiotic exposures and autoimmune diseases remains to be clearly defined. However, recent studies have raised the possibility that both genetic and environmental factors act...
Xenobiotic acceleration of idiopathic systemic autoimmunity in lupus-prone bxsb mice.
Pollard, K M, Pearson, D L, Hultman, P, Deane, T N, Lindh, U, Kono, D H
The diverse genetic backgrounds of lupus-prone murine models, which produce both quantitative and qualitative differences in disease expression, may be a valuable resource for studying the influence...
Lupus-prone mice as models to study xenobiotic-induced acceleration of systemic autoimmunity.
Pollard, K M, Pearson, D L, Hultman, P, Hildebrandt, B, Kono, D H
The linkage between xenobiotic exposures and autoimmune diseases remains to be clearly defined. However, recent studies have raised the possibility that both genetic and environmental factors act...
Anti-fibrillarin autoantibodies in mercury-treated mice.
Hultman, P, Eneström, S, Pollard, K M, Tan, E M
Using indirect immunofluorescence (IF) with HEp-2 cells as a substrate serially bled SJL mice were found to gradually develop a high titre of anti-nucleolar antibodies (ANuA) after 3-5 weeks of s.c....
Selective induction of anti-fibrillarin autoantibodies by silver nitrate in mice.
Hultman, P, Eneström, S, Turley, S J, Pollard, K M
Female SJL (H-2s) mice developed serum IgG anti-nucleolar antibodies (ANoA) after 5 weeks treatment with 0.05% or 0.01% silver nitrate (AgNO3) in drinking water. Five more weeks of treatment...
Female SJL and Balb/c mice were given subcutaneous injections of 1.6 mg HgCl2/kg body weight every third day for 2, 4, 8, or 12 weeks. Indirect immunofluorescence using HEp-2 cells as substrate...
Female Balb/c and SJL mice exposed to HgCl2 by subcutaneous injection or via drinking water for up to 6 months showed immunostimulation with increased concentrations of immunoglobulins (Ig) in the...
Effects of deviating the Th2-response in murine mercury-induced autoimmunity towards a Th1-response
T-helper cells type 1 (Th1) and type 2 (Th2) play an important role in the pathogenesis of autoimmune diseases. In many Th1-dependent autoimmune models, treatment with recombinant interleukin-12...
Interleukin-10 in murine metal-induced systemic autoimmunity
Systemic autoimmune diseases have a complicated and largely unknown aetiology and pathogenesis, but they are at least partly obeying the rules of an ordinary immune response. Cytokines are therefore...
The role of Fc-receptors in murine mercury-induced systemic autoimmunity
Inorganic mercury (Hg) in genetically susceptible mouse strains induces a T cell-dependent, systemic autoimmune condition (HgIA) characterized by immunostimulation, anti-nuclear antibodies (ANA) and...
Hg2+ induces lymphocyte proliferation when added to cell cultures from both healthy and mercury-allergic subjects. Consequently, when measuring DNA synthesis a possible Hg2+-specific response,...
Cytokines play an important and complex role in the pathogenesis of systemic autoimmune diseases. In susceptible H-2s mice, inorganic mercury (Hg) induces lymphoproliferation, antinucleolar...
Ekerfelt, C, Andersson, M, Olausson, A, Bergström, S, Hultman, P
Lyme borreliosis is a complex infection, where some individuals develop so-called ‘chronic borreliosis’. The pathogenetic mechanisms are unknown, but the type of immune response is probably...
Gold causes genetically determined autoimmune and immunostimulatory responses in mice
Havarinasab, S, Johansson, U, Pollard, K M, Hultman, P
Natrium aurothiomaleate (GSTM) is a useful disease-modifying anti-rheumatic drug, but causes a variety of immune-mediated adverse effects in many patients. A murine model was used to study further...