The Hamiltonian description of incompressible fluid ellipsoids (2008)
Morrison, P. J., Lebovitz, N. R., Biello, J. A.
We construct the noncanonical Poisson bracket associated with the phase space of first order moments of the velocity field and quadratic moments of the density of a fluid with a free- boundary,...
Antoniou, A.C., Hardy, R., Walker, L., Evans, D.G., Shenton, A., Eeles, R., ...
Objectives: Genetic testing for the breast and ovarian cancer susceptibility genes BRCA1 and BRCA2 has important implications for the clinical management of people found to carry a mutation. However,...
Hamiltonian formulation and analysis of a collisionless fluid reconnection model (2008)
Tassi, E., Morrison, P. J., Waelbroeck, F. L., Grasso, D.
The Hamiltonian formulation of a plasma four-field fluid model that describes collisionless reconnection is presented. The formulation is noncanonical with a corresponding Lie-Poisson bracket. The...
Self-Consistent Chaos in the Beam-Plasma Instability (2007)
Tennyson Stanford, J. L. Tennyson, J. D. Meiss, P. J. Morrison
The effect of self-consistency on Hamiltonian systems with a large number of degrees-of-freedom is investigated for the beam-plasma instability using the single-wave model of O'Neil, Winfrey,...
Predictive genetic testing for BRCA1/2 in a UK clinical cohort: three year follow up (2007)
Foster, C., Watson, M., Eeles, R., Eccles, D., Ashley, S., Davidson, R., ...
Predictive genetic testing for BRCA1/2 in a UK clinical cohort: three-year follow-up (2007)
Foster, C., Watson, M., Eeles, R., Eccles, D., Ashley, S., Davidson, R., ...
This prospective multicentre study assesses long-term impact of genetic testing for breast/ovarian cancer predisposition in a clinical cohort. Areas evaluated include risk management, distress and...
Quarrell, Oliver, Rigby, Alan S., Barron, L., Crow, Y., Dalton, A., Dennis, N., ...
Copyright © 2007 by the BMJ Publishing Group Ltd.
Quarrell, Oliver, Rigby, Alan S., Barron, L., Crow, Y., Dalton, A., Dennis, N., ...
Copyright © 2007 by the BMJ Publishing Group Ltd.
Quarrell, Oliver W.J., Rigby, Alan S., Barron, L., Crow, Y., Dalton, A., Dennis, N., ...
Objective: To obtain penetrance data for Huntington’s disease when DNA results are in the range of 36–39 CAG repeats and assess the consistency of reporting the upper allele from two reference...
On a new fixed point of the renormalization group operator for area-preserving maps (2006)
Fuchss, K., Wurm, A., Morrison, P. J.
The breakup of the shearless invariant torus with winding number $\omega=\sqrt{2}-1$ is studied numerically using Greene's residue criterion in the standard nontwist map. The residue behavior and...
On reconnection phenomena in the standard nontwist map (2006)
A. Wurm, A. Apte, P.J. Morrison
On reconnection phenomena in the standard nontwist map
Exonic STK11 deletions are not a rare cause of Peutz-Jeghers syndrome (2006)
Hearle, N.C.M., Rudd, M.F., Lim, W., Murday, V., Lim, A.G., Phillips, R.K., ...
Background: Peutz-Jeghers syndrome (PJS) is a rare, autosomal dominant cancer predisposition syndrome characterised by oro-facial pigmentation and hamartomatous polyposis of the gastrointestinal...
Breakup of Shearless Meanders and "Outer" Tori in the Standard Nontwist Map (2006)
Fuchss, K., Wurm, A., Apte, A., Morrison, P. J.
The breakup of shearless invariant tori with winding number $\omega=[0,1,11,1,1,...]$ (in continued fraction representation) of the standard nontwist map is studied numerically using Greene's residue...
Statistical mechanics of two-dimensional turbulence (2005)
Jung, Sunghwan, Morrison, P. J., Swinney, Harry L.
The statistical mechanical description of two-dimensional inviscid fluid turbulence is reconsidered. Using this description, we make predictions about turbulent flow in a rapidly rotating laboratory...
On reconnection phenomena in the standard nontwist map (2004)
Wurm,A., Apte,A., Morrison,P.J.
Separatrix reconnection in the standard nontwist map is described, including exact methods for determining the reconnection threshold in parameter space. These methods are implemented numerically for...
Meanders and Reconnection-Collision Sequences in the Standard Nontwist Map (2004)
Wurm, A., Apte, A., Fuchss, K., Morrison, P. J.
New global periodic orbit collision/separatrix reconnection scenarios in the standard nontwist map in different regions of parameter space are described in detail, including exact methods for...
Infrasound generation by turbulent convection (2004)
Akhalkatsi, M., Gogoberidze, G., Morrison, P. J.
Low frequency acoustic wave generation is studied taking into account the effect of stratification, inhomogeneity of background velocity profile and temperature fluctuations. It is shown that for the...
Foster, C., Evans, D. G., Eeles, R., Eccles, D., Ashley, S., Brooks, L., ...
BRCA1/2 test decliners/deferrers have received almost no attention in the literature and this is the first study of this population in the United Kingdom. The aim of this multicenter study is to...
Foster, C., Evans, D.G.R., Eeles, R., Eccles, D., Ashley, S., Brooks, L., ...
BRCA1/2 test decliners/deferrers have received almost no attention in the literature and this is the first study of this population in the United Kingdom. The aim of this multicenter study is to...
Watson, M., Foster, C., Eeles, R., Eccles, D., Ashley, S., Davidson, R., ...
This multi-centre UK study assesses the impact of predictive testing for breast and ovarian cancer predisposition genes (BRCA1/2) in the clinical context. In the year following predictive testing,...
Alam, N.A., Rowan, A.J., Wortham, N.C., Pollard, P.J., Mitchell, M., Tyrer, J.P., ...
Germline mutations of the fumarate hydratase (FH, fumarase) gene are found in the recessive FH deficiency syndrome and in dominantly inherited susceptibility to multiple cutaneous and uterine...
Renormalization and destruction of $1/\gamma^2$ tori in the standard nontwist map (2002)
Apte, A., Wurm, A., Morrison, P. J.
Extending the work of del-Castillo-Negrete, Greene, and Morrison, Physica D {\bf 91}, 1 (1996) and {\bf 100}, 311 (1997) on the standard nontwist map, the breakup of an invariant torus with winding...
Foster, C., Evans, D.G.R., Eeles, R., Eccles, D., Ashley, S., Brooks, L., ...
The aim of this multi-centre UK study is to examine the attributes of a cohort offered predictive genetic testing for breast/ovarian cancer predisposition. Participants are adults unaffected with...
Thiffeault, Jean-Luc, Morrison, P. J.
We describe a new type of top, the twisted top, obtained by appending a cocycle to the Lie-Poisson bracket for the charged heavy top, thus breaking its semidirect product structure. The twisted top...
Classification and Casimir Invariants of Lie-Poisson Brackets (1999)
Thiffeault, Jean-Luc, Morrison, P. J.
We classify Lie-Poisson brackets that are formed from Lie algebra extensions. The problem is relevant because many physical systems owe their Hamiltonian structure to such brackets. A classification...
Spectral reduction: a statistical description of turbulence (1999)
Bowman, John C., Shadwick, B. A., Morrison, P. J.
A method is described for predicting statistical properties of turbulence. Collections of Fourier amplitudes are represented by nonuniformly spaced modes with enhanced coupling coefficients. The...
A necessary and sufficient instability condition for inviscid shear flow (1998)
Balmforth, N. J., Morrison, P. J.
The linear stability of inviscid, incompressible, two-dimensional, plane parallel, shear flow was considered over a century ago by Rayleigh, Kelvin, and others. A principal result on the subject is...
Negative Energy Modes and Gravitational Instability of Interpenetrating Fluids (1998)
Casti, A. R. R., Morrison, P. J., Spiegel, E. A.
We study the longitudinal instabilities of two interpenetrating fluids interacting only through gravity. When one of the constituents is of relatively low density, it is possible to have a band of...
Invariants and Labels in Lie-Poisson Systems (1998)
Thiffeault, Jean-Luc, Morrison, P. J.
Reduction is a process that uses symmetry to lower the order of a Hamiltonian system. The new variables in the reduced picture are often not canonical: there are no clear variables representing...
Renormalization and Transition to Chaos in Area Preserving Nontwist Maps (1997)
D. Del-Castillo-Negrete, J.M. Greene, P. J. Morrison
The problem of transition to chaos, i.e. the destruction of invariant circles or KAM (Kolmogorov-Arnold-Moser) curves, in area preserving nontwist maps is studied within the renormalization group...
Exactly Conservative Integrators (1995)
Shadwick, B. A., Bowman, John C., Morrison, P. J.
Traditional numerical discretizations of conservative systems generically yield an artificial secular drift of any nonlinear invariants. In this work we present an explicit nontraditional algorithm...
Rogers, H.J., Bradbrook, I.D., Morrison, P.J., Spector, R.G., Cox, D.A., Lees, L.J.
Sultamicillin is an orally absorbed double ester of sulbactam (penicillanic acid sulphone, a semisynthetic inhibitor of the &eegr;-lactamases of many Gram-positive and Gram-negative species) and...
Effect of cimetidine on oral absorption of ampicillin and cotrimoxazole (1980)
ROGERS, H. J., JAMES, C. A., MORRISON, P. J., BRADBROOK, I. D.
Pharmacokinetics and tolerance of lomefloxacin after sequentially increasing oral doses.
Morrison, P J, Mant, T G, Norman, G T, Robinson, J, Kunka, R L
The pharmacokinetics of five dose levels of lomefloxacin (100, 200, 400, 600, and 800 mg) were examined in a single-dose, double-blind, placebo-controlled study involving 40 subjects. There were...
Pharmacokinetics of rufloxacin in patients with impaired renal function.
Perry, G, Mant, T G, Morrison, P J, Sacks, S, Woodcook, J, Wise, R, ...
The pharmacokinetics of rufloxacin were investigated in normal subjects and in patients with various degrees of renal failure after the administration of a single oral 400-mg dose. Twenty-four...
Pharmacokinetics of temafloxacin in humans after multiple oral doses.
Granneman, G R, Carpentier, P, Morrison, P J, Pernet, A G
The multiple-dose pharmacokinetics and tolerance of temafloxacin, a new fluoroquinolone antibacterial agent, were evaluated in healthy volunteers. Temafloxacin was found to be well tolerated when...
Pharmacokinetics of temafloxacin in humans after single oral doses.
Granneman, G R, Carpentier, P, Morrison, P J, Pernet, A G
Temafloxacin (A-63004) is a new quinolone antibacterial agent with a broad spectrum of activity against gram-positive and gram-negative aerobes and anaerobes. The pharmacokinetics and metabolism of...
Pharmacokinetics and tolerance of lomefloxacin after sequentially increasing oral doses.
Morrison, P J, Mant, T G, Norman, G T, Robinson, J, Kunka, R L
The pharmacokinetics of five dose levels of lomefloxacin (100, 200, 400, 600, and 800 mg) were examined in a single-dose, double-blind, placebo-controlled study involving 40 subjects. There were...
Pharmacokinetics of rufloxacin in patients with impaired renal function.
Perry, G, Mant, T G, Morrison, P J, Sacks, S, Woodcook, J, Wise, R, ...
The pharmacokinetics of rufloxacin were investigated in normal subjects and in patients with various degrees of renal failure after the administration of a single oral 400-mg dose. Twenty-four...
Pharmacokinetics of temafloxacin in humans after multiple oral doses.
Granneman, G R, Carpentier, P, Morrison, P J, Pernet, A G
The multiple-dose pharmacokinetics and tolerance of temafloxacin, a new fluoroquinolone antibacterial agent, were evaluated in healthy volunteers. Temafloxacin was found to be well tolerated when...
Pharmacokinetics of temafloxacin in humans after single oral doses.
Granneman, G R, Carpentier, P, Morrison, P J, Pernet, A G
Temafloxacin (A-63004) is a new quinolone antibacterial agent with a broad spectrum of activity against gram-positive and gram-negative aerobes and anaerobes. The pharmacokinetics and metabolism of...
The personality structure of 'normal' volunteers.
Ball, C J, McLaren, P M, Morrison, P J
The personality structure of 65 volunteers for a Phase 1 drug trial was examined using the Eysenck Personality Questionnaire. It revealed a common pattern of high extroversion, low neuroticism and...
ORG 10172: a low molecular weight heparinoid anticoagulant with a long half-life in man.
Bradbrook, I D, Magnani, H N, Moelker, H C, Morrison, P J, Robinson, J, Rogers, H J, ...
ORG 10172 is a heparinoid with mean molecular weight 6500 daltons. Intravenous bolus injections of ORG 10172 were compared with placebo and heparin injections in 91 separate studies in 83 healthy...
Effects of single and multiple doses of ketoconazole on adrenal function in normal subjects.
Bradbrook, I D, Gillies, H C, Morrison, P J, Robinson, J, Rogers, H J, Spector, R G
The plasma cortisol response to 0.25 mg tetracosactrin given by intramuscular injection was suppressed by nine oral doses of 200 mg ketoconazole given 12 hourly to nine normal female subjects. No...
Bradbrook, I D, Babiker, M, Crome, P, Gillies, H C, Morrison, P J, Rogers, H J, ...
Oxprenolol in an Oros 8/130 sustained release osmotic pump system (equivalent to 120 mg oxprenolol hydrochloride in a conventional formulation and releasing 8 mg h-1) was given to eight normal young...
Pharmacokinetics of single doses of sulphinpyrazone and its major metabolites in plasma and urine.
Bradbrook, I D, John, V A, Morrison, P J, Rogers, H J, Spector, R G
1 High pressure liquid chromatographic assays for the estimation of sulphinpyrazone and its sulphide, sulphone and p-hydroxy metabolites in plasma and urine are described. 2 Five normal volunteers...
Effect of pirprofen on glibenclamide kinetics and response.
Morrison, P J, Rogers, H J, Spector, R G, Bradbrook, I D, John, V A
Pirprofen (a new non-steroidal anti-inflammatory agent), 200 mg 8 hourly, or placebo was administered orally to eight normal volunteers to investigate its effect on the pharmacokinetics and glucose...
Morrison, P J, Bradbrook, I D, Rogers, H J
1 A quantitative thin layer chromatographic technique for the estimation of plasma prednisolone levels has been devised with a minimum level of estimation of 10 ng/ml. 2 A comparative study of the...
Morrison, P J, Bradbrook, I D, Rogers, H J
1 A gas chromatographic assay for the estimation of therapeutic concentrations of cinnarizine in plasma is described. 2 Cinnarizine (75 mg) was administered orally to twelve healthy subjects in the...
Comparison of the effect of drugs upon some commonly used measures of bowel transit time.
Rogers, H J, House, F R, Morrison, P J, Bradbrook, I D
1 To study the effect of drugs on methods of assessment of gut transit time a double-blind study of the effect of single doses of placebo, oxyphenisatin, anthracene purgatives, (+)-norpseudoephedrine...
Effect of cimetidine on the absorption of orally administered tetracycline.
Fisher, P, House, F, Inns, P, Morrison, P J, Rogers, H J, Bradbrook, I D
1 Six healthy female subjects received orally two 250 mg tetracycline tablets either with 400 mg cimetidine or placebo. In a separate experiment six healthy female volunteers received 500 mg...
Bradbrook, I. D., John, V. A., Morrison, P. J., Rogers, H. J., Spector, R. G.
1 The absorption kinetics of oxprenolol have been investigated in eight healthy volunteers after single dosing with 16/260 Oros drug delivery systems. Oxprenolol disposition kinetics in individual...
Age at onset in Huntington's disease and methylation at D4S95.
Reik, W, Maher, E R, Morrison, P J, Harding, A E, Simpson, S A
Age at onset in Huntington's disease (HD) is variable and is influenced by parental sex, paternal age, and genetic background. Several recent models have tried to explain this variable expressivity...
MacMillan, J C, Morrison, P J, Nevin, N C, Shaw, D J, Harper, P S, Quarrell, O W, ...
Benign hereditary chorea (BHC) is a rare autosomal dominant disorder characterised by the onset of non-progressive chorea in childhood and the absence of cognitive impairment. Using primers flanking...
Morrison, P J, Graham, C A, Nevin, N C
An analysis of the Northern Ireland Huntington's disease (HD) population of 75 families showed significant linkage disequilibrium between the HD gene and DNA markers at D4S95, D4S10, and D4S111. As...
Unknown syndrome: proportionate short stature, mandibular prognathism, and short femoral necks
Morrison, P J, Nevin, N C, Kendrick, R W
We describe a young woman with proportionate short stature, short femoral necks, limitation of wrist flexion, and a prominent mandible.
Nevin, N C, Morrison, P J, Jones, J, Reid, M M
At least 16 cases of inversion tandem duplications of the short arm of chromosome 8 have been reported. Structural rearrangements of chromosome 8 have made it possible to localise the gene for...
The epidemiology of Huntington's disease in Northern Ireland.
Morrison, P J, Johnston, W P, Nevin, N C
A survey of Huntington's disease (HD) in Northern Ireland, with a population of 1.5 million, has shown a 1991 prevalence rate of 6.4/100,000. Virtually complete ascertainment was achieved, enabling...
Morrison, P J, Godwin-Austen, R B, Raeburn, J A
We describe a three generation family with Parkinson's disease showing autosomal dominant inheritance with extreme anticipation. Familial Parkinson's disease in three living generations is extremely...
Multiple endocrine neoplasia type 2B (mucosal neuroma syndrome, Wagenmann-Froboese syndrome).
Multiple endocrine neoplasia type 2B (MEN 2B), or the mucosal neuroma syndrome, is an autosomal dominant hamartoneoplastic syndrome. Features include multiple mucosal neuromas, phaeochromocytoma,...
Leggo, J, Dalton, A, Morrison, P J, Dodge, A, Connarty, M, Kotze, M J, ...
Accurate clinical diagnosis of the spinocerebellar ataxias (SCAs) can be difficult because of overlap in phenotype with other disorders and variation in clinical manifestations. Six SCA loci have...
Unusual patellar tendon injury in an adolescent runner with generalised ligamentous laxity.
A case is reported of an acute traction injury of the patellar tendon in a boy of 14 with joint hypermobility. Such injuries are unusual but early diagnosis and surgical repair lead to a good long...
Huntington disease in County Donegal: epidemiological trends over four decades.
The prevalence rate of Huntington disease in County Donegal between 1961 and 1991 showed a decrease from 4.4 to 1.6 per 100,000 population. Emigration and reduction in family size probably account...
Familial craniosynostosis due to Pro250Arg mutation in the fibroblast growth factor receptor 3 gene.
Accuracy of the clinical diagnosis of Down syndrome.
OBJECTIVES: To determine the accuracy of clinical diagnosis of Down syndrome, identify problems in reaching a diagnosis, to provide recommendations for improvement and estimate a minimum prevalence...
Exonic STK11 deletions are not a rare cause of Peutz‐Jeghers syndrome
Hearle, N C M, Rudd, M F, Lim, W, Murday, V, Lim, A G, Phillips, R K, ...
Predictive genetic testing for BRCA1/2 in a UK clinical cohort: three-year follow-up
Foster, C, Watson, M, Eeles, R, Eccles, D, Ashley, S, Davidson, R, ...
This prospective multicentre study assesses long-term impact of genetic testing for breast/ovarian cancer predisposition in a clinical cohort. Areas evaluated include risk management, distress and...