P. J. Verschure

Heterochromatin protein 1 is recruited to various types of DNA damage (2009)

Luijsterburg, M.S., Dinant, C., Lans, W.J., Stap, J., Wiernasz, E., Lagerwerf, S., ...

Heterochromatin protein 1 (HP1) family members are chromatin-associated proteins involved in transcription, replication, and chromatin organization. We show that HP1 isoforms HP1-{alpha}, HP1-β, and...

Spatially confined folding of chromatin in the interphase nucleus (2009)

Mateos-Langerak, J., Bohn, M., Leeuw, W. De, Giromus, O., Manders, E.M.M., Verschure, P.J., ...

Genome function in higher eukaryotes involves major changes in the spatial organization of the chromatin fiber. Nevertheless, our understanding of chromatin folding is remarkably limited. Polymer...

Heterochromatin protein 1 is recruited to various types of DNA damage (2009)

Luijsterburg, M.S., Dinant, C., Lans, H., Stap, J., Wiernasz, E.S., Lagerwerf, S., ...

Heterochromatin protein 1 (HP1) family members are chromatin-associated proteins involved in transcription, replication, and chromatin organization. We show that HP1 isoforms HP1-α, HP1-β, and...

Pericentromeric heterochromatin domains are maintained without accumulation of HP1. (2007)

Mateos Langerak, J., Brink, M.C., Luijsterburg, M.S., Kraan, I. Van Der, Driel, R. Van, Verschure, P.J.

Compartmentalization of androgen receptor protein-protein interactions in living cells. (2007)

Royen, M.E. Van, Cunha, S.M., Brink, M.C., Mattern, K.A., Nigg, A.L., Dubbink, H.J., ...

Pericentromeric heterochromatin domains are maintained without accumulation of HP1. (2007)

Mateos Langerak, J., Brink, M.C., Luijsterburg, M.S., Kraan, I. Van Der, Driel, R. Van, Verschure, P.J.

Compartmentalization of androgen receptor protein-protein interactions in living cells. (2007)

Royen, M.E. Van, Cunha, S.M., Brink, M.C., Mattern, K.A., Nigg, A.L., Dubbink, H.J., ...

Visualization and analysis of large data collections: a case study applied to confocal microscopy data. (2006)

Leeuw, W. De, Verschure, P.J., Liere, R. Van

Chromosome organization and gene control: It is difficult to see the picture when you are inside the frame. (2006)

Verschure, P.J.

Step into the groove: ingineered transcription factors as modulators of gene expression. (2006)

Visser, A.E., Verschure, P.J., Gommans, W.M., Haisma, H.J., Rots, M.G.

Step out of the groove: epigenetic gene control systems and engineered transcription factors. (2006)

Verschure, P.J., Visser, A.E., Rots, M.G.

Truncated HP1 lacking a functional chromodomain induces heterochromatinization upon in vivo targeting. (2006)

Brink, M.C., Velden, Y. Van Der, Leeuw, W. De, Mateos Langerak, J., Belmont, A.S., Driel, R. Van, ...

Visualization and analysis of large data collections: a case study applied to confocal microscopy data. (2006)

Leeuw, W. De, Verschure, P.J., Liere, R. Van

Chromosome organization and gene control: It is difficult to see the picture when you are inside the frame. (2006)

Verschure, P.J.

Step into the groove: ingineered transcription factors as modulators of gene expression. (2006)

Visser, A.E., Verschure, P.J., Gommans, W.M., Haisma, H.J., Rots, M.G.

Step out of the groove: epigenetic gene control systems and engineered transcription factors. (2006)

Verschure, P.J., Visser, A.E., Rots, M.G.

Truncated HP1 lacking a functional chromodomain induces heterochromatinization upon in vivo targeting. (2006)

Brink, M.C., Velden, Y. Van Der, Leeuw, W. De, Mateos Langerak, J., Belmont, A.S., Driel, R. Van, ...

Imaging in situ protein-DNA interactions in the cell nucleus using FRET-FLIM (2005)

Cremazy, F.G.E., Manders, E.M.M., Bastiaens, P.I.H., Kramer, G., Hager, G.L., Munster, E.B. Van, ...

Although the distribution of DNA-binding proteins inside the cell nucleus can be analyzed by immunolabeling or by tagging proteins with GFP, we cannot establish whether the protein is bound to DNA or...

In vivo HP1 targeting causes large-scale chromatin condensation and enhanced histone lysine methylation. (2005)

Verschure, P.J., Kraan, K. Van Der, Leeuw, W. De, Vlag, J. Van Der, Carpenter, A.E., Belmont, A.S., ...

Changes in chromatin structure are a key aspect in the epigenetic regulation of gene expression. We have used a lac operator array system to visualize by light microscopy the effect of...

Functional organization of chromosomes in the interphase nucleus. (2004)

Visser, A.E., Driel, R. Van, Verschure, P.J.

Genetisch ongelijk. (2004)

Verschure, P.J.

Het DNA verwierf faam als blauwdruk van het leven. Alle informatie die bepaalt wie we zijn en wat onze cellen doen, zou erin geschreven staan. Maar dat beeld blijkt te simpel. Volgens de epigenetica,...

Positioning the genome within the nucleus. (2004)

Verschure, P.J.

Higher eukaryotic genomes contain both housekeeping genes and genes of which the expression is restricted to a defined time and space. It is well established that a correlation exists between...

Condensed chromatin domains in the mammalian nucleus are accessible to large macromolecules. (2003)

Verschure, P.J., Kraan, K. Van Der, Manders, E.M.M., Hoogstraten, D., Houtsmuller, A.B., Driel, R. Van

The eukaryotic genome: a system regulated at different hierarchical levels. (2003)

Driel, R. Van, Fransz, P.F., Verschure, P.J.

Polycomb group gene silencing proteins are concentrated in the perichromatin compartment of the mammalian nucleus. (2003)

Cmarko, D., Verschure, P.J., Otte, A.P., Driel, R. Van, Fakan, S.

Polycomb group gene silencing proteins localize to the same nuclear perichromatin compartment as transcriptionally active genes (2002)

Cmarko, D., Otte, A.P., Verschure, P.J., Driel, R. Van, Fakan, S.

Large-scale chromatin organization and the localization of proteins involved in gene expression in human cells. (2002)

Verschure, P.J., Kraan, I. Van Der, Enserink, J.M., Mone, M.J., Manders, E.M.M., Driel, R. Van

Local UV induced DNA damage in cell nuclei results in local transcription inhibition (2001)

Mone, M.J., Volker, M., Nikaido, O., Mullenders, L.H.F., Zeeland, A.A. Van, Verschure, P.J., ...

Visualization of Time Dependent Confocal Microscopy Data. (2000)

Leeuw, W.C. De, Liere, R. Van, Verschure, P.J., Visser, A.E., Manders, E.M.M., Driel, R. Van

Ultrastructural analysis of nucleolar transcription in the cells microinjected with 5-bromo-UTP. (2000)

Cmarko, D., Verschure, P.J., Rothblum, L.I., Hernandez-Verdun, D., Driel, R. Van, Amalric, F., ...

Ultrastructural analysis of transciption and splicing in the cell nucleus after BrUTP-microinjection. (1999)

Cmarko, D., Verschure, P.J., Martin, T.E., Dahmus, M.E., Krause, S., Fu, X.-D., ...

The contribution of quantitative confocal laser scanning microscopy in cartilage research: chondrocyte insulin-like growth factor-1 receptors in health and pathology (1997)

Verschure, P.J., Marle, J. Van, Noorden, C.J.F. Van, Berg, W.B. Van Den

The contribution of quantitative confocal laser scanning microscopy in cartilage research. Chondrocyte insulin-like growth factor-1 receptors in health and pathology (1997)

Berg, W.B., Van Den, Noorden, C.J.F., Van, Marle, J., Van, Verschure, P.J.

Articular cartilage destruction in experimental inflammatory arthritis: insulin-like growth factor-1 regulation of proteoglycan metabolism in chondrocytes (1996)

Berg, W.B., Van Den, Marle, J., Van, Noorden, C.J.F., Van, Verschure, P.J.

Histochemical analysis of insulin-like growth factor-1 binding sites in mouse normal and experimentally induced arthritic articular cartilage (1996)

Berg, W.B., Van Den, Joosten, L.A.B., Marle, J., Van, Verschure, P.J.

IGF-1 receptor immunolocalization by confocal scanning laser microscopy in human normal and osteoarthritic cartilage in comparison with PG synthesis and PG content (1996)

Berg, W.B., Van Den, Joosten, L.A.B., Lafeber, H.N., Marle, J., Van, Verschure, P.J.

Localization of insulin-like growth factor-1 receptor in human normal and osteoarthritic cartilage in relation to proteoglycan synthesis and content (1996)

Berg, W.B. Van Den, Lafeber, H.N., Helsen, M.M.A., Joosten, L.A.B., Marle, J. Van, Verschure, P.J.

LOCALIZATION OF INSULIN-LIKE GROWTH FACTOR-1 RECEPTOR IN HUMAN NORMAL AND OSTEOARTHRITIC CARTILAGE IN RELATION TO PROTEOGLYCAN SYNTHESIS AND CONTENT (1996)

VERSCHURE, P. J., MARLE, J. VAN, JOOSTEN, L. A. B., HELSEN, M. M. A., LAFEBER, F. P. J. G., VAN DEN BERG, W. B.

Insulin-like growth factor-1 (IGF-1) plays a key role in the regulation of chondrocyte proteoglycan (PG) metabolism. We investigated whether chondrocyte PG synthetic activity correlates with the...

Chondrocyte IGF-1 receptor expression and responsiveness to IGF-1 stimulation in mouse articular cartilage during various phases of experimentally-induced arthritis. (1995)

Berg, W.B., Van Den, Joosten, L.A.B., Marle, J., Van, Verschure, P.J.

Chondrocyte IGF-1 receptor expression and responsiveness to IGF-1 stimulation in mouse articular cartilage during various phases of experimentally induced arthritis. (1995)

Berg, W.B., Van Den, Joosten, L.A.B., Marle, J., Van, Verschure, P.J.

IL-1 has no direct role in the IGF-1 nonresponsive state during experimentally induced arthritis in murine knee joints. (1995)

Berg, W.B., Van Den, Loo, F.A.J., Van De, Joosten, L.A.B., Verschure, P.J.

Responsiveness of articular cartilage from normal and inflamed mouse knee joints to various growth factors.

Verschure, P J, Joosten, L A, Van Der Kraan, P M, Van Den Berg, W B

OBJECTIVE--Disturbed anabolic signalling might contribute to the decreased chondrocyte proteoglycan (PG) synthesis during joint inflammation. Articular cartilage obtained from mouse knee joints with...

Chondrocyte IGF-1 receptor expression and responsiveness to IGF-1 stimulation in mouse articular cartilage during various phases of experimentally induced arthritis.

Verschure, P J, Van Marle, J, Joosten, L A, Van Den Berg, W B

OBJECTIVE--To examine the distribution of insulin like growth factor-1 (IGF-1) receptors and the biological response to IGF-1 stimulation in articular cartilage of normal mouse knee joints and...

IL-1 has no direct role in the IGF-1 non-responsive state during experimentally induced arthritis in mouse knee joints.

Verschure, P J, Joosten, L A, Van De Loo, F A, Van Den Berg, W B

OBJECTIVE--To investigate the involvement of interleukin-1 (IL-1) in the induction or maintenance of the insulin-like growth factor 1 (IGF-1) non-responsive state of chondrocytes during experimental...