Parvez, N., Ahmed, T., Monif, T., Saha, N., Sharma, P. L.
Objective: To determine the bioequivalence of two marketed test formulations (A, B) as compared to a reference formulation (R) of slow release theophylline in healthy volunteers. Material and...
The effect of oxprenolol (CIBA 39,089-Ba), a recently introduced adrenergic beta-receptor antagonist, on adrenaline-evoked ventricular arrhythmias was studied in atropinized dogs anaesthetized with...
The effect of selective beta-receptor blockade on adrenaline-evoked ventricular arrhythmias was studied in atropinized dogs anaesthetized with halothane in oxygen. Cardiac beta-receptors were...
A new beta-receptor blocking agent N-isopropyl-p-nitrophenylethanolamine hydro-chloride (dl-INPEA) and its levo-rotatory (l-INPEA) and dextro-rotatory (d-INPEA) isomers have been used as tools to...
The effect of propranolol hydrochloride on arterial hypotension produced by halothane has been investigated in atropinized dogs during nitrous oxide-oxygen anaesthesia. Propranolol alone produced a...
Ventricular tachycardia was produced in the dog by intravenous injection of 2–3 μg/kg of adrenaline during nitrous oxide-halothane anaesthesia. On a weight basis, propiomazine was found to be...
In dogs under nitrous oxide-halothane anaesthesia, ventricular arrhythmias were produced by intravenous injection of adrenaline and noradrenaline 2–3 μg/kg or isoprenaline 1μg/kg, and completely...
A histidine protein kinase is involved in polar organelle development in Caulobacter crescentus.
Wang, S P, Sharma, P L, Schoenlein, P V, Ely, B
Mutations having pleiotropic effects on polar organelle development (pod) in Caulobacter crescentus have been identified and shown to occur in at least 13 genes scattered throughout the genome....
Zhang, J L, Sharma, P L, Li, C J, Dezube, B J, Pardee, A B, Crumpacker, C S
Topotecan (TPT), a known inhibitor of topoisomerase I, has previously been shown to inhibit the replication of several viruses. The mechanism of inhibition was proposed to be the inhibition of...
The Leu-74 to Val (Leu74Val) mutation in human immunodeficiency virus type 1 reverse transcriptase (RT) develops as a consequence of didanosine (ddI) therapy and is associated with a decreased...
Simian immunodeficiency virus displays complex patterns of RNA splicing.
Viglianti, G A, Sharma, P L, Mullins, J I
The human and simian immunodeficiency viruses encode at least six gene products that apparently serve regulatory functions. To evaluate the regulation of simian immunodeficiency virus gene expression...
The effect on myocardial contractility of a new beta-adrenergic receptor blocking drug, penbutolol.
1 The inotropic effect of penbutolol, a new beta-adrenergic receptor blocking drug, has been compared with that of propranolol in two similar groups of six subjects each. 2 Inotropic changes were...
The topical application of aconitine nitrate to the right atrial appendage in the “intact” anaesthetized dog produced atrial flutter. Premature systoles with fixed coupling preceded the...