Costs and outcomes of total hip and knee replacement for rheumatoid arthritis (2008)
March, L.M., Barcenilla, A.L., Cross, M.J., Lapsley, H.M., Parker, D., Brooks, P.M.
Development of the Effective Musculoskeletal Consumer Scale (2007)
Kristjansson, E., Tugwell, P. S., Wilson, A. J., Brooks, P. M., Driedger, S. M., Gallois, C., ...
Programs and initiatives have been created to empower, educate, and provide information to consumers; these are sometimes generically known as self-management interventions. Evaluating and comparing...
Public and private hospital total joint replacement surgery: any difference in outcomes? (2007)
March, L. M., Cross, M., Lapsley, H. M., Barcenilla, A., Courtney, A., Parker, D., ...
Anti-tumour necrosis factor-a: the dawn of a new era in the treatment of rheumatoid arthritis (2006)
Task substitution: where to from here? (2006)
Ellis, N., Robinson, L., Brooks, P. M.
Meeting future health workforce needs is a challenge for all health professionals.
Cross, M. J., March, L. M., Lapsley, H. M., Byrne, E., Brooks, P. M.
Objective. To explore the relationship between measures of self-efficacy, health locus of control, health status and direct medical expenditure among community-dwelling subjects with rheumatoid...
Challenges and progress in adverse event ascertainment and reporting in clinical trials (2005)
Lassere, M. N. D., Johnson, Kent R., Woodworth, T. G., Furst, D. E., Fries, J. F., Kirwan, J. R., ...
Toxicity, safety, and tolerability are integral facets of patient risk/benefit decisions, yet the capacity to define, measure, and compare these aspects is underdeveloped compared to aspects of...
Disease-modifying anti-rheumatic drugs (2005)
Bachmeier, C., Brooks, P. M., Day, R., Graham, G. G., Littlejohn, G. O., Morand, E., ...
Management of acute musculoskeletal pain (2005)
Spearing, N., March, L., Bellamy, N., Bogduk, N., Brooks, P. M.
Minimal disease activity for rheumatoid arthritis: A preliminary definition (2005)
Wells, G. A., Boers, M., Shea, B., Brooks, P. M., Simon, L. S., Strand, C. V., ...
Agreement on response criteria in rheumatoid arthritis (RA) has allowed better standardization and interpretation of clinical trial reports. With recent advances in therapy, the proportion of...
Expenpenditure, Outcomes and Satisfaction 8 Years After Hip and Knee Replacement (2005)
March, L. M., Lapsley, H. M., Cross, M.J., Byrne, E., Courtenay, B.G., Brooks, P. M.
Complementary Medicine Use By People with OA and RA: 1994 - 2003 (2005)
March, L. M., Byrne, E., Cross, M.J., Lapsley, H. M., Brooks, P. M.
Lassere, M. N. D., Johnson, Kent R., Boers, M., Carlton, K., Day, R. O., De Wit, M., ...
A presentation, demonstration, and discussion of recently developed adverse event instruments were the topics for the OMERACT 7 Drug Safety Module. The module began with a plenary introducing the...
Challenges and progress in adverse event ascertainment and reporting in clinical trials (2005)
Lassere, M. N. D., Johnson, Kent R., Woodworth, T. G., Furst, D. E., Fries, J. F., Kirwan, J. R., ...
Toxicity, safety, and tolerability are integral facets of patient risk/benefit decisions, yet the capacity to define, measure, and compare these aspects is underdeveloped compared to aspects of...
Minimal disease activity for rheumatoid arthritis: a preliminary definition (2005)
Wells, G. A., Boers, M., Shea, B., Brooks, P. M., Simon, L. S., Strand, C. V., ...
Agreement on response criteria in rheumatoid arthritis (RA) has allowed better standardization and interpretation of clinical trial reports. With recent advances in therapy, the proportion of...
Cross, M. J., March, L. M., Lapsley, H. M., Byrne, E., Brooks, P. M.
Objective. To explore the relationship between measures of self-efficacy, health locus of control, health status and direct medical expenditure among community-dwelling subjects with rheumatoid...
Undergraduate Teaching of Complementary Medicine (2004)
Some knowledge of complementary and alternative medicine is essential if we are to support patients in making healthcare choices.
Inflammation as an Important Feature of Osteoarthritis (2003)
This section looks back to some ground-breaking contributions to public health, reproducing them in their original form and adding a commentary on their significance from a modern-day perspective. To...
TO THE EDITOR: Let me congratulate the Editor and his team for their provocative issue on general practice in Australia (7 July 2003). Some of the major challenges are clearly delineated -...
COX-1 and COX-2 in Human Periodontal Disease States (2003)
Marshall, R. I., Gemmell, E., Carter, C. L., Bartold, P.M., Brooks, P. M., Seymour, G. J.
Cyclooxygenase (COX) catalyses the conversion of arachidonic acid into prostanoids and related compounds which have been implicated in periodontal bone loss. Therefore, the aim of this study was to...
Medical workforce issues in Australia: "tomorrow's doctors - too few, too far" (2003)
Brooks, P. M., Lapsley, H. M., Butt, D. B.
The Australian medical workforce, like those of most developed countries, is increasingly feminised and exposed to the global market for doctors. Demand for healthcare services is increasing in the...
OMERACT 6: International consensus conference on outcome measures in Rheumatology (2003)
Brooks, P. M., Tugwell, P., Strand, C. V., Simon, L., Boers, M.
Unconventional medicines for osteoarthritis - Are they an appropriate alternative? (2003)
Zochling, J., March, L., Lapsley, H. M., Cross, M, Tribe, K., Brooks, P. M., ...
What are the real direct health care costs of total joint replacement (TJR) in Australia? (2003)
March, L., Lapsley, H. M., Cross, M, Tribe, K., Courtney, B., Brooks, P. M., ...
Moore, J., Brooks, P. M., Milliken, S., Biggs, J.S., Ma, D., Handel, M. L., ...
Objective. Evidence from animal studies, case reports, and phase I studies suggests that hemopoietic stem cell transplantation (HSCT) can be effective in the treatment of rheumatoid arthritis (RA)....
Living with Rheumatoid Arthritis: Expenditures, Health Status, and Social Impact on Patients (2002)
Lapsley, H. M., March, L. M., Tribe, K. L., Cross, M. J., Courtenay, B. G., Brooks, P. M.
Objective: To determine costs related to living with rheumatoid arthritis (RA), and to identify the association between health status as measured by the Health Status Questionnaire short form-36...
Tomorrow's Doctors: Review of The Australian Medical Workforce Advisory Committee (AMWAC) (2002)
Butt, D., Lapsley, H., Brooks, P. M.
The aim of this Review, prepared under the auspices of the Australian Health Ministers' Advisory Council, is to 1. Assess AMWAC's performance to date against its original terms of reference and...
Moore, J., Brooks, P. M., Milliken, S., Biggs, J.S., Ma, D., Handel, M. L., ...
Objective. Evidence from animal studies, case reports, and phase I studies suggests that hemopoietic stem cell transplantation (HSCT) can be effective in the treatment of rheumatoid arthritis (RA)....
Bachmeier, C. J. M., March, L. M., Cross, M. J., Lapsley, H. M., Tribe, K. L., Courtenay, B. G, ...
Objective The aims of this study were to assess changes in physical function and quality of life with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and the instrument of...
Cyclooxygenase-2 (COX-2) inhibitors constitute a new group of non-steroidal anti-inflammatory drugs (NSAIDs) which, at recommended doses, block prostaglandin production by cyclooxygenase-2, but not...
Non-Steroidal Anti-Inflammatory Drug Toxicity in the Upper Gastrointestinal Tract (2000)
Sung, J. J. Y., Russell, R. I., Yeomans, N., Chan, F. K. L., Chen, S. I., Fock, K. M., ...
Non-steroidal anti-inflammatory drug (NSAID) toxicity in the upper gastrointestinal tract is the most common serious drug-induced toxicity reported to drug regulatory authorities. In the last two...
Cross, M. J., March, L. M., Tribe, K. L., Brnabic, A. J. M., Courtenay, B. G., Brooks, P. M.
Objectives. To determine whether patients with osteoarthritis (OA) would be willing to pay for joint replacement and whether patient characteristics or health outcomes, including pain, physical...
Male Systemic Sclerosis and Occupational Silica Exposure: A Population-Based Study (2000)
Englert, H., Small-McMahon, J., Davis, K., O'Connor, H., Chambers, P., Brooks, P. M.
BACKGROUND: The continuing uncertainty about the silica-systemic sclerosis relationship led to the investigation of its role as a disease determinant in a large population-based study of systemic...
Connective tissue and bone disorders (2000)
Day, R., Quinn, D., Williams, K., Handel, M. L., Brooks, P. M.
Cross, M. J., March, L., Lapsley, H. M., Tribe, K. L., Brnabic, A. J., Courtenay, B., ...
Objectives. To determine whether patients with osteoarthritis (OA) would be willing to pay for joint replacement and whether patient characteristics or health outcomes, including pain, physical...
Cross, M. J., March, L. M., Lapsley, H. M., Tribe, K. L., Brnabic, A. J. M., Courtenay, B. G., ...
Objectives. To determine whether patients with osteoarthritis (OA) would be willing to pay for joint replacement and whether patient characteristics or health outcomes, including pain,...
Privatisation of teaching hospitals (1999)
Australia's major academic health centres not only provide excellent healthcare, but are also involved in one of the most important aspects of the healthcare system - the training of our future...
Health online: the future isn't what it used to be (1999)
Yellowlees, P. M., Brooks, P. M.
Healthcare will be very different by 2010; the focus will be on the patient at home rather than the provider in the institution. There are three major drivers for this change. The first is the...
Familial Risk Estimation in Systemic Sclerosis (1999)
Englert, H., Small-McMahon, J., Chambers, P., O'Connor, H., Davis, K., Manolios, N., ...
BACKGROUND: Familial systemic sclerosis has been rarely reported. Assumptions have therefore been made implying no familial disease aggregation. This study critically challenges the assumption using...
Systemic Sclerosis Prevalence and Mortality in Sydney, 1974-88 (1999)
Englert, H., Small-McMahon, J., Davis, K., O'Connor, M., Chambers, P., Brooks, P. M.
BACKGROUND: Systemic sclerosis prevalence and mortality estimates have demonstrated wide variability. The sole Australian study published to date demonstrated high prevalence rates when compared to...
Disease-modifying anti-rheumatic drugs (1999)
Bachmeier, C., Handel, M. L., Conaghan, P. G., Williams, K. M., Graham, G. G., Brooks, P. M., ...
Outcomes after hip or knee replacement surgery for osteoarthritis (1999)
March, L. M., Cross, M. J., Lapsley, H., Brnabic, A. J., Tribe, K. L., Bachmeier, C., ...
Snowden, J. A., Nivison-Smith, I., Biggs, J. C., Brooks, P. M.
Objectives. Autologous haemopoietic stem cell transplantation (HSCT), which carries defined risks of early treatment-related mortality (TRM), has recently been proposed as an experimental therapy for...
Patient based methods for assessing adverse events in clinical trials (1999)
Gazarian, M., Tugwell, P., Boers, M., Bombardier, C., Brooks, P. M., Day, R., ...
Corticosteroids, osteoporosis and the Australian rheumatologist (1999)
Cheung, T. C., Hunter, D., Bellamy, N., Brooks, P. M., March, L., Sambrook, P.
Musculoskeletal Disability Among Elderly People in the Community (1998)
March, L. M., Brnabic, A. J. M., Skinner, J. C., Schwarz, J. M., Finnegan, T., Druce, J., ...
Objectives: To determine the prevalence and determinants of disability among elderly people living in the community. Design: A cross-sectional postal questionnaire survey. SETTING: Northern Sydney...
Jamal, O., Conaghan, P. G., Cunningham, A. M., Brooks, P. M., Munro, V. F., Scott, S. F.
To determine the localisation and level of expression of human type IIa secretory phospholipase A2 (sPLA2) in the synovium of rheumatoid arthritis (RA), osteoarthritis (OA), and non-arthritic (NA)...
Snowden, J. A., Biggs, J. C., Milliken, S. T., Fuller, A., Staniforth, D., Passuello, F., ...
Autologous haemopoietic stem cell transplantation (HSCT) represents a potential therapy for severe rheumatoid arthritis (RA). As a prelude to clinical trails, the safety and efficacy of haemopoietic...
A Copper-Salicylate Gel for Pain Relief in Osteoarthritis: a Randomised Controlled Trial (1997)
Shackel, N. A., Day, R. O., Brooks, P. M.
Objective: To assess the efficacy and safety of a copper-salicylate gel in osteoarthritis of the hip and knee. Design: Randomised, double-blind, placebo-controlled study. Setting: Rheumatology Clinic...
Toxicity of Antirheumatic Drugs (1997)
Lehmann, T., Day, R. O., Brooks, P. M.
Pharmacological treatments can have a major impact on the outcome of rheumatic diseases. To achieve the best results, individual treatment regimens comprising analgesic agents, non-steroidal...
INJECTABLE GOLD COMPOUNDS: AN OVERVIEW (1996)
Injectable gold compounds have enjoyed widespread, but occasionally controversial, use in rheumatoid arthritis since the 1920s. This overview examines the data from controlled trials and longer-term...
Silicone Breast Implantation: Doubts about the Fears (1995)
Silicone gel implantation mammoplasty is a common medical procedure peformed in the United States. In the 1980s, case reports linking a variety of connective tissue diseases and other symptoms with...
A 5-YEAR FOLLOW-UP OF A CONTROLLED TRIAL OF AN ARTHRITIS EDUCATION PROGRAMME (1995)
LINDROTH, Y., BAUMAN, A., BROOKS, P. M., PRIESTLEY, D.
A 5-yr follow-up of an arthritis education programme is reported. After adjustment for those lost, deceased or moved away, the 5-yr response rate was 75% among intervention subjects and...
An Australian Survey of Current Prescribing Practices of Methotrexate in Rheumatoid Arthritis (1994)
Bellamy, N., Brooks, P. M., Campbell, J., Drane, D., Dupen, F.
A 15-item questionnaire was distributed by Australia Post between October-December 1992, to Australian rheumatologists. The sample was ascertained from the Australian Rheumatology Association (ARA)...
What's New? Rheumatology (1994)
New ground has continued to be broken in the last eighteen months in basic mechanisms, clinical manifestations, epidemiology and cost of rheumatic diseases. There are a number of key areas setting...
March, L., Irwig, L., Schwarz, J., Simpson, J., Chock, C., Brooks, P. M.
Paracetamol appears to be as effective as diclofenac in alleviating pain associated with osteoarthritis when patients are given their choice of drug treatment. Paracetamol is also known as...
Scleroderma and Augmentation Mammoplasty: A Causal Relationship? (1994)
BACKGROUND: The studies implicating a causal relationship between silicone and scleroderma, other autoimmune disease, and fibromyalgia-like symptoms have been largely descriptive with absence of...
An Australian Survey of Current Prescribing Practices of Methotrexate in Rheumatoid Arthritis (1994)
Bellamy, N., Brooks, P. M., Campbell, J., Drane, D., Dupen, F.
A 15-item questionnaire was distributed by Australia Post between October-December 1992, to Australian rheumatologists. The sample was ascertained from the Australian Rheumatology Association (ARA)...
CROTTY, M., McFARLANE, A. C., BROOKS, P. M., HOPPER, J. L., BIERI, D., TAYLOR, S. J.
A longitudinal study of 75 young women (median age 43 yr) with early RA was performed with psychological, clinical and functional status measured every 4 months for up to 44 months. The aim was to...
Crotty, M., Ahern, M. J., McFarlane, A. C., Brooks, P. M.
Objective: To describe Australian medical graduates' knowledge, experiences and practical training in rheumatology and their attitudes towards rehabilitation and disability. Design: Cross-sectional...
Preventing Acute Gout When Starting Allopurinol Therapy: Colchicine Or NSAIDs? (1993)
Kot, T. V., Day, R. O., Brooks, P. M.
Acute gout is a well known complication of the commencement of allopurinol therapy. Prophylaxis is needed for some months, even after serum urate levels have returned to normal. Colchicine is usually...
Tenidap - A New Antiarthritic Agent (1993)
Tenidap sodium is a novel cytokine inhibitor. Early studies in rheumatoid arthritis suggest a disease modifying profile as well as providing symptomatic relief. The drug is also effective in OA at a...
Combination Therapy in Rheumatoid Arthritis (1993)
Current therapy with slow acting anti-rheumatic drugs (SAARDs) produce few remissions in rheumatoid arthritis. Significant numbers of patients become severely disabled and their life span is also...
The Use of Suppressive Agents for the Treatment of Rheumatoid Arthritis (1993)
This paper addresses the issue of slow-acting anti-rheumatic drugs as well as complementary therapies.
Non-Steroidal Anti-Inflammatory Drug Induced Upper Gastrointestinal Haemorrhage And Bleeding (1992)
Day, R. O., Henry, D. A., Muirden, K. D., Yeomans, N. D., Brooks, P. M., Steil, D., ...
Non-steroidal anti-inflammatory drugs are very widely used in our community. There has been much concern recently about the risks of NSAIDs-induced upper gastrointestinal haemorrhage and perforation....
Danis, V. A., Franic, G. M., Rathjen, D. A., Laurent, M. R., Brooks, P. M.
Interleukin 1 (IL-1), IL-6, and tumour necrosis factor (TNF) alpha are pleiotropic cytokines produced predominantly by macrophages which have been implicated in the pathogenesis of rheumatoid...
Nonsteroidal Anti-Inflammatory Drug Gastropathy: Is It Preventable? (1992)
Non-steroidal anti-inflammatory drugs (NSAIDs) are associated with a wide spectrum of side effects, including those involving renal, hepatic and haematological function and skin rashes. It is however...
IS DIET IMPORTANT IN RHEUMATOID ARTHRITIS? (1991)
BUCHANAN, HELEN M., PRESTON, SALLY J., BROOKS, P. M., BUCHANAN, W. WATSON
There is evidence from several well documented case reports that occasional patients with rheumatoid arthritis (RA) may develop aggravation of their arthritis as a result of allergy to some...
Tenoxicam Compared with Diclofenac in Patients with Ankylosing Spondylitis (1990)
Schwarzer, A. C., Cohen, M., Arnold, M. H., Kelly, D., McNaught, P., Brooks, P. M.
A randomized study was performed on 24 patients with ankylosing spondylitis to compare the efficacy and tolerability of 20 mg tenoxicam daily with 50 mg diclofenac twice daily. There were 6...
ARNOLD, M. H., O'CALLAGHAN, J., McCREDIE, M., BELLER, E. M., KELLY, D. E., BROOKS, P. M.
Fifty-three patients with rheumatoid arthritis who required immunosuppressive therapy were commenced in a randomized trial comparing azathioprine to weekly oral pulse ethotrexate. After an initial...
Bellamy, N., Brooks, P. M., Gilbert, R. J., Campbell, J., McCredie, M.
We recently have conducted a cross-sectional survey to determine the prescribing practices of rheumatologists and a random sample of general practitioners in New South Wales and Queensland. While in...
Assessment of a Patient-Completed Questionnaire for Kerato Conjunctivitis Sicca (1988)
Sargent, C., Ludlow, M., McCredie, M., Brooks, P. M., Webb, J.
A patient-completed questionnaire has been shown to be equivalent to an observer-administered format in discriminating between subjects with and without keratoconjunctivitis sicca. As well as saving...
Hutadilok, N., Ghosh, P., Brooks, P. M.
Synovial fluid from 201 normal and pathological knee joints was subjected to gel filtration by Sepharose CL-2B chromatography to separate hyaluronic acid (HA) from unbound proteins, which were...
D-Penicillamine Metabolism in an In-Vivo Model of Inflamed Synovium (1988)
Joyce, D. A., Forrest, M. J., Brooks, P. M.
Oxidation to disulphides is the chief metabolic transformation of D-penicillamine (D-pen) in patients with rheumatoid arthritis. Oxidation also occurs in many biological fluids in-vitro. Reduction of...
Tophaceous Gout of the Axial Skeleton (1988)
Arnold, M. H., Savvas, P., Brooks, P. M., Ruff, S.
A 72-year-old female with a recent episode of podagra, without peripheral tophi, presented with nocturnal back pain and a destructive lesion of the right lamina of L4. A tophus was excised at...
Methotrexate in Rheumatoid Arthritis (1988)
Over the past few years 'low dose pulse' methotrexate has gained increasing popularity as an effective treatment for refractory rheumatoid arthritis. Methotrexate has been shown to be better than...
DETERMINANTS OF DISABILITY IN RHEUMATOID ARTHRITIS (1988)
The longitudinal determinants of disability were studied in a group of 30 patients with rheumatoid arthritis over a 3-year period. The patients were investigated on two occasions using quantitative...
SCHRIEBER, LESLIE, McCREDIE, MARGARET, TUGWELL, P., BROOKS, P. M.
By means of a questionnaire, we have determined the combination of clinical features and laboratory tests which rheumatologists, nephrologists, immunologists, and neurologists in New South Wales...
Does Colchicine Really Work? The Results of the First Controlled Study in Acute Gout (1987)
Ahern, M. J., Reid, C., Gordon, T., McCredie, M., Brooks, P. M., Jones, M.
We have performed the first controlled study of colchicine in acute gout, to determine its efficacy and toxicity, and to define the natural history of acute gout. Two-thirds of colchicine-treated...
We report a case of oncogenic hypophosphatemic osteomalacia, a rare form of osteomalacia, secondary to a diffuse giant cell tumour of tendon sheath. Possible pathogenic factors are discussed in the...
Kowanko, I. C., Gordon, T. P., Rozenbilds, M. A. M., Brooks, P. M., Roberts-Thomson, P. J.
Subcutaneous injection of sterile air in rodents results in the formation of an air pouch with a lining morphologically similar to synovium (Edwards et al., 1981). We extended the comparison between...
Rheumatology Teaching in Australia: The Need for Review (1985)
In 1981, questionnaires seeking information about the teaching of medicine in general, and rheumatology in particular, were sent to random samples of undergraduates in Australian medical schools and...
The Effect of Tiaprofenic Acid on Blood Pressure Control in Treated Hypertensive Patients (1985)
Smith, M. D., Kupa, A., Weatherall, M., Brooks, P. M.
Eleven patients with osteoarthritis and mild hypertension completed an 8-week, double-blind crossover study in which 200 mg tiaprofenic acid 3-times daily or placebo were substituted for their normal...
Beveridge, S. J., Garrett, I. R., Whitehouse, M. W., Vernon-Roberts, B., Brooks, P. M.
64Cu was administered in two anti-inflammatory formulations to normal rats and to rats with 2 forms of local inflammation, namely (a) an acute paw oedema (elicited with carrageenan) or (b) a chronic...
Measuring Physicians' Judgment: The Use of Clinical Data by Australian Rheumatologists (1985)
Kirwan, J. R., Currey, H. L. F., Brooks, P. M.
Most therapeutic decisions depend upon the clinical judgment of physicians assessing their patients. However the inherent and wide variation in such judgments is usually ignored. Rheumatoid arthritis...
ANTIRHEUMATIC MEDICATION IN PREGNANCY (1985)
Drug effects on fetal physiology as well as possible teratogenesis need to be considered before prescribing for women of child-bearing age. All nonsteroidal anti-inflammatory drugs (NSAIDs), because...
ANTIRHEUMATIC MEDICATION DURING LACTATION (1985)
All nonsteroidal anti-inflammatory drugs (NSAIDs) and antirheumatic drugs are likely to be distributed into human milk to some extent; whether they are detected is a function of the assay...
Meffin, P. J., Brooks, P. M., Sallustio, B. C.
The disposition of total and free prednislone has been studied in four male and four female volunteers, each of whom received an intravenous dose of 0.075 mg/kg (low) and 1.5 mg/kg (high) at both...
Gold Therapy in Rheumatic Disease - 2 (1984)
Though many basic questions on the mechanism of action, dosage schedules, and long-term efficacy remain to be answered, gold therapy still plays a major role in the treatment of rheumatic diseases....
Vernon-Roberts, B., Garrett, I. R., Whitehouse, M. W., Brooks, P. M., Haynes, D. R.
The article examines the effects of aurothiomalate (ATM) and auranofin (AF) on adjuvant-induced polyarthritis and serum gold levels in three different strains of rats.
Vernon-Roberts, B., Hay, S., Cleary, E. G., Wiebkin, O. W., Garrett, I. R., Brooks, P. M., ...
Findings indicate that prednislone and methotrexate have profound effects on the cellular events of acute and chronic inflammation, and influence the synthesis or degradation of connective tissue...
Thrombokinetics in Patients with Rheumatoid Arthritis Treated with D-Penicillamine (1984)
Thomas, D., Gallus, A. S., Tampi, R., Brooks, P. M., Geddes, R., Hill, W. R.
The mechanism of D-penicillamine induced thrombocytopenia in rheumatoid arthritis was investigated by measuring platelet life-span and platelet production rate in 2 groups of rheumatoid arthritis...
Wanwimolruk, S., Thomas, D., Birkett, D. J., Miners, J. O., Brooks, P. M.
GP53,633 is a new basic non-steroidal anti-inflammatory drug showing analgesic and anti-inflammatory activity in animal models. Pharmacokinetic studies in 6 patients with rheumatoid arthritis show it...
Articular Condrocalcinosis in Hospital Population: An Australian Experience (1984)
Gordon, T. P., Smith, M., Ebert, B., McCredie, M., Brooks, P. M.
A group of hospital patients aged 55 years or over (53 men, 74 women) were screened for articular chondrocalcinosis (ACC) with high-resolution radiographs of knees, wrists, hand and pelvis. Two men...
Ranitidine Disposition in Patients with Renal Impairment (1983)
Meffin, P. J., Grgrinovich, N., Brooks, P. M., Miners, J. O., Cochran, M., Stranks, G.
Ranitidine disposition has been studied in 12 patients with renal impairment following 50mg given intravenously and 150mg by mouth on separate occasions. The clearance of ranitidine from plasma (y)...
Garrett, R., Manthey, R., Vernon-Roberts, B., Brooks, P. M.
The anti-inflammatory effect of single doses and combinations of aspirin and commonly used nonsteroidal anti-inflammatory drugs was investigated by the polyurethane sponge implantation model of acute...
Bertouch, J. V., Meffin, P. J., Sallustio, B. S., Brooks, P. M.
Plasma concentrations of methylprednislone following intra-articular injection were measured in rheumatoid arthritis and osteoarthritis patients. While substantial plasma concentrations were seen in...
Temporal Arteritis Presenting as a Symmetrical Polyarthritis (1983)
An 83 year old women presenting with a symetrical peripheral polyarthritis resembling rheumatoid arthritis subsequently developed biopsy-proven temporal arteritis.
Night-Time Indomethacin in Rheumatoid Arthritis (1982)
Carr, G., Dougan, M., Brooks, P. M., Maycock, S.
Indomethacin is commonly prescribed at night to relieve morning stiffness in patients with rheumatoid arthritis. Pharmacokinetic and pharmacodynamic interactions are frequently described with...
Asymptomatic Oosteolysis of Ribs and Clavicles in Progressive Systemic Sclerosis (1982)
Bertouch, J. V., Gordon, T. P., Henderson, D., Brooks, P. M.
The association of severe osteolysis of clavicles and ribs in a patient with progressive systemic sclerosis is reported. The disappearance of the clavicles and upper ribs was not associated with any...
Early Detection of Aortic Dilatation in Ankylosing Spondylitis Using Echocardiography (1982)
Thomas, D., Hill, W., Geddes, R., Sheppard, M., Arnold, J., Fritzsche, J., ...
Aortic root abnormalities including cusp thickening, subvalvular stenosis, and mild aortic root dilatation are the most common cardiac complications in patients with long standing ankylosing...
NAPROXEN AND DIFLUNISAL IN OSTEOARTHROSIS (1982)
BROOKS, P. M., DOUGAN, M. A., THOMAS, D., HILLS, L. J., SMITH, P. J.
Sixty-two patients with osteoarthrosis entered a 10-week double-blind cross-over trial of diflunisal and naproxen. Eight patients withdrew for drug-related reasons, and seven for other reasons....
EVALUATION OF A SINGLE DAILY DOSE NAPROXEN IN OSTEOARTHRITIS (1982)
BROOKS, P. M., CLELAND, L. G., HASKI, A. L., HEMPTON, D. B., MULLER, J. N., HILLS, L. J.
A six-week double-blind randomized cross-over trial comparing the safety and efficacy of 250 mg naproxen administered twice daily and 500 mg naproxen administered as a single dose at night in...
Role of Immune Complexes in Hypertrophic Osteoarthropathy and Nonmetastatic Polyarthritis (1981)
Awerbuch, M. S., Brooks, P. M.
Three case histories of patients with histologically proved malignant disease and an associated nonmetastatic symmetrical polyarthropathy are analysed. No evidence of a pathogenic role for immune...
Can Your Arthritis Patients Get To The Tablets? A Study of Medicine Bottle Opening (1981)
Brooks, P. M., Dougan, M., Mugford, S., May, F.
There has been increasing interest recently in the presentation and packaging of drugs for elderly patients and the manufacture of child-proof containers. This had led to the development of specially...
Diclofenac and Ibuprofen in Rheumatoid Arthritis and Osteoarthritis (1980)
Brooks, P. M., Hill, W., Geddes, R.
Forty patients with arthritis (26 rheumatoid and 14 osteoarthrosis) entered a five-week double-blind crossover trial of diclofenac and ibuprofen. Four patients failed to complete the 10-week trial....
Rebound Rise in Renin Concentrations after Cessation of Salicylates (1980)
Brooks, P. M., Cossum, P., Boyd, G. W.
Salicylates are widely used in the treatment of rheumatic disorders, and they have been shown to induce minor changes in renal function. One of the major mechanisms of action of salicylates is the...
Metabolism of Salicylate During Chronic Aspirin Therapy (1980)
Rumble, R.H., Brooks, P.M., Roberts, M.S.
1. The effects of chronic administration of aspirin in therapeutic doses (3.9 g/day) on plasma and salivary salicylate levels were studied in eight subjects. 2. The urinary excretion profile for free...
Salivary Salicylate Secretion and Flow Rate (1978)
Roberts, M. S., Rumble, R. H., Brooks, P. M.
The use of salivary drug levels is becoming increasingly popular in pharmacokinetic studies and as a measure of drug level in clinical medicine. We report a small study performed to assess the effect...
Pharmacokinetics of Sustained Release Aspirin (1978)
Brooks, P. M., Roberts, M. S., Patel, P.
Salivary salicylate concentrations were used to study the pharmacokinetics of a sustained release aspirin (SRA) in normal volunteers. The effect of fasting, food and metoclopramide were studied....
Salicylates and Creatinine Clearance Re-evaluated (1978)
Salicylates have been shown to increase the serum creatinine and decrease the creatinine clearance in normal volunteers and patients with rheumatoid arthritis and systemic lupus erythmatosus. Our...
Drug Treatment of Rheumatoid Arthritis (1978)
Inflammation is the central and essential component of rheumatoid arthritis, and control of inflammation by various drugs is paramount to the success of treatment of the disease. No specific cure is...
Reducing The Pill Swill: An Audit in Clinical Pharmacy (1977)
Brooks, P. M., Jones, J., Lawrence, R., Ali, R.
A drug surveillance program involving pharmacists in a general medical ward has been shown to reduce the number of drugs prescribed to patients and also to reduce the number of dispensing errors. The...
Flurbiprofen/Aspirin Interaction: A Double-Blind Crossover Study (1977)
Fifteen patients with seropositive rheumatoid arthritis were treated for 2-week periods with 150 mg flurbiprofen daily and with flubriprofen in the same dosage plus 3g aspirin daily, the treatments...
Phenylbutazone Dose Response Data in Patients with Rheumatoid Arthritis (1977)
Dick, W. C., Brooks, P. M., Buchanan, W. W., Fowler, P. D.
The object of this study was to look at both objective and subjective assessments of phenylbutazone therapy in a group of patients with rheumatoid arthritis. Results of the study are reported in this...
Prednisolone/Phenobarbitone Interaction in Rheumatoid Arthritis (1977)
Browning, M. C. K., Brooks, P. M., Buchanan, W. W., Downie, W. W.
Multiple drug therapy is commonly prescribed in patients with rheumatoid arthritis, and the list of drugs capable of inducing hepatic microsomal enzymes is growing rapidly. The effect of...
Iatrogenic Death in Patients with Rheumatoid Arthritis (1977)
Brooks, P. M., Buchanan, W. W., Stephens, M. E.
A study was carried out in Glasgow of the cause of death in patients with rheumatoid arthritis.
Salivary Antipyrine Half-Life: a Useful Measure of Hepatic Drug Metabolism (1976)
Brooks, P. M., Bell, M. A., Burns, J.
The rate of disappearance of antipyrine from plasma after a single oral dose is a useful indicator in man of the drug metabolising capacity of the liver (Vessell & Page, 1968). With the proliferation...
Bran, Hypertriglyceridemia and Urate Clearance (1976)
Eight subjects having raised triglyceride levels associated with conditions such s diabetes, hyperuricaemia, obesity and hypothyroidism were given 50g of bran per day to determine the effect of...
Brooks, P. M., Bridges-Webb, C.
Rheumatoid arthritis affects 2% to 3% of the population, and the prevalence of osteoarthritis increases with age to affect about 70% of those over 60 years of age. Rheumatic diseases place a...
An Assessment of the Therapeutic Potential of Azapropazone In Rheumatoid Arthritis (1976)
Brooks, P. M., Mason, D. I. R., McNeil, R., Anderson, J. A., Buchanan, W. W.
A trial to compare the therapeutic potential of 1200 mg. azapropazone daily with 3.9 g. aspirin daily was carried out in 108 out-patients with rheumatoid arthritis over a 14-day period. Analysis of...
Rooney, P. J., Grennan, D. P. I., Sturrock, R. D., Brooks, P. M., Dick, W. C.
A significant rise in immunoreactive gastrin in a proportion of patients with rheumatoid arthritis is confirmed. Such a rise does not seem to occur in other inflammatory or tissue destructive...
Effects of Enzyme Induction on Metabolism of Prednisolone (1976)
Brooks, P. M., Grove, M., Downie, W. W.
The addition of phenobarbitone in therapeutic dosage to the drug regimen of prednisolone-treated subjects with rheumatoid arthritis produced measurable deterioration in the clinical status of the...
Azapropazone: Its Place in the Management of Rheumatoid Conditions (1976)
Brooks, P. M., Buchanan, W. W.
The authors review the trials carried out on azapropazone in rheumatoid arthritis and other rheumatoid conditions. They comment that in terms of efficacy azapropazone would appear to be a useful...
A Novel Relationship Between Plasma Kininogen and Rheumatoid Disease (1976)
Sharma, J. N., Zeitlin, I. J., Brooks, P. M., Dick, W. C.
Plasma kininogen levels in the peripheral venous blood of untreated patients with active rheumatoid disease was found to be more than twice the levels measured in healthy normal individuals or in...
Zeitlin, I.J., Sharma, J.N., Brooks, P.M., Dick, W.C.
In the aetiology of rheumatoid arthritis there is some evidence to implicate the formation of kinins in synovial fluid (Melmon, Webster, Goldfinger & Seegmiller, 1967; Keele & Eisen, 1970). The...
Whaley, K., Sloane, D. P., Davidson, A. G., Brooks, P. M.
1. The effects of various anti-inflammatory and non-anti-inflammatory drugs on complement mediated haemolysis have been studied. Drugs which were significantly protein-bound were found to inhibit...
Phenylbutazone: A Clinico-Pharmacological Study in Rheumatoid Arthritis (1975)
Brooks, P. M., Walker, J. J., Dick, W. C., Anderson, J. A., Fowler, P. D.
A clinical trial of phenylbutazone in high dose - 300 mg daily - and low dose - 50 mg daily - is presented. By analysis of the data by different methods, significant differences in clinical efficacy...
Changes in Plasma Kininogen Levels associated with Rheumatoid Arthritis (1975)
Brooks, P. M., Dick, W. C., Sharma, J. N., Zeitlin, I. J.
During a control study, it was noticed that some elderly volunteers with untreated rheumatoid inflammation has abnormally raised plasma kininogen levels. The levels are not easily explained. They may...
Clinicopharmacological Studies On Ketoprofen (Orudis) (1975)
Mitchell, W. F., Scott, P., Kennedy, A. C., Brooks, P. M., Templeton, R., Jeffries, M. G.
A study was made of the plasma and synovial fluid levels of ketoprofen after single oral doses of 50mg and 100mg given to patients with rheumatoid arthritis. The drug was rapidly absorbed and plasma...
The Ups And Downs of Indomethacin Bioavailability (1975)
Brooks, P. M., Bell, M. A., Walker, J. J., Kennedy, A. C., Sturrock, R. D., Dick, W. C.
This paper reports results obtained during the preliminary part of a combined clinical and laboratory programme of investigation into the drug indomethacin.
Bran in Hypertriglyceridemia: A Failure of Response (1975)
Bremmer, W. F., Brooks, P. M., Lawrie, T. D. V.
Atheroma is still the major cause of mortality in the Western world, and the difference in prevalence of atheroma in developed and developing countries has caused speculation that absence of a...
Indomethacin/Aspirin Interaction: a Clinical Appraisal (1975)
Brooks, P. M., Walker, J. J., Bell, M. A., Buchanan, W. W., Rhymer, A. R.
Plasma profiles of indomethacin after a 50-mg oral dose were constructed in six healthy volunteers before and after a week of aspirin treatment. Aspirin did not interfere with indomethacin plasma...
Inpatient Prescribing in Rheumatic Disease Centre - a Study of Self-Abasement (1975)
Mason, D. I. R., Brooks, P. M., Lee, P., Kennedy, A. C., Buchanan, W. W.
In studies previously reported from our unit (Lee et al 1973) have described the prevalence of adverse reactions among patients with rheumatic diseases and the prescribing habits of doctors in the...
Brooks, P. M., Stephens, W. H., Stephens, M. E. D., Buchanan, W. W.
Rheumatoid arthritis is generally regarded as a non-fatal disease, Although there is evidence that paatients with the disease have a diminished life expectancy, the causes of death are, by and large,...
The Effect of Frusemide on Indomethacin Plasma Levels (1974)
Brooks, P. M., Sturrock, R. D., Famaey, J. P., Dick, W. C.
The pharmacokinetic and clinical effects of concurrent oral indomethacin and frusemide administration were determined in eight patients with rheumatoid arthritis. Oral frusemide significantly reduces...
The Clinical Significance of Indomethacin-Probenicid Interaction (1974)
Brooks, P. M., Bell, M. A., Sturrock, R. D., Famaey, J. P., Dick, W. C.
The effect of the addition of probenecid to oral and rectal regimes of indomethacin was studied in three groups of rheumatoid arthritic patients. The addition of probenecid increases plasma levels of...
Sturrock, R. D., Watkin, C. P., Lee, P., Brooks, P. M., Dick, W. C.
The merits of intra-articular urokinase in the treatment of rheumatoid arthritis are discussed. The results of a double-blind controlled study of its use in the knee joints following intra-articular...
Clinical Evaluation of Tolmetin (1974)
Brooks, P. M., Watkin, C. P., Sturrock, R. D., Lee, P.
A clincial therapeutic trial of tolmetin in daily doses of 1200 and 1600 mg. is reported in 16 patients with rheumatoid arthritis. The drug was given for a period of two weeks at both dose levels....
Clinical Evaluation of Niflumic Acid (Squibb) in Rheumatoid Arthritis (1974)
Kennedy, A. C., Watkins, C. F., Brooks, P. M., Grennan, D. M.
The effect of 750 mg of niflumic acid per day administered orally was studied in 15 patients with active rheumatoid arthritis in a double-blind crossover trial. The patients were followed over a...
Observations on Drug Prescribing in Rheumatoid Arthritis (1974)
Lee, P., Ahola, S. J., Grennan, D. M., Brooks, P. M., Buchanan, W. W.
A total of 125 patients with rheumatoid arthritis were investigated about their drug therapy before referral to a specialist centre. Most referrals were from general practitioners. Only 47 of the...
Gall Bladder Disease and the Heart (1973)
Brooks, P. M., Cutforth, R. H.
Fifty patients subjected to operation for gall bladder disease undertook cardiac stress tests before and two months after surgery. Fourteen showed evidence of preexisting coronary heart disease and...
Serum Lipid Abnormalities and Atrial Pacing Test (1972)
Mundy, G. R., Cutforth, R., Brooks, P. M.
Estimations of serum lipids and lipoprotein patterns were made in 32 patients with an abnormal repsonse to an atrial pacing test, and compared with similar estimations in 32 patients giving a normal...
The Value of the Atrial Pacing Test (1971)
The atrial pacing test was performed on 62 subjects - 10 fit medical students, 15 patients with proven coronary artery disease and 37 patients referred for the elucidation of equivocal chest pain....