P. N. Cockerill

The human IL-3 locus is regulated cooperatively by two NFAT-dependent enhancers that have distinct tissue-specific activities (2002)

Hawwari, A., Burrows, J., Vadas, M. A., Cockerill, P. N.

The human IL-3 locus is regulated cooperatively by two NFAT-dependent enhancers that have distinct tissue-specific activities (2002)

Hawwari, A., Burrows, J., Vadas, M. A., Cockerill, P. N.

Reconstitution of T cell-specific transcription directed by composite NFAT/Oct elements (2000)

Bert, A. G., Burrows, J., Hawwari, A., Vadas, M. A., Cockerill, P. N.

Generation of an improved luciferase reporter gene plasmid that employs a novel mechanism for high-copy replication (2000)

Bert, A. G., Burrows, J., Osborne, C. S., Cockerill, P. N.

Reconstitution of T cell-specific transcription directed by composite NFAT/Oct elements (2000)

Bert, A. G., Burrows, J., Hawwari, A., Vadas, M. A., Cockerill, P. N.

Generation of an improved luciferase reporter gene plasmid that employs a novel mechanism for high-copy replication (2000)

Bert, A. G., Burrows, J., Osborne, C. S., Cockerill, P. N.

Signals for activation of the GM-CSF promoter and enhancer in T cells. (1997)

Shannon, M. F., Coles, L. S., Vadas, M. A., Cockerill, P. N.

Activation of a T cell-specific enhancer upstream of the interleukin-3 gene involves cooperation between overlapping Oct and NFAT motifs and changes in chromatin structure. (1997)

Duncliffe, K. N., Bert, A. G., Vadas, M. A., Cockerill, P. N.

Signals for activation of the GM-CSF promoter and enhancer in T cells. (1997)

Shannon, M. F., Coles, L. S., Vadas, M. A., Cockerill, P. N.

Activation of a T cell-specific enhancer upstream of the interleukin-3 gene involves cooperation between overlapping Oct and NFAT motifs and changes in chromatin structure. (1997)

Duncliffe, K. N., Bert, A. G., Vadas, M. A., Cockerill, P. N.

Multiple signals are required for function of the human granulocyte-macrophage colony-stimulating factor gene promotor in T cells (1995)

Jenkins, F., Cockerill, P. N., Bohmann, D., Shannon, M. F.

Human granulocyte-macrophage colony-stimulating factor enhancer function is associated with co-operative interactions between AP-1 and NFATp/c (1995)

Cockerill, P. N., Bert, A. G., Jenkins, F., Ryan, G. R., Shannon, M. F., Vadas, M. A.

Regulation of granulocyte-macrophage colony-stimulating factor and E-selection expression in endothelial cells by cyclosporin A and the T cell transcription factor NFAT. (1995)

Cockerill, G. W., Bert, A. G., Ryan, G. R., Gamble, J. R., Vadas, M. A., Cockerill, P. N.

Transcriptional regulation of mouse granulocyte-macrophage colony-stimulating factor/IL-3 locus (1995)

Osborne, C. S., Vadas, M. A., Cockerill, P. N.

Human granulocyte-macrophage colony-stimulating factor enhancer function is associated with co-operative interactions between AP-1 and NFATpc. (1995)

Cockerill, P. N., Bert, A. G., Jenkins, F., Ryan, G. R., Shannon, M. F., Vadas, M. A.

Multiple signals are required for function of the human granulocyte-macrophage colony-stimulating factor gene promotor in T cells (1995)

Jenkins, F., Cockerill, P. N., Bohmann, D., Shannon, M. F.

Human granulocyte-macrophage colony-stimulating factor enhancer function is associated with co-operative interactions between AP-1 and NFATp/c (1995)

Cockerill, P. N., Bert, A. G., Jenkins, F., Ryan, G. R., Shannon, M. F., Vadas, M. A.

Regulation of granulocyte-macrophage colony-stimulating factor and E-selection expression in endothelial cells by cyclosporin A and the T cell transcription factor NFAT. (1995)

Cockerill, G. W., Bert, A. G., Ryan, G. R., Gamble, J. R., Vadas, M. A., Cockerill, P. N.

Transcriptional regulation of mouse granulocyte-macrophage colony-stimulating factor/IL-3 locus (1995)

Osborne, C. S., Vadas, M. A., Cockerill, P. N.

Human granulocyte-macrophage colony-stimulating factor enhancer function is associated with co-operative interactions between AP-1 and NFATpc. (1995)

Cockerill, P. N., Bert, A. G., Jenkins, F., Ryan, G. R., Shannon, M. F., Vadas, M. A.

The granulocyte-macrophage colony-stimulating factor/interleukin 3 locus is regulated by an inducible cyclosporin A-sensitive enhancer.

Cockerill, P N, Shannon, M F, Bert, A G, Ryan, G R, Vadas, M A

Granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin 3 (IL-3) are pleiotropic hemopoietic growth factors whose genes are closely linked and induced in T lymphocytes in a...

Human granulocyte-macrophage colony-stimulating factor enhancer function is associated with cooperative interactions between AP-1 and NFATp/c.

Cockerill, P N, Bert, A G, Jenkins, F, Ryan, G R, Shannon, M F, Vadas, M A

The promoter of the human granulocyte-macrophage colony-stimulating factor gene is regulated by an inducible upstream enhancer. The enhancer encompasses three previously defined binding sites for the...

Identification within the simian virus 40 genome of a chromosomal loop attachment site that contains topoisomerase II cleavage sites.

Pommier, Y, Cockerill, P N, Kohn, K W, Garrard, W T

We demonstrate that the simian virus 40 genome contains a single MAR (matrix association region) that maps within a large T-antigen coding region (nucleotides 4071 to 4377). This region contains...

The nuclease sensitivity of active genes.

Nicolas, R H, Wright, C A, Cockerill, P N, Wyke, J A, Goodwin, G H

Brief micrococcal nuclease digestion of chick embryonic red blood cells results in preferential excision and solubilization of monomer nucleosomes associated with beta-globin sequences and also...

Nuclear matrix attachment occurs in several regions of the IgH locus.

Cockerill, P N

The genome is thought to be divided into domains by DNA elements which mediate anchorage of chromosomal DNA to the nuclear matrix or chromosome scaffold. The positions of nuclear matrix anchorage...

The effect of salt extraction on the structure of transcriptionally active genes; evidence for a DNAseI-sensitive structure which could be dependent on chromatin structure at levels higher than the 30 nm fibre.

Goodwin, G H, Nicolas, R H, Cockerill, P N, Zavou, S, Wright, C A

The procedure developed by Lawson and Cole (Biochemistry, 1979, 18 2161-2166) for removing lysine-rich histones from nuclei at low pH also quantitatively extracts proteins HMG14 and 17. The effect of...

Octamer-binding proteins in diverse hemopoietic cells.

Cockerill, P N, Klinken, S P

The immunoglobulin genes have B-cell-specific promoter and enhancer elements. The regulation of these elements is thought to be mediated to a large degree by the trans-activating factor oct-2, which...

The granulocyte-macrophage colony-stimulating factor/interleukin 3 locus is regulated by an inducible cyclosporin A-sensitive enhancer.

Cockerill, P N, Shannon, M F, Bert, A G, Ryan, G R, Vadas, M A

Granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin 3 (IL-3) are pleiotropic hemopoietic growth factors whose genes are closely linked and induced in T lymphocytes in a...

Human granulocyte-macrophage colony-stimulating factor enhancer function is associated with cooperative interactions between AP-1 and NFATp/c.

Cockerill, P N, Bert, A G, Jenkins, F, Ryan, G R, Shannon, M F, Vadas, M A

The promoter of the human granulocyte-macrophage colony-stimulating factor gene is regulated by an inducible upstream enhancer. The enhancer encompasses three previously defined binding sites for the...

Identification within the simian virus 40 genome of a chromosomal loop attachment site that contains topoisomerase II cleavage sites.

Pommier, Y, Cockerill, P N, Kohn, K W, Garrard, W T

We demonstrate that the simian virus 40 genome contains a single MAR (matrix association region) that maps within a large T-antigen coding region (nucleotides 4071 to 4377). This region contains...

The nuclease sensitivity of active genes.

Nicolas, R H, Wright, C A, Cockerill, P N, Wyke, J A, Goodwin, G H

Brief micrococcal nuclease digestion of chick embryonic red blood cells results in preferential excision and solubilization of monomer nucleosomes associated with beta-globin sequences and also...

Nuclear matrix attachment occurs in several regions of the IgH locus.

Cockerill, P N

The genome is thought to be divided into domains by DNA elements which mediate anchorage of chromosomal DNA to the nuclear matrix or chromosome scaffold. The positions of nuclear matrix anchorage...

The effect of salt extraction on the structure of transcriptionally active genes; evidence for a DNAseI-sensitive structure which could be dependent on chromatin structure at levels higher than the 30 nm fibre.

Goodwin, G H, Nicolas, R H, Cockerill, P N, Zavou, S, Wright, C A

The procedure developed by Lawson and Cole (Biochemistry, 1979, 18 2161-2166) for removing lysine-rich histones from nuclei at low pH also quantitatively extracts proteins HMG14 and 17. The effect of...

Octamer-binding proteins in diverse hemopoietic cells.

Cockerill, P N, Klinken, S P

The immunoglobulin genes have B-cell-specific promoter and enhancer elements. The regulation of these elements is thought to be mediated to a large degree by the trans-activating factor oct-2, which...