Borden, K L, Lally, J M, Martin, S R, O'Reilly, N J, Solomon, E, Freemont, P S
Acute promyelocytic leukemia (APL) has been ascribed to a chromosomal translocation event which results in a fusion protein comprising the PML protein and retinoic acid receptor alpha. PML is...
Identification and preliminary characterization of a protein motif related to the zinc finger.
Lovering, R, Hanson, I M, Borden, K L, Martin, S, O'Reilly, N J, Evan, G I, ...
We have identified a protein motif, related to the zinc finger, which defines a newly discovered family of proteins. The motif was found in the sequence of the human RING1 gene, which is proximal to...
Rothwell, D. G., Hang, B., Gorman, M. A., Freemont, P. S., Singer, B., Hickson, I. D.
HAP1, also known as APE/Ref-1, is the major apurinic/apyrimidinic (AP) endonuclease in human cells. Previous structural studies have suggested a possible role for the Asp-210 residue of HAP1 in the...
RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor.
Satijn, D P, Gunster, M J, Van Der Vlag, J, Hamer, K M, Schul, W, Alkema, M J, ...
The Polycomb (Pc) protein is a component of a multimeric, chromatin-associated Polycomb group (PcG) protein complex, which is involved in stable repression of gene activity. The identities of...
Cocrystal structure of an editing complex of Klenow fragment with DNA.
Freemont, P S, Friedman, J M, Beese, L S, Sanderson, M R, Steitz, T A
High-resolution crystal structures of editing complexes of both duplex and single-stranded DNA bound to Escherichia coli DNA polymerase I large fragment (Klenow fragment) show four nucleotides of...
Borden, K L, Lally, J M, Martin, S R, O'Reilly, N J, Etkin, L D, Freemont, P S
Xenopus nuclear factor XNF7, a maternally expressed protein, functions in patterning of the embryo. XNF7 contains a number of defined protein domains implicated in the regulation of some...
Vrielink, A, Rüger, W, Driessen, H P, Freemont, P S
Bacteriophage T4 beta-glucosyltransferase (EC 2.4.1.27) catalyses the transfer of glucose from uridine diphosphoglucose to hydroxymethyl groups of modified cytosine bases in T4 duplex DNA forming...
Borden, K L, Boddy, M N, Lally, J, O'Reilly, N J, Martin, S, Howe, K, ...
Acute promyelocytic leukaemia (APL) has been ascribed to a chromosomal translocation event which results in a fusion protein comprising the PML protein and the retinoic acid receptor alpha. PML is...
De, A, Brown, D G, Gorman, M A, Carr, M, Sanderson, M R, Freemont, P S
Porcine pancreatic spasmolytic polypeptide (PSP) belongs to a large family of homologous growth factor-like polypeptides characterized by a disulfide-linked "trefoil motif," duplicated and conserved...
Microcrystals of the beta 1 isoenzyme of protein kinase C: an electron microscopic study.
Newman, R H, Carpenter, E, Freemont, P S, Blundell, T L, Parker, P J
Microcrystals of protein kinase C beta 1 have been grown from solutions of poly(ethylene glycol). Image analysis of electron micrographs of the protein crystals, which diffracted to 5.0 nm, revealed...
The complete amino acid sequence of human skeletal-muscle fructose-bisphosphate aldolase.
Freemont, P S, Dunbar, B, Fothergill-Gilmore, L A
The complete amino acid sequence of human skeletal-muscle fructose-bisphosphate aldolase, comprising 363 residues, was determined. The sequence was deduced by automated sequencing of CNBr-cleavage,...
The predicted secondary structures of class I fructose-bisphosphate aldolases.
Sawyer, L, Fothergill-Gilmore, L A, Freemont, P S
The results of several secondary-structure prediction programs were combined to produce an estimate of the regions of alpha-helix, beta-sheet and reverse turns for fructose-bisphosphate aldolases...
Gorman, M A, Morera, S, Rothwell, D G, De La Fortelle, E, Mol, C D, Tainer, J A, ...
The structure of the major human apurinic/ apyrimidinic endonuclease (HAP1) has been solved at 2.2 A resolution. The enzyme consists of two symmetrically related domains of similar topology and has...
Structure of an XRCC1 BRCT domain: a new protein-protein interaction module.
Zhang, X, Moréra, S, Bates, P A, Whitehead, P C, Coffer, A I, Hainbucher, K, ...
The BRCT domain (BRCA1 C-terminus), first identified in the breast cancer suppressor protein BRCA1, is an evolutionarily conserved protein-protein interaction region of approximately 95 amino acids...
Borden, K L, Lally, J M, Martin, S R, O'Reilly, N J, Solomon, E, Freemont, P S
Acute promyelocytic leukemia (APL) has been ascribed to a chromosomal translocation event which results in a fusion protein comprising the PML protein and retinoic acid receptor alpha. PML is...
Identification and preliminary characterization of a protein motif related to the zinc finger.
Lovering, R, Hanson, I M, Borden, K L, Martin, S, O'Reilly, N J, Evan, G I, ...
We have identified a protein motif, related to the zinc finger, which defines a newly discovered family of proteins. The motif was found in the sequence of the human RING1 gene, which is proximal to...
Rothwell, D. G., Hang, B., Gorman, M. A., Freemont, P. S., Singer, B., Hickson, I. D.
HAP1, also known as APE/Ref-1, is the major apurinic/apyrimidinic (AP) endonuclease in human cells. Previous structural studies have suggested a possible role for the Asp-210 residue of HAP1 in the...
RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor.
Satijn, D P, Gunster, M J, Van Der Vlag, J, Hamer, K M, Schul, W, Alkema, M J, ...
The Polycomb (Pc) protein is a component of a multimeric, chromatin-associated Polycomb group (PcG) protein complex, which is involved in stable repression of gene activity. The identities of...
Cocrystal structure of an editing complex of Klenow fragment with DNA.
Freemont, P S, Friedman, J M, Beese, L S, Sanderson, M R, Steitz, T A
High-resolution crystal structures of editing complexes of both duplex and single-stranded DNA bound to Escherichia coli DNA polymerase I large fragment (Klenow fragment) show four nucleotides of...
Borden, K L, Lally, J M, Martin, S R, O'Reilly, N J, Etkin, L D, Freemont, P S
Xenopus nuclear factor XNF7, a maternally expressed protein, functions in patterning of the embryo. XNF7 contains a number of defined protein domains implicated in the regulation of some...
Vrielink, A, Rüger, W, Driessen, H P, Freemont, P S
Bacteriophage T4 beta-glucosyltransferase (EC 2.4.1.27) catalyses the transfer of glucose from uridine diphosphoglucose to hydroxymethyl groups of modified cytosine bases in T4 duplex DNA forming...
Borden, K L, Boddy, M N, Lally, J, O'Reilly, N J, Martin, S, Howe, K, ...
Acute promyelocytic leukaemia (APL) has been ascribed to a chromosomal translocation event which results in a fusion protein comprising the PML protein and the retinoic acid receptor alpha. PML is...
De, A, Brown, D G, Gorman, M A, Carr, M, Sanderson, M R, Freemont, P S
Porcine pancreatic spasmolytic polypeptide (PSP) belongs to a large family of homologous growth factor-like polypeptides characterized by a disulfide-linked "trefoil motif," duplicated and conserved...
Microcrystals of the beta 1 isoenzyme of protein kinase C: an electron microscopic study.
Newman, R H, Carpenter, E, Freemont, P S, Blundell, T L, Parker, P J
Microcrystals of protein kinase C beta 1 have been grown from solutions of poly(ethylene glycol). Image analysis of electron micrographs of the protein crystals, which diffracted to 5.0 nm, revealed...
The complete amino acid sequence of human skeletal-muscle fructose-bisphosphate aldolase.
Freemont, P S, Dunbar, B, Fothergill-Gilmore, L A
The complete amino acid sequence of human skeletal-muscle fructose-bisphosphate aldolase, comprising 363 residues, was determined. The sequence was deduced by automated sequencing of CNBr-cleavage,...
The predicted secondary structures of class I fructose-bisphosphate aldolases.
Sawyer, L, Fothergill-Gilmore, L A, Freemont, P S
The results of several secondary-structure prediction programs were combined to produce an estimate of the regions of alpha-helix, beta-sheet and reverse turns for fructose-bisphosphate aldolases...
Gorman, M A, Morera, S, Rothwell, D G, De La Fortelle, E, Mol, C D, Tainer, J A, ...
The structure of the major human apurinic/ apyrimidinic endonuclease (HAP1) has been solved at 2.2 A resolution. The enzyme consists of two symmetrically related domains of similar topology and has...
Structure of an XRCC1 BRCT domain: a new protein-protein interaction module.
Zhang, X, Moréra, S, Bates, P A, Whitehead, P C, Coffer, A I, Hainbucher, K, ...
The BRCT domain (BRCA1 C-terminus), first identified in the breast cancer suppressor protein BRCA1, is an evolutionarily conserved protein-protein interaction region of approximately 95 amino acids...