HOUSTON, T.E., MUTTER, L.C., BLANKE, R.V., GUZELIAN, P.S.
Chlordecone Alcohol Formation in the Mongolian Gerbil (Meriones unguiculatus): A Model for Human Metabolism of Chlordecone (Kepone). Houston, T.E., Mutter, L.C., Blanke, R.V. and Guzelian, P.S....
Burger, H J, Schuetz, J D, Schuetz, E G, Guzelian, P S
The family 3A cytochromes P-450, among the most abundant members of this supergene family of microsomal hemoproteins expressed in animal and human liver, are inducible by glucocorticoids but also by...
Aoyama, T, Yamano, S, Guzelian, P S, Gelboin, H V, Gonzalez, F J
Twelve forms of human hepatic cytochrome P450 were expressed in hepatoma cells by means of recombinant vaccinia viruses. The expressed P450s were analyzed for their abilities to activate the potent...
In vitro effect of fluoroquinolones on theophylline metabolism in human liver microsomes.
Sarkar, M, Polk, R E, Guzelian, P S, Hunt, C, Karnes, H T
Some quinolone antibiotics cause increases in levels of theophylline in plasma that lead to serious adverse effects. We investigated the mechanism of this interaction by developing an in vitro system...
Guzelian, P S, Li, D, Schuetz, E G, Thomas, P, Levin, W, Mode, A, ...
Results of studies of hypophysectomized rats suggest that growth hormone serves as a final common mediator through which gonadal steroids and other modifiers of pituitary function alter the...
Identification of the fetal liver cytochrome CYP3A7 in human endometrium and placenta.
Schuetz, J D, Kauma, S, Guzelian, P S
Placenta and endometrium carry out steroidogenic biotransformation reactions such as 6-beta-hydroxylation of cortisol, a reaction characteristic of the dominant family of cytochromes P450 in human...
Watkins, P B, Murray, S A, Winkelman, L G, Heuman, D M, Wrighton, S A, Guzelian, P S
The major P-450IIIA gene family member present in human liver is HLp which, like its rat liver orthologue P-450p, is inducible by glucocorticoids and catalyzes erythromycin N-demethylation. To...
Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver.
Molowa, D T, Schuetz, E G, Wrighton, S A, Watkins, P B, Kremers, P, Mendez-Picon, G, ...
HLp is a human liver cytochrome P-450 that is immunochemically related to the glucocorticoid-inducible liver cytochrome P-450p in the rat and its homologue in the rabbit, P-450 LM3c. To investigate...
Primary monolayer cultures of nonproliferating parenchymal cells prepared from adult rat liver and maintained in serum-free medium responded to additions of phenobarbital with concentration-dependent...
The conversion of endogenous hepatic heme to bilirubin and CO is established. However, it is unknown whether this process is quantitative or whether heme may be degraded to other products as well. To...
Identification of an inducible form of cytochrome P-450 in human liver.
Watkins, P B, Wrighton, S A, Maurel, P, Schuetz, E G, Mendez-Picon, G, Parker, G A, ...
It has not yet been determined whether human liver contains inducible cytochromes P-450 similar to those that catalyze the oxidative metabolism of foreign substances in animals. We carried out...
Wrighton, S A, Thomas, P E, Willis, P, Maines, S L, Watkins, P B, Levin, W, ...
Among characterized forms of liver microsomal cytochromes P-450 in rats are four related isozymes (P-450f-i) notable for their lack of inducibility. Immunoblot analyses demonstrated that human livers...
Watkins, P B, Wrighton, S A, Schuetz, E G, Molowa, D T, Guzelian, P S
We used monoclonal antibodies and complementary DNAs (cDNAs) to glucocorticoid-inducible liver cytochromes P-450 in rats (P-450p) and in man (HLp) to search for related cytochromes in intestinal...
Immunochemical evidence for multiple steroid-inducible hepatic cytochromes P-450 in the rat.
Hostetler, K A, Wrighton, S A, Kremers, P, Guzelian, P S
It has been established that there are glucocorticoid-inducible hepatic cytochromes P-450 in the rat (P-450p), the rabbit (LM3c) and man (HLp) which share extensive structural, functional and...
Science funding. The National Advisory Environmental Health Sciences Council.
Barfield, N C, Buffler, P A, Graham, D G, Gray-Little, B, Greenberger, P, Guzelian, P S, ...
Clinical evaluation of liver structure and function in humans exposed to halogenated hydrocarbons.
An unresolved question is whether humans exposed to comparatively low doses of persistent environmental chemicals such as polyhalogenated biphenyls or organochlorine pesticides are at risk for injury...
Research needs for hepatic injury due to environmental agents.
This report presents an overview of the patterns of liver injury produced by presently recognized toxic substances in the environment. Current concepts of the metabolic disposition of these...
Burger, H J, Schuetz, J D, Schuetz, E G, Guzelian, P S
The family 3A cytochromes P-450, among the most abundant members of this supergene family of microsomal hemoproteins expressed in animal and human liver, are inducible by glucocorticoids but also by...
Aoyama, T, Yamano, S, Guzelian, P S, Gelboin, H V, Gonzalez, F J
Twelve forms of human hepatic cytochrome P450 were expressed in hepatoma cells by means of recombinant vaccinia viruses. The expressed P450s were analyzed for their abilities to activate the potent...
In vitro effect of fluoroquinolones on theophylline metabolism in human liver microsomes.
Sarkar, M, Polk, R E, Guzelian, P S, Hunt, C, Karnes, H T
Some quinolone antibiotics cause increases in levels of theophylline in plasma that lead to serious adverse effects. We investigated the mechanism of this interaction by developing an in vitro system...
Guzelian, P S, Li, D, Schuetz, E G, Thomas, P, Levin, W, Mode, A, ...
Results of studies of hypophysectomized rats suggest that growth hormone serves as a final common mediator through which gonadal steroids and other modifiers of pituitary function alter the...
Identification of the fetal liver cytochrome CYP3A7 in human endometrium and placenta.
Schuetz, J D, Kauma, S, Guzelian, P S
Placenta and endometrium carry out steroidogenic biotransformation reactions such as 6-beta-hydroxylation of cortisol, a reaction characteristic of the dominant family of cytochromes P450 in human...
Watkins, P B, Murray, S A, Winkelman, L G, Heuman, D M, Wrighton, S A, Guzelian, P S
The major P-450IIIA gene family member present in human liver is HLp which, like its rat liver orthologue P-450p, is inducible by glucocorticoids and catalyzes erythromycin N-demethylation. To...
Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver.
Molowa, D T, Schuetz, E G, Wrighton, S A, Watkins, P B, Kremers, P, Mendez-Picon, G, ...
HLp is a human liver cytochrome P-450 that is immunochemically related to the glucocorticoid-inducible liver cytochrome P-450p in the rat and its homologue in the rabbit, P-450 LM3c. To investigate...
Primary monolayer cultures of nonproliferating parenchymal cells prepared from adult rat liver and maintained in serum-free medium responded to additions of phenobarbital with concentration-dependent...
The conversion of endogenous hepatic heme to bilirubin and CO is established. However, it is unknown whether this process is quantitative or whether heme may be degraded to other products as well. To...
Identification of an inducible form of cytochrome P-450 in human liver.
Watkins, P B, Wrighton, S A, Maurel, P, Schuetz, E G, Mendez-Picon, G, Parker, G A, ...
It has not yet been determined whether human liver contains inducible cytochromes P-450 similar to those that catalyze the oxidative metabolism of foreign substances in animals. We carried out...
Wrighton, S A, Thomas, P E, Willis, P, Maines, S L, Watkins, P B, Levin, W, ...
Among characterized forms of liver microsomal cytochromes P-450 in rats are four related isozymes (P-450f-i) notable for their lack of inducibility. Immunoblot analyses demonstrated that human livers...
Watkins, P B, Wrighton, S A, Schuetz, E G, Molowa, D T, Guzelian, P S
We used monoclonal antibodies and complementary DNAs (cDNAs) to glucocorticoid-inducible liver cytochromes P-450 in rats (P-450p) and in man (HLp) to search for related cytochromes in intestinal...
Immunochemical evidence for multiple steroid-inducible hepatic cytochromes P-450 in the rat.
Hostetler, K A, Wrighton, S A, Kremers, P, Guzelian, P S
It has been established that there are glucocorticoid-inducible hepatic cytochromes P-450 in the rat (P-450p), the rabbit (LM3c) and man (HLp) which share extensive structural, functional and...
Science funding. The National Advisory Environmental Health Sciences Council.
Barfield, N C, Buffler, P A, Graham, D G, Gray-Little, B, Greenberger, P, Guzelian, P S, ...
Clinical evaluation of liver structure and function in humans exposed to halogenated hydrocarbons.
An unresolved question is whether humans exposed to comparatively low doses of persistent environmental chemicals such as polyhalogenated biphenyls or organochlorine pesticides are at risk for injury...
Research needs for hepatic injury due to environmental agents.
This report presents an overview of the patterns of liver injury produced by presently recognized toxic substances in the environment. Current concepts of the metabolic disposition of these...