Spread of ragweed plants and ragweed sensitisation in the Netherlands (2008)
Weger, L.A., Linden, A.C., Terreehorst, I., Slikke, W.J., Hiemstra, P.S.
Urinary Eosinophil Protein X in Children with Atopic Asthma (2007)
M. Nuijsink, P. J. Sterk, E. J. Duiverman, P. S. Hiemstra
The aim of this study was to investigate the relationship between urinary eosinophil protein X (uEPX) and asthma symptoms, lung function, and other markers of eosinophilic airway inflammation in...
Urinary Eosinophil Protein X in Children with Atopic Asthma (2007)
M. Nuijsink, P. J. Sterk, E. J. Duiverman, P. S. Hiemstra
The aim of this study was to investigate the relationship between urinary eosinophil protein X (uEPX) and asthma symptoms, lung function, and other markers of eosinophilic airway inflammation in...
Sequential migration of neutrophils across monolayers of endothelial and epithelial cells (2000)
Mul, F.P.J., Zuurbier, A.E.M., Janssen, H., Calafat, J., Wetering, S. Van, Hiemstra, P.S., ...
Asthma severity and susceptibility to air pollution. (1998)
Hilterman, T.J.N., Stolk, J., Brunekreef, B., Fischer, P.H., ...
Activation of factor B of the complement system by kallikrein and its light chain (1985)
Hiemstra, P.S., Daha, M.R., Bouma, B.N.
The cleavage of factor B, a protein of the alternative pathway of complement, by kallikrein was studied. Like factor D, kallikrein can cleave B to generate the alternative pathway C3 convertase...
Visser, L G, Hiemstra, P S, Van Den Barselaar, M T, Ballieux, P A, Van Furth, R
The virulence plasmid pYVe of Yersinia enterocolitica codes for the production of the outer membrane protein YadA and the secretion of several proteins, called Yops, which may protect this bacterium...
Antibacterial activity of antileukoprotease.
Hiemstra, P S, Maassen, R J, Stolk, J, Heinzel-Wieland, R, Steffens, G J, Dijkman, J H
Antileukoprotease (ALP), or secretory leukocyte proteinase inhibitor, is an endogenous inhibitor of serine proteinases that is present in various external secretions. ALP, one of the major inhibitors...
Hiemstra, P S, Annema, A, Schippers, E F, Van Furth, R
The aim of the present study was to determine whether pertussis toxin (PT)-sensitive GTP-binding proteins (G proteins) are involved in the signal transduction pathway(s) used for phagocytosis and...
Antimicrobial proteins of murine macrophages.
Hiemstra, P S, Eisenhauer, P B, Harwig, S S, Van Den Barselaar, M T, Van Furth, R, Lehrer, R I
Three murine microbicidal proteins (MUMPs) were purified from cells of the murine macrophage cell line RAW264.7 that had been activated by gamma interferon. Similar proteins were also present in...
Complete and partial deficiencies of complement factor D in a Dutch family.
Hiemstra, P S, Langeler, E, Compier, B, Keepers, Y, Leijh, P C, Van Den Barselaar, M T, ...
A young man suffering from recurrent Neisseria infections was shown to lack detectable serum complement factor D hemolytic activity. Addition to the patient's serum of purified factor D to a final...
Welling, M M, Hiemstra, P S, Van Den Barselaar, M T, Paulusma-Annema, A, Nibbering, P H, Pauwels, E K, ...
Neutrophil defensins (or human neutrophil peptides-HNP) are major constituents of the azurophilic granules of human neutrophils and have been shown to display broad-spectrum antimicrobial activity....
Visser, L G, Hiemstra, P S, Van Den Barselaar, M T, Ballieux, P A, Van Furth, R
The virulence plasmid pYVe of Yersinia enterocolitica codes for the production of the outer membrane protein YadA and the secretion of several proteins, called Yops, which may protect this bacterium...
Antibacterial activity of antileukoprotease.
Hiemstra, P S, Maassen, R J, Stolk, J, Heinzel-Wieland, R, Steffens, G J, Dijkman, J H
Antileukoprotease (ALP), or secretory leukocyte proteinase inhibitor, is an endogenous inhibitor of serine proteinases that is present in various external secretions. ALP, one of the major inhibitors...
Hiemstra, P S, Annema, A, Schippers, E F, Van Furth, R
The aim of the present study was to determine whether pertussis toxin (PT)-sensitive GTP-binding proteins (G proteins) are involved in the signal transduction pathway(s) used for phagocytosis and...
Antimicrobial proteins of murine macrophages.
Hiemstra, P S, Eisenhauer, P B, Harwig, S S, Van Den Barselaar, M T, Van Furth, R, Lehrer, R I
Three murine microbicidal proteins (MUMPs) were purified from cells of the murine macrophage cell line RAW264.7 that had been activated by gamma interferon. Similar proteins were also present in...
Complete and partial deficiencies of complement factor D in a Dutch family.
Hiemstra, P S, Langeler, E, Compier, B, Keepers, Y, Leijh, P C, Van Den Barselaar, M T, ...
A young man suffering from recurrent Neisseria infections was shown to lack detectable serum complement factor D hemolytic activity. Addition to the patient's serum of purified factor D to a final...
Welling, M M, Hiemstra, P S, Van Den Barselaar, M T, Paulusma-Annema, A, Nibbering, P H, Pauwels, E K, ...
Neutrophil defensins (or human neutrophil peptides-HNP) are major constituents of the azurophilic granules of human neutrophils and have been shown to display broad-spectrum antimicrobial activity....
Binding of human IgA1 to rat peritoneal macrophages.
Gorter, A, Hiemstra, P S, Van Der Voort, E A, Van Es, L A, Daha, M R
In the present study we have investigated whether bovine erythrocytes (Eb) specifically sensitized with human polyclonal IgA1 (Eb-IgA1) are able to bind to resident adherent rat peritoneal cells (PM...
Gorter, A, Hiemstra, P S, Klar-Mohamad, N, Van Es, L A, Daha, M R
In the present study the in vitro binding, internalization and degradation of IgA immune complexes (IC) by phagocytes was studied. As a model for IgA IC, heat-aggregated human secretory IgA (AsIgA)...
Complement-mediated enhancement of IgA-induced H2O2 release by human polymorphonuclear leucocytes.
Gorter, A, Hiemstra, P S, Leijh, P C, Van Der Sluys, M E, Van Den Barselaar, M T, Van Es, L A, ...
In a previous study we have demonstrated that heat-killed Staphylococcus aureus opsonized with either purified human serum IgA or secretory IgA (sIgA) can induce a respiratory burst (measured as H2O2...
Gorter, A, Hiemstra, P S, Leijh, P C, Van Der Sluys, M E, Van Den Barselaar, M T, Van Es, L A, ...
The aim of the present study was to investigate whether corpuscular immune complexes containing human IgA were able to interact with human polymorphonuclear leucocytes (PMN). As a model for...
Chronic obstructive pulmonary disease: role of bronchiolar mast cells and macrophages.
Grashoff, W. F., Sont, J. K., Sterk, P. J., Hiemstra, P. S., De Boer, W. I., Stolk, J., ...
Chronic obstructive pulmonary disease (COPD) is considered to be caused in part by smoking-induced inflammation, but it is unknown which inflammatory cells within the small airways are associated...
Anti-endothelial cell antibodies in patients with rheumatoid arthritis complicated by vasculitis.
Heurkens, A H, Hiemstra, P S, Lafeber, G J, Daha, M R, Breedveld, F C
IgG antibodies reactive with human umbilical vein endothelial cells were found in 19 out of 28 patients with rheumatoid vasculitis (RV), in four out of 24 patients with rheumatoid arthritis (RA), in...
Serum levels and in vitro production of IgA subclasses in patients with primary IgA nephropathy.
Daha, M R, Hiemstra, P S, Radl, J, Van Es, L A
Patients with primary IgA nephropathy have deposits of IgA1 in their kidneys, and increased plasma levels of macromolecular IgA1. Total serum IgA concentrations are frequently elevated, but studies...
Cytokine release and its modulation by dexamethasone in whole blood following exercise
Smits, H H, Grünberg, K, Derijk, R H, Sterk, P J, Hiemstra, P S
Glucocorticoids (GC) play an important role in the treatment of inflammatory diseases like asthma. However, in selected patients a relative resistance to GC has been reported. Recently, it has been...
Urinary Eosinophil Protein X in Children with Atopic Asthma
Nuijsink, M., Hop, W. C. J., Sterk, P. J., Duiverman, E. J., Hiemstra, P. S., De Jongste, J. C.
The aim of this study was to investigate the relationship between urinary eosinophil protein X (uEPX) and asthma symptoms, lung function, and other markers of eosinophilic airway inflammation in...
Regulation and production of IL-8 by human proximal tubular epithelial cells in vitro
GERRITSMA, J S J, HIEMSTRA, P S, GERRITSEN, A F, PRODJOSUDJADI, W, VERWEIJ, C L, VAN ES, L A, ...
A number of inflammatory kidney diseases are associated with interstitial nephritis and influx of leucocytes in the renal interstitium. Potentially the influx of neutrophils in the interstitium may...