P. Samoggia

Coordinate expression and proliferative role of HOXB genes in activated adult T lymphocytes.

Carè, A, Testa, U, Bassani, A, Tritarelli, E, Montesoro, E, Samoggia, P, ...

We investigated the expression of HOXB cluster genes in purified phytohemagglutinin (PHA)-activated T lymphocytes from normal adult peripheral blood by reverse transcription PCR and RNase protection....

Effects on differentiation by the promyelocytic leukemia PML/RARalpha protein depend on the fusion of the PML protein dimerization and RARalpha DNA binding domains.

Grignani, F, Testa, U, Rogaia, D, Ferrucci, P F, Samoggia, P, Pinto, A, ...

The block of terminal differentiation is a prominent feature of acute promyelocytic leukemia (APL) and its release by retinoic acid correlates with disease remission. Expression of the APL-specific...

The PML/RARalpha fusion protein inhibits tumor necrosis factor-alpha-induced apoptosis in U937 cells and acute promyelocytic leukemia blasts.

Testa, U, Grignani, F, Samoggia, P, Zanetti, C, Riccioni, R, Lo Coco, F, ...

We investigated the effect of the acute promyelocytic leukemia (APL) specific PML/RARalpha fusion protein on the sensitivity to TNF-alpha-mediated apoptosis. The U937 leukemia cell line was...

Coordinate expression and proliferative role of HOXB genes in activated adult T lymphocytes.

Carè, A, Testa, U, Bassani, A, Tritarelli, E, Montesoro, E, Samoggia, P, ...

We investigated the expression of HOXB cluster genes in purified phytohemagglutinin (PHA)-activated T lymphocytes from normal adult peripheral blood by reverse transcription PCR and RNase protection....

Effects on differentiation by the promyelocytic leukemia PML/RARalpha protein depend on the fusion of the PML protein dimerization and RARalpha DNA binding domains.

Grignani, F, Testa, U, Rogaia, D, Ferrucci, P F, Samoggia, P, Pinto, A, ...

The block of terminal differentiation is a prominent feature of acute promyelocytic leukemia (APL) and its release by retinoic acid correlates with disease remission. Expression of the APL-specific...

The PML/RARalpha fusion protein inhibits tumor necrosis factor-alpha-induced apoptosis in U937 cells and acute promyelocytic leukemia blasts.

Testa, U, Grignani, F, Samoggia, P, Zanetti, C, Riccioni, R, Lo Coco, F, ...

We investigated the effect of the acute promyelocytic leukemia (APL) specific PML/RARalpha fusion protein on the sensitivity to TNF-alpha-mediated apoptosis. The U937 leukemia cell line was...

Mechanisms underlying T-lymphocyte activation: mitogen initiates and IL-2 amplifies the expression of transferrin receptors via intracellular iron level.

Pelosi-Testa, E, Samoggia, P, Giannella, G, Montesoro, E, Caravita, T, Salvo, G, ...

Peripheral blood mononuclear cells (PBM) pulsed with lectin (PHA or Con A for 0.25-3 hr) show a low expression of interleukin-2 and transferrin receptors (IL-2Rs, TfRs) and a mild decline of...

Activation and proliferation of normal resting human T lymphocytes in serum-free culture: role of IL-4 and IL-6

Habetswallner, D., Pelosi, E., Bulgarini, D., Camagna, A., Samoggia, P., Montesoro, E., ...

Purified human T lymphocytes, completely depleted of accessory cells [i.e. monocytes, large granular lymphocytes (LGL) and B lymphocytes], have been grown in serum-free culture in presence of a...