Serotonin receptor cDNA cloned from Lymnaea stagnalis.
Sugamori, K S, Sunahara, R K, Guan, H C, Bulloch, A G, Tensen, C P, Seeman, P, ...
Serotonin (5-HT) is a major neurotransmitter that influences various behaviors, neuronal plasticity, learning, and memory in molluscs. Although the physiology of 5-HT transmission in molluscs is well...
A human serotonin 1D receptor variant (5HT1D beta) encoded by an intronless gene on chromosome 6.
Demchyshyn, L, Sunahara, R K, Miller, K, Teitler, M, Hoffman, B J, Kennedy, J L, ...
An intronless gene encoding a serotonin receptor (5HT1D beta) has been cloned and functionally expressed in mammalian fibroblast cultures. Based on the deduced amino acid sequence, the gene encodes a...
D1 and D2 dopamine receptor mRNA in rat brain.
Weiner, D M, Levey, A I, Sunahara, R K, Niznik, H B, O'Dowd, B F, Seeman, P, ...
Physiological and pharmacological criteria have divided dopamine receptors into D1 and D2 subtypes, and genes encoding these subtypes have recently been cloned. Based on the sequences of the cloned...
Link between D1 and D2 dopamine receptors is reduced in schizophrenia and Huntington diseased brain.
Seeman, P, Niznik, H B, Guan, H C, Booth, G, Ulpian, C
Dopamine receptor types D1 and D2 can oppose or enhance each other's actions for electrical, biochemical, and psychomotor effects. We report a D1-D2 interaction in homogenized tissue as revealed by...
A procedure was developed to identify receptors for dopamine and serotonin separately and selectively by means of [3H]spiperone and to measure the density of each receptor in different regions of the...
Brain receptors for antipsychotic drugs and dopamine: direct binding assays.
Seeman, P, Chau-Wong, M, Tedesco, J, Wong, K
In order to test the suggestion that antipsychotic drugs act by blocking dopamine receptors in the brain, the direct effects of such neuroleptic drugs were tested on the stereospecific binding of...
Because it was known that [3H]dihydroergocryptine can label α-adrenergic receptors as well as dopamine receptors, this study was done to establish the conditions under which [3H]dihydroergocryptine...
Selective labeling of serotonin receptors by d-[3H]lysergic acid diethylamide in calf caudate.
Since it was known that d-lysergic acid diethylamide (LSD) affected catecholaminergic as well as serotoninergic neurons, the objective in this study was to enhance the selectivity of [3H]LSD binding...
Multiple receptors for brain dopamine.
Titeler, M, Weinreich, P, Sinclair, D, Seeman, P
This study was done to obtain direct in vitro evidence for the possible existence of more than one type of dopaminergic binding site in homogenates of the caudate nucleus from calf brain. Five...
Dopamine receptors in human and calf brains, using [3H]apomorphine and an antipsychotic drug.
Seeman, P, Chau-Wong, M, Tedesco, J, Wong, K
In order to develop a better dopamine receptor radioligand, [3H[apomorphine was prepared and tested for dopamine-like binding properties in both calf and human brain tissues. Specific binding of...
New detection of brain dopamine receptors with (3H)dihydroergocryptine.
Tittler, M, Weinreich, P, Seeman, P
Because dihydroergocryptine (DHE) and closely related ergots are dopamine-mimetic agonists, we tested [3H]DHE as a possible ligand for [3H]dopamine receptors in the calf caudate. In order to avoid...
The human serotonin-7 receptor pseudogene: variation and chromosome location.
Nam, D, Qian, I H, Kusumi, I, Ulpian, C, Tallerico, T, Liu, I S, ...
We report a variation of the pseudogene for the serotonin-7 receptor in human DNA. Human genomic DNA was amplified, using the polymerase chain reaction method and degenerate oligonucleotide primers...
RATIONALE AND OBJECTIVE: While the blockade of dopamine D2 receptors are necessary for antipsychotic action, antipsychotic agents differ nearly a thousand-fold in their affinity for the D2 receptor....
Serotonin receptor cDNA cloned from Lymnaea stagnalis.
Sugamori, K S, Sunahara, R K, Guan, H C, Bulloch, A G, Tensen, C P, Seeman, P, ...
Serotonin (5-HT) is a major neurotransmitter that influences various behaviors, neuronal plasticity, learning, and memory in molluscs. Although the physiology of 5-HT transmission in molluscs is well...
A human serotonin 1D receptor variant (5HT1D beta) encoded by an intronless gene on chromosome 6.
Demchyshyn, L, Sunahara, R K, Miller, K, Teitler, M, Hoffman, B J, Kennedy, J L, ...
An intronless gene encoding a serotonin receptor (5HT1D beta) has been cloned and functionally expressed in mammalian fibroblast cultures. Based on the deduced amino acid sequence, the gene encodes a...
D1 and D2 dopamine receptor mRNA in rat brain.
Weiner, D M, Levey, A I, Sunahara, R K, Niznik, H B, O'Dowd, B F, Seeman, P, ...
Physiological and pharmacological criteria have divided dopamine receptors into D1 and D2 subtypes, and genes encoding these subtypes have recently been cloned. Based on the sequences of the cloned...
Link between D1 and D2 dopamine receptors is reduced in schizophrenia and Huntington diseased brain.
Seeman, P, Niznik, H B, Guan, H C, Booth, G, Ulpian, C
Dopamine receptor types D1 and D2 can oppose or enhance each other's actions for electrical, biochemical, and psychomotor effects. We report a D1-D2 interaction in homogenized tissue as revealed by...
A procedure was developed to identify receptors for dopamine and serotonin separately and selectively by means of [3H]spiperone and to measure the density of each receptor in different regions of the...
Brain receptors for antipsychotic drugs and dopamine: direct binding assays.
Seeman, P, Chau-Wong, M, Tedesco, J, Wong, K
In order to test the suggestion that antipsychotic drugs act by blocking dopamine receptors in the brain, the direct effects of such neuroleptic drugs were tested on the stereospecific binding of...
Because it was known that [3H]dihydroergocryptine can label α-adrenergic receptors as well as dopamine receptors, this study was done to establish the conditions under which [3H]dihydroergocryptine...
Selective labeling of serotonin receptors by d-[3H]lysergic acid diethylamide in calf caudate.
Since it was known that d-lysergic acid diethylamide (LSD) affected catecholaminergic as well as serotoninergic neurons, the objective in this study was to enhance the selectivity of [3H]LSD binding...
Multiple receptors for brain dopamine.
Titeler, M, Weinreich, P, Sinclair, D, Seeman, P
This study was done to obtain direct in vitro evidence for the possible existence of more than one type of dopaminergic binding site in homogenates of the caudate nucleus from calf brain. Five...
Dopamine receptors in human and calf brains, using [3H]apomorphine and an antipsychotic drug.
Seeman, P, Chau-Wong, M, Tedesco, J, Wong, K
In order to develop a better dopamine receptor radioligand, [3H[apomorphine was prepared and tested for dopamine-like binding properties in both calf and human brain tissues. Specific binding of...
New detection of brain dopamine receptors with (3H)dihydroergocryptine.
Tittler, M, Weinreich, P, Seeman, P
Because dihydroergocryptine (DHE) and closely related ergots are dopamine-mimetic agonists, we tested [3H]DHE as a possible ligand for [3H]dopamine receptors in the calf caudate. In order to avoid...
The human serotonin-7 receptor pseudogene: variation and chromosome location.
Nam, D, Qian, I H, Kusumi, I, Ulpian, C, Tallerico, T, Liu, I S, ...
We report a variation of the pseudogene for the serotonin-7 receptor in human DNA. Human genomic DNA was amplified, using the polymerase chain reaction method and degenerate oligonucleotide primers...
RATIONALE AND OBJECTIVE: While the blockade of dopamine D2 receptors are necessary for antipsychotic action, antipsychotic agents differ nearly a thousand-fold in their affinity for the D2 receptor....
MEMBRANE LESIONS IN IMMUNE LYSIS : Surface Rings, Globule Aggregates, and Transient Openings
Iles, G. H., Seeman, P., Naylor, D., Cinader, B.
It is known that there are 100 Å-wide circular structures associated with the erythrocyte membrane in immune lysis. To determine whether these structures were functional holes extending through the...
STRUCTURE OF MEMBRANE HOLES IN OSMOTIC AND SAPONIN HEMOLYSIS
Seeman, P., Cheng, D., Iles, G. H.
Serial section electron microscopy of hemolysing erythrocytes (fixed at 12 s after the onset of osmotic hemolysis) revealed long slits and holes in the membrane, extending to around 1 µm in length....