IFN-β for the treatment of rheumatoid arthritis? (2003)
Tak, P, Holten, J Van, Reedquist, K, Sattonet-Roche, P, Smeets, T, Vervoordeldonk, M, ...
No abstract available.
Search for the precursor of ectopic follicular dendritic cells (2003)
Groot, C De, Groot, C De, Muller, F, Haringman, J, Tak, P
No abstract available.
Stahl, H., Hubner, B., Seidl, B., Liebert, U., Van Der Heijden, I. M, Wilbrink, B., ...
OBJECTIVE—Viruses have a role in the pathogenesis of various forms of arthritis. This study aimed at determining whether viral DNA can be detected in joint samples in the early stages of idiopathic...
Verschueren, P., Voskuyl, A., Smeets, T, Zwinderman, K., Breedveld, F., Tak, P.
OBJECTIVE—Histological analysis of random quadriceps muscle biopsy specimens can be used to detect vasculitis in patients with rheumatoid arthritis (RA). This study aimed at determining the...
Kraan, M, Smith, M, Weedon, H, Ahern, M, Breedveld, F, Tak, P
OBJECTIVE—Digital image analysis (DIA) offers the opportunity to quantify the stained area and staining intensity when synovial tissue (ST) is investigated by immunohistochemical analysis. This...
Smeets, T, Kraan, M, Galjaard, S, Youssef, P, Smith, M, Tak, P
OBJECTIVES—Examination of synovial tissue (ST) obtained at surgery because of end stage destructive rheumatoid arthritis (RA) showed that macrophages and fibroblasts are the major cell types at the...
Crotti, T, Smith, M, Weedon, H, Ahern, M, Findlay, D, Kraan, M, ...
Objectives: To compare receptor activator of NF-κB ligand (RANKL) production in the synovial tissue from patients with active rheumatoid arthritis (RA), inactive RA, spondyloarthropathies (SpA),...
Smith, M, Barg, E, Weedon, H, Papengelis, V, Smeets, T, Tak, P, ...
Background: Synovial biopsies are used to study synovial immunopathology and are increasingly applied for the evaluation of new therapeutic strategies in chronic arthritis. Therefore, it is essential...
Smeets, T, Barg, E, Kraan, M, Smith, M, Breedveld, F, Tak, P
Background: Synovial tissue (ST) from end stage destructive rheumatoid arthritis (RA) and arthroscopic biopsies obtained during active inflammation might exhibit different characteristics.
Haringman, J, Kraan, M, Smeets, T, Zwinderman, K, Tak, P
Background: Chemokines and their receptors are considered important contributors in cell migration and inflammation in chronic inflammatory disorders. Chemokines affecting monocytes/macrophages are...
Activation of the STAT1 pathway in rheumatoid arthritis
Kasperkovitz, P, Verbeet, N, Smeets, T, Van Rietschoten, J G I, Kraan, M, Van Der Pouw, Kraa... T C T M, ...
Background: Expression of signal transducer and activator of transcription 1 (STAT1), the mediator of interferon (IFN) signalling, is raised in synovial tissue (ST) from patients with rheumatoid...
Kraan, M, Haringman, J, Weedon, H, Barg, E, Smith, M, Ahern, M, ...
Objective: To determine immunohistological markers in synovial tissue of patients with early rheumatoid arthritis (RA) which are associated with unfavourable disease outcome.
Goedkoop, A, Kraan, M, Teunissen, M, Picavet, D, De Rie, M A, Bos, J, ...
Background: Tumour necrosis factor α (TNFα) blockade using infliximab, a chimeric anti-TNFα antibody, is an effective treatment for both psoriasis and psoriatic arthritis (PsA).
Differential effects of leflunomide and methotrexate on cytokine production in rheumatoid arthritis
Kraan, M, Smeets, T, Van Loon, M J, Breedveld, F, Dijkmans, B, Tak, P
Background: T cells have a pivotal role in RA. Leflunomide inhibits pyrimidine biosynthesis, to which T cells are especially susceptible, and therefore may have a different cytokine profile than...
Van Holten, J, Pavelka, K, Vencovsky, J, Stahl, H, Rozman, B, Genovese, M, ...
Objective: To assess the efficacy of interferon beta (IFNß) in combination with methotrexate in treatment of patients with rheumatoid arthritis.
Tumour necrosis factor α blockade in treatment resistant pigmented villonodular synovitis
Kroot, E, Kraan, M, Smeets, T, Maas, M, Tak, P, Wouters, J
Case report: A patient presented with severe treatment resistant PVNS of the right knee joint. Several conventional treatment regimens, including open surgical synovectomy and intra-articular...
Van Mello, N M, Pillemer, S, Tak, P, Sankar, V
Conclusion: This report underlines the advantages of performing LSG biopsies as a routine part of screening for SS, and shows that it may in some instances lead to early diagnosis of MALT lymphomas...
Discussion: Assessment of psoriatic arthritis
Mease, P, Behrens, F, Boehncke, W, Feldman, S, FitzGerald, O, Gladman, D, ...
Goldbach-Mansky, R, Suson, S, Wesley, R, Hack, C, El-Gabalawy, H, Tak, P
Background: Raised granzyme B in serum and synovium of patients with rheumatoid arthritis suggests a role for cytotoxic T cells and natural killer cells in the pathogenesis of this disease.
Wolbink, G, Voskuyl, A, Lems, W, De Groot, E, Nurmohamed, M, Tak, P, ...
Objective: To investigate the relationship between serum trough infliximab levels and clinical response to infliximab treatment in patients with rheumatoid arthritis (RA).
Haringman, J, Gerlag, D, Zwinderman, A, Smeets, T, Kraan, M, Baeten, D, ...
Background: Previous work identified synovial sublining macrophage numbers as a potential biomarker for clinical efficacy in rheumatoid arthritis.